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Utilizing Precision Technologies To Validate A Real-Time Location System For Dairy Cattle And Monitor Calf Behaviors During Heat Stress, Emily Rice Jan 2023

Utilizing Precision Technologies To Validate A Real-Time Location System For Dairy Cattle And Monitor Calf Behaviors During Heat Stress, Emily Rice

Theses and Dissertations--Animal and Food Sciences

With the increase in on-farm precision dairy technologies (PDT) utilization, large quantities of information are readily available to producers. A more recently available technology for use in livestock species is the real-time location system. These technologies offer dairy producers the opportunity to monitor and track real-time locations of cows, track locomotion patterns, and summarize specific area usage. However, the usefulness of these insights is heavily dependent on the performance of the technology. Therefore, the first objective of this dissertation was to assess the positioning recording performance and the usefulness of the data recorded of a real-time location system (Smartbow GmbH; …


Interface: Technology & Portraiture, Mullins Sydney Jan 2023

Interface: Technology & Portraiture, Mullins Sydney

Graduate Thesis Exhibition Catalogue Gallery, 2023

In Interface, five Kentucky-area artists explore a new language of representation with the aid of digital tools like Artificial Intelligence (AI) and Automatic Facial Recognition Software (AFR). Some artists use algorithms to alter celebrity faces beyond recognition, others feed data sets of existing art to AI models in an attempt to generate portraits of no one in particular. Others still create tools for understanding the very act of facial recognition or obfuscation. All have one thing in common: they wish to stretch the limits of and critique the genre of portraiture, as well as to cause viewers to question …


A Process Intensification Approach To Improve Volatile Fatty Acids Production, Extraction, And Valorization, Can Liu Jan 2023

A Process Intensification Approach To Improve Volatile Fatty Acids Production, Extraction, And Valorization, Can Liu

Theses and Dissertations--Biosystems and Agricultural Engineering

Anaerobic digestion (AD) is a widely used biowaste conversion method. Recent studies have explored arrested methanogenesis as an alternative approach to leverage existing AD facilities and produce volatile fatty acids (VFAs) instead of biogas. VFAs have been recognized as precursors for a range of value-added chemicals and bioproducts. Arrested methanogenesis involves inducing acidic fermentation by halting the AD process before methanogenesis. It has been found that higher organic loading and thermophilic conditions enhance VFA accumulation and stabilize the acidic fermentation (AF) system.

Brewer's spent grain (BSG), a significant by-product of the brewing industry, was employed as the feedstock for VFA …


Personalized Point Of Interest Recommendations With Privacy-Preserving Techniques, Longyin Cui Jan 2023

Personalized Point Of Interest Recommendations With Privacy-Preserving Techniques, Longyin Cui

Theses and Dissertations--Computer Science

Location-based services (LBS) have become increasingly popular, with millions of people using mobile devices to access information about nearby points of interest (POIs). Personalized POI recommender systems have been developed to assist users in discovering and navigating these POIs. However, these systems typically require large amounts of user data, including location history and preferences, to provide personalized recommendations.

The collection and use of such data can pose significant privacy concerns. This dissertation proposes a privacy-preserving approach to POI recommendations that address these privacy concerns. The proposed approach uses clustering, tabular generative adversarial networks, and differential privacy to generate synthetic user …


Quality Control Methods Through Pre-Determination Of Fields For Usrap Projects, Zachary Heath Jan 2023

Quality Control Methods Through Pre-Determination Of Fields For Usrap Projects, Zachary Heath

Theses and Dissertations--Civil Engineering

The United States Road Assessment Program (usRAP) was designed to rate highways for their ability to protect road users and to make recommendations to engineers and policy makers for investments to enhance road safety. The program is heavily dependent on local road data or characteristics. Pre-populating usRAP requires coders to evaluate sixty-six attributes at 100-meter intervals along a subject highway. In this thesis, methods for obtaining and assuring the quality of some of the usRAP data elements are proposed. Kentucky Transportation Cabinet Highway Information System (HIS) data are used as “ground truth” for roadway grade and curvature. Methods of using …


Historical And Forecasted Kentucky Specific Slope Stability Analyses Using Remotely Retrieved Hydrologic And Geomorphologic Data, Daniel M. Francis Jan 2023

Historical And Forecasted Kentucky Specific Slope Stability Analyses Using Remotely Retrieved Hydrologic And Geomorphologic Data, Daniel M. Francis

Theses and Dissertations--Civil Engineering

Hazard analyses of rainfall-induced landslides have typically been observed to experience a lack of inclusion of measurements of soil moisture within a given soil layer at a site of interest. Soil moisture is a hydromechanical variable capable of both strength gains and reductions within soil systems. However, in situ monitoring of soil moisture at every site of interest is an unfeasible goal. Therefore, spatiotemporal estimates of soil moisture that are representative of in-situ conditions are required for use in subsequent landslide hazard analyses.

This study brings together various techniques for the acquisition, modeling, and forecasting of spatiotemporal retrievals of soil …


Clustering States To Improve The Strategic Highway Safety Plan, Victoria Cambron Jan 2023

Clustering States To Improve The Strategic Highway Safety Plan, Victoria Cambron

Theses and Dissertations--Civil Engineering

Each update to a Strategic Highway Safety Plan (SHSP) can require a large amount of time, resources, and funding. From the requirements in U.S.C.148(a)(13)(E-F), in the SHSP update process states must consider the results of other transportation planning processes and develop a list of strategies to reduce or eliminate fatal and serious injury crashes (United States, 2023). To fulfill these requirements more efficiently and to gain the largest amount of benefit from said research, this thesis asks the question: how do we select other state transportation plans to study for ideas on improving our own SHSP? In this thesis, a …


Value Propositions, Adoption Factors, And Implementation Considerations: Building A Path Towards Construction Innovation, Makram Bou Bou Hatoum Jan 2023

Value Propositions, Adoption Factors, And Implementation Considerations: Building A Path Towards Construction Innovation, Makram Bou Bou Hatoum

Theses and Dissertations--Civil Engineering

The construction industry has been influenced by a wave of technological advancements and trends that were introduced by the fourth industrial revolution or Industry 4.0. Mapped as Construction 4.0, these technologies are disrupting the way projects are designed, planned, constructed, delivered, and operated. While existing research has predominantly focused on technology adoption and use cases across the project lifecycle, limited attention has been given to the organizational perspective and explored Construction 4.0 as a transformative vision. As such, there is a significant need for decision science research to support decision-makers in understanding the value of Construction 4.0, gaining leadership buy-in, …


Implementation Of Digital Twins For Small Water Systems, Aidan Gill Jan 2023

Implementation Of Digital Twins For Small Water Systems, Aidan Gill

Theses and Dissertations--Civil Engineering

The main objective of this thesis is to develop a working digital twin for a small water system in central Kentucky which will serve as a general format for other similar systems in the region wishing to implement digital twins for operator support. While the benefit of having a calibrated hydraulic and water quality model is widely understood, small distribution systems tend to not have the same financial and economic means to properly support these tools. Creation of a digital twin using this methodology provides a means for operators to predict pressure, flows, chlorine residuals, and total trihalomethane (TTHM) concentrations …


Soil Moisture And Geomorphologic Data For Use In Dynamic And Forecastable Landslide Hazard Analyses In Eastern Kentucky, Daniel M. Francis, L. Sebastian Bryson Jan 2023

Soil Moisture And Geomorphologic Data For Use In Dynamic And Forecastable Landslide Hazard Analyses In Eastern Kentucky, Daniel M. Francis, L. Sebastian Bryson

Civil Engineering Research Data

These data are the geomorphologic and land information system-based soil moisture estimates from assimilation of NASA SMAP satellite-based observations and NOAH 3.6 Land Surface Model estimates over known landslides in Eastern Kentucky. Additionally Long Short-Term Memory Recurrent Neural Network and logistic regression machine learning codes, as well as an Application programming interface code are included. Finally, in-situ data from Eastern Kentucky is included.


The Future Is Electric: Nuclear Energy’S Role In Combating Climate Change And The Regulatory Measures To Enable Its Advancement, Autumn Clark Jan 2023

The Future Is Electric: Nuclear Energy’S Role In Combating Climate Change And The Regulatory Measures To Enable Its Advancement, Autumn Clark

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.


An Agricultural Plastic Crisis: How Federally Endorsed Biodegradable Plastics Could Liberate The Industry In The Eleventh Hour, Samantha Davenport Jan 2023

An Agricultural Plastic Crisis: How Federally Endorsed Biodegradable Plastics Could Liberate The Industry In The Eleventh Hour, Samantha Davenport

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.


Examining A Blood Biomarker Approach To Blood-Brain Barrier Disruption, Samantha Ford Jan 2023

Examining A Blood Biomarker Approach To Blood-Brain Barrier Disruption, Samantha Ford

Theses and Dissertations--Medical Sciences

Blood-brain barrier disruption has been identified to associate with the pathogenesis several neurological diseases such as dementia [1, 2], multiple sclerosis[3, 4], acute or chronic cerebral ischemia[5], brain trauma[5], meningitis[5], encephalitis[5], stroke[6], and seizures[7]. Being able to effectively identify blood-brain barrier disruption is limited in methodology. The current standard is using a cerebrospinal fluid (CSF) albumin to serum albumin index, which requires the use of a lumbar puncture. A novel method of identifying blood-brain barrier disruption utilizing blood biomarkers is proposed in this study. Participants in this study had previously collected blood and CSF samples, which were analyzed to compare …


A Laboratory And Numerical Investigation Of The Strength Of Irregularly Shaped Pillars, Zachary Wedding Jan 2023

A Laboratory And Numerical Investigation Of The Strength Of Irregularly Shaped Pillars, Zachary Wedding

Theses and Dissertations--Mining Engineering

Underground mining operations utilize the room-and-pillar mining method that extracts the orebody and creates ‘rooms’ and leaves the remaining in-situ material as ‘pillars’ to support the overburden. Room-and-pillar mines are traditionally designed in square or rectangular-shaped pillars. This work presents laboratory experiments testing the compressive strengths of specimens modeled after square and parallelogram-shaped pillars and numerical models of square and -parallelogram-shaped pillar systems. The uniaxial compressive strength of the specimens’ shape and the observations of the extent of the specimen core post-failure were analyzed. There was insufficient evidence from the laboratory experiments to conclude that there is a difference in …


Measurementus Magnetic Moment To 0.20 Ppm Of The Positive Muon Anomalo, The Muon G − 2 Collaboration Jan 2023

Measurementus Magnetic Moment To 0.20 Ppm Of The Positive Muon Anomalo, The Muon G − 2 Collaboration

Physics and Astronomy Faculty Publications

We present a new measurement of the positive muon magnetic anomaly, aμ(gμ-2)/2, from the Fermilab Muon g-2 Experiment using data collected in 2019 and 2020. We have analyzed more than 4 times the number of positrons from muon decay than in our previous result from 2018 data. The systematic error is reduced by more than a factor of 2 due to better running conditions, a more stable beam, and improved knowledge of the magnetic field weighted by the muon distribution, p′, and of the anomalous precession frequency corrected for beam dynamics effects, ωa. From the ratio ωa/p′, together with precisely …


Ai-Assisted Optimization Of The Ecce Tracking System At The Electron Ion Collider, C. Fanelli, Z. Papandreou, K. Suresh Jan 2023

Ai-Assisted Optimization Of The Ecce Tracking System At The Electron Ion Collider, C. Fanelli, Z. Papandreou, K. Suresh

Physics and Astronomy Faculty Publications

The Electron-Ion Collider (EIC) is a cutting-edge accelerator facility that will study the nature of the ‘‘glue’’ that binds the building blocks of the visible matter in the universe. The proposed experiment will be realized at Brookhaven National Laboratory in approximately 10 years from now, with detector design and R&D currently ongoing. Notably, EIC is one of the first large-scale facilities to leverage Artificial Intelligence (AI) already starting from the design and R&D phases. The EIC Comprehensive Chromodynamics Experiment (ECCE) is a consortium that proposed a detector design based on a 1.5 T solenoid. The EIC detector proposal review concluded …


Scientific Computing Plan For The Ecce Detector At The Electron Ion Collider, J. C. Bernauer, C. T. Dean, C. Fanelli, J. Huang, K. Kauder, D. Lawrence, J. D. Osborn Jan 2023

Scientific Computing Plan For The Ecce Detector At The Electron Ion Collider, J. C. Bernauer, C. T. Dean, C. Fanelli, J. Huang, K. Kauder, D. Lawrence, J. D. Osborn

Physics and Astronomy Faculty Publications

The Electron Ion Collider (EIC) is the next generation of precision QCD facility to be built at Brookhaven National Laboratory in conjunction with Thomas Jefferson National Laboratory. There are a significant number of software and computing challenges that need to be overcome at the EIC. During the EIC detector proposal development period, the ECCE consortium began identifying and addressing these challenges in the process of producing a complete detector proposal based upon detailed detector and physics simulations. In this document, the software and computing efforts to produce this proposal are discussed; furthermore, the computing and software model and resources required …


Spatiotemporal Retrievals Of Soil Moisture And Geomorphologic Data For Landslide Sites In Eastern Kentucky, Lindsey Sebastian Bryson, Daniel M. Francis Jan 2023

Spatiotemporal Retrievals Of Soil Moisture And Geomorphologic Data For Landslide Sites In Eastern Kentucky, Lindsey Sebastian Bryson, Daniel M. Francis

Civil Engineering Research Data

These data are the soil texture, land information system-based soil moisture estimates from assimilation of NASA SMAP satellite-based observations and NOAH 3.6 Land Surface Model estimates, artificial neural network machine learning code, and in-situ soil moisture measurements.


Classifying Multi-Generational Products For The Circular Economy, Buddhika M. Hapuwatte, Fazleena Badurdeen, I. S. Jawahir Jan 2023

Classifying Multi-Generational Products For The Circular Economy, Buddhika M. Hapuwatte, Fazleena Badurdeen, I. S. Jawahir

Institute for Sustainable Manufacturing Faculty Publications

Manufacturers are increasingly interested in the circular economy (CE) and potential of circular productions. To fully utilize CE, better guidance at the design stage is needed to establish closed-loop flows and prioritize higher value retaining end-of-use (EoU) practices such as reuse and remanufacture (i.e., parts harvesting). Intergenerational commonality (IC) is a method to increase EoU parts harvesting. However, closed-loop parts harvesting potential depends on the compatible timing between design generations’ production and EoU returns curves. Therefore, in this paper, we explore an approach to make an initial assessment on where IC as a closed-loop CE strategy can produce most benefit, …


Local News Deserts In China: The Role Of Social Media And Personal Communication Networks, Zixue Tai, Bai He, Jianping Liu Jan 2023

Local News Deserts In China: The Role Of Social Media And Personal Communication Networks, Zixue Tai, Bai He, Jianping Liu

Journalism and Media Faculty Publications

The field of local news is often associated with news deserts, commonly defined as geo‐based communities without news‐ papers or other legacy media as providers of locally oriented news and civic information. This phenomenon is expanding in global society due to the diminishing presence of newspapers at moments of accelerated digitization. This study examines the multiplex nature of news deserts in rural and suburban areas in China. Data were collected through a multi‐methods approach combining two focus groups and 44 semi‐structured in‐depth interviews. Patterns of engagement among inter‐ viewees reveal that smartphone‐based social media applications and digital platforms function as …


Macrophage Polarization Status Impacts Nanoceria Cellular Distribution But Not Its Biotransformation Or Ferritin Effects, Uschi M. Graham, Alan K. Dozier, David James Feola, Michael T. Tseng, Robert Yokel Jan 2023

Macrophage Polarization Status Impacts Nanoceria Cellular Distribution But Not Its Biotransformation Or Ferritin Effects, Uschi M. Graham, Alan K. Dozier, David James Feola, Michael T. Tseng, Robert Yokel

Nanobiotechnology Center Faculty Publications

The innate immune system is the first line of defense against external threats through the initiation and regulation of inflammation. Macrophage differentiation into functional pheno- types influences the fate of nanomaterials taken up by these immune cells. High-resolution electron microscopy was used to investigate the uptake, distribution, and biotransformation of nanoceria in human and murine M1 and M2 macrophages in unprecedented detail. We found that M1 and M2 macrophages internalize nanoceria differently. M1-type macrophages predominantly sequester nanoceria near the plasma membrane, whereas nanoceria are more uniformly distributed throughout M2 macrophage cytoplasm. In contrast, both macrophage phenotypes show identical nanoceria biotransformation …


Low-Head Dams (Aka Drowning Machines) Are Deadly: An Analysis Of Liability For Landowners And States, And Recommendations For Legislation And Warning Signs, Forrest R. Hansen, Rollin H. Hotchkiss Jan 2023

Low-Head Dams (Aka Drowning Machines) Are Deadly: An Analysis Of Liability For Landowners And States, And Recommendations For Legislation And Warning Signs, Forrest R. Hansen, Rollin H. Hotchkiss

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.


A New Rule: Why Broad Jurisdiction Under § 404 Of The Clean Water Act Will Protect Wetlands, Gracie Sandlin Jan 2023

A New Rule: Why Broad Jurisdiction Under § 404 Of The Clean Water Act Will Protect Wetlands, Gracie Sandlin

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.


Surficial Geologic Map Of The Hadley 7.5-Minute Quadrangle, Warren County, Kentucky, Matthew Massey, Meredith Swallom, Antonia Bottoms, Wes Buchanan, Bailee Nicole Hodelka, Emily Morris Jan 2023

Surficial Geologic Map Of The Hadley 7.5-Minute Quadrangle, Warren County, Kentucky, Matthew Massey, Meredith Swallom, Antonia Bottoms, Wes Buchanan, Bailee Nicole Hodelka, Emily Morris

Contract Reports--KGS

The Hadley 7.5-minute quadrangle is located in Warren County northwest of Bowling Green, Kentucky. Regionally, the quadrangle is entirely within the Mammoth Cave plateau, which is located in the Mississippian Plateaus physiographic region (McDowell, 1986). The Mammoth Cave plateau is a regional west-dipping cuesta, that has been extensively incised by the Green and Barren Rivers and their tributaries. The area is underlain by Upper Mississippian to Lower Pennsylvanian (Rainey, 1963): the lowest fluvial valleys are underlain by Ste. Genevieve Limestone; Girkin Formation is exposed on the steep slopes between the lower valleys and higher plateau; the plateau is underlain by …


Surficial Geologic Map Of The Bowling Green North 7.5-Minute Quadrangle, Warren County, Kentucky, Meredith Swallom, Matthew Massey, Wes Buchanan, Bailee Nicole Hodelka, Hannah Hayes, Charles Wells Iii, Emily Morris Jan 2023

Surficial Geologic Map Of The Bowling Green North 7.5-Minute Quadrangle, Warren County, Kentucky, Meredith Swallom, Matthew Massey, Wes Buchanan, Bailee Nicole Hodelka, Hannah Hayes, Charles Wells Iii, Emily Morris

Contract Reports--KGS

The Bowling Green North 7.5-minute quadrangle is located in Warren County immediately north of Bowling Green, Kentucky. Regionally, the quadrangle includes parts of the Pennyroyal and Mammoth Cave plateau, both within the Mississippian Plateaus physiographic region (McDowell, 1986). The Dripping Springs escarpment, which separates the lower-elevation Pennyroyal from the higher-elevation Mammoth Cave plateau is highly dissected in the quadrangle. Topography in the Pennyroyal is characterized by pervasive sinkhole development across the low-relief Pennyroyal, which is mostly underlain by the Mississippian St. Louis Limestone, Ste. Genevieve Limestone, and Girkin Formation (Shawe, 1963). Higher-relief topography is restricted to the slopes of the …


Circulating And Eddy Current Losses In Coreless Axial Flux Pm Machine Stators With Pcb Windings, Yaser Chulaee, Donovin Lewis, Ali Mohammadi, Greg Heins, Dean Patterson, Dan Ionel Jan 2023

Circulating And Eddy Current Losses In Coreless Axial Flux Pm Machine Stators With Pcb Windings, Yaser Chulaee, Donovin Lewis, Ali Mohammadi, Greg Heins, Dean Patterson, Dan Ionel

Power and Energy Institute of Kentucky Faculty Publications

Printed circuit board (PCB) stators in coreless axial flux permanent magnet (AFPM) machines have been proposed, designed, and studied for use in multiple industries due to their design flexibility and reduction of manufacturing costs, volume, and weight compared to conventional stators. This paper investigates mechanisms and methods of approximating open circuit losses in PCB stators within example wave and spiral winding topologies for a dual rotor, single stator configuration using 3D FEA, analytical hybrid techniques and experiments. The effect of rotor magnet shape, end winding, and active conductor geometry on eddy currents is studied, and some mitigation techniques are proposed. …


Assessing Compressed Air Energy Storage (Caes) Potential In Kentucky To Augment Energy Production From Renewable Resources, J Richard Bowersox, John B. Hickman Jan 2023

Assessing Compressed Air Energy Storage (Caes) Potential In Kentucky To Augment Energy Production From Renewable Resources, J Richard Bowersox, John B. Hickman

Report of Investigations--KGS

Fossil fuel power plants in Kentucky have some of the highest emissions of greenhouse gasses in the United States. One potential strategy for mitigating greenhouse gasses from electric power generation is the co-installation of Compressed Air Energy Storage (CAES) and a renewable source such as photovoltaic solar electricity generation (PV solar generation). CAES with complementary co-installed PV solar generation enhances stand-alone PV solar generation because CAES power is available at night.

CAES, however, requires both a site where large volumes of compressed air can be stored in the subsurface, and a heat source to prepare the stored air prior to …


Artificial Intelligence And The Practice Of Law Part 1: Lawyers Must Be Professional And Responsible Supervisors Of Ai, Michael D. Murray Jan 2023

Artificial Intelligence And The Practice Of Law Part 1: Lawyers Must Be Professional And Responsible Supervisors Of Ai, Michael D. Murray

Law Faculty Popular Media

No abstract provided.


Paper Gowns, Cold Hands, Or Something Else? Black Women's Barriers To Gynecologic Screening, Nadia Ayesha Sesay Jan 2023

Paper Gowns, Cold Hands, Or Something Else? Black Women's Barriers To Gynecologic Screening, Nadia Ayesha Sesay

Theses and Dissertations--Communication

Cervical cancer mortality burden is carried disproportionately by African American women. Early indicators of cervical cancer are identified through prevention screening, a procedure typically performed by a gynecologist. Ideally, the patient group with the most severe mortality would likewise be the group with the most robust communication exchange with their physician to prevent cervical cancer incidence. However, a slew of factors contributes to continued mortalities among Black women. This study uses semi-structured interviews (n=10) and the health belief model to examine one barrier to Black women’s prosocial behaviors regarding routine gynecologic care—awkwardness, which here is conceptualized as social anxiety. The …


Potent Mor Agonists From 2′-Hydroxy-5,9-Dimethyl-N-Phenethyl Substituted-6,7-Benzomorphans And From C8-Hydroxy, Methylene And Methyl Derivatives Of N-Phenethylnormetazocine, Madhurima Das, George W. Ward, Agnieszka Sulima, Dan Luo, Thomas E. Prisinzano, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice Jan 2023

Potent Mor Agonists From 2′-Hydroxy-5,9-Dimethyl-N-Phenethyl Substituted-6,7-Benzomorphans And From C8-Hydroxy, Methylene And Methyl Derivatives Of N-Phenethylnormetazocine, Madhurima Das, George W. Ward, Agnieszka Sulima, Dan Luo, Thomas E. Prisinzano, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice

Pharmaceutical Sciences Faculty Publications

(−)-5,9-Dimethyl-6,7-benzomorphan (normetazocine) derivatives with a para-OH or ortho-F substituent in the aromatic ring of the N-phenethyl moiety were synthesized and found to have subnanomolar potency at MOR, and both were fully efficacious in vitro. These new compounds, (1R,5R,9R)-6,11-dimethyl-3-(2-fluorophenethyl)-1,2,3,4,5,6-hexahydro-2,6-methanobenzo[d]azocin-8-ol and (1R,5R,9R)-6,11-dimethyl-3-(4-hydroxyphenethyl)-1,2,3,4,5,6-hexahydro-2,6-methanobenzo[d] azocin-8-ol, were more potent than the unsubstituted compound N-phenethylnormetazocine and about 30 or 40 times more potent than morphine, respectively. A variety of substituents in the ortho, meta, or para position in the aromatic ring of the N-phenethyl moiety were synthesized, 25 of these compounds, and found to have varying effects on potency and efficacy as determined by the forskolin-induced …