Digital Commons Network^™

Hydrogen-Bonding Trends In A Bithiophene With 3- And/Or 4-Pyridyl Substituents, Alison M. Costello, Rebekah Duke, Stephanie Sorensen, Nadeesha Kothalawala, Moses Ogbaje, Nandini Sarkar, Doo Young Kim, Chad Risko, Sean Parkin, Aron J. Huckaba

UK CARES Faculty Publications

To improve the charge-carrier transport capabilities of thin-film organic materials, the intermolecular electronic couplings in the material should be maximized. Decreasing intermolecular distance while maintaining proper orbital overlap in highly conjugated aromatic molecules has so far been a successful way to increase electronic coupling. We attempted to decrease the intermolecular distance in this study by synthesizing cocrystals of simple benzoic acid coformers and dipyridyl-2,2′- bithiophene molecules to understand how the coformer identity and pyridine N atom placement affected solid-state properties. We found that with the 5-(3-pyridyl)-5′-(4-pyridyl)-isomer, the 4- pyridyl ring interacted with electrophiles and protons more strongly. Synthesized cocrystal powders …

Axial Flux Permanent Magnet Vernier Machine With Single-Wound Dual-Stator And Spoke Permanent Magnet Rotor For Electric Vehicle In-Wheel Traction, Ali Mohammadi, Yaser Chulaee, Aaron M. Cramer, Ion G. Boldea, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

In this paper, a dual-stator axial flux permanent magnet machine with a spoke-type rotor for electric vehicle applications is investigated. The rotor PMs are positioned in a spoke-type field-concentrating arrangement, which provides high flux concentration. Two stators—one stator configuration with double-layer wound coils and another without winding—are employed. The usage of single-layer wound coils is possible in this topology, and by using this type of winding it is possible to implement advanced in-slot cooling systems. Analytical and electromagnetic finite element analysis (FEA) studies considering its geometrical and electrical properties have been performed on this machine. The performance indices for the …

Optimal Power Sharing Speed Compensation In On-Road Wireless Ev Charging Systems, Donovin Lewis, Omer Onar, Veda Prakash Galigekere, Mostak Mohammad, Dan Ionel

Electrical and Computer Engineering Graduate Research

Dynamic wireless charging of electric vehicles (EV) is an emerging technology with the potential to address range anxiety and reduce the size of batteries or provide charge sustaining operation. Charging demand for dynamic wireless charging systems (DWCS) varies greatly in response to location specific traffic behaviors including the number and speed of vehicles. This paper highlights the potential reduction of load variation with speed compensation and simulates opportunities to maximize the number of cars charged concurrently through ”power sharing” or altering power output to slower cars while maintaining a maximum delivered energy. An improved sub- minute model for synthetic traffic …

Co-Simulation Of Electric Power Distribution Systems And Buildings Including Ultra-Fast Hvac Models And Optimal Der Control, Evan S. Jones, Rosemary E. Alden, Huangjie Gong, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Smart homes and virtual power plant (VPP) controls are growing fields of research with potential for improved electric power grid operation. A novel testbed for co-simulation of electric power distribution systems and distributed energy resources (DERs), is employed to evaluate VPP scenarios and propose an optimization procedure. DERs of specific interest include behind-the-meter (BTM) solar photovoltaic (PV) systems as well as heating, ventilation, and air-conditioning (HVAC) systems. Simulation of HVAC systems is enabled by a machine learning procedure that produces ultra-fast models for electric power and indoor temperature of associated buildings that are up to 133 times faster than typical …

Realizing Innovation And Sustainability: A Case Study Of Macau Sar’S Smart City Development Capabilities, Yujia He, Felix Ter Chian Tan, Carmen Leong, Jingbo Huang, Don Rodney Junio

Patterson School of Diplomacy and International Commerce Faculty Publications

The emergence of digital technologies has transformed organizational innovation with important implications for a city, its economy and policymaking. Despite this, research on how capabilities underpin innovation through smart city initiatives is still lacking. To address this gap, we conduct an empirical investigation of smart city initiatives in Macau, a former Portuguese colony and now special administrative region (SAR) of China. The case study adopts a qualitative approach, using data collected through fieldwork observations and in-depth interviews with stakeholders, and analysis of secondary documents. The study develops a stage-based assessment of innovation capabilities related to the use of technologies in …

A Case For Accelerating Standards To Achieve The Fair Principles Of Environmental Health Research Experimental Data, Rance Nault, Matthew C. Cave, Gabriele Ludewig, Hunter N. B. Moseley, Kelly G. Pennell, Tim Zacharewski

Markey Cancer Center Faculty Publications

BACKGROUND: Funding agencies, publishers, and other stakeholders are pushing environmental health science investigators to improve data sharing; to promote the findable, accessible, interoperable, and reusable (FAIR) principles; and to increase the rigor and reproducibility of the data collected. Accomplishing these goals will require significant cultural shifts surrounding data management and strategies to develop robust and reliable resources that bridge the technical challenges and gaps in expertise.

OBJECTIVE : In this commentary, we examine the current state of managing data and metadata—referred to collectively as (meta)data—in the experimental environmental health sciences. We introduce new tools and resources based on in vivo …

A Proposed Fair Approach For Disseminating Geospatial Information System Maps, P. Travis Thompson, Sweta Ojha, Christian D. Powell, Kelly G. Pennell, Hunter N. B. Moseley

Markey Cancer Center Faculty Publications

We present a draft Minimum Information about Geospatial Information System (MIaGIS) standard for facilitating public deposition of geospatial information system (GIS) datasets that follows the FaIR (Findable, accessible, Interoperable and Reusable) principles. the draft MIaGIS standard includes a deposition directory structure and a minimum javascript object notation (JSON) metadata formatted file that is designed to capture critical metadata describing GIS layers and maps as well as their sources of data and methods of generation. the associated miagis Python package facilitates the creation of this MIAGIS metadata file and directly supports metadata extraction from both Esri JSON and GEOJSON GIS data …

Differential Inhibition Of Anaplerotic Pyruvate Carboxylation And Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity Of Selenium Agents In Human Lung Cancer, Teresa W-M Fan, Jason Winnike, Ahmad Al-Attar, Alex C. Belshoff, Pawel Lorkiewicz, Jin Lian Tan, Min Wu, Richard M. Higashi, Andrew N. Lane

Markey Cancer Center Faculty Publications

Past chemopreventive human trials on dietary selenium supplements produced controversial outcomes. They largely employed selenomethionine (SeM)-based diets. SeM was less toxic than selenite or methylseleninic acid (MSeA) to lung cancer cells. We thus investigated the toxic action of these Se agents in two non-small cell lung cancer (NSCLC) cell lines and ex vivo organotypic cultures (OTC) of NSCLC patient lung tissues. Stable isotope-resolved metabolomics (SIRM) using 13C6-glucose and 13C5,15N2-glutamine tracers with gene knockdowns were employed to examine metabolic dysregulations associated with cell type- and treatment-dependent phenotypic changes. Inhibition of key anaplerotic processes, pyruvate carboxylation (PyC) and glutaminolysis were elicited by …

Identifying And Sharing Per-And Polyfluoroalkyl Substances Hot-Spot Areas And Exposures In Drinking Water, Sweta Ojha, P. Travis Thompson, Christian D. Powell, Hunter N. B. Moseley, Kelly G. Pennell

Markey Cancer Center Faculty Publications

Exposure to per- and polyfluoroalkyl substances (PFAS) in drinking water is widely recognized as a public health concern. Decision-makers who are responsible for managing PFAS drinking water risks lack the tools to acquire the information they need. In response to this need, we provide a detailed description of a Kentucky dataset that allows decision-makers to visualize potential hot-spot areas and evaluate drinking water systems that may be susceptible to PFAS contamination. The dataset includes information extracted from publicly available sources to create five different maps in ArcGIS Online and highlights potential sources of PFAS contamination in the environment in relation …

Merging Multiple Existing Geotechnical Databases, Charlie Sun, Brad Rister, Eileen Grady

Kentucky Transportation Center Research Report

This report discusses a project undertaken by Kentucky Transportation Center (KTC) researchers to create a comprehensive geotechnical database for highway planning, design, maintenance, and repair. The project consolidated multiple geotechnical data sources into a unified database accessible to Kentucky Transportation Cabinet (KYTC) staff, enabling informed decision making and improving project outcomes. Databases were merged with great attention to detail, ensuring data integrity and coherence. A geotechnical data collector app developed as part of the project supports convenient and efficient data collection in the field, even when phones or tablets lack network connectivity. A rockfall rating app and landslide hazard rating …

Microcalorimeter As A Biologic Activity Monitor For The Study Of Brachiaria Brizantha Seed Germination Process, M. A. Barboza, P. L. O. Volpe, R. Usberti, J. F. G. Faigle, R. H. Aguiar

IGC Proceedings (1977-2023)

Calorimetry helps better understanding of biological processes (Calvet & Prat, 1963). Very sensitive thermal sensors and microcalorimeters allow real time investigation and monitoring heat production of seed germination but few experiments have been performed in this area (Sigstad & Prado, 1999). Moreover, experimental procedures correlating germination phenomena and chemical thermodynamics are exceptional (Barboza, 2002). One can detect calorimetrically the heat flow produced during seed germination and compare the results with data recorded using standard germination methodology (ISTA, 1985). Seed germination and the biomass increase respiration and determination of the energy involved aids understanding of the energetic cycle involved. This work …

Meiotic Arrest Compromises Pollen Fertility In An Interspecific Hybrid Between Brachiaria Ruziziensis X Brachiaria Decumbens (Gramineae), M. S. Pagliarini, Cacilda B. Do Valle, A. B. Mendes-Bonato, C. Risso-Pascotto

IGC Proceedings (1977-2023)

Disruptions in meiosis, development of the free microspores, microspore mitosis, pollen differentiation or anthesis can result in male-sterile plants (Glover et al., 1998). An understanding of the meiotic process is pivotal to work on reproduction, fertility, genetics and breeding in plants, with serious implications in crop production (Armstrong & Jones, 2003). Some African species of Brachiaria are the most important for pastures in the American tropics due to good adaptation and production. Artificial hybridization is underway in Embrapa to improve production, quality and insect resistance (Valle & Miles, 2001). For a cultivar to be successfully adopted good seed production …

Devices And Methods For Removing Perflourinated Compounds From Contaminted Water, Dibakar Bhattacharyya Phd, Anthony Saad Phd, Rollie Mills Phd, L. E. Ormsbee Phd, M Abdul Mottaleb Phd

Civil Engineering Faculty Patents

PFAS compounds have emerged as a persistent and harmful environmental pollutant that present significant challenges to health and remediation. This patent describes a new technology that employs membrane technology along with thermo-responsive adsorption-desorption processes to remove perfluorinated compounds from contaminate water.

Torque And Power Capabilities Of Coreless Axial Flux Machines With Surface Pms And Halbach Array Rotors, Yaser Chulaee, Donovin Lewis, Matin Vatani, John F. Eastham, Dan Ionel

Power and Energy Institute of Kentucky Faculty Publications

This paper investigates employing a Halbach PM rotor array to increase torque and power density within coreless axial flux permanent magnet (AFPM) machines. Analytical and 2/3-dimensional finite element analysis (FEA) methods are developed to study torque and power capabilities within an example double-rotor, single-stator coreless AFPM machine with a PCB stator. Compared to a surface PM topology of the same mass and volume, employing a Halbach array increases torque density by as much as 30% through increased airgap flux density amplitude. Multiple parametric studies are performed to explore methods of increasing torque and power density while employing Halbach arrays combined …

Design Optimization Of A Direct-Drive Wind Generator With Non-Rare-Earth Pm Flux Intensifying Stator And Reluctance Rotor, Ali Mohammadi, Oluwaseun A. Badewa, Yaser Chulaee, Dan Ionel, Somasundaram Essakiappan, Madhav Manjrekar

Power and Energy Institute of Kentucky Faculty Publications

This paper presents a multi-objective design optimization for a novel direct-drive wind turbine generator. The proposed electric machine topology employs an outer rotor of the reluctance type and a special modular stator including three phase-windings and spoke-type permanent magnets (PMs). Each stator module includes a single coil toroidally wound around the ferromagnetic core. Consecutive stator modules are separated by PMs and include coils belonging to a different phase. An optimization method with three objectives: total power loss, weight, and torque ripple, and with one constraint for a minimum acceptable value for the power factor, is described. The design examples are …

Flood Fatalities In Eastern Kentucky And The Public Health Legacy Of Mountaintop Removal Coal Mining, W. Jay Christian, Beverly May, Jeffery E. Levy

UK CARES Faculty Publications

Heavy rains at night caused severe flooding in eastern Kentucky on 28 July 2022, resulting in 39 deaths. Using publicly available information, we assembled a database of these fatalities, including demographic characteristics and location of death. We perturbed fatality locations and plotted them on a topographical map highlighting mountaintop removal mining with valley fill sites, where mountaintops were excavated to mine thin seams of coal. This map reveals many flood fatalities occurred along rivers or streams near such sites. Previous research suggests that surface mining has contributed to the majority of land cover change in this region, and this has …

Combination Therapy With Trastuzumab And Niraparib: Quantifying Early Proliferative Alterations In Her2+ Breast Cancer Models, Ameer Mansur, Patrick N. Song, Yun Lu, Andrew C. Burns, Luke Sligh, Eddy S. Yang, Anna G. Sorace

Markey Cancer Center Faculty Publications

HER2–targeted treatments have improved survival rates in HER2+ breast cancer patients, yet poor responsiveness remains a major clinical obstacle. Recently, HER2+ breast cancer cells, both resistant and responsive to HER2–targeted therapies, have demonstrated sensitivity to poly–(ADP– ribose) polymerase (PARP) inhibition, independent of DNA repair deficiencies. This study seeks to describe biological factors that precede cell viability changes in response to the combination of trastuzumab and PARP inhibition. Treatment response was evaluated in HER2+ and HER2– breast cancer cells. Further, we evaluated the utility of 3′–Deoxy–3′–[18F]–fluorothymidine positron emission tomography ([18F]FLT–PET) imaging for early response assessment in a HER2+ patient derived xenograft …

Predictive Modeling Of Cave Entrance Locations: Relationships Between Surface And Subsurface Morphology, William Blitch, Adia R. Sovie, Benjamin Tobin

Faculty, Staff, and Affiliated Publications--KGS

Cave entrances directly connect the surface and subsurface geomorphology in karst landscapes. Understanding the spatial distribution of these features can help identify areas on the landscape that are critical to flow in the karst groundwater system. Sinkholes and springs are major locations of inflow and outflow from the groundwater system, respectively, however not all sinkholes and springs are equally connected to the main conduit system.

Predicting where on the landscape zones of high connectivity exist is a challenge because cave entrances are difficult to detect and imperfectly documented. Wildlife research has a similar issue of understanding the complexities of where …

Single Fraction And Hypofractionated Radiation Cause Cochlear Damage, Hearing Loss, And Reduced Viability Of Merlin-Deficient Schwann Cells, Christine T. Dinh, Si Chen, Aida Nourbakhsh, Kyle Padgett, Perry Johnson, Stefania Goncalves, Olena Bracho, Esperanza Bas, Jorge Bohorquez, Paula V. Monje, Cristina Fernandez-Valle, Nagy Elsayyad, Xuezhong Liu, Scott M. Welford, Fred Telischi

Markey Cancer Center Faculty Publications

Background: Vestibular schwannomas (VS) are benign intracranial tumors caused by loss of function of the merlin tumor suppressor. We tested three hypotheses related to radiation, hearing loss (HL), and VS cell survival: (1) radiation causes HL by injuring auditory hair cells (AHC), (2) fractionation reduces radiation-induced HL, and (3) single fraction and equivalent appropriately dosed multi-fractions are equally effective at controlling VS growth. We investigated the effects of single fraction and hypofractionated radiation on hearing thresholds in rats, cell death pathways in rat cochleae, and viability of human merlin-deficient Schwann cells (MD-SC). Methods: Adult rats received cochlear irradiation with single …

Fiscal Year 2021 Fhwa-536 Report For The Kentucky Transportation Cabinet, Doug Kreis, Candice Wallace, Bryan Gibson, Sarah Mccormack

Kentucky Transportation Center Research Report

No abstract provided.

A Better Life: Factors That Help And Hinder Entry And Retention In Mat From The Perspective Of People In Recovery, Adam D. Baus, Martha Carter, Jennifer Boyd, Erin Mcmullen, Trey Bennett, Alexandra Persily, Danielle M. Davidov, Christa Lilly

Journal of Appalachian Health

Introduction: Opioid addiction and opioid-related overdoses and deaths are serious public health problems nationally and in West Virginia, in particular. Medication-assisted treatment (MAT) is an effective yet underutilized treatment for opioid use disorder (OUD).

Purpose: Research examining factors that help individuals succeed in MAT has been conducted from provider and program perspectives, but little research has been conducted from the perspective of those in recovery.

Methods: This study, co-developed with individuals in recovery, took place in West Virginia-based MAT programs using an exploratory sequential mixed methods approach. The survey was open February through August 2021. Data were analyzed late 2021 …

Physical And Quality Seed Traits Observed In New Pigeon Pea (Cajanus Cajan) Hybrids, R. Usberti, J. A. Usberti Jr., R. H. Aguiar, F. C. Simoes, F. N. Cavalcante, M. Harris, Maria T. Colozza, J. C. T. Freitas

IGC Proceedings (1977-2023)

Pigeon pea seed production may be affected by factors such as % of pure seeds, mean seed weight, incidence of pests and diseases and environmental stresses. Harvested seeds from different cultivars may also vary in germination %, hardseededness and germination speed. Hardseededness (seed coat impermeability to water) commonly occurs in forage legume species (Hopkinson, 1993). There is considerable variation among different entries for seed characters but this is not considered within genetic materials. This research analysed harvested seeds of selected individuals of two segregating F₂ pigeon pea populations for the above cited traits and assessed the range of variation …

Effects Of A Recurrent Selection Scheme, Applied To An Interspecific Hybrid Pennisetum Purpureum Schum. (Elephantgrass) X Pennisetum Glaucum (L.) R. Br. Stuntz (Pearl Millet), On Several Seed Quality Parameters, R. Usberti, J. A. Usberti Jr., R. H. Aguiar, L. M. T. A. Carneiro, J. B. Fantinati, F. G. Francisco

IGC Proceedings (1977-2023)

Elephantgrass cultivars and introductions show practically no viable pure seeds and their uses in cultivated grasslands are exclusively dependent on vegetative propagation. Therefore, in large areas, sowing operation costs make unfeasible setting up new pastures. On the other hand, pearl millet is a high seed producer species though presenting some forage constraints (poor forage production, low regrowth potential after cutting or grazing and low field persistence). Recently, an hexaploid interespecific hybrid between the two species was developed (Schank & Diz, 1996), which is able to produce viable pure seeds, in variable amounts according to the genotype considered (Diz & Schank, …

Future Directions In The Molecular Breeding Of Forage And Turf, G. C. Spangenberg, J. W. Forster, D. Edwards, U. John, A. Mouradov, M. Emmerling, J. Batley, S. Felitti, N. O. I. Cogan, K. F. Smith, M. P. Dobrowolski

IGC Proceedings (1977-2023)

Key points

1. Molecular breeding of forage and turf plants and their endosymbionts has entered the post-genomic era with a large amount of structural genomics information and genomic resources available for key forage and turf species and relevant model systems.
2. A primary future challenge is the conversion of this information into useful functional knowledge for the development of molecular breeding technologies and products that address a range of high impact outcome scenarios in forage and turf.
3. High-throughput approaches for spatial and temporal analysis, from genome to phenome, and the respective data integration in a systems biology context will be critical for …

Random Amplified Polymorphic Dna Analysis In Section Pnigma Of The Genus Bromus L., M. Tuna, O. Barzani, K. P. Vogel, Avi Golan-Goldhirsh

IGC Proceedings (1977-2023)

The section Pnigma consists of about 60 species. It was shown that Eurasian species of the section with the same ploidy level have similar nuclear DNA contents (Tuna et al., 2001). A linear correlation between nuclear DNA content and ploidy level was also found (Tuna et al., 2001). Furthermore, karyotypes of Eurasian species are similar (Tuna et al., 2004a) but differ from the North American species (Tuna et al., 2004b). Yet, the genetic relationship among species within the section is poorly known (Armstrong, 1991). The objective of this study was to assess the phylogenetic relationships among …

Use Of Cellular Automata Modelling Approaches To Understand Potential Impacts Of Gm Grasses On Grassland Communities, R. Colasanti, R. Hunt, L. S. Watrud

IGC Proceedings (1977-2023)

In order to predict the potential unintended ecological impacts of genetically modified (GM) grasses, we must understand how the engineered traits, in this case herbicide resistance, are expressed in an ecological context. It would be a daunting task to experimentally evaluate the full multiplicity of potential pair-wise interactions between GM plants and native plants under a broad variety of actual environmental conditions. We have employed the modelling methodology of cellular automata (CA), where a plant's distribution within a two-dimensional environmental grid is determined by rules relating to phenomena such as seed dispersal, clonal expansion and interactions with adjacent plants. We …

A Novel Genotype Independent Protocol For In Vitro Plant Regeneration From Mature Seed Derived Callus Of Tall Fescue (Festuca Arundinacea Schreb.), S. Chennareddy, R. V. Sairam, S. L. Goldman

IGC Proceedings (1977-2023)

Tall fescues (Festuca arundinacea Schreb.) are cool season forage and turf grasses of significant agricultural importance in different grassland countries. Genetic improvement of tall fescues by conventional selection procedures is slow, since these are predominantly, cross-pollinated, hexaploid and generally infertile (Jauhar, 1993). Genetic Engineering approaches for incorporation of agronomically useful traits may contribute to the development of improved tall fescue cultivars (Spangenberg et al., 1998). However for any genetic engineering studies, it is essential to develop a genotype-independent, reproducible and efficient in vitro plant regeneration protocol. In the present study, we analyzed the effects of different sterilization procedures …

Genetic Engineering For Breeding For Drought Resistance And Salt Tolerance In Agropyron Spp. (Wheatgrass), Fugui Mi, Y. Jinfeng, H. Xiuwen

IGC Proceedings (1977-2023)

Genetic engineering for breeding for drought resistance and salt tolerance in wheatgrass, lucerne and tall fescue is one of the main projects in a major national programs as part of the10^th’five-year national plan: “Research of gene transfer in plants and its industrialisation”. It is a large project that has financial support for work on forage crops in China and many research institutes and universities take part in it. The Inner Mongolia Agricultural University is in charge of the project on wheatgrass. The research was started in Nov. 2002. The general situation and the primary results are introduced and …

Genetic Transformation Of Rhodesgrass (Chloris Gayana Kunth.) By Particle Bombardment, J. Matsumoto, S. Tsuruta, T. Gondo, Ryo Akashi

IGC Proceedings (1977-2023)

Rhodesgrass (Chloris gayana Kunth) has been cultivated as one of the most important warm-season grasses in the world. One of the major limitations for cattle production on forage grasses, especially warm-season grasses is poor digestibility if compared to temperate grasses (Gondo et al., 2003). It is believed that the low digestibility of warm-season grasses is due to high lignin contents (Akashi et al., 2003). Recently, modification of the lignin content of plants appears to be feasible using genetic engineering strategies. We have established a methodology for high-frequency somatic embryogenesis and multiple shoot formation from seed-derived shoot apical …

Genetic Engineering For Breeding For Drought Resistance And Salt Tolerance In Agropyron Spp. (Wheatgrass), Fugui Mi, Jinfeng Yun, Xiuwen Huo

IGC Proceedings (1977-2023)

Genetic engineering for breeding for drought resistance and salt tolerance in wheatgrass, lucerne and tall fescue is one of the main projects in major national programs of 10^th five-year national plan: Research of gene transfer in plants and its industrialisation. The project is a large one that has the financial support for forage crops in China and many research institutes and universities take part in it. The Inner Mongolia Agricultural University is in charge of the project on wheatgrass. The research was started in Nov. 2002. The general situation and the primary results are introduced and summarised in this …