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Manipulation Of Components Of The Renin Angiotensin System In Renal Proximal Tubules Fails To Alter Atherosclerosis In Hypercholesterolemic Mice, Masayoshi Kukida, Naofumi Amioka, Dien Ye, Hui Chen, Jessica J. Moorleghen, Ching-Ling Liang, Deborah A. Howatt, Yuriko Katsumata, Motoko Yanagita, Hisashi Sawada, Alan Daugherty, Hong S. Lu Jan 2023

Manipulation Of Components Of The Renin Angiotensin System In Renal Proximal Tubules Fails To Alter Atherosclerosis In Hypercholesterolemic Mice, Masayoshi Kukida, Naofumi Amioka, Dien Ye, Hui Chen, Jessica J. Moorleghen, Ching-Ling Liang, Deborah A. Howatt, Yuriko Katsumata, Motoko Yanagita, Hisashi Sawada, Alan Daugherty, Hong S. Lu

Saha Cardiovascular Research Center Faculty Publications

Background and objective: Whole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis development. A deficit in the literature has been a lack of attention to the effects of sex. Also, based on data with gene-deleted mice, the site of RAS activity that influences lesion formation is at an unknown distant location. Since angiotensin (AngII) concentrations are high in kidney and the major components of the RAS are present in renal proximal tubule cells (PTCs), this study evaluated the role of the RAS in PTCs in atherosclerosis development.

Methods and results: Mice with an LDL …


Mascs: Masculinity Reimagined, Josh Porter Jan 2023

Mascs: Masculinity Reimagined, Josh Porter

Graduate Thesis Exhibition Catalogue Gallery, 2023

MASCS: Masculinity Reimagined explores how performances of contemporary masculinities can counteract traditional binary understandings of gender. Justin Korver, John Paul Morabito, Betsy Odom, Moises Salazar, and Darryl DeAngelo Terrell expose, question, and subvert the ways that we culturally define masculinity by focusing on gender as performance. These artists not only critique cisgender, heteronormative binary understandings of masculinity, but also embrace the performative nature of gender and celebrate non-normative, alternative, and queer masculinities. By encompassing a range of gender and sexual identifications, these artists share their own personal experiences, interpretations, performances, rejections, and embodiments of masculinity. Breaking down the barrier created …


Local News Deserts In China: The Role Of Social Media And Personal Communication Networks, Zixue Tai, Bai He, Jianping Liu Jan 2023

Local News Deserts In China: The Role Of Social Media And Personal Communication Networks, Zixue Tai, Bai He, Jianping Liu

Journalism and Media Faculty Publications

The field of local news is often associated with news deserts, commonly defined as geo‐based communities without news‐ papers or other legacy media as providers of locally oriented news and civic information. This phenomenon is expanding in global society due to the diminishing presence of newspapers at moments of accelerated digitization. This study examines the multiplex nature of news deserts in rural and suburban areas in China. Data were collected through a multi‐methods approach combining two focus groups and 44 semi‐structured in‐depth interviews. Patterns of engagement among inter‐ viewees reveal that smartphone‐based social media applications and digital platforms function as …


Organizational Access Points And Substance Use Disorder Treatment Utilization Among Black Women: A Longitudinal Cohort Study, Sugy Choi, Amanda Bunting, Talia Nadel, Charles J. Neighbors, Carrie B. Oser Jan 2023

Organizational Access Points And Substance Use Disorder Treatment Utilization Among Black Women: A Longitudinal Cohort Study, Sugy Choi, Amanda Bunting, Talia Nadel, Charles J. Neighbors, Carrie B. Oser

Sociology Faculty Publications

Introduction Health and social service organizations, including the emergency department (ED) and public assistance programs, constitute a social safety net that may serve as an “access point” for substance use treatment utilization. Racialization of substance use disorder (SUD) and gender disparities in access to treatment contribute to differences in health and social service utilization, including substance use treatment for Black women. We therefore explored the role of various access points in facilitating the use of substance use treatment among Black women with substance use and involvement in the criminal justice system.

Methods We used data from the Black Women in …


Intentions To Seek Mental Health Services Among Arabs In The United States: The Effect Of A Tailored Web-Based Educational Video, Ohoud Alosais Jan 2023

Intentions To Seek Mental Health Services Among Arabs In The United States: The Effect Of A Tailored Web-Based Educational Video, Ohoud Alosais

Theses and Dissertations--Nursing

Arabs in the United States (U.S.) are exposed to different stressors that place them at high risk of developing adverse mental health outcomes. Compared to other minority groups, Arabs in the U.S. have reported significantly higher levels of anxiety and depression. Researchers have found disparities between the need for mental health services (MHS) and actual utilization among Arabs in the U.S. Understanding the intrapersonal factors involved in MHS’ help-seeking behavior among Arabs in the U.S. is essential to reduce the burdens caused by untreated mental health disorders in this population. Therefore, the purpose of this dissertation was to enhance our …


The Effects Of Escalated Fentanyl Intake On Decision-Making Dynamics, Trinity Shaver Jan 2023

The Effects Of Escalated Fentanyl Intake On Decision-Making Dynamics, Trinity Shaver

Theses and Dissertations--Psychology

Opioid Use Disorder is characterized partially as a decision-making disorder. Decision-making theories, such as habit theory and relative value theory, have aimed to better understand the shift in preference for drug over other alternatives. In order to compare these two contrasting theories, an allomorphic concurrent choice task will run in tandem with an escalation procedure. Male and female Sprague-Dawley rats were tested for choice differences in an allomorphic choice procedure. Reward dimensions, such as relative reward rate, were manipulated within sessions, and magnitude (remifentanil dose), was manipulated between sessions. To study the effects of escalated fentanyl intake on relative valuation, …


Southeastern Law Librarian 2023 Special Election Edition, Seaall Jan 2023

Southeastern Law Librarian 2023 Special Election Edition, Seaall

Newsletters

No abstract provided.


Southeastern Law Librarian Winter 2023, Seaall Jan 2023

Southeastern Law Librarian Winter 2023, Seaall

Newsletters

No abstract provided.


Offshoring And Subordinate Financialization In Developing Countries, Logan Kuegel Jan 2023

Offshoring And Subordinate Financialization In Developing Countries, Logan Kuegel

Undergraduate Public Policy Capstone Projects

This study will investigate the relationship between global value chain integration and financialization in the Global South. It is intended for policy research committees in international organizations such as the United Nations (Commission on Trade and Development Special Committee on Cization), the International Monetary Fund (Development Committee), the World Trade Organization, and World Bank. The global production network represents the international division of production through intermediate offshoring, while financialization represents the entrance of traditionally nonfinancial actors (namely firms, governments/banks, and households) into the financial system.

Attempting to use a heterodox framework, this paper builds upon literature that synthesizes the two …


Bolstering Resistance To Misinformation Through K-12 Education, Allison Johnson Jan 2023

Bolstering Resistance To Misinformation Through K-12 Education, Allison Johnson

Undergraduate Public Policy Capstone Projects

Misinformation online and in news media is a problem because it degrades truth and hinders legitimate democratic discourse. As misinformation becomes more prevalent, we need to start finding ways to limit the extent of the problem. To do so, I recommend a policy solution based on inoculation theory. Inoculation theory, as the name suggests, uses the metaphor of a vaccine. When receiving the flu shot, we get a weakened dose of the virus, which in turn helps us to create antibodies and later be more effective at fighting the real flu. In this instance, people are exposed to weakened doses …


Curbing Diabetes Prevalence And Reducing Risk Through Policy, Grayson Blount Jan 2023

Curbing Diabetes Prevalence And Reducing Risk Through Policy, Grayson Blount

Undergraduate Public Policy Capstone Projects

The purpose of this policy brief is to illuminate the dire circumstances surrounding the ongoing diabetes epidemic in Kentucky. Type II diabetes mellitus, a preventable and manageable chronic illness, affects nearly 465,000 Kentuckians currently. Beyond the daily struggle associated with diabetes, many acute complications can arise that are severly detrimental to quality of life, such as blindness or lower extremeity amputation. Additionally, the costs associated with diabetes are tremendous, to patients, to providers, and to the state. It is in the best interest of all stakeholders to do whatever we can in order to reduce prevalence and improve management of …


Child Welfare And The Opioid Crisis In The Bluegrass State, Irina Mohler Jan 2023

Child Welfare And The Opioid Crisis In The Bluegrass State, Irina Mohler

Undergraduate Public Policy Capstone Projects

This brief discusses the challenges facing Kentucky's child welfare system, particularly due to the opioid epidemic, childhood adversity, mental health needs, and limited social services. Kentucky has one of the highest child neglect rates and opioid dispensing rates in the nation. The state's child welfare system includes services like the Child and Family Services Plan, Independent Living Program, and Sobriety Treatment and Recovery Team (START), but it faces issues such as high caseloads and data gaps. It aims to emphasizes the importance of providing the highest standard of care for children in Kentucky and seeking effective recommendations by examining similar …


Homeownership And Mortgage Loans: How Important Is A Conventional Loan?, Zachary Owen Jan 2023

Homeownership And Mortgage Loans: How Important Is A Conventional Loan?, Zachary Owen

Undergraduate Public Policy Capstone Projects

Communities across the United States face a housing crisis that stems in part from a scarcity of conventional home mortgage loans. Conventional mortgage loan application numbers have decreased, and racial disparities persist in mortgage application denial rates. In 2020, the Urban Institute reported that when applying for a mortgage, Black applicants were denied 27.1% of the time, yet White applicants were denied only 13.6% of the time. These denial rates are highly correlated with homeownership rates. Today, despite policy efforts, the difference in White and Black homeownership rates is higher than in the 1960s when the government enforced discriminatory housing …


Making Transportation Safer, Jack Reynolds Jan 2023

Making Transportation Safer, Jack Reynolds

Undergraduate Public Policy Capstone Projects

While often overlooked, the overreliance on private transportation across the United States has become a major source of danger, with thousands of lives lost every year to motor vehicle crashes. These deaths have been taken for granted, yet what is often forgotten is that in the face of increasing rates of motor vehicle crash deaths, we have the capability to prevent future tragedies like these from occurring through targeted policy decisions. While certain reforms to private transportation were found to be effective in improving traffic safety, such as implementing graduated licensing systems and lowering speed limits, the primary component of …


Generative And Ai Authored Artworks And Copyright Law, Michael D. Murray Jan 2023

Generative And Ai Authored Artworks And Copyright Law, Michael D. Murray

Law Faculty Scholarly Articles

Generative art linked to non-fungible tokens (NFTs) is an extremely popular genre of art in the NFT universe. Many of the most famous NFT projects—CryptoPunks, Bored Ape Yacht Club, World of Women, Azuki, Chromie Squiggles, Clone X, and Moonbirds, just to name a few—involve generative art. But there is a potential copyrightability problem with generative art:

Under current United States copyright law, many examples of generative art might be held to be uncopyrightable.

Why does generative art fail in the copyrightability analysis? As discussed below, it is because the work might lack a human author. And at present, the U.S. …


Copyright Transformative Fair Use After Andy Warhol Foundation For The Visual Arts, Inc. V. Goldsmith, Michael D. Murray Jan 2023

Copyright Transformative Fair Use After Andy Warhol Foundation For The Visual Arts, Inc. V. Goldsmith, Michael D. Murray

Law Faculty Scholarly Articles

On May 18, 2023, the United States Supreme Court entered its opinion in Andy Warhol Foundation for the Visual Arts, Inc. v. Goldsmith. The Court examined the work of the renowned artist Andy Warhol (Warhol), posthumously represented by his eponymously named foundation, who had incorporated a significant portion of the visual elements from Lynn Goldsmith’s photograph of the deceased rock star Prince without Goldsmith’s permission. In a 7-2 opinion, the Court held that Warhol’s use of the Goldsmith photograph was not “transformative” and thus did not constitute fair use of the photographer’s work. This article will explain and analyze …


Interbranch Equity, Jonathan Shaub Jan 2023

Interbranch Equity, Jonathan Shaub

Law Faculty Scholarly Articles

In recent years, Congress has increasingly turned to the courts to challenge executive actions. In these suits, the executive branch has strenuously pressed several distinct doctrinal arguments that interbranch cases are nonjusticiable and must be dismissed. These arguments, though expressed in the relevant language of each individual justiciability doctrine, are all centered on a single fundamental point—the judiciary should not be involved in refereeing a dispute that is solely between the legislative and executive branches. The briefs and judicial opinions explicitly identify a coherent category of cases—interbranch cases. But these cases are treated haphazardly as a matter of doctrine. Within …


Race Conscious Affirmative Action By Tax Exempt 501(C)(3) Institutions After Students For Fair Admissions V. Harvard And Unc, David A. Brennen Jan 2023

Race Conscious Affirmative Action By Tax Exempt 501(C)(3) Institutions After Students For Fair Admissions V. Harvard And Unc, David A. Brennen

Law Faculty Scholarly Articles

In 1983, several years after its 1954 decision in Brown v. Board of Education, the United States Supreme Court decided a case that significantly impacted tax-exempt § 501(c)(3) charitable schools that consider race in making admissions decisions. In Bob Jones University v. United States, the Court held that a private school that discriminates against African Americans in admissions is not entitled to § 501(c)(3) tax-exempt status. The Court based its decision on the public policy doctrine, an off-shoot of the well established illegality doctrine. Pursuant to the public policy doctrine, the Court upheld the IRS’s decision to deny …


Opioid Lawsuits: Is There Any End In Sight?, Richard C. Ausness Jan 2023

Opioid Lawsuits: Is There Any End In Sight?, Richard C. Ausness

Law Faculty Scholarly Articles

Numerous lawsuits have been filed since 2014 against opioid manufacturers, distributors and retail pharmacies by state and local governments and other plaintiffs. Unfortunately, although some settlements with some defendants have been negotiated, a comprehensive “global” resolution of the opioid controversy remains elusive. This article traces the history of opioid litigation and considers whether there is a better way to deal with such a massive problem.


Beneficiaries As Trustees: Here's The State Of Things, Richard C. Ausness Jan 2023

Beneficiaries As Trustees: Here's The State Of Things, Richard C. Ausness

Law Faculty Scholarly Articles

It is not unusual for settlors to appoint beneficiaries as trustees. However, there are serious risks associated with this practice. This Article will examine some of these risks and suggest ways to reduce them. Part II describes why settlors appoint beneficiaries as trustees. Part III identifies some of the cases that have arisen where other trust beneficiaries have charged trustee beneficiaries with breach of fiduciary duties such as the duty of loyalty, impartiality, and prudence, as well as the duty to inform and report. Part IV explores a number of cases which have involved common trust arrangements such as revocable …


So You Want To Be A Leader? Examining Pathways To Special Collections Administration, Sarah Horowitz, Colleen W. Barrett Jan 2023

So You Want To Be A Leader? Examining Pathways To Special Collections Administration, Sarah Horowitz, Colleen W. Barrett

Library Faculty and Staff Publications

This article seeks to understand the current state of the field of special collections library administration in the United States. Using a dataset gathered through publicly available information about special collections directors from the Association of Research Libraries (ARL), Independent Research Libraries Association (IRLA), and the Oberlin Group institutional members, the authors explore the educational backgrounds of directors, the types of positions they held prior to taking on their current roles, and the effect of gender on leadership advancement. This article also discusses the similarities and differences between institution types as well as promotions within institutions and across types of …


Looking Back: Kentucky And Children’S Book Publishers, Reinette F. Jones, Charlotte Stephens Jan 2023

Looking Back: Kentucky And Children’S Book Publishers, Reinette F. Jones, Charlotte Stephens

Library Faculty and Staff Publications

Though Kentucky was not a leader in the early publishing industry for children, it was an active participant. Printers within the state, as in the rest of the country, saw the potential in producing literature for young readers. Through the end of the eighteenth and beginning of the nineteenth centuries, this literature became more established. Slowly, children’s books started to step away from solemn moral instruction toward the playful stories we know and love today.


Looking Back: Woman's Library Club In Kentucky, Reinette F. Jones Jan 2023

Looking Back: Woman's Library Club In Kentucky, Reinette F. Jones

Library Faculty and Staff Publications

The Woman’s Library Club Movement arrived in Kentucky around 1896. It was not a true movement, but rather a period when dissociated groups named Woman’s Library Club were established throughout the United States. There was not a national office or state offices. Each club functioned independently. The state of Kentucky was a minor player in the Woman’s Library Club Movement. Had it not been for the Paducah newspaper articles, the state as whole may have been overlooked.


Low-Head Dams (Aka Drowning Machines) Are Deadly: An Analysis Of Liability For Landowners And States, And Recommendations For Legislation And Warning Signs, Forrest R. Hansen, Rollin H. Hotchkiss Jan 2023

Low-Head Dams (Aka Drowning Machines) Are Deadly: An Analysis Of Liability For Landowners And States, And Recommendations For Legislation And Warning Signs, Forrest R. Hansen, Rollin H. Hotchkiss

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.


Making Sense Of “Commence” In The Clean Water Act’S Diligent Prosecution Bar, Isa Harrison Jan 2023

Making Sense Of “Commence” In The Clean Water Act’S Diligent Prosecution Bar, Isa Harrison

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.


50 Shades Of Green: How Inconsistencies In State Regulatory Regimes Threaten To Doom The Legal Cannabis Market In The United States, Shawn Harkins Jan 2023

50 Shades Of Green: How Inconsistencies In State Regulatory Regimes Threaten To Doom The Legal Cannabis Market In The United States, Shawn Harkins

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.


A New Rule: Why Broad Jurisdiction Under § 404 Of The Clean Water Act Will Protect Wetlands, Gracie Sandlin Jan 2023

A New Rule: Why Broad Jurisdiction Under § 404 Of The Clean Water Act Will Protect Wetlands, Gracie Sandlin

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.


Delta-Late: How The Contentious And Hazy Legal Status Of Delta-8 Thc Reveals Kentucky’S Need For Federal Regulatory Guidance, Georgiana Ledford Jan 2023

Delta-Late: How The Contentious And Hazy Legal Status Of Delta-8 Thc Reveals Kentucky’S Need For Federal Regulatory Guidance, Georgiana Ledford

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.


Let Kids Be Kids: Why The Fair Labor Standards Act Of 1938 Desperately Needs A Revision, Cori Agnoni Jan 2023

Let Kids Be Kids: Why The Fair Labor Standards Act Of 1938 Desperately Needs A Revision, Cori Agnoni

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.


Horsing Around With Protecting The Horse Industry: Should California Adopt An Equine Activity Liability Act?, Kara Legg Jan 2023

Horsing Around With Protecting The Horse Industry: Should California Adopt An Equine Activity Liability Act?, Kara Legg

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.