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Goat Products, Breeding Objectives And Flock Structure On The Tibetan Plateau, Xusheng Guo, Ruijun Long, Luming Ding, Wolfgang Bayer Dec 2020

Goat Products, Breeding Objectives And Flock Structure On The Tibetan Plateau, Xusheng Guo, Ruijun Long, Luming Ding, Wolfgang Bayer

IGC Proceedings (1977-2023)

No abstract provided.


The Influence Of Breed And Maternal Education On Goat Kids' Intake Of A Tannin‐Rich Shrub, T. A. Glasser, S. Y. Landau, Avi Perevolotsky, H. Muklada, Eugene D. Ungar Dec 2020

The Influence Of Breed And Maternal Education On Goat Kids' Intake Of A Tannin‐Rich Shrub, T. A. Glasser, S. Y. Landau, Avi Perevolotsky, H. Muklada, Eugene D. Ungar

IGC Proceedings (1977-2023)

No abstract provided.


Effect Of The Pasture, In Different Seasons, And Of The Ripening Time On The Caciocavallo Palermitano Cheese, C. Giosuè, M. Alabiso, M. L. Alicata, V. Ilardi, D. Giambalvo, G. Maniaci Dec 2020

Effect Of The Pasture, In Different Seasons, And Of The Ripening Time On The Caciocavallo Palermitano Cheese, C. Giosuè, M. Alabiso, M. L. Alicata, V. Ilardi, D. Giambalvo, G. Maniaci

IGC Proceedings (1977-2023)

No abstract provided.


Anthelmintic Property Of Fresh Cassava (Manihot Esculenta) Leaves Incorporated In The Diet Of West African Dwarf Goats, E. Tedonkeng Pamo, J. Awah-Ndukum, B. Boukila, F. Tendonkeng, F. Matumuini Ndzanie Essie Dec 2020

Anthelmintic Property Of Fresh Cassava (Manihot Esculenta) Leaves Incorporated In The Diet Of West African Dwarf Goats, E. Tedonkeng Pamo, J. Awah-Ndukum, B. Boukila, F. Tendonkeng, F. Matumuini Ndzanie Essie

IGC Proceedings (1977-2023)

No abstract provided.


Acaricidal Activity Of Essential Oils From Leaves Of Chromolaena Odorata (L.) King & Robins., Eucalyptus Saligna Smith. & Chenopodium Ambrosioides On Ticks (Rhipicepha Luslunulatus Neumann, 1907) Of West African Dwarf Goats (Wadg) In Cameroon, E. Tedonkeng Pamo, B. Boukila, J. Awah-Ndukum, F. Tendonkeng Dec 2020

Acaricidal Activity Of Essential Oils From Leaves Of Chromolaena Odorata (L.) King & Robins., Eucalyptus Saligna Smith. & Chenopodium Ambrosioides On Ticks (Rhipicepha Luslunulatus Neumann, 1907) Of West African Dwarf Goats (Wadg) In Cameroon, E. Tedonkeng Pamo, B. Boukila, J. Awah-Ndukum, F. Tendonkeng

IGC Proceedings (1977-2023)

No abstract provided.


Appropriate Stocking Rate Of Yak On Alpine Pastures In The Three Rivers Headwater Region Of The Qinghai‐Tibetan Plateau, M. Dong, X. Q. Zhao, Y. S. Ma, Julia A. Klein, J. J. Shi, Y. L. Wang, L. Sheng, S. H. Yang, X. D. Sun Dec 2020

Appropriate Stocking Rate Of Yak On Alpine Pastures In The Three Rivers Headwater Region Of The Qinghai‐Tibetan Plateau, M. Dong, X. Q. Zhao, Y. S. Ma, Julia A. Klein, J. J. Shi, Y. L. Wang, L. Sheng, S. H. Yang, X. D. Sun

IGC Proceedings (1977-2023)

No abstract provided.


Effects Of Herbal Medicines On Proliferation Of Cow Mammary Epithelial Cells In Vitro, Yueyun Ding, Hongduo Bao, Fang Jiang, Lili Zhang, Tian Wang Dec 2020

Effects Of Herbal Medicines On Proliferation Of Cow Mammary Epithelial Cells In Vitro, Yueyun Ding, Hongduo Bao, Fang Jiang, Lili Zhang, Tian Wang

IGC Proceedings (1977-2023)

No abstract provided.


Astragalus Membranaceus, Seed Of Cowheb Alters Milk Protein Yields And Lactoferrin, Casein Gene Expression In Cow Mammary Epithelial Cells, Yueyun Ding, Lili Zhang, Hongduo Bao, Tian Wang Dec 2020

Astragalus Membranaceus, Seed Of Cowheb Alters Milk Protein Yields And Lactoferrin, Casein Gene Expression In Cow Mammary Epithelial Cells, Yueyun Ding, Lili Zhang, Hongduo Bao, Tian Wang

IGC Proceedings (1977-2023)

No abstract provided.


Sheep On The Tibetan Plateau Flock Structure And Breeding Strategies, Luming Ding, Ruijun Long, Xusheng Guo, Wolfgang Bayer Dec 2020

Sheep On The Tibetan Plateau Flock Structure And Breeding Strategies, Luming Ding, Ruijun Long, Xusheng Guo, Wolfgang Bayer

IGC Proceedings (1977-2023)

No abstract provided.


Evaluation Of The Intake Of Fresh Mulberry In Crossbred Large White Pigs: Morphometric, Histological And Hematological Study, Yuvan Contino, F. Ojeda, R. Herrera, Nancy Altunaga, Guadalupe Pérez, J. L. Moliner Dec 2020

Evaluation Of The Intake Of Fresh Mulberry In Crossbred Large White Pigs: Morphometric, Histological And Hematological Study, Yuvan Contino, F. Ojeda, R. Herrera, Nancy Altunaga, Guadalupe Pérez, J. L. Moliner

IGC Proceedings (1977-2023)

No abstract provided.


Use Of A Simulation Model To Develop Feeding Strategies For Cattle At Pasture In Small Scale Dairy Farming Systems In The Highlands Of Central Mexico: Methodological Frame Work, O. A. Castelán-Ortega, J. G. Estrada‐Flores, A. M. J. Espinoza‐Ortega, E. Sánchez‐Vera, M. Hernández‐Ortega, M. A. Rojas‐Garduño, V. Ambriz‐Vilchis Dec 2020

Use Of A Simulation Model To Develop Feeding Strategies For Cattle At Pasture In Small Scale Dairy Farming Systems In The Highlands Of Central Mexico: Methodological Frame Work, O. A. Castelán-Ortega, J. G. Estrada‐Flores, A. M. J. Espinoza‐Ortega, E. Sánchez‐Vera, M. Hernández‐Ortega, M. A. Rojas‐Garduño, V. Ambriz‐Vilchis

IGC Proceedings (1977-2023)

No abstract provided.


The Utilization Of Stored Soil Moistures For Forage Legumes Supply In The Dry Season In West Timor, Indonesia, Esnawan Budisantoso, Neal Dalgliesh, P. Th. Fernandez, T. Basuki, E. Hosang, D. Kana Hau, Jacob Nulik Dec 2020

The Utilization Of Stored Soil Moistures For Forage Legumes Supply In The Dry Season In West Timor, Indonesia, Esnawan Budisantoso, Neal Dalgliesh, P. Th. Fernandez, T. Basuki, E. Hosang, D. Kana Hau, Jacob Nulik

IGC Proceedings (1977-2023)

No abstract provided.


Cultivating The Surface Soil To Renovate A Grama Rhodes (Chloris Gayana K. Cv. Callide) Pasture In Northwest Argentine (Noa). 2. Effect Of Nitrogen Fertilization, R. N. Berti Dec 2020

Cultivating The Surface Soil To Renovate A Grama Rhodes (Chloris Gayana K. Cv. Callide) Pasture In Northwest Argentine (Noa). 2. Effect Of Nitrogen Fertilization, R. N. Berti

IGC Proceedings (1977-2023)

No abstract provided.


Cultivating The Surface Soil To Renovate A Grama Rhodes (Chloris Gayana K. Cv. Callide) Pasture In Northwest Argentine (Noa). 1. Effect Of Implements, R. N. Berti Dec 2020

Cultivating The Surface Soil To Renovate A Grama Rhodes (Chloris Gayana K. Cv. Callide) Pasture In Northwest Argentine (Noa). 1. Effect Of Implements, R. N. Berti

IGC Proceedings (1977-2023)

No abstract provided.


Productivity Of Different Lamb Production Systems In Temperate And Tropical Pasture Of The Southern Region Of Brazil, Alda L. G. Monteiro, Cesar H. E. C. Poli, T. D. M. Ribeiro, Anibal De Moraes, O. R. Prado, H. Von L. Piazzetta Dec 2020

Productivity Of Different Lamb Production Systems In Temperate And Tropical Pasture Of The Southern Region Of Brazil, Alda L. G. Monteiro, Cesar H. E. C. Poli, T. D. M. Ribeiro, Anibal De Moraes, O. R. Prado, H. Von L. Piazzetta

IGC Proceedings (1977-2023)

No abstract provided.


Loss-Of-Function Genomic Variants Highlight Potential Therapeutic Targets For Cardiovascular Disease, Jonas B. Nielsen, Oren Rom, Ida Surakka, Sarah E. Graham, Wei Zhou, Tanmoy Roychowdhury, Lars G. Fritsche, Sarah A. Gagliano Taliun, Carlo Sidore, Yuhao Liu, Maiken E. Gabrielsen, Anne Heidi Skogholt, Brooke Wolford, William Overton, Ying Zhao, Jin Chen, He Zhang, Whitney E. Hornsby, Akua Acheampong, Austen Grooms, Amanda Schaefer, Gregory J. M. Zajac, Luis Villacorta, Jifeng Zhang, Ben Brumpton, Mari Løset, Vivek Rai, Pia R. Lundegaard, Morten S. Olesen, Kent D. Taylor, Donna K. Arnett Dec 2020

Loss-Of-Function Genomic Variants Highlight Potential Therapeutic Targets For Cardiovascular Disease, Jonas B. Nielsen, Oren Rom, Ida Surakka, Sarah E. Graham, Wei Zhou, Tanmoy Roychowdhury, Lars G. Fritsche, Sarah A. Gagliano Taliun, Carlo Sidore, Yuhao Liu, Maiken E. Gabrielsen, Anne Heidi Skogholt, Brooke Wolford, William Overton, Ying Zhao, Jin Chen, He Zhang, Whitney E. Hornsby, Akua Acheampong, Austen Grooms, Amanda Schaefer, Gregory J. M. Zajac, Luis Villacorta, Jifeng Zhang, Ben Brumpton, Mari Løset, Vivek Rai, Pia R. Lundegaard, Morten S. Olesen, Kent D. Taylor, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide analyses of participants in the HUNT Study in Norway (n = 69,479) to search for protein-altering variants with beneficial impact on quantitative blood traits related to cardiovascular disease, but without detrimental impact on liver function. We identify 76 (11 previously unreported) presumed causal protein-altering variants associated with one or more CVD- or liver-related blood traits. Nine of the variants are predicted to result in loss-of-function of …


Epigenetic Regulation Of Wnt Signaling By Carboxamide-Substituted Benzhydryl Amines That Function As Histone Demethylase Inhibitors, Wen Zhang, Vitaliy M. Sviripa, Yanqi Xie, Tianxin Yu, Meghan G. Haney, Jessica S. Blackburn, Charles A. Adeniran, Chang-Guo Zhan, David S. Watt, Chunming Liu Dec 2020

Epigenetic Regulation Of Wnt Signaling By Carboxamide-Substituted Benzhydryl Amines That Function As Histone Demethylase Inhibitors, Wen Zhang, Vitaliy M. Sviripa, Yanqi Xie, Tianxin Yu, Meghan G. Haney, Jessica S. Blackburn, Charles A. Adeniran, Chang-Guo Zhan, David S. Watt, Chunming Liu

Molecular and Cellular Biochemistry Faculty Publications

Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis Coli (APC) or CTNNB1 (β-catenin) is a hallmark of colorectal cancers (CRC). As part of a program to develop epigenetic regulators for cancer therapy, we developed carboxamide-substituted benzhydryl amines (CBAs) bearing either aryl or heteroaryl groups that selectively targeted histone lysine demethylases (KDMs) and functioned as inhibitors of the Wnt pathway. A biotinylated variant of N-((5-chloro-8-hydroxyquinolin-7-yl) (4-(diethylamino)phenyl)-methyl)butyramide (CBA-1) identified KDM3A as a binding partner. KDM3A is a Jumonji (JmjC) domain-containing demethylase that is significantly upregulated in CRC. KDM3A regulates the demethylation of histone H3's lysine …


Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, And Increase Plasma Β-Hydroxybutyrate, Terry D. Hinds Jr., Justin F. Creeden, Darren M. Gordon, Donald F. Stec, Matthew C. Donald, David E. Stec Dec 2020

Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, And Increase Plasma Β-Hydroxybutyrate, Terry D. Hinds Jr., Justin F. Creeden, Darren M. Gordon, Donald F. Stec, Matthew C. Donald, David E. Stec

Pharmacology and Nutritional Sciences Faculty Publications

The inverse relationship of plasma bilirubin levels with liver fat accumulation has prompted the possibility of bilirubin as a therapeutic for non-alcoholic fatty liver disease. Here, we used diet-induced obese mice with non-alcoholic fatty liver disease treated with pegylated bilirubin (bilirubin nanoparticles) or vehicle control to determine the impact on hepatic lipid accumulation. The bilirubin nanoparticles significantly reduced hepatic fat, triglyceride accumulation, de novo lipogenesis, and serum levels of liver dysfunction marker aspartate transaminase and ApoB100 containing very-low-density lipoprotein. The bilirubin nanoparticles improved liver function and activated the hepatic β-oxidation pathway by increasing PPARα and acyl-coenzyme A oxidase 1. …


Experimental Manipulations To Test Theory-Driven Mechanisms Of Cognitive Behavior Therapy, Matthew W. Southward, Shannon Sauer-Zavala Dec 2020

Experimental Manipulations To Test Theory-Driven Mechanisms Of Cognitive Behavior Therapy, Matthew W. Southward, Shannon Sauer-Zavala

Psychology Faculty Publications

Despite decades of randomized-controlled trials demonstrating the efficacy of cognitive-behavior therapy (CBT), the mechanisms by which CBT achieves its effects remain unclear. Here, we describe how one adaptive intervention, the sequential multiple assignment randomized trial (SMART), can be used to randomize patients at multiple decision points in treatment to draw stronger causal claims about mechanisms unfolding in the course of CBT. We illustrate this design using preliminary data and case examples from an ongoing SMART in which we are testing the role of aversive reactions to negative emotions as a hypothesized mechanism of change in the Unified Protocol. Finally, we …


Reference Gene Selection For Transcriptional Profiling In Cryptocercus Punctulatus, An Evolutionary Link Between Isoptera And Blattodea, Zhen Li, Xiangrui Li, Qingwen Zhang, Ling Yuan, Xuguo Zhou Dec 2020

Reference Gene Selection For Transcriptional Profiling In Cryptocercus Punctulatus, An Evolutionary Link Between Isoptera And Blattodea, Zhen Li, Xiangrui Li, Qingwen Zhang, Ling Yuan, Xuguo Zhou

Plant and Soil Sciences Faculty Publications

The subsocial life style and wood-feeding capability of Cryptocercus gives us an evolutionary key to unlock some outstanding questions in biology. With the advent of the Genomics Era, there is an unprecedented opportunity to address the evolution of eusociality and the acquisition of lignocellulases at the genetic level. However, to quantify gene expression, an appropriate normalization strategy is warranted to control for the non-specific variations among samples across different experimental conditions. To search for the internal references, 10 housekeeping genes from a gut transcriptome of a wood-feeding cockroach, Cryptocercus punctulatus, were selected as the candidates for the RT-qPCR analysis. The …


The Evaluation Of Two Cultivation Methods To Over‐Sow Perennial Clovers Into Kikuyu, Philip R. Botha, Robin Meeske, Hennie A. Snyman Dec 2020

The Evaluation Of Two Cultivation Methods To Over‐Sow Perennial Clovers Into Kikuyu, Philip R. Botha, Robin Meeske, Hennie A. Snyman

IGC Proceedings (1977-2023)

No abstract provided.


Temporal Mobility Patterns Of Livestock In Semi‐Arid Communal Rangelands In South Africa, Igshaan Samuels, Nicky Allsopp, Timm Hoffman Dec 2020

Temporal Mobility Patterns Of Livestock In Semi‐Arid Communal Rangelands In South Africa, Igshaan Samuels, Nicky Allsopp, Timm Hoffman

IGC Proceedings (1977-2023)

No abstract provided.


Energetic Supplementation For Beef Heifers Grazing Temperate Pasture, Marta G. Da Rocha, L. Potter Dec 2020

Energetic Supplementation For Beef Heifers Grazing Temperate Pasture, Marta G. Da Rocha, L. Potter

IGC Proceedings (1977-2023)

No abstract provided.


Annual Legumes With Greater Water Use Efficiency Can Overcome Seasonal Feed Imbalance, Belinda Hackney, B. Dear, G. Dyce, C. Rodham, G. Li Dec 2020

Annual Legumes With Greater Water Use Efficiency Can Overcome Seasonal Feed Imbalance, Belinda Hackney, B. Dear, G. Dyce, C. Rodham, G. Li

IGC Proceedings (1977-2023)

No abstract provided.


Productive And Sustainable Pasture Systems: Responding To Climate Variability In The South West Of Australia, Ned Crossley Dec 2020

Productive And Sustainable Pasture Systems: Responding To Climate Variability In The South West Of Australia, Ned Crossley

IGC Proceedings (1977-2023)

No abstract provided.


Performance Of Beef Cattle Females Grazing Under Different Feeding Systems Based On Native Pastures In Southern Brazil, Carlos Nabinger, Teresa C. M. Genro, F. F. Cardoso, M. G. Orqis, M. M. Oliveira, D. P. Montardo Dec 2020

Performance Of Beef Cattle Females Grazing Under Different Feeding Systems Based On Native Pastures In Southern Brazil, Carlos Nabinger, Teresa C. M. Genro, F. F. Cardoso, M. G. Orqis, M. M. Oliveira, D. P. Montardo

IGC Proceedings (1977-2023)

No abstract provided.


Cd47 Differentially Regulates White And Brown Fat Function, Heather Norman-Burgdolf, Dong Li, Patrick G. Sullivan, Shuxia Wang Dec 2020

Cd47 Differentially Regulates White And Brown Fat Function, Heather Norman-Burgdolf, Dong Li, Patrick G. Sullivan, Shuxia Wang

Pharmacology and Nutritional Sciences Faculty Publications

Mechanisms that enhance energy expenditure are attractive therapeutic targets for obesity. Previously we have demonstrated that mice lacking cd47 are leaner, exhibit increased energy expenditure, and are protected against diet-induced obesity. In this study, we further defined the physiological role of cd47 deficiency in regulating mitochondrial function and energy expenditure in both white and brown adipose tissue. We observed that cd47 deficient mice (under normal chow diet) had comparable amount of white fat mass but reduced white adipocyte size as compared to wild-type mice. Subsequent ex vivo and in vitro studies suggest enhanced lipolysis, and not impaired lipogenesis or energy …


Compositions And Methods For Treating Retinal Degradation, Jayakrishna Ambati, Benjamin Fowler Dec 2020

Compositions And Methods For Treating Retinal Degradation, Jayakrishna Ambati, Benjamin Fowler

Ophthalmology and Visual Science Faculty Patents

The present disclosure relates to compositions and methods for treating retinal damage and/or retinal degradation. More specifically, this disclosure relates to methods for treating degradation of the retinal pigment epithelium by administering compositions comprising a nucleoside and/or a nucleoside or nucleotide reverse transcriptase inhibitor.


K2p2.1 (Trek-1) Potassium Channel Activation Protects Against Hyperoxia-Induced Lung Injury, Tatiana Zyrianova, Benjamin Lopez, Riccardo Olcese, John Belperio, Christopher M. Waters, Leanne Wong, Victoria Nguyen, Sriharsha Talapaneni, Andreas Schwingshackl Dec 2020

K2p2.1 (Trek-1) Potassium Channel Activation Protects Against Hyperoxia-Induced Lung Injury, Tatiana Zyrianova, Benjamin Lopez, Riccardo Olcese, John Belperio, Christopher M. Waters, Leanne Wong, Victoria Nguyen, Sriharsha Talapaneni, Andreas Schwingshackl

Physiology Faculty Publications

No targeted therapies exist to counteract Hyperoxia (HO)-induced Acute Lung Injury (HALI). We previously found that HO downregulates alveolar K2P2.1 (TREK-1) K+ channels, which results in worsening lung injury. This decrease in TREK-1 levels leaves a subset of channels amendable to pharmacological intervention. Therefore, we hypothesized that TREK-1 activation protects against HALI. We treated HO-exposed mice and primary alveolar epithelial cells (AECs) with the novel TREK-1 activators ML335 and BL1249, and quantified physiological, histological, and biochemical lung injury markers. We determined the effects of these drugs on epithelial TREK-1 currents, plasma membrane potential (Em), and intracellular Ca …


Antibodies Against Lysophosphatidic Acid Protect Against Blast-Induced Ocular Injuries, Peethambaran Arun, Franco Rossetti, James C. Demar, Ying Wang, Andrew B. Batuure, Donna M. Wilder, Irene D. Gist, Andrew J. Morris, Roger A. Sabbadini, Joseph B. Long Dec 2020

Antibodies Against Lysophosphatidic Acid Protect Against Blast-Induced Ocular Injuries, Peethambaran Arun, Franco Rossetti, James C. Demar, Ying Wang, Andrew B. Batuure, Donna M. Wilder, Irene D. Gist, Andrew J. Morris, Roger A. Sabbadini, Joseph B. Long

Internal Medicine Faculty Publications

Exposure to blast overpressure waves is implicated as the major cause of ocular injuries and resultant visual dysfunction in veterans involved in recent combat operations. No effective therapeutic strategies have been developed so far for blast-induced ocular dysfunction. Lysophosphatidic acid (LPA) is a bioactive phospholipid generated by activated platelets, astrocytes, choroidal plexus cells, and microglia and is reported to play major roles in stimulating inflammatory processes. The levels of LPA in the cerebrospinal fluid have been reported to increase acutely in patients with traumatic brain injury (TBI) as well as in a controlled cortical impact (CCI) TBI model in mice. …