Digital Commons Network^™

Genetic Contributors Of Incident Stroke In 10,700 African Americans With Hypertension: A Meta-Analysis From The Genetics Of Hypertension Associated Treatments And Reasons For Geographic And Racial Differences In Stroke Studies, Nicole D. Armstrong, Vinodh Srinivasasainagendra, Amit Patki, Rikki M. Tanner, Bertha A. Hidalgo, Hemant K. Tiwari, Nita A. Limdi, Ethan M. Lange, Leslie A. Lange, Donna K. Arnett, Marguerite R. Irvin

Epidemiology and Environmental Health Faculty Publications

Background: African Americans (AAs) suffer a higher stroke burden due to hypertension. Identifying genetic contributors to stroke among AAs with hypertension is critical to understanding the genetic basis of the disease, as well as detecting at-risk individuals.

Methods: In a population comprising over 10,700 AAs treated for hypertension from the Genetics of Hypertension Associated Treatments (GenHAT) and Reasons for Geographic and Racial Differences in Stroke (REGARDS) studies, we performed an inverse variance-weighted meta-analysis of incident stroke. Additionally, we tested the predictive accuracy of a polygenic risk score (PRS) derived from a European ancestral population in both GenHAT and REGARDS AAs …

Nondestructive Detection Of Codling Moth Infestation In Apples Using Pixel-Based Nir Hyperspectral Imaging With Machine Learning And Feature Selection, Nader Ekramirad, Alfadhl Y. Khaled, Lauren E. Doyle, Julia R. Loeb, Kevin D. Donohue, Raul T. Villanueva, Akinbode A. Adedeji

Electrical and Computer Engineering Faculty Publications

Codling moth (CM) (Cydia pomonella L.), a devastating pest, creates a serious issue for apple production and marketing in apple-producing countries. Therefore, effective nondestructive early detection of external and internal defects in CM-infested apples could remarkably prevent postharvest losses and improve the quality of the final product. In this study, near-infrared (NIR) hyperspectral reflectance imaging in the wavelength range of 900–1700 nm was applied to detect CM infestation at the pixel level for three organic apple cultivars, namely Gala, Fuji and Granny Smith. An effective region of interest (ROI) acquisition procedure along with different machine learning and data processing …

Late-Life Exercise Mitigates Skeletal Muscle Epigenetic Aging, Kevin A. Murach, Andrea L. Dimet-Wiley, Yuan Wen, Camille R. Brightwell, Christine M. Latham, Cory M. Dungan, Christopher S. Fry, Stanley J. Watowich

Center for Muscle Biology Faculty Publications

There are functional benefits to exercise in muscle, even when performed late in life, but the contributions of epigenetic factors to late-life exercise adaptation are poorly defined. Using reduced representation bisulfite sequencing (RRBS), ribosomal DNA (rDNA) and mitochondrial-specific examination of methylation, targeted high-resolution methylation analysis, and DNAge™ epigenetic aging clock analysis with a translatable model of voluntary murine endurance/resistance exercise training (progressive weighted wheel running, PoWeR), we provide evidence that exercise may mitigate epigenetic aging in skeletal muscle. Late-life PoWeR from 22–24 months of age modestly but significantly attenuates an age-associated shift toward promoter hypermethylation. The epigenetic age of muscle …

Adipose-Specific Pparα Knockout Mice Have Increased Lipogenesis By Pask–Srebp1 Signaling And A Polarity Shift To Inflammatory Macrophages In White Adipose Tissue, Terry D. Hinds, Jr., Zachary A. Kipp, Mei Xu, Frederique B. Yiannikouris, Andrew J. Morris, Donald F. Stec, Walter Wahli, David E. Stec

Pharmacology and Nutritional Sciences Faculty Publications

The nuclear receptor PPARα is associated with reducing adiposity, especially in the liver, where it transactivates genes for β-oxidation. Contrarily, the function of PPARα in extrahepatic tissues is less known. Therefore, we established the first adipose-specific PPARα knockout (Ppara^FatKO) mice to determine the signaling position of PPARα in adipose tissue expansion that occurs during the development of obesity. To assess the function of PPARα in adiposity, female and male mice were placed on a high-fat diet (HFD) or normal chow for 30 weeks. Only the male Ppara^FatKO animals had significantly more adiposity in the inguinal white …

The Efficacy Of Sequential Biologic Agents In Refractory Rheumatoid Arthritis After Failure Of Initial Dmard And Anti-Tumor Necrosis Factor Therapy, Antonio Giovanni Versace, Caterina Oriana Aragona, Daniela La Rosa, Marianna Chiappalone, Maria Concetta Tringali, Alberta De Gaetano, Charles Frederick Moore Jr., Donatella Sangari, William Neal Roberts, Gianluca Bagnato

Internal Medicine Faculty Publications

Introduction/Objective: The efficacy of biologic therapy in the treatment of rheumatoid arthritis (RA) has been well-established but, in practice, a quarter of patients will either not respond to the first biologic agent or will suffer an adverse event requiring a switch to a different drug. While clinical guidelines exist to help guide therapy and previous studies have examined sequential use of anti-TNF agents, there is little data to inform a multiple switch strategy. Our aim was to measure the efficacy of multiple switches of biologic in severe refractory RA. Methods: We enrolled 111 patients whose therapy with one anti-TNF agent …

Sheep Performance In Italian Ryegrass Swards At Contrasting Sward Heights, Paulo C. De F. Carvalho, L. S. Pontes, E. O. Silveira, C. H. E. C. Poli, Carlos Nabinger, O. A. Pereira Neto, G. E. Maraschin

IGC Proceedings (1977-2023)

The objective of this study was to assess the effect of Italian ryegrass (Lolium multiflorum Lam.) sward height on lamb performance. The experiment was carried out at the Research Station of UFRGS, Eldorado do Sul, Brazil. Yearling no-castrated male lambs were assessed in terms of individual animal performance and gain per hectare. The experiment was carried out in a randomised block design with three replications of four treatments: 5, 10, 15 and 20 cm of sward surface height (SSH), which were maintained using continuous variable stocking, and monitored by a sward stick. Samples of 0.25 m² were cut …

Animal Performance In Pastures Of Panicum Maximum Cv. Ipr 86 Fertilized With Nitrogen, S. M. B. Lugão, L. R. De A. Rodrigues, E. B. Malheiros, J. J. Dos S. Abrahão, A. De Morais

IGC Proceedings (1977-2023)

The experiment was carried out at the Experimental Station of the IAPAR in Paranavaí– PR, Brazil, from October 1998 to May 1999 to evaluate the response of crossbred steers grazing pastures of Panicum maximum cv. IPR 86 fertilized with four doses of N (0; 150; 300 and 450 kg.ha^-1.year). The grass was grazed according to a rotational grazing system with grazing cycles (GCs) of 40 days (grazing period of 5 days and rest period of 35 days). It was used a randomized complete block design, with split-plots, and two replications per treatment, being the N-doses studied in the …

Dairy Cow Performance On Pasture-Based Feeding Systems And In Confinement, Renato S. Fontaneli, Lynn E. Sollenberger, C. R. Staples

IGC Proceedings (1977-2023)

Interest in grazing systems is growing among farmers in the USA as a means of reducing feed costs for lactating dairy cows. An experiment was conducted near Gainesville, FL to compare milk production and composition and milk income minus feed costs from two pasture-based systems with those of a conventional confinement housing system over a 276-d period. System 1 was based on a mixture of rye (Secale cereale L.), annual ryegrass (Lolium multiflorum Lam.), crimson clover (Trifolium incarnatum L.), and red clover (Trifolium pratense L.) during the winter-spring seasons and pearl millet (Pennisetum glaucum [L.] …

Mansouramycins E–G, Cytotoxic Isoquinolinequinones From Marine Streptomycetes, Mohamed Shaaban, Khaled A. Shaaban, Gerhard Kelter, Heinz Herbert Fiebig, Hartmut Laatsch

Center for Pharmaceutical Research and Innovation Faculty Publications

Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E ( …

Principal Component Analysis In Paspalum Germplasm Characterization, A. Regitano Neto, L. A. R. Batista

IGC Proceedings (1977-2023)

In a survey, through principal component analyses, for the most representative descriptors to be used in Paspalum germplasm characterization, 16 agronomic traits, 16 reproductive traits and 21 vegetative traits were evaluated in 32 accessions comprising Paspalum plicatulum (19) and Paspalum compressifolium (13) from the institutional germplasm collection. ANOVA for agronomic descriptors showed significant differences among accessions, except for percentage of dry matter in winter (DMW) which was not significant. Principal component analyses allowed reduction of 69%, 69% and 62%, respectively, in the initial number of descriptors, and the election of the most important for agronomic traits: DMYS, DMYW, RGS, CPPW …

Production And Quality Of Paspalum Forage In State Of São Paulo, L. A. R. Batista, A. Regitano Neto, Rodolfo Godoy

IGC Proceedings (1977-2023)

Biomass produced by accessions of 26 species, belonging to 12 botanical groups of the genus Paspalum, collected in the south and central regions of Brazil, were evaluated during the first year of establishment for quantitative characteristics: production of dry biomass (DMY), percentage of dry matter (PDM) and regrowth score and qualitative traits: concentration of neutral detergent fiber (NDF), “in vitro” dry matter digestibility (IVDMD) and crude protein percentage in dry matter (CPPDM) -, in the central area of the state of São Paulo, in a completely randomized block design with two replications. The largest averages of DMY were obtained …

Study Of The Diversity Of Soil Animals Community In The Songnen Plain Grassland Of China, Xiuqin Yin, Tingcheng Zhu

IGC Proceedings (1977-2023)

This paper dealt with the diversity in eight habitat soil animals communities in Songnen plain grassland. The results showed the better habitat condition the higher diversity index of soil animals, and vice-versa. The diversity of soil animals communities correlated positively with soil organic matter, total nitrogen, and negatively with soil pH; there was a poor correlation with soil water content and total soil phosphorus. The diversity of soil animals communities decreased with increasing depth of soil layer and has surface-collection.

Evaluating Varieties Of Alfalfa And Tall Fescue For Tolerance To Over-Grazing By Cattle, Robert F. Spitaleri, Jimmy C. Henning, Charles T. Dougherty, Garry D. Lacefield, B. T. Larson

IGC Proceedings (1977-2023)

Cultivars of alfalfa (Medicago sativa L.) and tall fescue (Festuca arundinacea Schreb.) were seeded in small (1.5 m x 4.6 m) plots and harvested for estimating yield the following spring. Plots were then grazed by cattle continuously for the remainder of the season so as to keep stand heights at 7.5 cm or less. This procedure was repeated for one or two more grazing seasons, depending on stand survival. Stands were visually rated for stand in the fall and spring. Marked differences in grazing tolerance were observed among alfalfa cultivars, following closely the commercial designations as grazing-type or …

The Role Of Cattle Dung In Seed Dispersal Of Major Species In A Zoysia Japonica Pasture In Japan, K. Shimoda, S. Sakanoue

IGC Proceedings (1977-2023)

To evaluate the role of cattle dung in seed dispersal of major species in Zoysia japonica pasture in Japan, we investigated the species composition and density of seeds in cattle dung by means of a germination test. Of 20 major species which had a mean coverage of more than 0.1%, 90% were detected as seeds in cattle dung. In addition, the species composition and density of seeds in cattle dung differed among three sampling seasons. Seeds of the six most prevalent species in terms of coverage were detected from cattle dung during the growing season. Hence, we conclude that it …

Can Activated Titanium Interbody Cages Accelerate Or Enhance Spinal Fusion? A Review Of The Literature And A Design For Clinical Trials, Nathaniel Toop, Connor Gifford, Rouzbeh Motiei-Langroudi, Arghavan Farzadi, Daniel Boulter, Reza Forghani, H. Francis Farhadi

Neurosurgery Faculty Publications

While spinal interbody cage options have proliferated in the past decade, relatively little work has been done to explore the comparative potential of biomaterial technologies in promoting stable fusion. Innovations such as micro-etching and nano-architectural designs have shown purported benefits in in vitro studies, but lack clinical data describing their optimal implementation. Here, we critically assess the pre-clinical data supportive of various commercially available interbody cage biomaterial, topographical, and structural designs. We describe in detail the osteointegrative and osteoconductive benefits conferred by these modifications with a focus on polyetheretherketone (PEEK) and titanium (Ti) interbody implants. Further, we describe the rationale …

Biodiversity And Spatial Heterogeneity In Semi-Natural Grasslands In A Mountain Area In Slovakia, Masae Shiyomi, N. Gáborèík, H. Koizumi, A. Javorkova, E. Uhliarova, O. Jezikova

IGC Proceedings (1977-2023)

The spatial pattern of vegetation in the following 3 semi-natural grasslands in Banska Bystrica, Slovakia, was observed in August, 1998: (1) a grassland sown with improved herbage plants after plowing in 1991, (2) a grassland oversown with improved herbage plants in 1991, and (3) a natural grassland without any treatment at the time of establishment. A new method of measuring vegetation was adopted: in each grassland, 50 quadrats 50 cm × 50 cm, composed of 4 smaller cells 25 cm × 25 cm, were set up, and all the species in each cell were recorded. The sown grassland displayed the …

Optimum Area Of Semi-Natural Grassland To Maintain Maximum Butterfly And Avian Species Richness In Japan, A. Shoji, K. Kohyama, H. Sasaki

IGC Proceedings (1977-2023)

To evaluate the optimum area of semi-natural grassland to maintain maximum butterfly and avian species richness in Japan, digitalized grid data of butterfly and avian distribution, as well as vegetation distribution, throughout the country were used. After obtaining logistic regression models explaining the probabilities of occurrence of each species with semi-natural grassland area and latitude as variables, the optimum value was calculated. The expected maximum species richness of butterflies in the country was the highest in the case of about 40 square kilometers of semi-natural grassland per 100 square kilometers, though the value varied somewhat with latitude. The expected maximum …

Managing Grassy Woodlands: Balancing Production And Conservation Of Resources, John G. Mcivor, Neil D. Macleod, S. Mcintyre

IGC Proceedings (1977-2023)

Eastern Australian eucalypt woodlands are important agricultural areas that have been widely modified during two centuries of European-style use. Despite this they contain important natural resources including significant biodiversity. Long term sustainability of production depends on maintaining resources and management must be for both production and conservation. A research program on four properties in south east Queensland showed the properties were in generally good condition although all had some problems, and has highlighted a number of significant costs and barriers to adopting a more balanced approach to production and conservation.

Species Segregation And Functional Groups In The Hill Country Of New Zealand, I. López, I. Valentine, D. Hedderley, M. G. Lambert

IGC Proceedings (1977-2023)

In the hill country of New Zealand, the soil-sward relationship on hill microrelief was studied. Three categories of slope or microsites were distinguished: low, medium and high. The hypothesis was that soil variables of neighbouring microsites differ, and because of this, there is a segregation of species or functional groups of species between the microsites. Soil features, botanical composition and total annual yield were measured in the slope categories in two similar paddocks; one of which had received long-term phosphorus fertilisation and a non-fertilised paddock. ANOVA, cluster analysis and canonical variate analysis were performed on the data. Unsaturated hydraulic conductivity, …

A Literature Review Of Wetland Treatment Systems Used To Treat Runoff Mixtures Containing Antibiotics And Pesticides From Urban And Agricultural Landscapes, Emily R. Nottingham, Tiffany L. Messer

Biosystems and Agricultural Engineering Faculty Publications

Wetland treatment systems are used extensively across the world to mitigate surface runoff. While wetland treatment for nitrogen mitigation has been comprehensively reviewed, the implications of common-use pesticides and antibiotics on nitrogen reduction remain relatively unreviewed. Therefore, this review seeks to comprehensively assess the removal of commonly used pesticides and antibiotics and their implications for nitrogen removal in wetland treatment systems receiving non-point source runoff from urban and agricultural landscapes. A total of 181 primary studies were identified spanning 37 countries. Most of the reviewed publications studied pesticides (n = 153) entering wetlands systems, while antibiotics (n = 29) had …

Influence Of Grassland Management And Grazing By Different Farm Animals On Animal Performance And Flora Alterations, W. Jentsch, H.-D. Matthes, A. Admasu, H. Möhring

IGC Proceedings (1977-2023)

The objectives of this study were to test the possibilities of using different farm animals for landscape care on extensive pasture, taking into account their particular performance, and to analyse alterations of the flora in consequence of grazing by different animals and various pasture management. Salers had the highest (836g/d) and Galloways (584g/d) the lowest live weight gain as compared with the other breeds (771g/d). Lambs had higher live weight when grazing together with cattle and horses (mixed grazing) than under one species grazing. The number of legume increased and that of grass decreased. Following 3 years the grazing animals …

Animal Production From Tropical Pastures Renovated By Subsoiling And Fertilization In The Cerrados Of Brazil, Valéria P. B. Euclides, Manuel C. M. Macedo, M. P. Oliveira

IGC Proceedings (1977-2023)

A grazing trial was conducted, to study the effects of fertilization on the maintenance of the productivity of four tropical grasses. The paddocks were subsoiled, and dived into halves: one (LF1) received 400 kg/ha of a fertilizer formula 0-20-20.and the other (LF2) 800 kg/ha of the same fertilizers, in January 1995. Annually, 50 kg/ha of N was applied. The productivity on LF2 pastures was greater than that on FL1 pastures, averaging 520 and 410 kg of liveweight gain/ha/year. A double strategy should be followed to sustain animal production in the savanna: maintain soil P over a critical value of 3.0 …

Performance Of Nellore Cattle Under Two Grazing Management Systems, L. De A. Corrêa, Maurício M. De Alencar, Rogério T. Barbosa, P. F. Barbosa, Geraldo M. Da Cruz, I. U. Packer, C. A. Cordeiro

IGC Proceedings (1977-2023)

The objective of this study was to evaluate the effects of grazing intensification on birth weight (BW), weaning weight (WW, standartized to 205 days), average daily gain from birth to weaning (ADG), and gestation length (GL) of calves, cow weight at calving (CWC) and at weaning (CWW), cow condition score at calving (CCC) and at weaning (CCW), and BW/CWC (BWR), WW/CWC (WWRC) and WW/CWW (WWRW) ratios. One hundred and sixty eight Nellore calves born in 1998 and 1999, out of dams maintained in two grazing management systems were evaluated: an extensive 1.0 animal unity (AU). ha^-1 system on unfertilized …

Orchardgrass Pastures For Early-Weaned Beef Calves, J. C. Waller, H. A. Fribourg, C. Dixon, A. E. Fisher, B. V. Conger

IGC Proceedings (1977-2023)

Orchardgrass (Dactylis glomerata) grown alone or with ladino white (Trifolium repens) and red (T. pratense) clovers, provides a high quality March to June pasture. However, many beef producers have their cows calving in January-March, thus producing offspring that are too young to utilize spring forage well. As an alternative, some producers have their cows bred so that calves are born in autumn (September-November). By spring, these calves are old enough to consume pasture forage. The few earlier studies on early weaning of fall-born calves consist of drylot feeding of high quality hay or concentrates. …

Management Of Meadow Fescue Pasture For High-Producing Dairy Cows In Northern Japan, K. Sudo, K. Ochiai, T. Ikeda

IGC Proceedings (1977-2023)

The objective of this study was to establish an intensive grazing system of meadow fescue (Festuca elatior L.) pasture for high-producing dairy cows in some areas of Japan where soil freezes in winter. Plant succession of meadow fescue pastures that had been grazed at different plant heights and milk production from cows grazed on meadow fescue pasture compared to that from cows grazed on perennial ryegrass pasture were surveyed over a five year period. Succession of meadow fescue pasture depended on the management of plant height before grazing use. Milk production from cows grazed on meadow fescue pasture was …

Leaf Blade Selection By Sheep In Kleingrass (Panicum Coloratum L.) Pastures With Different Deferment Periods, P. Sierra, M. S. Cid, M. A. Brizuela, C. M. Ferri

IGC Proceedings (1977-2023)

The winter use of standing dead biomass produced by warm season grasses during the previous growing season may be an alternative to grazing systems in the semi-arid Pampean Region of Argentina. This study evaluated: 1) the effect of different deferment periods on the leaf blade percentage and quality of ‘kleingrass’ (Panicum coloratum L.), a warm season specie recently introduced to that region, and 2) whether rams grazing the vegetation accumulated during these different periods are able to select leaf blades to maintain the quality of their diets. It was generated three treatments by deferment of the forage produced after …

Microhistological Estimation Of Leaf Blade Percentage In Diets From Monoespecific Pastures, P. Sierra, M. S. Cid, M. A. Brizuela, C. M. Ferri

IGC Proceedings (1977-2023)

Although a decrease in the leaf-stem ratio affects the nutritive value of pastures, herbivores can reinforce selection for leaf blades to maintain the quality of their diets. This study evaluated whether the percentage of fragments with furrows in blades could be used to estimate the relative intake of this part of the leaves by herbivores grazing monoespecific pastures. It was worked with vegetation of kleingrass (Panicum coloratum L.) from paddocks with three deferment periods. Blade samples, and different plant part mixtures hand compounded were in vitro digested. The digestion residues were microhistological analyzed determining the number of fragment with …

Evaluation Of Kentucky Bluegrass (Poa Pratensis L.) For Creating Sustainable Grazing Swards In Hokkaido, T. Saigusa, S. Tejima, Y. Ogawa, S. Takahashi

IGC Proceedings (1977-2023)

Kentucky bluegrass (Poa pratensis L.) is generally considered to be a weed in the meadows of Hokkaido. However, a revaluation of this species should be undertaken in terms of its useful characteristics for labor-saving management on farms in marginal areas. The performance of steers (Holstein-Friesian) and botanical composition of Kentucky bluegrass swards were investigated under the stocking methods of set and rotational grazing and compared with timothy (Phleum pratense L.) swards. Kentucky bluegrass was stable over the grazing season under both methods, although timothy decreased rapidly. The average daily gain of steers raised on Kentucky bluegrass swards was …

Effect Of Biofertilizer In Organic And Conventional Systems On Growth, Yield And Baking Quality Of Hard Red Winter Wheat, Ammar Al-Zubade, Timothy D. Phillips, Mark A. Williams, Krista L. Jacobsen, David Van Sanford

Horticulture Faculty Publications

A two-year study (harvest years 2019 and 2020) was conducted to investigate the effect of a commercially available biofertilizer, in combination with variable nitrogen (N) rate, on bread baking quality and agronomic traits in hard winter wheat grown in conventional (CONV) and organic (ORG) farming systems in Kentucky, USA. The hard red winter wheat cultivar ‘Vision 45’ was used with three N rates (44, 89.6 and 134.5 kg/ha as Low, Med and High, respectively) and three biofertilizer spray regimes (no spray, one spray and two sprays). All traits measured were significantly affected by the agricultural production system (CONV or ORG) …

Finland, A Package Deal: Disciplinary Climate In Science Classes, Science Dispositions And Science Literacy, Larry J. Grabau, Jari Levonen, Kalle Juuti

Plant and Soil Sciences Faculty Publications

Finland’s educational prowess, though tempered by recent international assessments, has remained intact. This report focused on lessons that could be learned regarding secondary-level science education from the Program for International Student Assessment (PISA) 2015, science-focused assessment. That PISA iteration included not only science literacy but also students’ science dispositions (epistemology, enjoyment, interest, and self-efficacy) and the schools’ science climate measures (disciplinary climate and teaching support). Due to the hierarchical nature of the PISA data, multilevel models were employed in this Finnish study, involving 5582 students from 167 schools. Science dispositions (as outcome measures) were differently associated with teaching support and …