Time Spent Exercising And Obesity: An Application Of Lewbel’S Instrumental Variables Method, Charles J. Courtemanche, Joshua C. Pinkston, Jay Stewart

Institute for the Study of Free Enterprise Working Papers

This paper examines the role physical activity plays in determining body mass using data from the American Time Use Survey. Our work is the first to address the measurement error that arises when time use during a single day—rather than average daily time use over an extended period—is used as an explanatory variable. We show that failing to account for day-to-day variation in activities results in the effects of time use on a typical day being understated. Furthermore, we account for the possibility that physical activity and body mass are jointly determined by implementing Lewbel’s instrumental variables estimator that exploits …

Early Acid/Base And Electrolyte Changes In Permanent Middle Cerebral Artery Occlusion: Aged Male And Female Rats, Sarah R. Martha, Lisa A. Collier, Stephanie M. Davis, Sarah J. Goodwin, David Powell, Doug Lukins, Justin F. Fraser, Keith R. Pennypacker

Neurosurgery Faculty Publications

BACKGROUND: Early changes in acid/base and electrolyte concentrations could provide insights into the development of neuropathology at the onset of stroke. We evaluated associations between acid/base and electrolyte concentrations, and outcomes in permanent middle cerebral artery occlusion (pMCAO) model.

METHODS: 18-month-old male and female Sprague-Dawley rats underwent pMCAO. Pre-, post- (7 min after occlusion), and at 72 hr of pMCAO venous blood samples provided pH, carbon dioxide, oxygen, glucose, hematocrit, hemoglobin, and electrolyte values of ionized calcium, potassium, and sodium. Multiple linear regression determined predictors of infarct and edema volumes from these values, Kaplan-Meier curve analyzed morality between males and …

North Fork: Whitesburg Tributaries Watershed Plan, Letcher County, Ky, Kentucky Water Resources Research Institute

KWRRI Research Reports

Crafts Colly, Sandlick, and Dry Fork are tributaries to the North Fork of the Kentucky River. The three tributaries are located immediately north of the North Fork of the Kentucky and flow southward into the river within or near the City of Whitesburg in Letcher County, Kentucky. Letcher County is found in the Appalachian coalfields of southeastern Kentucky.

To improve water quality in the Kentucky River, water quality impairments in the upper reaches of the watershed must be addressed. In focusing efforts in Crafts Colly, Sandlick, and Dry Fork, three headwater tributaries of the North Fork Kentucky River, pollution loading …

2019 Kentucky River Watershed Watch: Annual Report, Malissa Mcalister, Steven Evans

Kentucky River Watershed Watch

No abstract provided.

From Petri Dish To Main Dish: The Legal Pathway For Cell-Based Meat, Brian P. Sylvester, Nathan A. Beaver, Kara Schoonover, Jonathan I. Tietz

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

Meat grown outside an animal is no longer simply science fiction, and the market is poised for introduction of a variety of so-called cell-based meat products. Commercializing these products will require a clear regulatory path forward. In this Article, we explore that legal pathway. We introduce the concepts of cellular agriculture and cell-based meat, including the science, the state and history of the industry, and the general regulatory background, in which the USDA and FDA are the major players. Further, we explore in particular regulatory aspects of food safety and labeling in the context of cell-based meat. Overall, we contend …

What The Brita Won’T Purify: Why Kentucky Is In Need Of Strict Pharmaceutical Disposal Regulations, Caroline K. Mitchell

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Communication Of Professional Readiness In Dietetics And Human Nutrition Undergraduates: A Pilot Study, Heather Norman-Burgdolf, Emily M. Dewitt, Nathan L. Vanderford, Julie Plasencia

Dietetics and Human Nutrition Faculty Publications

Learning experiences within the dietetics and human nutrition undergraduate curricula develop knowledge and skills pertinent to student career goals. Core competency requirements are extensively assessed in these programs, yet the communication of transferable skills gained and student professional readiness are rarely examined. The purpose of this study was to evaluate undergraduate students' perceived professional readiness following six professional development workshops on transferable skills and career preparedness communicated through resumes and personal statements. In this pilot study, twelve upper-level dietetics and human nutrition students self-assessed their resumes and personal statements with rubrics and completed surveys before and after the intervention. Following …

Defying The Odds: Exploring The Ways First-Generation College Students Enact Resilience, Paris Lauren Nelson

Theses and Dissertations--Communication

This thesis examined the experiences of first-generation college students in the context of higher education. This thesis was framed by the communication theory of resilience to discover how first-generation college students enact five processes of resilience: crafting normalcy, affirming identity anchors, maintaining and using communication networks, employing alternate logics, and foregrounding productive action. First-generation college students face academic preparation, financial, social capital, personal, and college completion adversities that may necessitate engagement in resilience processes. Participants (N = 8) participated in focus groups and interviews where they discussed messages from family, peers, and university faculty and staff involving reactive and proactive …

Recipes For Anger Appeals: A Systematic Review, Tianen Chen

Theses and Dissertations--Communication

Although there is an increasing use of anger appeals in communication research, scholars have yet to fully explore the causes of anger. Anger is elicited in situations where individuals perceive that their desired goals are blocked or needs are not fulfilled (Harmon-Jones & Harmon-Jones, 2016). Using Maslow’s hierarchy of human needs model (Maslow, 1943), the current study aims to systematically review communication studies on anger appeals to synthesize and categorize the violations of goals/needs that have been studied or utilized to elicit anger. A comprehensive literature search was conducted in eight relevant databases: ProQuest Dissertation & Thesis Global, Web of …

Boundaries And Infomediaries: A Qualitative Study Of The Information Practices Of Community Health Workers, Robert M. Shapiro Ii

Theses and Dissertations--Communication

Despite successful efforts to treat and manage diseases, public health officials have recently begun a campaign to refocus efforts toward initiatives to alleviate the pressures that are often referred to as social determinants of health. In eastern Kentucky, and in other geographical regions labeled as health professional shortage areas or medically underserved areas, issues stemming from social determinants are compounded with health care systems that are often lacking the human resources to meet basic medical needs. One strategy has been to utilize volunteers and paraprofessionals such as community health workers to lessen the burden on the primary care and hospital …

Isotopic And Geochemical Tracers Of Groundwater Flow In The Shivwits Plateau, Grand Canyon National Park, Jonathan W. Wilson

Theses and Dissertations--Earth and Environmental Sciences

As the impacts of global climate change on water resources continue to become more apparent, proper understanding and management of groundwater resources will be needed as supplies become more strained. Traditional methods of characterizing groundwater systems are time-intensive, costly, and can be difficult to complete in remote areas. Using ambient geochemical tracers from discrete sampling could aid in characterizing spring systems through determining flow paths, recharge areas, and carbon cycling. However, using discrete seasonal samples to understand the hydrogeology of complex, mixed-lithology aquifers has not been extensively examined. Here we explore using δ¹³C of dissolved organic carbon (DOC), …

Effect Of Different Fat Sources And Vitamin E Isoforms/ Levels On Carcass Characteristics, Meat Quality, And Belly/Bacon Characteristics Of Pigs Grown To Heavy Slaughter Weights (>150kg), Marlee Kelley

Theses and Dissertations--Animal and Food Sciences

Two separate studies were conducted to evaluate the potential interaction of fat sources and vitamin E (VE) on heavy slaughter weights. In Study 1, a total of 64 individually-fed pigs (28.41 ± 0.83 kg) were randomly assigned to 8 dietary treatments in a 4×2 factorial arrangement. Fat treatments included cornstarch (CS), tallow (TW), corn oil (CO), and coconut-oil (CN). VE treatments were dietary alpha-tocopheryl-acetate (ATA) at 11 and 200 ppm. In Study 2, a total of 72 individually fed pigs (28.55 ± 1.16 kg) were randomly assigned to 12 dietary treatments in a 2 × 6 factorial arrangement. Fat treatments …

Impact Of Ergot Alkaloid And Estradiol 17b On Whole-Body Protein Turnover And Expression Of Mtor Pathway Proteins In Muscle Of Cattle, Taylor Dawn Ferguson

Theses and Dissertations--Animal and Food Sciences

Beef cattle consuming endophyte infected tall fescue typically exhibit reduced performance in terms of both decreased dry matter intake (DMI) and growth rates. It has been suggested that lower concentrations of circulating IGF-1 (an important stimulator of the mTOR pathway and ultimately protein synthesis), as observed with consumption of ergot alkaloids, contribute to reduced growth rates. The objective of the current study was to determine if fescue-derived alkaloids decrease muscle protein synthesis though inhibitory action on the mTOR pathway via a direct effect on signal proteins, and if these negative effects can be alleviated by implantation with anabolic agents. Thirty-two …

Aging Induces B Cell Defects And Decreased Antibody Responses To Influenza Infection And Vaccination, Daniela Frasca, Bonnie B. Blomberg

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Background: Aging is characterized by a progressive decline in the capacity of the immune system to fight influenza virus infection and to respond to vaccination. Among the several factors involved, in addition to increased frailty and high-risk conditions, the age-associated decrease in cellular and humoral immune responses plays a relevant role. This is in large part due to inflammaging, the chronic low-grade inflammatory status of the elderly, associated with intrinsic inflammation of the immune cells and decreased immune function.

Results: Aging is usually associated with reduced influenza virus-specific and influenza vaccine-specific antibody responses but some elderly individuals with higher pre-exposure …

Ethanol Induced Neurotoxicity Through Dysregulation Of Ampk In A Fetal Alcohol Syndrome Model, Jessica Gebhardt

Theses and Dissertations--Medical Sciences

Ethanol consumption during pregnancy is rising in the U.S., including the rate of binge drinking. It is reported around 1 in 27 women engage in binge drinking activities while pregnant. The third trimester is a sensitive period of neuronal growth in which ethanol induced neurotoxicity can cause many harmful effects including Fetal Alcohol Spectrum Disorders. It has been shown that ethanol decreases the activity of AMPK through increasing lipid peroxidation, both of which are correlated to neurotoxicity. AICAR is a synthetic analog of AMP which significantly increases AMPK activity and may have beneficial effects in an organotypic hippocampal model of …

Examining The Role Of Metabolic Pathways As Therapeutic Modalities For Triple Negative Breast Cancer, Jeremy Andrew Johnson

Theses and Dissertations--Toxicology and Cancer Biology

Triple negative breast cancer (TNBC) comprises 15-20% of breast cancers, affects a younger patient population than other subtypes, and is very aggressive. TNBC is comprised of a diverse group of tumors that have proven refractory to targeted therapy and can be difficult to treat. Patients generally receive neoadjuvant chemotherapy (NAC), surgery, and radiotherapy. The standard of care for NAC includes a taxane, an anthracycline, and/or cyclophosphamide, and administration of NAC has resulted in pathological complete response (pCR) in 30-40% of patients. However, a majority of TNBC patients will not reach pCR and instead have residual disease (RD), which is associated …

Instructional Strategies Manual, 4th Edition: For The Helpful Entry Level Skills Checklist, 4th Edition, Beth S. Rous

Educational Leadership Studies Faculty Publications

The Instructional Strategies Manual, 4th Edition is a companion resource for the Helpful Entry Level Skills Checklist. The manual provides teachers, families, and early childhood teams with strategies, activities, and adaptations to support young children’s development of social, behavioral, communication, classroom, work, and self-management skills during the transition from preschool to school-age programs. The manual is organized around five major skill areas: classroom rules, work skills, communication skills, social behavior skills, and self-management skills. It includes strategies that can be embedded into daily classroom routines, family activities, and individualized supports, with adaptations for children with hearing, vision, cognitive, physical, speech/language, …

Growing Green Minds: Implementation Of A School Garden & Nutrition Program For The Freedom Area School District In Rural Wisconsin, Marissa Schuh

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Most children in the U.S. consume too few fruits and vegetables which is putting them at risk to develop obesity and other lifestyle diseases. The 2015-2020 Dietary Guidelines for Americans recommends that individuals should increase the amount and variety of fruits and vegetables consumed in order to prevent weight gain and other chronic diseases. Research shows that garden-based educational programs can increase children’s fruit and vegetable intake as well as change their preferences and attitudes towards eating and trying new fruits and vegetables. Incorporating a garden and nutrition curriculum into a school setting is an ideal opportunity to improve children’s …

Biopsychological Predictors Of Pain And Function In Patients With Rotator Cuff Conditions, Nicole Cascia

Theses and Dissertations--Rehabilitation Sciences

Predicting worse patient-reported outcomes in those with Rotator Cuff (RC) conditions is dependent on examining both biological and psychological impairments. In order to help determine which biopsychological factors are associated with pain and function in patients with RC related conditions and to determine who may be at an increased risk for worse outcomes after Reverse Shoulder Arthroplasty (RSA), biopsychological associations between patient demographics, scapular motion, humeral motion, RC tear size, pain associated psychological distress, and function were clinically evaluated to investigate prediction models for pain and function. The central hypothesis is that in a group of patients with symptomatic Cuff …

Physical And Occupational Therapy For Young Children With Delayed Motor Development: Exploring Current Practices, Challenges, And Families’ Implementation Of Home Activities In Early Intervention, Afnan Gmmash

Theses and Dissertations--Rehabilitation Sciences

The literature supports the use of family-centered early intervention(EI) for young children with or at risk for cerebral palsy (CP) to promote the children’s motor development. Young children with or at risk for delayed motor development in their first three years of life are entitled to EI under Part C of The Individuals with Disabilities Education Improvement Act. Identifying current EI provided for young children with delayed motor development is essential to detect possible gaps and factors that could prevent therapists from providing the best EI. Understanding the parent’s perspective on the implementation of activities outside therapy to maximize the …

Anterior Cruciate Ligament Injury-Induced Alterations In Inflammation And Muscle Physiology, Emily R. Hunt

Theses and Dissertations--Rehabilitation Sciences

Long term weakness and atrophy of the quadriceps muscle are a direct result of anterior cruciate ligament (ACL) injuries and persist for up to 10 years post injury. Muscle atrophy ensues regardless of ligamentous reconstruction surgery, indicating that muscle atrophy following injury is a function of the ligament rupture and not reconstruction surgery. Elucidating the mechanisms underlying quadriceps atrophy following ACL rupture is crucial for developing interventions to restore proper quadriceps size and mitigate weakness thereby allowing for improved patient function. In addition to understanding the specific mechanisms that contribute to quadriceps atrophy following ACL rupture, the timing of atrophic …

Determining The Role Of Satellite Cells During Skeletal Muscle Adaptation, Davis A. Englund

Theses and Dissertations--Rehabilitation Sciences

Physical inactivity, advancing age, limb immobilization, degenerative diseases and various systemic diseases (many cancers, sepsis, HIV, COPD, kidney disease) all lead to skeletal muscle wasting. The loss of muscle mass is of major clinical importance because it leads to an increased risk for morbidity, disability, and the loss of independence; collectively contributing to a substantive increase in healthcare utilization and cost. The prevalence of cachexia (disease-induced muscle wasting) can reach as high as 80% in certain patient populations and the average cost per hospital stay is $4,641 more than in non-cachectic patients. Direct healthcare costs attributable to sarcopenia were estimated …

Prevalence Of Restricted Spirometry Within Two Eastern Kentucky Counties A Cross Sectional Study, Quincy Bascombe

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objective: This study examines the prevalence of restrictive spirometry in Eastern Kentucky and its association among men and women with various demographic and exposure (occupational and environmental) factors.

Methods: A cross sectional, cluster sample (N = 685) of participants from Letcher and Harlan Counties, aged 21 and over, answered a questionnaire focused on risk factors for respiratory health outcomes including questions on demographic, health, occupational, and environmental exposures variables. Pulmonary function tests were administered to all participants with no significant cardiovascular or cerebrovascular events within the past 30 days. Log-binomial regression was used to calculate prevalence ratios (PRs) …

Analysis Of High Potency Anticholinergic Prescribing In Scottish Nursing Home Patients, Alexandra Nugent

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Purpose: The aim of this study was to compare the use of two or more high-potency anticholinergic (HPA) medications between patients 65 years and older in nursing homes and in the greater community using prescribing data. Methods: This secondary data analysis of the NHS Scotland PIS databased used prescription data from a nationally representative patient-level database. Patients were included were ≥65 years old, received ≥2HPA prescriptions from 2011Q2-2012Q1(11/12), 2016Q1-2017Q2(16/17), 2018Q2-2017Q1(18/19). The principle endpoint of this study was to assess for a change in patient’s relative risk of receiving ≥2HPA prescriptions. Results: 29,301 patients were identified. From 11/12 to 16/17 all …

Policy Analysis Of California Senate Bill 1138: Mandating Plant-Based Meal Options In Hospitals And Prisons, David Morton

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Obesity, chronic disease, and poor nutrition are prevalent in the United States while healthcare costs rise. Nutritional research advancements have suggested the healthfulness of plant-based diets. In 2018, the California state senate passed Senate Bill 1138, requiring plant-based meal options in hospitals and prisons. This paper sought to examine the context surrounding the bill, determine the appropriateness of the bill, and recommend next steps for nutritional policies in the United States. In a review of the literature, malnutrition in hospitals and prisons is highly prevalent, and state governments have already made efforts to improve their citizens’ nutrition. In this analysis, …

Analysis Of Health Survey Data To Address Topics In Environmental And Public Health, Nimish Valvi

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Introduction: Manganese is an essential trace element that can cause adverse health effects with deficiency and in excess amounts. The purpose of this study is to determine the asscociation of blood manganese levels and the prevalence of myocardial infarction, stroke, and renal dysfunction in a general US population.

Methods: Data were used from the National Health and Nutritional Examination Survey (NHANES) of non-institutionalized US adults 20 years and older using the 2011-2012, 2013-2014, and 2015-2016 survey cycles (n=16629). Weighted multivariable logistic regression models adjusted for age, race/ethnicity, sex, and poverty income ratio (PIR), were used to determine the association of …

An Evaluation Of Sensory Paths As An Antecedent Intervention For Decreasing Off-Task Behavior In Children With Disabilities During Small Group Instruction, Hannah Keene

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

The purpose of this study was to evaluate the use of sensory paths as an antecedent intervention to decrease off-task behavior and increase on-task behavior in three elementary-aged participants with disabilities. A withdrawal design was used to evaluate the effectiveness of the intervention. The results are corollary due to the unintentional A-B design (schools closed during this time period). There is some evidence that the sensory path intervention was no more effective in decreasing off-task behavior and increasing on-task behavior than baseline conditions. Future research is needed to further investigate the sensory path intervention.

The Application Of The Food Safety Modernization Act’S Produce Safety Rule For Produce Auctions, Mari Schroeder

Theses and Dissertations--Animal and Food Sciences

Produce is a high-risk commodity that is associated with numerous foodborne outbreaks each year. The Food Safety Modernization Act’s Produce Safety Rule was designed to address these issues by requiring farms that grow, harvest, package, and/or hold produce to comply with science-based minimum guidelines. However, with the revival of the local food movement there is a subsequent flux in alternative food networks that handle produce but are not covered by this rule. Produce auctions represent only a fraction of these alternative food networks but are the focus of this study because of their interaction with the Plain community whose relationship …

The Role Of Feed Additives In Mitigating The Effect Of Stressors On Growth, Digestibility, Intestinal Morphology, Permeability, And Immune Response In Poultry, Yemi Olojede Burden

Theses and Dissertations--Animal and Food Sciences

Three experiments were conducted to evaluate the interactive effects of dietary supplements in birds exposed to different stressors, on growth performance, nutrient, and energy digestibility, antioxidant status, intestinal permeability, and immune status. The first study was conducted to evaluate the effect of a commercially available algae-based antioxidant, containing Selenium yeast (EconomasE™, EcoE) and two inorganic sodium sources (NaCl and NaCl+NaHCO3) on growth performance, nutrient and energy digestibility and utilization, antioxidant, and immune status of broilers challenged with oral gavage of dexamethasone (DEX). The inclusion of either of the sodium sources did not affect plasma corticosterone and antioxidant status levels, growth …

The Fragile Future Of Aquifer Storage And Recovery, Zachary A. Bray

Law Faculty Scholarly Articles

Buda, Texas-a small town that lies between Austin and San Antonio,

on the banks of Onion Creek and above the Edwards Aquifer-is perhaps

best known, though it is not particularly well known, as the "Wiener Dog

Capital of Texas." Buda's claim to this title is based upon its annual

dachshund races, which are opposed by the Dachshund Club of America

but lauded by locals, tourists, and the international press as an "event that

combines the pageantry of the Kentucky Derby and the excitement of

NASCAR with dachshunds, animals known for their small stature." Buda

is certainly unusual in relying so …