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Evaluation Of Biased And Balanced Salvinorin A Analogs In Preclinical Models Of Pain, Kelly F. Paton, Andrew Biggerstaff, Sophia Kaska, Rachel S. Crowley, Anne C. La Flamme, Thomas E. Prisinzano, Bronwyn M. Kivell Jul 2020

Evaluation Of Biased And Balanced Salvinorin A Analogs In Preclinical Models Of Pain, Kelly F. Paton, Andrew Biggerstaff, Sophia Kaska, Rachel S. Crowley, Anne C. La Flamme, Thomas E. Prisinzano, Bronwyn M. Kivell

Pharmaceutical Sciences Faculty Publications

In the search for safer, non-addictive analgesics, kappa opioid receptor (KOPr) agonists are a potential target, as unlike mu-opioid analgesics, they do not have abuse potential. Salvinorin A (SalA) is a potent and selective KOPr agonist, however, clinical utility is limited by the short duration of action and aversive side effects. Biasing KOPr signaling toward G-protein activation has been highlighted as a key cellular mechanism to reduce the side effects of KOPr agonists. The present study investigated KOPr signaling bias and the acute antinociceptive effects and side effects of two novel analogs of SalA, 16-Bromo SalA and 16-Ethynyl SalA. 16-Bromo …


The Study On The Inflorescence Differentiation Of Bromus Ciliatus L. Cv. Xilinguole, G. You, F. Shi, L. Wang Jul 2020

The Study On The Inflorescence Differentiation Of Bromus Ciliatus L. Cv. Xilinguole, G. You, F. Shi, L. Wang

IGC Proceedings (1977-2023)

No abstract provided.


Dynamics Change Of Water‐Soluble Carbohydrate Contents In Roots System During Greening Stage Of Leymus Chinensis Populations In Saline‐Alkaline Soil On The Songnen Plains Of China, Y. S. Ye, S. Pan, J. B. Wang, Kun Wang Jul 2020

Dynamics Change Of Water‐Soluble Carbohydrate Contents In Roots System During Greening Stage Of Leymus Chinensis Populations In Saline‐Alkaline Soil On The Songnen Plains Of China, Y. S. Ye, S. Pan, J. B. Wang, Kun Wang

IGC Proceedings (1977-2023)

No abstract provided.


Clonal Morphology Of Artemisia Frigida In The Grassland With Different Degradation, S. Y. Ye, S. Pan, J. B. Wang, Kun Wang Jul 2020

Clonal Morphology Of Artemisia Frigida In The Grassland With Different Degradation, S. Y. Ye, S. Pan, J. B. Wang, Kun Wang

IGC Proceedings (1977-2023)

No abstract provided.


Response Of Dominant Species Population Importance Value To Different Grazing Systems In Stipa Breviflora Steppe, Ruirui Yan, Zhijun Wei, Jing Yang, Wenbing Chu Jul 2020

Response Of Dominant Species Population Importance Value To Different Grazing Systems In Stipa Breviflora Steppe, Ruirui Yan, Zhijun Wei, Jing Yang, Wenbing Chu

IGC Proceedings (1977-2023)

No abstract provided.


Influence Of Different Sampling Strategies On The Relationship Of Biodiversity And Grassland Primary Production, Liang Zhao, Huimin Yang, Zhongling Liu, Honglang Xiao Jul 2020

Influence Of Different Sampling Strategies On The Relationship Of Biodiversity And Grassland Primary Production, Liang Zhao, Huimin Yang, Zhongling Liu, Honglang Xiao

IGC Proceedings (1977-2023)

No abstract provided.


Experiencing Cancer In Appalachian Kentucky, Melanie Mccomsey, David Ahern, Robin C. Vanderpool, Timothy W. Mullett, Ming-Yuan Chih, Meghan Johnson, Michele Ellison, Karen Onyeije, Bradford W. Hesse, Eliah Aronoff-Spencer Jul 2020

Experiencing Cancer In Appalachian Kentucky, Melanie Mccomsey, David Ahern, Robin C. Vanderpool, Timothy W. Mullett, Ming-Yuan Chih, Meghan Johnson, Michele Ellison, Karen Onyeije, Bradford W. Hesse, Eliah Aronoff-Spencer

Journal of Appalachian Health

Nothing tells the story of people working together better than a community quilt. A diversity of talents, colors, and materials brought together through skill and shared purpose. Perhaps never before have we as Americans needed a stronger reminder that many hands make short work of big problems. The work presented here by the L.A.U.N.C.H. Collaborative offers a new framework for health care that could be compared to a digital quilt, powered by community-based participatory design, with lived expertise and the newest advances in broadband-enabled connected health solutions. This work demonstrates the value and need to engage local communities and what …


Changes Of Cap Of Creeping Bentgrass As Affected By Light Intensity During Summer Stress, Zhiming Yang, Zhihua Li Jul 2020

Changes Of Cap Of Creeping Bentgrass As Affected By Light Intensity During Summer Stress, Zhiming Yang, Zhihua Li

IGC Proceedings (1977-2023)

No abstract provided.


Storage And Output Of Bud Banks On Rhizomes Of Different Age Classes Of Reed Population In The Dryland Habitat In Alkalinized Meadow In The Songnen Plains Of China, Yunfei Yang, Baotian Zhang Jul 2020

Storage And Output Of Bud Banks On Rhizomes Of Different Age Classes Of Reed Population In The Dryland Habitat In Alkalinized Meadow In The Songnen Plains Of China, Yunfei Yang, Baotian Zhang

IGC Proceedings (1977-2023)

No abstract provided.


The Effect Of Growth Age On Alfalfa's Aboveground Biomass, Y. G. Yang, Q. Wang, J. M. Cheng, J. H. Gao Jul 2020

The Effect Of Growth Age On Alfalfa's Aboveground Biomass, Y. G. Yang, Q. Wang, J. M. Cheng, J. H. Gao

IGC Proceedings (1977-2023)

No abstract provided.


Studies On Geographic Distribution Of Wild Poa Pratensis Population And Its Community Type In Yangtze, Yellow And Lancang River Source Region, Shihai Yang, Y. S. Ma, Q. M. Dong, J. J. Shi, Y. L. Wang, L. Sheng, X. D. Sun Jul 2020

Studies On Geographic Distribution Of Wild Poa Pratensis Population And Its Community Type In Yangtze, Yellow And Lancang River Source Region, Shihai Yang, Y. S. Ma, Q. M. Dong, J. J. Shi, Y. L. Wang, L. Sheng, X. D. Sun

IGC Proceedings (1977-2023)

No abstract provided.


Root Colonization By Arbuscular Mycorrhizal Fungi In Plants Of Lhalu Wetland, Jingping Gai, Yan Dai, Guizhen Li, He Zhou, Xianglin Li, Yunwei Zhang, Fuyu Yang Jul 2020

Root Colonization By Arbuscular Mycorrhizal Fungi In Plants Of Lhalu Wetland, Jingping Gai, Yan Dai, Guizhen Li, He Zhou, Xianglin Li, Yunwei Zhang, Fuyu Yang

IGC Proceedings (1977-2023)

No abstract provided.


Allelic Share Among Two Taxonomically Related Elymus Species, Hexaploidy E. Nutans Griseb And Tetraploid E. Burchan‐Buddae (Nevski) Tzvelev, Xuebing Yan, Chengzhang Wang, Yuxia Guo, Yibao Jiang, Defeng Li Jul 2020

Allelic Share Among Two Taxonomically Related Elymus Species, Hexaploidy E. Nutans Griseb And Tetraploid E. Burchan‐Buddae (Nevski) Tzvelev, Xuebing Yan, Chengzhang Wang, Yuxia Guo, Yibao Jiang, Defeng Li

IGC Proceedings (1977-2023)

No abstract provided.


Ecological Genetic Study On Flowering Phenology In Red Clover, Y. Aoyagi, T. Hirata, T. Yamada Jul 2020

Ecological Genetic Study On Flowering Phenology In Red Clover, Y. Aoyagi, T. Hirata, T. Yamada

IGC Proceedings (1977-2023)

No abstract provided.


The Effect Factors On Regeneration System Of Tissue Culture Using Mature Embryo Of Wheatgrass, Chunbo Xu, Fugui Mi, Yong W., Xingyou Li Jul 2020

The Effect Factors On Regeneration System Of Tissue Culture Using Mature Embryo Of Wheatgrass, Chunbo Xu, Fugui Mi, Yong W., Xingyou Li

IGC Proceedings (1977-2023)

No abstract provided.


Comparison Of The Production Performance Between Two Populations Of Lespedeza Davurica, Xi Ying, Xiang Zhao, Kuanhu Dong Jul 2020

Comparison Of The Production Performance Between Two Populations Of Lespedeza Davurica, Xi Ying, Xiang Zhao, Kuanhu Dong

IGC Proceedings (1977-2023)

No abstract provided.


Molecular Characterization Of Bermudagrass Germplasm Using Sequence‐Related Amplified Polymorphism Markers, Z. Y. Wang, J. X. Liu Jul 2020

Molecular Characterization Of Bermudagrass Germplasm Using Sequence‐Related Amplified Polymorphism Markers, Z. Y. Wang, J. X. Liu

IGC Proceedings (1977-2023)

No abstract provided.


Effect Of Substrate Characteristics On The Growth And Sporulation Of Two Biocontrol Microorganisms During Solid State Cultivation, Ga Young Lee, Wenqi Li, Ulalo M. Chirwa, Jian Shi Jul 2020

Effect Of Substrate Characteristics On The Growth And Sporulation Of Two Biocontrol Microorganisms During Solid State Cultivation, Ga Young Lee, Wenqi Li, Ulalo M. Chirwa, Jian Shi

Biosystems and Agricultural Engineering Faculty Publications

Biocontrol agents are a group of naturally occurring organisms capable of interrupting the lifespan and suppressing the propagation of disease organisms. The use of biocontrol agents offers an environment-friendly and sustainable solution to the synthetic agrochemicals. In this study, we investigated parboiled rice and millets as substrates for spore production of two model biocontrol microorganisms (Bacillus pumilus and Streptomyces griseus) under solid state cultivation (SSC) conditions. The effects of cultivation parameters such as initial moisture content, water activity, and cultivation time on microbial growth and spore production were studied. Furthermore, texture profile analysis was performed to test the …


Plasma And Serum Proteins Bound To Nanoceria: Insights Into Pathways By Which Nanoceria May Exert Its Beneficial And Deleterious Effects In Vivo, D. Allan Butterfield, Binghui Wang, Peng Wu, Sarita S. Hardas, Jason M. Unrine, Eric A. Grulke, Jian Cai, Jon B. Klein, William M. Pierce, Robert A. Yokel, Rukhsana Sultana Jul 2020

Plasma And Serum Proteins Bound To Nanoceria: Insights Into Pathways By Which Nanoceria May Exert Its Beneficial And Deleterious Effects In Vivo, D. Allan Butterfield, Binghui Wang, Peng Wu, Sarita S. Hardas, Jason M. Unrine, Eric A. Grulke, Jian Cai, Jon B. Klein, William M. Pierce, Robert A. Yokel, Rukhsana Sultana

Chemistry Faculty Publications

Nanoceria (CeO2, cerium oxide nanoparticles) is proposed as a therapeutic for multiple disorders. In blood, nanoceria becomes protein-coated, changing its surface properties to yield a different presentation to cells. There is little information on the interaction of nanoceria with blood proteins. The current study is the first to report the proteomics identification of plasma and serum proteins adsorbed to nanoceria. The results identify a number of plasma and serum proteins interacting with nanoceria, proteins whose normal activities regulate numerous cell functions: antioxidant/detoxification, energy regulation, lipoproteins, signaling, complement, immune function, coagulation, iron homeostasis, proteolysis, inflammation, protein folding, protease inhibition, adhesion, protein/RNA …


Statistic Of Psammophyte In Otindag Sandy Land, X. L. Wang, X. H. Wu, T. T. Yang Jul 2020

Statistic Of Psammophyte In Otindag Sandy Land, X. L. Wang, X. H. Wu, T. T. Yang

IGC Proceedings (1977-2023)

No abstract provided.


Effect Of Frequency And Time Of Cutting On The Production Of Three Strains Of Tropical Forage Legume Aeschynomene Americana L. In Drained Paddy Field And Upland Field, Manabu Tobisa, M. Shimojo, Y. Nakano, K. Okano, Y. Masuda Jul 2020

Effect Of Frequency And Time Of Cutting On The Production Of Three Strains Of Tropical Forage Legume Aeschynomene Americana L. In Drained Paddy Field And Upland Field, Manabu Tobisa, M. Shimojo, Y. Nakano, K. Okano, Y. Masuda

IGC Proceedings (1977-2023)

No abstract provided.


Study Of Environmental Factors Effects On Vegetation, Case Study: Iran, A. Tavili Jul 2020

Study Of Environmental Factors Effects On Vegetation, Case Study: Iran, A. Tavili

IGC Proceedings (1977-2023)

No abstract provided.


Studying Physiological‐Morphological Chanages Of Agropyron Cristatum Against Water Deficiency, A. Fakhireh, A. Tavili Jul 2020

Studying Physiological‐Morphological Chanages Of Agropyron Cristatum Against Water Deficiency, A. Fakhireh, A. Tavili

IGC Proceedings (1977-2023)

No abstract provided.


Yield And Quality Of Whipgrass Mixed With Different Levels Of White Clover, Zhisong Tang, Chunhua Yang, Xiantao Fu, Lingzhi Chen, Huijun Huang Jul 2020

Yield And Quality Of Whipgrass Mixed With Different Levels Of White Clover, Zhisong Tang, Chunhua Yang, Xiantao Fu, Lingzhi Chen, Huijun Huang

IGC Proceedings (1977-2023)

No abstract provided.


Effect Of Topography On Utilization From Mountain Rangelands Of Mazandaran Province--Case Study: Rangelands Of Babolrood Basin, Ir‐Iran, Reza Tamartash, Hamid Jalilvand, Karim Soleimani, Maryam Saeidi Jul 2020

Effect Of Topography On Utilization From Mountain Rangelands Of Mazandaran Province--Case Study: Rangelands Of Babolrood Basin, Ir‐Iran, Reza Tamartash, Hamid Jalilvand, Karim Soleimani, Maryam Saeidi

IGC Proceedings (1977-2023)

No abstract provided.


Effect Of Water Stress And Rehydration On The Physiological And Biochemical Indices Of Alfalfa, Y. B. Sheng, G. L. Wang, C. L. Jia, S. Y. Chen, Q. L. Yang, B. Wu Jul 2020

Effect Of Water Stress And Rehydration On The Physiological And Biochemical Indices Of Alfalfa, Y. B. Sheng, G. L. Wang, C. L. Jia, S. Y. Chen, Q. L. Yang, B. Wu

IGC Proceedings (1977-2023)

No abstract provided.


Forests, Steppes And Grasslands In Morocco: Diversity, Ecological Importance And Socio‐Economic Role, Mohammed Sghir Taleb, Mohamed Fennane Jul 2020

Forests, Steppes And Grasslands In Morocco: Diversity, Ecological Importance And Socio‐Economic Role, Mohammed Sghir Taleb, Mohamed Fennane

IGC Proceedings (1977-2023)

No abstract provided.


Irish Grasslands 2010: A Sustainable Environment?, R. P. O. Schulte, N. Culleton Jul 2020

Irish Grasslands 2010: A Sustainable Environment?, R. P. O. Schulte, N. Culleton

IGC Proceedings (1977-2023)

No abstract provided.


Nanohybrid Membrane Synthesis With Phosphorene Nanoparticles: A Study Of The Addition, Stability And Toxicity, Joyner Eke, Philip Alexander Mills, Jacob Ryan Page, Garrison P. Wright, Olga V. Tsyusko, Isabel C. Escobar Jul 2020

Nanohybrid Membrane Synthesis With Phosphorene Nanoparticles: A Study Of The Addition, Stability And Toxicity, Joyner Eke, Philip Alexander Mills, Jacob Ryan Page, Garrison P. Wright, Olga V. Tsyusko, Isabel C. Escobar

Center of Membrane Sciences Faculty Publications

Phosphorene is a promising candidate as a membrane material additive because of its inherent photocatalytic properties and electrical conductance which can help reduce fouling and improve membrane properties. The main objective of this study was to characterize structural and morphologic changes arising from the addition of phosphorene to polymeric membranes. Here, phosphorene was physically incorporated into a blend of polysulfone (PSf) and sulfonated poly ether ether ketone (SPEEK) doping solution. Protein and dye rejection studies were carried out to determine the permeability and selectivity of the membranes. Since loss of material additives during filtration processes is a challenge, the stability …


Oral Ingestion Of Bacterially Expressed Dsrna Can Silence Genes And Cause Mortality In A Highly Invasive, Tree-Killing Pest, The Emerald Ash Borer, Ramya Shanivarsanthe Leelesh, Lynne K. Rieske Jul 2020

Oral Ingestion Of Bacterially Expressed Dsrna Can Silence Genes And Cause Mortality In A Highly Invasive, Tree-Killing Pest, The Emerald Ash Borer, Ramya Shanivarsanthe Leelesh, Lynne K. Rieske

Entomology Faculty Publications

RNA interference (RNAi) is a naturally occurring process inhibiting gene expression, and recent advances in our understanding of the mechanism have allowed its development as a tool against insect pests. A major challenge for deployment in the field is the development of convenient and efficient methods for production of double stranded RNA (dsRNA). We assessed the potential for deploying bacterially produced dsRNA as a bio-pesticide against an invasive forest pest, the emerald ash borer (EAB). EAB feeds on the cambial tissue of ash trees (Fraxinus spp.), causing rapid death. EAB has killed millions of trees in North America since …