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Evaluation Of Forages Ensiled In Concrete Stave And Oxygen-Limiting Silos, J O'Leary, R W. Hemken, L S. Bull Jun 2026

Evaluation Of Forages Ensiled In Concrete Stave And Oxygen-Limiting Silos, J O'Leary, R W. Hemken, L S. Bull

IGC Proceedings (1977-2023)

This study evaluated corn silages stored in concrete stave and oxygen-limiting silos during 1978-1980. Factors considered in­cluded the effect of environmental conditions in each silo on silage stability and feeding value. Milk production was evaluated using Holstein cows, intake studies used Holstein heifers or steers. Weekly measurements of intake, milk production, silage temperature, pH, and yeast and mold content were made for each silage. Aerobic stability was determined monthly. Silo type had no effect on intake or milk production. Silage temperatures from the oxygen-limiting silo were higher, and the silage was less stable than that from concrete stave silos. No …

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Round Baling From Field Practices Through Storage And Feeding, W L. Kjelgaard, P M. Anderson, L D. Hoffman, L L. Wilson, H W. Harpster Jun 2026

Round Baling From Field Practices Through Storage And Feeding, W L. Kjelgaard, P M. Anderson, L D. Hoffman, L L. Wilson, H W. Harpster

IGC Proceedings (1977-2023)

A model analysis compared labor and fuel requirements for round and rectangular bale systems. Round baling reduced harvesting, transport, and handling labor by one-half but increased fuel use by a factor of 1.6. When data from field studies of all dry matter (DM) losses were included, round baling required 80 % as much labor and 200 % as much fuel as did rectangular bal­ing. Baling losses for round balers and stackers averaged 10 % compared with 3 % for rectangular balers. ·Dry-matter losses from mowing through feeding of field-cured round bales, including 6 months of outdoor storage, totaled 41 % …

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Harvesting And Processing Effects On Alfalfa Protein Utilization By Ruminants, R Britton, D Rock, T Klopfenstein, J Ward, J Merrill Jun 2026

Harvesting And Processing Effects On Alfalfa Protein Utilization By Ruminants, R Britton, D Rock, T Klopfenstein, J Ward, J Merrill

IGC Proceedings (1977-2023)

Alfalfa (Medicago sativa) is an efficient and important means of producing supplemental protein for ruminants. This research was undertaken to characterize the value of alfalfa protein for ruminants and to show how the protein is affected by different harvesting or processing regimens. The effects of maturity (prebloom, one-tenth, one half, and full bloom) and processing method (freeze dried [FD], sun cured [SC], and oven heated [HJ), on percentage of nitrogen (N), acid detergent insoluble N (ADIN), in-vitro rumen ammonia release (NH3), and in-situ rumen protein degradation, using dacron bags (BAG), were studied on irrigated alfalfa harvested over 2 years. …

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Comparison Of Conservation Methods Under Controlled Practical Conditions, H Honig, K Rohr, E Zimmer Jun 2026

Comparison Of Conservation Methods Under Controlled Practical Conditions, H Honig, K Rohr, E Zimmer

IGC Proceedings (1977-2023)

The most common forage conservation methods (direct-cut and low-moisture silage, barn,dried hay, and dehydration) have been compared under practical, but strictly controlled, conditions to determine their relative value for meeting the increasing demands of high-yielding ruminants. A grass mixture was used as forage, at different stages of maturity in different ex­periments. Parameters determined were changes of nutrient content; losses of DM and net energy; and, in three experiments, forage intake by dairy cows. From the results of the experiments, the following conclusions could be drawn: (1) roughage quality is influenced more by cuttng time than by preservation methods; (2) low-moisture …

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Wet Fractionation Of Alfalfa: A Direct Forage-Harvesting System, M Collins, R G. Koegel, N A. Jorgensen, H W. Ream Jun 2026

Wet Fractionation Of Alfalfa: A Direct Forage-Harvesting System, M Collins, R G. Koegel, N A. Jorgensen, H W. Ream

IGC Proceedings (1977-2023)

In this syst􀀇m, termed wet fractionation, fresh forage is macerated and pressed to remove approximately 50 % of the moisture. The result is a forage product containing 32 %-38 % dry matter (DM) that can be ensiled directly. In addition, the protein con­tained in the plant juice can be coagulated and removed. The remaining deproteinized juice contains large quantities of mineral nutrients that can be returned to the soil. This process has several potential advantages: (1) less weather-dependent harvesting, which minimizes harvest losses; (2) reduced harvesting time; (3) reduced fertilizer requirements; and (4) ability to harvest protein from land unsuited …

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Hastening Hay Drying, J W. Thomas, T R. Johnson, M A. Wieghart, C M. Hansen, M B. Tesar, Z Helsel Jun 2026

Hastening Hay Drying, J W. Thomas, T R. Johnson, M A. Wieghart, C M. Hansen, M B. Tesar, Z Helsel

IGC Proceedings (1977-2023)

The objectives of these studies were to increase the drying rate of cut alfalfa (Medicago sativa) by treating with chemical solu­tions and to examine factors that influence drying. Time to dry and drying rate of cut alfalfa were studied under laboratory and field conditions. Treatment consisted of spraying the cut alfalfa with methyl esters of long-chain fatty acids, an emulsifier alone, or a combination of an emulsifier and a potassium carbonate solution. Alfalfa sprayed with solutions of each chemical under specified conditions increased drying rate and decreased drying time to 60% or 75 % dry matter (DM) or …

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Alternative Treatment Systems To Increase The Drying Rates Of Green Forage Crops, W E. Klinner, O D. Hale Jun 2026

Alternative Treatment Systems To Increase The Drying Rates Of Green Forage Crops, W E. Klinner, O D. Hale

IGC Proceedings (1977-2023)

Forms of conditioning treatment are being developed that aim to minimize the barrier effect of the crop cuticle without sacrificing too much of the structural strength of the herbage. Effective surface abrasion and favorable windrow structure can be achieved with steel-spoked rotors, which are now beginning to be offered commercially. More recently, plastic brushes have been developed because the higher population density and yielding ability of the crop-engaging elements, plus the absence of metal components, appeared to offer additional advantages. Four different brush conditioner systems have been evaluated in the laboratory and in replicated field experiments. Tufted brushes using trilobar …

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Effects Of Microwave Treatment On Drying And Respiration In Cut Alfalfa, S A. Seif, D A. Holt, V L. Lechtenberg, R J. Vetter Jun 2026

Effects Of Microwave Treatment On Drying And Respiration In Cut Alfalfa, S A. Seif, D A. Holt, V L. Lechtenberg, R J. Vetter

IGC Proceedings (1977-2023)

After forage crops are cut mechanically, they usually undergo some degree of natural drying before being stored or further processed. During early stages of drying, plant respiration continues. Treatments or management practices that hasten drying and reduce postharvest respiration are desirable, because they minimize quantity and quality losses. Our objective was to determine the effects of brief microwave treatment on subsequent natural drying rate and respiration of alfalfa (Medicago sativa L. ). Duplicate samples of field grown Apollo alfalfa were subjected to focused microwave energy (2,450 MHz) generated at 0.25, 0.50, or 1.0 kilowatt of power for 3, 6, …

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Effect Of Formic Acid- Formaldehyde Treatments On The Nitrogenous Constituents In Annual Ryegrass Silage, M L. Fishman, F Mchan, D Burdick Jun 2026

Effect Of Formic Acid- Formaldehyde Treatments On The Nitrogenous Constituents In Annual Ryegrass Silage, M L. Fishman, F Mchan, D Burdick

IGC Proceedings (1977-2023)

Prevention of proteolysis during ensiling is important in preserving the nutritive value of silage. Hence, the mechanism by which silage protein is protected against degradation was studied in wilted annual ryegrass (Lolium multiflorium Lam.) silage pretreated with formic acid, formaldehyde, and a formic acid-formaldehyde mixture. Raw-wilted ryegrass, control ryegrass silage, and treated ryegrass silage were extracted and fractionated under conditions previously found to maximize yield of nitrogenous constituents and minimize proteolysis during the extraction of fresh grass. Extractions were by boric acid-borate buffer at pH 8.0 with and without detergent (1 % sodium dodecyl sulfate). Sodium metabisulfite, an antioxidant, was …

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Addition Of Lactobacillus Sp. To Aid The Fermentation Of Alfalfa, Corn, Sorghum, And Wheat Forages, N J. Moon, L O. Ely Jun 2026

Addition Of Lactobacillus Sp. To Aid The Fermentation Of Alfalfa, Corn, Sorghum, And Wheat Forages, N J. Moon, L O. Ely

IGC Proceedings (1977-2023)

As preservation of forage by ensiling has increased, so has the use of additives to enhance acid fermentation. Many of the fermentation aids currently on the market contain microflora to insure a lactic acid fermentation. The objectives of this study were to characterize the basic patterns of fermentation in a variety of crops and to evaluate the effects of adding selected microflora to forages to enhance the fermentation. Four crops were ensiled in each of three seasons. Alfalfa was harvested at 20 %-40 % bloom, second cut; wheat was cut in the early dough stage; corn was cut in the …

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Interrelationships Between Pattern Of Fermentation During Ensilage And Initial Crop Composition, J M. Wilkinson, P F. Chapman, R J. Wilkins, R F. Wilson Jun 2026

Interrelationships Between Pattern Of Fermentation During Ensilage And Initial Crop Composition, J M. Wilkinson, P F. Chapman, R J. Wilkins, R F. Wilson

IGC Proceedings (1977-2023)

Relationships between crop composition and silage composition were examined for 231 silages made at the Grassland Research Institute from 1968 to 1978 without additives. A test was made of the model of Weissbach et al. (1974) in which silage characteristics were related to the percentage of dry matter in the crop (OM) and the ratio of sugar (Z) to buffering capacity (PK). Although these factors accounted for significant variance, the percentage accounted for was low at 36 % for lactic acid (percentage of total acids), 26 % for Flieg's score, 22 % for ammonia N (percentage of total N), and …

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Effect Of Delayed Sealing During Ensiling On Fermentation And Dry-Matter Loss, N Takano, Y Masaoka, T Manda Jun 2026

Effect Of Delayed Sealing During Ensiling On Fermentation And Dry-Matter Loss, N Takano, Y Masaoka, T Manda

IGC Proceedings (1977-2023)

Two experiments were carried out from 1976 to 1980 to ascertain the effect of delayed sealing of silo on fermentation, dry· matter (DM) loss, digestibility, and silage intake. The effect of delayed sealing (up to 72 hours) of grass and corn silage was tested in laboratory silos on fermentation quality with storage temperatures at 15°C and 30°C, moisture content from 49% to 85 % , water-soluble carbohydrate (WSC) content ranging from 11.1 % to 17.5%, and with and without an addition of 0.25% formic acid. In all cases, delayed sealing resulted in poor-quality silage with high pH values and low …

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Improving Hay Quality By Ammoniation, K J. Moore, V L. Lechtenberg, K S. Hendrix, J M. Hertel Jun 2026

Improving Hay Quality By Ammoniation, K J. Moore, V L. Lechtenberg, K S. Hendrix, J M. Hertel

IGC Proceedings (1977-2023)

Experiments were conducted to determine the effect of hay ammoniation on hay consumption and weight gain by steers when the hay was fed unsupplemented and supplemented with energy and protein. Mature orchardgrass (Dacrylis glomerata L.) hay was baled in early June 1979 and treated with anhydrous ammonia at 30 g/kg of hay. Seven weeks after treatment the hay was uncovered and allowed to aerate for 3 days. It was then fed to weanling steer calves weighing approximately 225 kg each. Similar hay baled from the same field but not ammoniated was fed to separate groups of steers. Both the treated …

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Evaluations Of Low-Quality Roughages And Fibrous Cereal Grains Treated With Various Chemicals, G C. Fahey Jr, L L. Berger, M I. Mora, P J. Van Der Aar Jun 2026

Evaluations Of Low-Quality Roughages And Fibrous Cereal Grains Treated With Various Chemicals, G C. Fahey Jr, L L. Berger, M I. Mora, P J. Van Der Aar

IGC Proceedings (1977-2023)

Large improvements in the feeding value of low-quality roughages have resulted from treatment of them with various chemicals. Chemical treatment of grains may also be a potentially useful practice. The research reported here was designed (1) to determine how Chelating Metal Caustic Swelling (CMCS), a nontoxic, alkaline, aqueous reagent, compares with sodium hydroxide (NaOH) in enhancing in-vitro cellulose digestion (IVCD) of cornstalks (CS) (Zea mays) and soybean residues (SBR) (G!),cine max.), and (2) to evaluate the effects of NaOH and CMCS treatments of fibrous grains using in-situ techniques. CMCS or 7.5% NaOH solutions were added to CS or SBR at …

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Effect Of Solvent Treatments On Intake And Digestibility Of Corn Stover, D M. Schaefer, M R. Ladisch, C H. Noller, V L. Lechtenberg Jun 2026

Effect Of Solvent Treatments On Intake And Digestibility Of Corn Stover, D M. Schaefer, M R. Ladisch, C H. Noller, V L. Lechtenberg

IGC Proceedings (1977-2023)

Treatment of crop residues with low levels of sodium hydroxide has been shown to improve organic-matter digestibility and animal performance. One objective of these experiments was to evaluate the effects of three treatments -water, sodium hydrox­ide, and chelating metal cellulose-swelling solution-on solubilization of cell-wall components in corn (Zea m£rys) stover. The two latter treatments were balanced for level of sodium hydroxide application, which was .3 .2 % of stover dry matter. The second objective was to determine the effects of these treatments on in-vitro and in-vivo digestibility as well as on consumption of corn stover. Twelve growing ram lambs were …

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Factors Causing Greater In-Vitro Than In-Vivo Digestibility Of Sodium Hydroxide - Treated Roughages, L L. Berger, T J. Klopfenstein, R A. Britton Jun 2026

Factors Causing Greater In-Vitro Than In-Vivo Digestibility Of Sodium Hydroxide - Treated Roughages, L L. Berger, T J. Klopfenstein, R A. Britton

IGC Proceedings (1977-2023)

Research on sodium hydroxide (NaOH) treatment oflow-quality roughages generally indicates that in-vivo digestion is lower than in-vitro digestion. The purpose of this research was to identify factors that may cause less of the potentially digestible fiber to be digested in vivo than in vitro. Corn (Zea mays) cobs were raised to 60% moisture and treated to contain 0%, 2.5%, 5.0%, 7.5 % , and 10.0% NaOH. Lambs were fed diets containing 80% cobs and 20% supplement, giving a complete mixed diet con· taining 0%, 2.0%, 4.0%, 6.0%, and 8.0% NaOH. Five abomasally cannulated lambs were assigned to a 5 x …

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Relationship Between Silage Quality And 15 N-Nitrate Reduction During Ensilage, K Ataku, M Horiguchi, T Matsumoto Jun 2026

Relationship Between Silage Quality And 15 N-Nitrate Reduction During Ensilage, K Ataku, M Horiguchi, T Matsumoto

IGC Proceedings (1977-2023)

Nitrate in forage has been proven to occasionally poison ruminants. Our recent studies, however, have shown that a high con­centration of nitrate inhibits butyric acid fermentation to the advantage of the silage quality. This work was undertaken to see the relationship between silage quality and the pattern of nitrate reduction during ensilage.

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Maximizing Room-Temperature Red Phosphorescence In Contorted Hexabenzocoronene Derivatives, Marko R. Ivancevic, Moses D. Ogbaje, Jesse A. Wisch, Daniel G. Oblinsky, Alice S. Fergerson, Emily C. Davidson, Gregory D. Scholes, Barry P. Rand, Chad Risko, Quinn C. Burlingame, Yueh Lin Loo Jun 2026

Maximizing Room-Temperature Red Phosphorescence In Contorted Hexabenzocoronene Derivatives, Marko R. Ivancevic, Moses D. Ogbaje, Jesse A. Wisch, Daniel G. Oblinsky, Alice S. Fergerson, Emily C. Davidson, Gregory D. Scholes, Barry P. Rand, Chad Risko, Quinn C. Burlingame, Yueh Lin Loo

Chemistry Faculty Publications

Organic molecules exhibiting second-scale room-temperature phosphorescence (RTP) in the red/near-infrared are particularly rare because low-energy excited states that are characteristic of these chromophores are susceptible to nonradiative deactivation. Here, we observe second-scale red RTP from contorted hexabenzocoronene (cHBC) embedded in a rigid polymer. This RTP is uniquely efficient as approximately 23% of the steady-state photoluminescence originates from triplets. We propose that this efficient triplet generation stems from intersystem crossing (ISC) that outcompetes symmetry-forbidden fluorescence. Density functional theory and time-dependent density functional theory calculations suggest that ISC occurs from the lowest energy singlet state of cHBC into a nearly resonant triplet …

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Endoplasmic Reticulum-Resident Α-Glucosidase Ii Drives Non-Small Cell Lung Cancer Progression Via Regulation Of Secretory Glycoproteins, Shike Wang, Na Ding, Angelo Chen, Derrick Cardin, Yuting Xu, Kate Grimley, William K. Russell, Jun Xu, Jonathan M. Kurie, Guan Yu Xiao, Xiaochao Tan Jun 2026

Endoplasmic Reticulum-Resident Α-Glucosidase Ii Drives Non-Small Cell Lung Cancer Progression Via Regulation Of Secretory Glycoproteins, Shike Wang, Na Ding, Angelo Chen, Derrick Cardin, Yuting Xu, Kate Grimley, William K. Russell, Jun Xu, Jonathan M. Kurie, Guan Yu Xiao, Xiaochao Tan

Markey Cancer Center Faculty Publications

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, yet its molecular drivers are not fully defined. Emerging evidence highlights the importance of tumor-stroma interactions mediated by secreted glycoproteins. However, the mechanisms by which cancer cells regulate the secretion of these protumorigenic proteins remain largely unknown. Endoplasmic reticulum-resident (ER-resident) N-glycan-processing enzymes regulate proper protein folding, a prerequisite for glycoproteins to exit the ER and undergo secretion. By evaluating their prognostic significance in lung tumors and conducting functional screening in lung cancer cells, we identify α-glucosidase II (α-Glc II) as a key regulator of NSCLC progression. α-Glc …

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Improving The Clinical Trial Landscape For Patients With Atypical Variants Of Alzheimer's Disease, Nick Corriveau-Lecavalier, Neus Falgàs, Deepti Putcha, Jonathan Graff-Radford, Keir X.X. Yong, Baayla D.C. Boon, Rosaleena Mohanty, Eric Westman, Colin Groot, David T. Jones, Lea T. Grinberg, Gil D. Rabinovici, Jennifer L. Whitwell, Liana G. Apostolova, Melissa E. Murray, Dustin B. Hammers, Suzanne E. Schindler, Inga Atonsdottir, Elizabeth K. Rhodus, Jonathan M. Schott, Ignacio Illán-Gala, Ogbuagu Chukwuanugo, Jorge J.Llibre Guerra, Ruth Peters, Erin L. Abner, Carla Abdelnour, Albert Lladó, Renaud La Joie Jun 2026

Improving The Clinical Trial Landscape For Patients With Atypical Variants Of Alzheimer's Disease, Nick Corriveau-Lecavalier, Neus Falgàs, Deepti Putcha, Jonathan Graff-Radford, Keir X.X. Yong, Baayla D.C. Boon, Rosaleena Mohanty, Eric Westman, Colin Groot, David T. Jones, Lea T. Grinberg, Gil D. Rabinovici, Jennifer L. Whitwell, Liana G. Apostolova, Melissa E. Murray, Dustin B. Hammers, Suzanne E. Schindler, Inga Atonsdottir, Elizabeth K. Rhodus, Jonathan M. Schott, Ignacio Illán-Gala, Ogbuagu Chukwuanugo, Jorge J.Llibre Guerra, Ruth Peters, Erin L. Abner, Carla Abdelnour, Albert Lladó, Renaud La Joie

Epidemiology and Environmental Health Faculty Publications

Patients with atypical variants of Alzheimer's disease (AD) often present at a younger age with predominantly non-amnestic impairments and a more aggressive disease course. Historically, individuals with atypical presentations have not been included in large-scale clinical trials, which typically focus on late-onset, sporadic amnestic-predominant AD. Consequently, treatment options and research efforts specific to atypical AD remain limited. The emergence of amyloid-targeting therapies that slow disease progression underscores these challenges, as evidence supporting their efficacy in early-onset amnestic and non-amnestic AD variants is scarce. This perspective article argues that atypical AD represents an excellent disease model for clinical trials and proposes …

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The Polysubstance Assessment Tool, Amanda M. Bunting, Charles M. Cleland, S. Michaela Barratt, Brittany Griffin, Jaimee Williams, Carrie B. Oser, Joshua D. Lee, Jennifer Mcneely Jun 2026

The Polysubstance Assessment Tool, Amanda M. Bunting, Charles M. Cleland, S. Michaela Barratt, Brittany Griffin, Jaimee Williams, Carrie B. Oser, Joshua D. Lee, Jennifer Mcneely

Sociology Faculty Publications

Background and aims: There are currently no brief quantitative assessments that capture the drug patterns of people who engage in use of more than one drug on the same day or simultaneously. The current study examined the retest reliability, acceptability and feasibility of a new quantitative assessment to measure polysubstance use. Design: A tool for assessing simultaneous and same-day polysubstance behaviors, the polysubstance assessment tool (PAT) was developed in interviewer-administered and electronic self-administered formats. Participants were allocated 1:1 to receive either version of the PAT and returned one to three days later to repeat the assessment. Setting: New York City, …

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From Lineage Discovery To Conservation Prioritisation, Zachary G. Macdonald, Joscha Beninde, Julian R. Dupuis, Thomas W. Gillespie, H. Bradley Shaffer, Gregory F. Grether Jun 2026

From Lineage Discovery To Conservation Prioritisation, Zachary G. Macdonald, Joscha Beninde, Julian R. Dupuis, Thomas W. Gillespie, H. Bradley Shaffer, Gregory F. Grether

Entomology Faculty Publications

Accurate inferences of diversification and evolutionary processes depend on knowing how many independently evolving lineages exist within nominally widespread taxa. Uncertainty in lineage number and composition also limits our ability to meaningfully prioritise conservation efforts. Addressing these knowledge gaps requires frameworks that sequentially identify distinct lineages, assess mechanisms that contribute to their divergence, and quantify spatial and environmental determinants of their genomic diversity. With these goals in mind, we apply whole-genome, ecological, and morphological analyses to the American rubyspot damselfly (Hetaerina americana), a widespread and well-studied North American insect that has been long regarded as a single species of least …

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Adhesion Index Integrates Cell And Bacterial Responses To Titanium Across Protein Conditioning And Surface Roughness, Sahar Afshari, James D. Boyd, Victoria L. Stanton, Arnold Stromberg, Katherine L. Thompson, David M. Devito, Craig S. Miller, Martha E. Grady Jun 2026

Adhesion Index Integrates Cell And Bacterial Responses To Titanium Across Protein Conditioning And Surface Roughness, Sahar Afshari, James D. Boyd, Victoria L. Stanton, Arnold Stromberg, Katherine L. Thompson, David M. Devito, Craig S. Miller, Martha E. Grady

Mechanical Engineering Faculty Publications

Biofilm formation is a primary cause of implant-associated infections in dental and orthopedic devices. Early interactions between bacteria and host cells at the implant surface critically influence subsequent infection or successful integration. Therefore, biocompatibility screening should evaluate both biofilm formation and cell adhesion. Adhesion Index, defined as the ratio of cell adhesion to biofilm adhesion, provides a non-dimensional number to optimize towards that end. In this work, the laser spallation technique is implemented to compare the effects of implant surface characteristics (rough and smooth titanium) and protein coatings (blood plasma and fibronectin) on bacterial biofilm (Streptococcus mutans, Staphylococcus aureus) and …

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Thermodynamics Of Binding Between Adeno-Associated Viruses And Heparin In Bulk And At Interfaces Via Isothermal Titration Calorimetry, Elizabeth Adeogun, Jude C. Obijiaku, Ronny Horax, Kayla E. Daugherty, Joshua Sakon, Xianghong Qian, Barbara Knutson, Stephen E. Rankin, Karthik Nayani Jun 2026

Thermodynamics Of Binding Between Adeno-Associated Viruses And Heparin In Bulk And At Interfaces Via Isothermal Titration Calorimetry, Elizabeth Adeogun, Jude C. Obijiaku, Ronny Horax, Kayla E. Daugherty, Joshua Sakon, Xianghong Qian, Barbara Knutson, Stephen E. Rankin, Karthik Nayani

Chemical and Materials Engineering Faculty Publications

Adeno-associated viruses (AAVs) have emerged as promising vectors for gene therapy due to their non-pathogenic nature and ability to transduce various cell types efficiently. In recent years, there has been an increasing effort to optimize the production and purification of AAV to support clinical applications; however, challenges exist in affinity ligand design, synthesis, and characterization. Understanding the binding interactions of these viruses with functional molecules is pivotal for the development of affinity-based separation methods of AAVs. Classical methods to measure thermodynamic parameters such as Isothermal Titration Calorimetry (ITC) are challenging to employ in these scenarios, as the concentrations of the …

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Use Of Function Diagrams In Physiology Education, Thad E. Wilson, Brian A. Jackson, B. Peter Sawaya Jun 2026

Use Of Function Diagrams In Physiology Education, Thad E. Wilson, Brian A. Jackson, B. Peter Sawaya

Physiology Faculty Publications

Function diagrams focus on physiological concepts rather than associated structures and can serve as elaboration tools and mnemonic aids. A function diagram prototype of the gastrointestinal system was recently described (Wilson TE, Barrett KE. Adv Physiol Educ 45: 264-268, 2021). In this article, a functional diagram of the glomerulus, nephron, urinary system, and bladder is proposed. Colloquially named "Nessie the Nephron" to loosely capture the looping structure and elusive understanding of renal blood flow, glomerular filtration, and epithelial transport for the student, not to mention the nearly mythical countercurrent multiplier. "Navigating the Lochs" references Nessie's possible habitat and more importantly …

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Provider And Patient Perspectives On The Diagnosis And Treatment Of Alzheimer's Disease, Philippe Amouyel, Sandrine Andrieu, Angela Bradshaw, Ralph C. Carmona, Magali Dumont, Lea Tenenholz Grinberg, Takeshi Iwatsubo, Oskar Hansson, Clifford R. Jack, Gregory A. Jicha, Simin Mahinrad, Eric Mcdade, Catherine J. Mummery, Ronald C. Petersen, Shelagh Robinson, Julie A. Schneider, Lenny Shellcross, Amanda G. Smith, Heather M. Snyder, Beth Tapply, Charlotte Teunissen, Wiesje M. Van Der Flier, Bruno Vellas, David Wallon, Jeff D. Williamson, Donna Wilcock, Maria C. Carrillo Jun 2026

Provider And Patient Perspectives On The Diagnosis And Treatment Of Alzheimer's Disease, Philippe Amouyel, Sandrine Andrieu, Angela Bradshaw, Ralph C. Carmona, Magali Dumont, Lea Tenenholz Grinberg, Takeshi Iwatsubo, Oskar Hansson, Clifford R. Jack, Gregory A. Jicha, Simin Mahinrad, Eric Mcdade, Catherine J. Mummery, Ronald C. Petersen, Shelagh Robinson, Julie A. Schneider, Lenny Shellcross, Amanda G. Smith, Heather M. Snyder, Beth Tapply, Charlotte Teunissen, Wiesje M. Van Der Flier, Bruno Vellas, David Wallon, Jeff D. Williamson, Donna Wilcock, Maria C. Carrillo

Neurology Faculty Publications

Since 2016, the Alzheimer's Association and the Fondation Alzheimer have hosted Global Alzheimer's Leadership Series (GoALS) global think tanks, with world-leading experts for innovative discussions to advance Alzheimer's disease (AD) research and care. The second GoALS think tank, held in June 2024 in Paris, focused on the relationship between biological changes and clinical manifestations of AD in the context of the evolving therapeutic landscape. Discussions spanned real-world experiences of providers, patients, and their families, theoretical considerations, and health system challenges. The lived experience perspective was central to these discussions. The importance of shared decision-making, clear and transparent communication, and the …

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Volumetric Differences Of Thalamic Nuclei Are Associated With Posttrauma Psychopathology, Nick Steele, Ahmed Hussain, C. Lexi Baird, Courtney C. Haswell, Delin Sun, Leonel Rangel-Jimenez, Chadi G. Abdallah, Michael Angstadt, Geoffrey May, Hannah Berg, Jennifer U. Blackford, Josh M. Cisler, Judith K. Daniels, Nicholas D. Davenport, Richard J. Davidson, Maria Densmore, Seth G. Disner, Wissam El-Hage, Amit Etkin, Negar Fani, Jessie L. Frijling, Evan M. Gordon, Daniel W. Grupe, Ryan J. Herringa, Anna R. Hudson, Neda Jahanshad, Tanja Jovanovic, Anthony King, Saskia B.J. Koch, Ruth Lanius, Amit Lazarov, Gen Li Jun 2026

Volumetric Differences Of Thalamic Nuclei Are Associated With Posttrauma Psychopathology, Nick Steele, Ahmed Hussain, C. Lexi Baird, Courtney C. Haswell, Delin Sun, Leonel Rangel-Jimenez, Chadi G. Abdallah, Michael Angstadt, Geoffrey May, Hannah Berg, Jennifer U. Blackford, Josh M. Cisler, Judith K. Daniels, Nicholas D. Davenport, Richard J. Davidson, Maria Densmore, Seth G. Disner, Wissam El-Hage, Amit Etkin, Negar Fani, Jessie L. Frijling, Evan M. Gordon, Daniel W. Grupe, Ryan J. Herringa, Anna R. Hudson, Neda Jahanshad, Tanja Jovanovic, Anthony King, Saskia B.J. Koch, Ruth Lanius, Amit Lazarov, Gen Li

Psychiatry Faculty Publications

Background: Previous investigations of whole thalamus and thalamic nuclei volumes in posttrauma psychopathology have been sparse and limited in scope and have yielded inconsistent results. To address this, volumetric estimates of whole thalamus and thalamic nuclei were obtained from structural brain magnetic resonance imaging scans from 2058 participants across 20 worldwide sites in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Posttraumatic Stress Disorder (PTSD) working group. Methods: Thalamic volumes were compared in trauma-exposed participants with PTSD (n = 238), major depressive disorder (MDD) (n = 184), and comorbid PTSD+MDD (n = 618) and in trauma-exposed control participants (n …

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Alterations Of Cerebral Extracellular Vesicle Microrna Profiling Potentially Disrupts Brain Homeostasis Following Myocardial Infarction, Md Monowarul Islam, Shouyi Liang, Lijun Sun, Guoku Hu, Neha Dhyani, Lie Gao, Tara L. Rudebush, Xue Xu, Jinpeng Liu, Irving H. Zucker, Changhai Tian Jun 2026

Alterations Of Cerebral Extracellular Vesicle Microrna Profiling Potentially Disrupts Brain Homeostasis Following Myocardial Infarction, Md Monowarul Islam, Shouyi Liang, Lijun Sun, Guoku Hu, Neha Dhyani, Lie Gao, Tara L. Rudebush, Xue Xu, Jinpeng Liu, Irving H. Zucker, Changhai Tian

Markey Cancer Center Faculty Publications

Cognitive impairment (CI) is prevalent among heart failure (HF) patients. Although the brain injury in HF is multifactorial, oxidative stress and neuroinflammation are common pathological features of neurological disorders and are increasingly recognized as key mechanisms underlying CI. Extracellular vesicles (EVs) are well-established mediators of biological signaling in myocardial function and are widely recognized for transporting a variety of microRNAs. However, whether myocardial injury alters the miRNA profiles of brain EVs, potentially contributing to cognitive impairment (CI) by disrupting brain homeostasis, remains poorly understood. Using a rodent myocardial infarction (MI) model, we isolated brain EVs and characterized their miRNA profiling …

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Antioxidant Therapy Reverses Hepatotoxicity Induced By Microcystin-Lr In A Cellular Model Of Metabolic Dysfunction-Associated Steatotic Liver Disease (Masld), Apurva Lad, Jason Kindle, Prajwal Hegde, Gabriel G. Kleer, Andrew L. Kleinhenz, Johnna A. Birbeck, Judy Westrick, Nicholas J. Peraino, Terry D. Hinds, Neeraja Purandare, Andrew M. Fribley, Steven T. Haller, David J. Kennedy Jun 2026

Antioxidant Therapy Reverses Hepatotoxicity Induced By Microcystin-Lr In A Cellular Model Of Metabolic Dysfunction-Associated Steatotic Liver Disease (Masld), Apurva Lad, Jason Kindle, Prajwal Hegde, Gabriel G. Kleer, Andrew L. Kleinhenz, Johnna A. Birbeck, Judy Westrick, Nicholas J. Peraino, Terry D. Hinds, Neeraja Purandare, Andrew M. Fribley, Steven T. Haller, David J. Kennedy

Markey Cancer Center Faculty Publications

Microcystin-LR (MC-LR) is a potent hepatotoxin that has been shown to cause liver damage even at doses lower than the established Low Observable Adverse Effect Level (LOAEL) of 200 μg/kg in animal models. We have previously observed that low-dose exposure to MC-LR in animals with diet-induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and subsequent treatment with antioxidants like N-acetylcysteine (NAC) and the Na+/K+ ATPase-Src kinase inhibitor pNaKtide significantly alleviated hepatic infiltration of immune cells, downregulated markers of inflammation and hepatotoxicity, increased the breakdown of the toxin molecule, and restored phase I and II drug metabolism pathways, including …

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Chemical Structure Representation Standardization Is Needed To Generalize Metabolite-Pathway Involvement Prediction Across Kegg, Reactome, And Metacyc Knowledgebases, Erik D. Huckvale, Hunter N.B. Moseley Jun 2026

Chemical Structure Representation Standardization Is Needed To Generalize Metabolite-Pathway Involvement Prediction Across Kegg, Reactome, And Metacyc Knowledgebases, Erik D. Huckvale, Hunter N.B. Moseley

Markey Cancer Center Faculty Publications

Background/Objectives: Due to the utility of knowing the pathway involvement of metabolites detected in biological experiments, knowledgebases such as the Kyoto Encyclopedia of Genes and Genomes (KEGG), Reactome, and MetaCyc have annotated compound entries to specific pathways defined by the knowledgebase. However, these compound-pathway annotations are largely incomplete and are costly to obtain experimentally or curate from published scientific literature. This metabolite-pathway annotation incompleteness problem is amenable to machine learning (ML)-based solutions. But to date, no machine learning model has been trained on all three knowledgebases to maximize its performance and robustness. This may be due to inconsistencies in chemical …

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