Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Law (4081)
- Engineering (1862)
- Social and Behavioral Sciences (1511)
- Life Sciences (1468)
- Civil and Environmental Engineering (1436)
-
- Transportation Engineering (1375)
- Medicine and Health Sciences (1213)
- Physical Sciences and Mathematics (1035)
- Arts and Humanities (814)
- State and Local Government Law (623)
- Plant Sciences (615)
- Earth Sciences (569)
- Constitutional Law (482)
- Soil Science (449)
- Library and Information Science (441)
- Plant Pathology (439)
- Agronomy and Crop Sciences (418)
- Plant Biology (415)
- Agricultural Science (399)
- Weed Science (392)
- Medical Specialties (369)
- Law Librarianship (366)
- Education (284)
- History (272)
- Medical Sciences (269)
- Criminal Law (249)
- Torts (246)
- Sociology (216)
- Environmental Sciences (200)
- Public Affairs, Public Policy and Public Administration (195)
- Keyword
-
- Kentucky (662)
- Law libraries (353)
- Law librarians (352)
- SEAALL (344)
- Humans (221)
-
- Animals (180)
- Engineering (124)
- Kentucky transportation (121)
- SCOTUS (120)
- State government (106)
- State legislature (105)
- Kentucky history (103)
- Representatives (103)
- Senators (103)
- Female (94)
- Male (92)
- United States (79)
- Mice (77)
- Commonwealth of Kentucky (67)
- Bridges (51)
- Safety (50)
- UCC (49)
- Supreme Court of the United States (47)
- Liability (46)
- Education (45)
- Negligence (45)
- Constitution (44)
- Race (44)
- Divorce (42)
- Signal Transduction (41)
- Publication Year
- Publication
-
- Kentucky Law Journal (3241)
- Kentucky Transportation Center Research Report (1301)
- Law Faculty Scholarly Articles (580)
- IGC Proceedings (1977-2023) (392)
- University of Kentucky Doctoral Dissertations (300)
-
- Journal of Natural Resources & Environmental Law (231)
- Kentucky Journal of Equine, Agriculture, & Natural Resources Law (183)
- Correspondence (180)
- University of Kentucky Master's Theses (171)
- disClosure: A Journal of Social Theory (158)
- MPA/MPP/MPFM Capstone Projects (118)
- KWRRI Research Reports (116)
- Journals of the General Assembly of the Commonwealth of Kentucky (103)
- Newsletters (101)
- The Kentucky Review (85)
- Theses and Dissertations--Geography (82)
- Theses and Dissertations--English (76)
- Administrative Materials (69)
- Kentucky's Annual Forum on Transportation (64)
- Markey Cancer Center Faculty Publications (63)
- Theses and Dissertations--Communication (61)
- Continuing Legal Education Materials (60)
- Theses and Dissertations--Music (60)
- Microbiology, Immunology, and Molecular Genetics Faculty Publications (59)
- Molecular and Cellular Biochemistry Faculty Publications (59)
- Physics and Astronomy Faculty Publications (58)
- Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.) (58)
- Theses and Dissertations--Mechanical and Aerospace Engineering (55)
- Theses and Dissertations--History (54)
- World of Coal Ash Proceedings (54)
- Publication Type
- File Type
Articles 331 - 360 of 11455
Full-Text Articles in Entire DC Network
Cynodon Dactylon Pers. A Common Fodder Grass Of Grasslands Of The Upper Gangetic Plain Of India, H R. Sant
Cynodon Dactylon Pers. A Common Fodder Grass Of Grasslands Of The Upper Gangetic Plain Of India, H R. Sant
IGC Proceedings (1977-2023)
The grasslands of the Upper Gangetic Plain of India are composed ofUttar Pradesh, Bihar and Bengal, and this area is fertile. The chief climatic factors, the temperature and rainfall together are responsible for a distinct type of vegetation. The rainfall is less than 70 cm. in west Uttar Pradesh being more than 150 cm. in Bengal.
In India, natural grasslands are hardly present, and most of them are maintained in their present serial stages due to biotic influence. Hence the grasslands occupy vast chunks of land in the outskirts of villages. Given proper care and managements either for available cultivation …
Perennial Legumes And Grass-Legume Associations Adapted To Poorly Drained Savannas In Tropical South America, B Grof, D Thomas, R P. De Andrade, J.L F. Zoby, M A. De Souza
Perennial Legumes And Grass-Legume Associations Adapted To Poorly Drained Savannas In Tropical South America, B Grof, D Thomas, R P. De Andrade, J.L F. Zoby, M A. De Souza
IGC Proceedings (1977-2023)
Seasonally flooded areas and swamp grasslands constitute a significant percentage ot the savannas and represent an important source of supplementary forage during the dry season. Approximately 21 % (170 million ha) of the central lowlands of tropical South America is poorly drained ; 82 % of these lands (139 million ha) is covered with forest and the remaining 31 million ha by native savannas (Cochrane et al.,1985). The poorly drained savanna lands have been used successfully since colonial times for extensive cattle production. Significant areas are found in the Brazilian Pantanal, in Brazil's southwest Amazonia, the Casanare plains of northeast …
Structural Assembly Of The Pas Domain Drives The Catalytic Activation Of Metazoan Pask, Sajina Dhungel, Michael Xiao, Rajesh Rajaian Pushpabai, Chintan K. Kikani
Structural Assembly Of The Pas Domain Drives The Catalytic Activation Of Metazoan Pask, Sajina Dhungel, Michael Xiao, Rajesh Rajaian Pushpabai, Chintan K. Kikani
Biology Faculty Publications
PAS domains are ubiquitous sensory modules that transduce environmental signals into cellular responses through tandem PAS folds and PAS-associated C-terminal (PAC) motifs. While this conserved architecture underpins their regulatory roles, here we uncover a structural divergence in the metazoan PAS domain-regulated kinase (PASK). By integrating evolutionary-scale domain mapping with deep learning-based structural models, we identified two PAS domains in PASK, namely PAS-B and PAS-C, in addition to the previously known PAS-A domain. Unlike canonical PAS domains, the PAS fold and PAC motif in the PAS-C domain are spatially segregated by an unstructured linker, yet a functional PAS module is assembled …
Closing Ceremony Speech, S. Ray Smith
Closing Ceremony Speech, S. Ray Smith
IGC Proceedings (1977-2023)
No abstract provided.
Changes In Vegetation Of Various Meadows Under Differential Mineral Fertilization, S Benedycki, S Grzegorczyk, M Mlynarczyk, K Grabowski
Changes In Vegetation Of Various Meadows Under Differential Mineral Fertilization, S Benedycki, S Grzegorczyk, M Mlynarczyk, K Grabowski
IGC Proceedings (1977-2023)
Permanent meadows and pastures occurring in the Mazurian Lake District (North-eastern part of Poland) constitute 32 % of arable lands. Most meadows are situated on peat soils (Olkowski, 1972). Continuous and successive changes take place in such populations. The moment some species decline, the number of others increases which are better adjusted to site conditions or human activity such as fertilization and the way of land use. These changes occur with different intensity depending on fertilizer doses, land use and site conditions which have not been well recognized with regard to permanent meadows (Olkowski and Olesinski, 1976, Eilart, 1986). Determination …
Macroevolutionary Inference Of Complex Modes Of Chromosomal Speciation In A Cosmopolitan Plant Lineage, Carrie M. Tribble, José Ignacio Márquez-Corro, Michael R. May, Andrew L. Hipp, Marcial Escudero, Rosana Zenil-Ferguson
Macroevolutionary Inference Of Complex Modes Of Chromosomal Speciation In A Cosmopolitan Plant Lineage, Carrie M. Tribble, José Ignacio Márquez-Corro, Michael R. May, Andrew L. Hipp, Marcial Escudero, Rosana Zenil-Ferguson
Biology Faculty Publications
The effects of single chromosome number change—dysploidy – mediating diversification remain poorly understood. Dysploidy modifies recombination rates, linkage, or reproductive isolation, especially for one-fifth of all eukaryote lineages with holocentric chromosomes. Dysploidy effects on diversification have not been estimated because modeling chromosome numbers linked to diversification with heterogeneity along phylogenies is quantitatively challenging. We propose a new state-dependent diversification model of chromosome evolution that links diversification rates to dysploidy rates considering heterogeneity and differentiates between anagenetic and cladogenetic changes. We apply this model to Carex (Cyperaceae), a cosmopolitan flowering plant clade with holocentric chromosomes. We recover two distinct modes of …
Quantifying Temporal Dynamics Of E. Coli Concentration And Quantitative Microbial Risk Assessment Of Pathogen In A Karst Basin, Shishir K. Sarker, Ryan T. Dapkus, Diana M. Byrne, Alan E. Fryar, Justin M. Hutchison
Quantifying Temporal Dynamics Of E. Coli Concentration And Quantitative Microbial Risk Assessment Of Pathogen In A Karst Basin, Shishir K. Sarker, Ryan T. Dapkus, Diana M. Byrne, Alan E. Fryar, Justin M. Hutchison
Earth and Environmental Sciences Faculty Publications
Karst aquifers can be highly productive water sources but are vulnerable to contamination by pathogens because of integrated surface and subsurface drainage. Our study focuses on the karstic Royal Spring basin in Kentucky, encompassing urban and agricultural land uses. The city of Georgetown distributes treated water from Royal Spring to over 33,000 customers. We examined E. coli dynamics at Royal Spring from June 2021 through June 2022, assessing variability under wet versus dry weather conditions. We also used quantitative microbial risk assessment (QMRA) to estimate potential health risks from the pathogenic bacterium E. coli O157:H7. E. coli concentrations in weekly …
Development Of Measures For Highway Criticality Assessment, Xu Zhang, Mei Chen
Development Of Measures For Highway Criticality Assessment, Xu Zhang, Mei Chen
Kentucky Transportation Center Research Report
Existing network criticality assessments, often biased towards heavily used highways in populous areas by incorporating traffic and sociodemographic attributes, can lead to an underestimation of the vital role of rural infrastructure. Consequently, rural highways, particularly low-volume roads, often receive less consideration despite their critical role in network connectivity and local access to services and economic opportunities. To address this, we develop a criticality framework based on the egalitarian principle, which prioritizes equitable consideration of all network links regardless of traffic volume or population density, comprising two complementary measures. First, the normalized betweenness centrality quantifies a road's relative importance in efficiently …
Varied Uses Of Class Time: A Case Study Of Epe 301, Zitsi Mirakhur, Spencer Crawford, Wyatt Driskell
Varied Uses Of Class Time: A Case Study Of Epe 301, Zitsi Mirakhur, Spencer Crawford, Wyatt Driskell
Greater Faculties: A Review of Teaching and Learning
No abstract provided.
Groupme In The Classroom, Christopher Huggins
Groupme In The Classroom, Christopher Huggins
Greater Faculties: A Review of Teaching and Learning
No abstract provided.
Dysregulated Alveolar Epithelial Cell Progenitor Function And Identity In Hermansky-Pudlak Syndrome, Joanna Y. Wang, Sylvia N. Michki, Sneha Sitaraman, Brandon J. Banaschewski, Reshma Jamal, Jason J. Gokey, Susan M. Lin, Jeremy B. Katzen, Maria C. Basil, Edward Cantu, Jonathan A. Kropski, Jarod A. Zepp, David B. Frank, Lisa R. Young
Dysregulated Alveolar Epithelial Cell Progenitor Function And Identity In Hermansky-Pudlak Syndrome, Joanna Y. Wang, Sylvia N. Michki, Sneha Sitaraman, Brandon J. Banaschewski, Reshma Jamal, Jason J. Gokey, Susan M. Lin, Jeremy B. Katzen, Maria C. Basil, Edward Cantu, Jonathan A. Kropski, Jarod A. Zepp, David B. Frank, Lisa R. Young
Surgery Faculty Publications
Hermansky-Pudlak syndrome (HPS) is a genetic disorder of endosomal protein trafficking associated with pulmonary fibrosis in specific subtypes, including HPS-1 and HPS-2. Single-mutant HPS1 and HPS2 mice display increased fibrotic sensitivity while double-mutant HPS1/2 mice exhibit spontaneous fibrosis with aging, which has been attributed to HPS mutations in alveolar epithelial type II (AT2) cells. We utilized HPS mouse models and human lung tissue to investigate mechanisms of AT2 cell dysfunction driving fibrotic remodeling in HPS. Starting at 8 weeks of age, HPS mice exhibited progressive loss of AT2 cell numbers. HPS AT2 cell function was impaired ex vivo and in …
Males Differ More Between Developmental Stages Than Females, And Plasticity To Light Is Stage-Dependent In The Tropical Plant Marchantia Inflexa, Jonathan D. Moore, D. Nicholas Mcletchie
Males Differ More Between Developmental Stages Than Females, And Plasticity To Light Is Stage-Dependent In The Tropical Plant Marchantia Inflexa, Jonathan D. Moore, D. Nicholas Mcletchie
Biology Faculty Publications
Plants have evolved strategies to maintain photosynthesis and mitigate tissue-damaging high light. In some dioecious seed plants, these strategies are sexually dimorphic and are linked to spatial segregation of the sexes (SSS) along light gradients. In vascular tissue-free plants (bryophytes) with separate sexes, SSS is common, but how light gradients, sexual dimorphisms, and SSS correlate is not well understood. To test if sexual dimorphisms in vegetative or sexual stages lead to light-associated SSS in bryophytes, we used Marchantia inflexa whose males occupy a wider range of light conditions, including higher light conditions, than females. We also tested if changes in …
Current Practices In Rock Scaling, Daryl J. Greer, Kean H. Ashurst Jr
Current Practices In Rock Scaling, Daryl J. Greer, Kean H. Ashurst Jr
Kentucky Transportation Center Research Report
Rockfalls, which result from the chemical and physical weathering of aging exposed rock cuts, occur frequently along many Kentucky roadways and can endanger travelers. Mitigating rockfalls often requires substantial excavation, procuring additional right of way, and/or hiring specialty contractors. An alternative to these expensive processes is rock scaling, which can be a cost-effective tool for mitigating rockfalls. Rock scaling entails removing loose and unstable rocks from rock cut slopes within the right of way to reduce rockfall risk and is being used with increased frequency by state transportation agencies around the country. The Kentucky Transportation Cabinet (KYTC) has completed several …
Coccidia Vaccine Challenge And Exogenous Enzyme Supplementation In Broiler Chicken 2—Effect On Apparent Ileal Nutrient And Energy Digestibility And Intestinal Morphology 7 And 14 Days Post-Challenge, Sunday A. Adedokun, Andrew Dunaway, Richard Adefioye
Coccidia Vaccine Challenge And Exogenous Enzyme Supplementation In Broiler Chicken 2—Effect On Apparent Ileal Nutrient And Energy Digestibility And Intestinal Morphology 7 And 14 Days Post-Challenge, Sunday A. Adedokun, Andrew Dunaway, Richard Adefioye
Animal and Food Sciences Faculty Publications
The efficiency with which the nutrients and energy in any diet are digested, absorbed, and utilized depends on several factors, with the health status of the bird’s gastrointestinal tract playing an important role. The protozoan parasite Eimeria has been reported to significantly reduce the performance of birds because of poor absorption of nutrients in the small intestine. In this study, the effect of Eimeria sp. challenge and exogenous enzyme supplementation on performance and nutrient digestibility in broilers fed corn-soybean meal- or wheat-corn–SBM-based diets was examined. During the first 7 days post-challenge (days 14–21), in birds fed the corn–soybean-meal-based diets, the …
Bridge Load Posting Based On Load Testing, Cody Hutchinson, Abheetha Peiris, Issam Harik
Bridge Load Posting Based On Load Testing, Cody Hutchinson, Abheetha Peiris, Issam Harik
Kentucky Transportation Center Research Report
AASHTO’s Manual for Bridge Evaluation (MBE) provides guidance for analytically evaluating bridge capacity based on available design information and the results of field inspections. This analysis results in a rating factor (RF), which quantifies a bridge’s safe load carrying capacity. RF accuracy, however, depends on the availability of information about structural details and material properties. As such, load rating bridges without design plans is difficult as field inspections alone often cannot provide enough information to perform detailed analysis. In many instances this means that a bridge would possess a substandard rating factor (RF < 1.0) simply due to the conservative assumptions required to perform traditional analysis. The most effective method for safely modifying such conservative theoretical rating factors is through load testing. Load testing measures actual bridge behavior and, for most bridges in good health, finds an increase in load rating is justified. This project utilized load testing to load rate 14 bridges in Kentucky that lack structural plans. Researchers first determined theoretical ratings using MBE-prescribed methods. For information typically taken from design plans, but which could not be measured directly, data-backed methods for making conservative assumptions were developed. For most bridges included in the study, theoretical rating factors alone suggested load postings were necessary. Load testing was then carried out utilizing tandem rear-axle dump trucks with measured axle weights. Multiple single-lane load cases were selected to maximize the effects being rated. Strain data were collected in real time using a wireless reusable strain gage system. Using these data, researchers computed a field test adjustment factor using MBE methods which directly modified the calculated theoretical RFs. Ultimately, load testing provided sufficient evidence to safely recommend that load postings were not necessary for any bridges in this study.
Powered Haulage Fatalities In Appalachian Coal Mines, Nirmala T. Myers, Noemi B. Hall, Nadia T. Saif, A. Scott Laney
Powered Haulage Fatalities In Appalachian Coal Mines, Nirmala T. Myers, Noemi B. Hall, Nadia T. Saif, A. Scott Laney
Journal of Appalachian Health
The recent death of a 33-year-old mother of three at a Central Appalachian surface coal mine highlights the persistent dangers faced by miners, particularly from powered haulage incidents. As of December 2, 28 mining fatalities have occurred in the U.S. in 2024, with four in Appalachian coal mines attributed to powered haulage. These deaths underscore the urgent need to address this cause of fatalities in the mining industry and to provide a safe workplace to protect all miners.
Parents Who Make America Great Again: Identity Politics In Right-Wing Populist Discourses On Gender Ideology And Immigration, Alina Hechler
Parents Who Make America Great Again: Identity Politics In Right-Wing Populist Discourses On Gender Ideology And Immigration, Alina Hechler
Theses and Dissertations--Gender and Women's Studies
This dissertation explores how anti-immigration and anti-(trans)gender campaigns in the United States engage in an identity politics in which a group benefiting from heteronormative, white supremacist, and nationalist social structures discursively positions itself as an oppressed minority facing an elitist, oppressive, and parasitic establishment. While anti-transgender and anti-immigration platforms represent two distinct issues, they need to be situated within the broader context of right-wing politics. With a focus on the construction of parenthood, my dissertation juxtaposes these two forms of right-wing campaigns through a mixed-method approach by tracing the depiction of two parental figures that have recently emerged in right-wing …
Lagrange Multipliers As A Metric For Early-Stage Shipboard Power System Design, Magdalen A. Barnes
Lagrange Multipliers As A Metric For Early-Stage Shipboard Power System Design, Magdalen A. Barnes
Theses and Dissertations--Electrical and Computer Engineering
Integrated power systems are essential in the operation of electric ships and must function under a diverse range of conditions. In addition to routine operation, ships should be prepared to respond to challenging events that require significant amounts of power. Demanding scenarios, coupled with complex and interconnected power systems, present challenging issues. The power and energy ratings of equipment are crucial factors in the operational success of the ship; however, to meet economic constraints, balance between performance and cost must be upheld. Details regarding equipment models and specifications are typically unavailable during early-stage design. Power system modeling and simulation can …
A Radioactive Circuit Split: Addressing Nuclear Waste Storage And Disposal In The United States, Madison King
A Radioactive Circuit Split: Addressing Nuclear Waste Storage And Disposal In The United States, Madison King
Kentucky Journal of Equine, Agriculture, & Natural Resources Law
In this note, Madison King analyzes the emerging circuit split concerning the Nuclear Regulatory Commission’s (NRC) authority to license interim, away-from-reactor nuclear waste storage facilities. King explains that while the D.C. and Tenth Circuits have upheld the NRC’s authority under the Atomic Energy Act, the Fifth Circuit recently rejected that interpretation, ruling the NRC lacks such authority and invoking the major questions doctrine. King argues for a legislative solution to resolve the legal uncertainty and long-standing stalemate over nuclear waste disposal. King proposes that Congress should pass the Nuclear Waste Task Force Act to reevaluate federal policy, eliminate exemptions for …
Puppy Dog Eyes: Begging For Treats And The Regulation Of Dog Breeding, Abigail Barford
Puppy Dog Eyes: Begging For Treats And The Regulation Of Dog Breeding, Abigail Barford
Kentucky Journal of Equine, Agriculture, & Natural Resources Law
In this note, Abigail Barford explores the lack of regulation over dog breeding in Kentucky, particularly the harms caused by puppy mills and backyard breeders. Barford explains that loopholes in the Animal Welfare Act and Kentucky’s absence of state-level protections contribute to dog overpopulation, inhumane conditions, environmental damage, and financial burdens on taxpayers. Barford argues for Kentucky to adopt strong breeding regulations modeled on Pennsylvania’s laws and its own equine breeding system. She proposes statewide legislation to license breeders, enforce humane standards of care, and regulate small-scale breeding to curb overpopulation and protect animal welfare.
Stigma And Isolation: The Lived Experiences Of Male Sexual Assault Survivors In College, Vanessa Vela
Stigma And Isolation: The Lived Experiences Of Male Sexual Assault Survivors In College, Vanessa Vela
Theses and Dissertations--Family Sciences
Male sexual assault survivors on college campuses face barriers to disclosure, support, and recovery due to stigma, societal expectations of masculinity, and inadequate institutional resources. This hermeneutic phenomenological study explored the lived experiences of six male survivors of sexual assault enrolled in college, focusing on their perceptions of sexual violence before and after their assault, the psychological burden of disclosure, and their experiences with available support systems. Participants described challenges including rape myths, feelings of isolation, fear of emasculation, and limited access to gender-inclusive resources. While online communities provided some support, institutional services often failed to meet their needs due …
A Systems-Based Framework For Product Circularity Assessment, Gisele Bortolaz Guedes, Junwon Ko, Fazleena Badurdeen, I. S. Jawahir, K. C. Morris, Vincenzo Ferrero
A Systems-Based Framework For Product Circularity Assessment, Gisele Bortolaz Guedes, Junwon Ko, Fazleena Badurdeen, I. S. Jawahir, K. C. Morris, Vincenzo Ferrero
Mechanical Engineering Faculty Publications
One of the key aspects of Circular Economy (CE), particularly when focusing on the product level, lies in its emphasis on designing products to facilitate the circulation of resources and maximize value throughout their entire lifecycle. To effectively develop such products an understanding of the characteristics of circular products (CP) is needed. Adopting a systems perspective that considers the total lifecycle and stakeholders involved and recognizing interdependencies among them is essential for identifying factors that characterize CPs. Existing methods for assessing product circularity do not identify all factors that charac- terize CPs and have limitations in the measurement methods proposed, …
A Franciscan Friar’S Defiant Journey: The Extent Of Individual Power In Colonial Mexico, 1782, Genesis Pena-Lozada
A Franciscan Friar’S Defiant Journey: The Extent Of Individual Power In Colonial Mexico, 1782, Genesis Pena-Lozada
Lewis Honors College Thesis Collection
During Spanish occupation of Mexico from 1521 to 1821, religion was used as an extension of the Spanish crown as Mexico’s native populations were forcibly converted to Catholicism. Religious orders, including Franciscan friars, a group of men who wandered and preached to help the poor and sick, were used in the systematic conversion of native populations. Because of the sheer scale of religious conversion of these native populations, the Spanish crown’s efforts in New Spain are sometimes described as a “spiritual conquest” rather than a military conquest. However, like military conquest, this evangelization was still enacted through power and domination. …
Promoting Physical Activity (Pa) Among Latinas In Fayette County, Ky, Vanessa Diaz Mph
Promoting Physical Activity (Pa) Among Latinas In Fayette County, Ky, Vanessa Diaz Mph
Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)
In the United States, the prevalence of overweight and obesity continues to rise at a disproportionate rate that is greatly affecting Latinas. This paper outlines the implementation of an adapted version of Fe en Acción, a faith-based evidence-based physical activity (PA) intervention that was initially implemented in San Diego, CA. The program targets Latinas in Fayette County, KY through culturally tailored, faith-based PA classes held at local Catholic churches. By using promotoras– health promoters– the program works to increase self-efficacy and social support while promoting sustainable behavior change. Key adaptations include a reduction in class frequency (four times a week), …
Developing Novel Therapeutic Strategies For Mcrc With A Brafv600e Mutation, Mariah Geisen
Developing Novel Therapeutic Strategies For Mcrc With A Brafv600e Mutation, Mariah Geisen
Theses and Dissertations--Toxicology and Cancer Biology
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. The overall incidence rates of CRC have decreased in those over 50, but there is an increasing incidence rate in those under 50. Risk factors for CRC include diet, family history, and a sedentary lifestyle. Early detection of CRC is key to patient survival and treatment response. Localized CRC has a survival rate of 90% and allows for surgical resection and chemotherapy. The 5-year survival for metastatic CRC (mCRC) is significantly reduced to around 14%. Despite early detection, 50% of patients will develop metastasis after surgical resection and …
Investigating Plk1 In Pulmonary Fibrosis, Tempany Arbogast
Investigating Plk1 In Pulmonary Fibrosis, Tempany Arbogast
Theses and Dissertations--Toxicology and Cancer Biology
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease, with a median survival of only 2–3 years following diagnosis. In the United States, the disease contributes to more than 40,000 deaths annually, underscoring its severe clinical burden. Alveolar type II (AT2) lung epithelial cells serve as progenitors that maintain alveolar integrity by replenishing epithelial populations and producing surfactants, while fibroblasts and myofibroblasts regulate the extracellular matrix and structural support. In pulmonary fibrosis (PF) injury to AT2 cells promotes cytokine and growth factor release, driving inflammation, fibroblast proliferation, myofibroblast accumulation, and excessive extracellular matrix deposition. Aberrant AT2 cell …
“A Safe Place”: Exploring Black Couples’ Perceptions Of Black Love And Relationship Coping In The Context Of Their Lived Experiences With Racism, Melinda Murdock
“A Safe Place”: Exploring Black Couples’ Perceptions Of Black Love And Relationship Coping In The Context Of Their Lived Experiences With Racism, Melinda Murdock
Theses and Dissertations--Family Sciences
Historically, Black couples have not been studied within the context of their lived experiences as it relates to the effects of racism on relationship health. Only in the last decade have relationship scholars begun to consistently link racism-related stressors to relationship processes and outcomes. Despite the growing literature, recent studies are primarily quantitative in method and rely on samples, theoretical models, and measures that predominantly represent White couples’ experiences. It remains unclear how Black couples’ perceptions of love and relationship coping lead to resilient outcomes despite the negative effects of racism.
Therefore, the goal of the present study is to …
Impacts Of School-Based Agricultural Education On The Resilience Of Senior Appalachian High School Students Living In Economically Disadvantaged Counties In Kentucky And Virginia, Ruth D. Toole
Theses and Dissertations--Community & Leadership Development
Students in Central Appalachia, particularly those in economically disadvantaged (ED) counties, may face unique risks related to their geographic and socioeconomic circumstances. However, school-based and youth development programs have been shown to foster resilience among youth. This convergent mixed-methods study aimed to explore whether involvement in School-Based Agricultural Education (SBAE) can enhance youth resilience. Data were collected through a resilience questionnaire and semi-structured focus group interviews, which were analyzed, interpreted, and integrated to uncover key findings. Results indicated that participants living in ED areas exhibited relatively high resilience scores. Focus group discussions revealed that, despite the challenges they face, participants …
A Framework For Ai Implementation In Construction: Use Cases, Challenges, And Benefits For Contractors, Jaqueline De Aquino Leite Gomes
A Framework For Ai Implementation In Construction: Use Cases, Challenges, And Benefits For Contractors, Jaqueline De Aquino Leite Gomes
Theses and Dissertations--Civil Engineering
The construction industry is one of the most important sectors that contribute to the economy worldwide, but it has been very slow in adopting digital transformation. Artificial Intelligence is the backbone of digital innovation, and it can help solve inefficiencies, improve safety, and enhance decision-making in construction. This thesis reviews 85 academic papers, identifies 354 AI use-cases, 180 benefits, and 173 challenges. Key findings have looked at the role of AI in safety monitoring, design optimization, and operational efficiency, while barriers involve data scarcity, high costs, and readiness of the workforce.
All of these challenges have one very handy framework …
Multi-Scale Computational Mechanical Modeling Of Complex Multi-Phase Materials Systems, Naji Al-Mashrafi
Multi-Scale Computational Mechanical Modeling Of Complex Multi-Phase Materials Systems, Naji Al-Mashrafi
Theses and Dissertations--Chemical and Materials Engineering
This thesis employs finite-element–based computational methods to investigate how microstructural features and material heterogeneity govern mechanical behavior across three distinct complex systems. First, the elastic response of open-cell metallic foams is analyzed using large ensembles of model RVEs generated with the Kentucky Random Structures Toolkit (KRaSTk); finite-element homogenization reveals that effective stiffness is not dictated by relative density alone, as the skewness of ligament-length distributions—captured by the second Pearson’s coefficient—exerts a strong and previously unrecognized influence, with structures enriched in short load-bearing ligaments exhibiting consistently higher stiffness even at fixed density and connectivity. The second study examines heterogeneous polycrystalline solids …