Digital Commons Network^™

Terrestrial Ecosystem Transformations In Response To Rapid Climate Change During The Last Deglaciation Around Mono Lake, California, Usa, Adam J. Benfield, Sarah J. Ivory, Bailee Nicole Hodelka, Susan R. H. Zimmerman, Michael M. Mcglue

Earth and Environmental Sciences Faculty Publications

We examine major reorganizations of the terrestrial ecosystem around Mono Lake, California during the last deglacial period from 16,000–9,000 cal yr BP using pollen, microcharcoal, and coprophilous fungal spores (Sporormiella) from a deep-water sediment core. The pollen results record the assemblage, decline, and replacement of a mixed wooded community of Sierran and Great Basin taxa with Alkali Sink and Sagebrush Steppe biomes around Mono Lake. In particular, the enigmatic presence of Sequoiadendron-type pollen and its extirpation during the early Holocene hint at substantial biogeographic reorganizations on the Sierran-Great Basin ecotone during deglaciation. Rapid regional hydroclimate changes produced structural alterations in …

Recovery Of Valuable Metals From Electronic Waste Using A Novel Ammonia-Based Hydrometallurgical Process, Peijia Lin

Theses and Dissertations--Mining Engineering

The growing quantity of waste electrical and electronic equipment (WEEE), also known as electronic waste (E-waste), has been an area of growing public concern. The abundance of valuable metals contained in waste printed circuit boards (WPCBs) has made it a promising secondary resource, especially for Cu and Au. Although the recovery of metals from WPCBs via hydrometallurgical routes has been studied extensively over the past 20 years, most of the research has been limited in the laboratory. In current hydrometallurgical processes, strong acids and expensive oxidizers are often used to ensure a high recovery of metals without considering the sustainability …

Operationalizing A Culture For Successful Lean Transformations: A Framework And Model-Based Tools, Amir Najarzadeh Dr.

Theses and Dissertations--Manufacturing Systems Engineering

Lean manufacturing has been embraced by many companies as a business model to promote operational excellence. However, a high percentage of lean implementation attempts have failed; many organizations have not been able to sustain continuous improvements to achieve lean transformations. This failure is often attributed to the sole focus on the hard-side (tools) of lean, at the expense of the soft side (culture). The majority of research exploring the cultural dimensions of lean either aims to increase awareness about culture or addresses it only in a cursory manner. To bridge this gap this study aims to identify and assess the …

Association Of Notch3 With Elastic Fiber Dispersion In The Infrarenal Abdominal Aorta Of Cynomolgus Monkeys, Sohei Ito, Naofumi Amioka, Michael K. Franklin, Pengjun Wang, Ching-Ling Liang, Yuriko Katsumata, Lei Cai, Ryan E. Temel, Alan Daugherty, Hong S. Lu, Hisashi Sawada

Saha Cardiovascular Research Center Faculty Publications

BACKGROUND: The regional heterogeneity of vascular components and transcriptomes is an important determinant of aortic biology. This notion has been explored in multiple mouse studies. In the present study, we examined the regional heterogeneity of aortas in nonhuman primates.

METHODS: Aortic samples were harvested from the ascending, descending thoracic, suprarenal, and infrarenal regions of young control monkeys and adult monkeys with high fructose consumption for 3 years. The regional heterogeneity of aortic structure and transcriptomes was examined by histological and bulk RNA sequencing analyses, respectively.

RESULTS: Immunostaining of CD31 and αSMA (alpha-smooth muscle actin) revealed that endothelial and smooth muscle …

Predictors And Outcomes Of Acute Pulmonary Embolism In Covid-19; Insights From Us National Covid Cohort Collaborative, Muhammad H. Gul, Zin Mar Htun, Vinicio De Jesus Perez, Muhammad Suleman, Samiullah Arshad, Muhammad Imran, Mahender Vyasabattu, Jeremy P. Wood, Michael I. Anstead, Peter E. Morris

Saha Cardiovascular Research Center Faculty Publications

Objectives To investigate whether COVID-19 patients with pulmonary embolism had higher mortality and assess the utility of d-dimer in predicting acute pulmonary embolism.

Patients and methods Using the National Collaborative COVID-19 retrospective cohort, a cohort of hospitalized COVID-19 patients was studied to compare 90-day mortality and intubation outcomes in patients with and without pulmonary embolism in a multivariable cox regression analysis. The secondary measured outcomes in 1:4 propensity score-matched analysis included length of stay, chest pain incidence, heart rate, history of pulmonary embolism or DVT, and admission laboratory parameters.

Results Among 31,500 hospitalized COVID-19 patients, 1117 (3.5%) patients were diagnosed …

Relative Adrenal Insufficiency Is A Risk Factor And Endotype Of Sepsis - A Proof-Of- Concept Study To Support A Precision Medicine Approach To Guide Glucocorticoid Therapy For Sepsis, Chia-Hua Wu, Ling Guo, Dan Hao, Qian Wang, Xiang Ye, Misa Ito, Bin Huang, Chieko Mineo, Philip W. Shaul, Xiang-An Li

Saha Cardiovascular Research Center Faculty Publications

Introduction: 25-60% of septic patients experience relative adrenal insufficiency (RAI) and glucocorticoid (GC) is frequently used in septic patients. However, the efficacy of GC therapy and whether GC therapy should be based on the status of RAI are highly controversial. Our poor understanding about the pathogenesis of RAI and a lack of RAI animal model present significant barriers to address these critical issues.

Methods: Scavenger receptor BI (SR-BI) regulates stress-induced GC (iGC) production in response to stress. We generated SF1CreSR-BIfl/fl mice and utilized the mice as a RAI model to elucidate the pathogenesis of RAI and GC therapy in sepsis. …

Effects Of Biosynthesized Bromoform On Enteric Methane Production, Animal Performance And Tissue Residues In Cattle, Sydney Davis

Theses and Dissertations--Animal and Food Sciences

Greenhouse gas (GHG) emissions have been implicated in global warming and extreme climate change conditions. The Environmental Protection Agency (EPA) has identified agriculture, more specifically cattle production, as a major contributor to global GHG production. When expressed as liters of gas, CO2 is considered the primary GHG produced, however, in terms of global warming potential (GWP), CH4 has 25-times greater potential than that of CO2. Due to the elevated GWP of CH4, we have constructed a series of experiments to investigate the use of a halogenated CH4 analogue derived from kelp (i.e., bromoform) as an inhibitor of enteric CH4 production …

Interface: Technology & Portraiture, Mullins Sydney

Graduate Thesis Exhibition Catalogue Gallery, 2023

In Interface, five Kentucky-area artists explore a new language of representation with the aid of digital tools like Artificial Intelligence (AI) and Automatic Facial Recognition Software (AFR). Some artists use algorithms to alter celebrity faces beyond recognition, others feed data sets of existing art to AI models in an attempt to generate portraits of no one in particular. Others still create tools for understanding the very act of facial recognition or obfuscation. All have one thing in common: they wish to stretch the limits of and critique the genre of portraiture, as well as to cause viewers to question …

An Investigation Of Individualized Education Programs For Students With Autism, Jordan Findley

Theses and Dissertations--Educational, School, and Counseling Psychology

Autism is one of the fastest growing educational disability groups (U.S. Department of Education, Office of Special Education Programs, 2021). The Individuals with Disabilities Education Improvement Act (IDEIA, 2004) ensures all students have access to a free and appropriate public education. Individualized Education Programs (IEP) have been described as central to IDEIA (2004) and are the most common service received by children with autism (Berrcera et al., 2017; Yell et al., 2003). Despite the frequent use of the IEP in service provision for students with autism, there is relatively little research on the content and quality of IEPs for students …

Microglia Proliferation Underlies Synaptic Dysfunction In The Prefrontal Cortex: Implications For The Pathogenesis Of Hiv-1- Associated Neurocognitive And Affective Alterations, Hailong Li, Kristen A. Mclaurin, Charles F. Mactutus, Rosemarie M. Booze

Neuroscience Faculty Publications

Microglia, which are productively infected by HIV-1, are critical for brain development and maturation, as well as synaptic plasticity. The pathophysiology of HIV-infected microglia and their role in the pathogenesis of HIV-1-associated neurocognitive and affective alterations, however, remains understudied. Three complementary aims were undertaken to critically address this knowledge gap. First, the expression of HIV-1 mRNA in the dorsolateral prefrontal cortex of postmortem HIV-1 seropositive individuals with HAND was investigated. Utilization of a combined RNAscope multiplex fluorescent and immunostaining assay revealed prominent HIV-1 mRNA in microglia of postmortem HIV-1 seropositive individuals with HAND. Second, measures of microglia proliferation and neuronal …

Personalized Point Of Interest Recommendations With Privacy-Preserving Techniques, Longyin Cui

Theses and Dissertations--Computer Science

Location-based services (LBS) have become increasingly popular, with millions of people using mobile devices to access information about nearby points of interest (POIs). Personalized POI recommender systems have been developed to assist users in discovering and navigating these POIs. However, these systems typically require large amounts of user data, including location history and preferences, to provide personalized recommendations.

The collection and use of such data can pose significant privacy concerns. This dissertation proposes a privacy-preserving approach to POI recommendations that address these privacy concerns. The proposed approach uses clustering, tabular generative adversarial networks, and differential privacy to generate synthetic user …

Quality Control Methods Through Pre-Determination Of Fields For Usrap Projects, Zachary Heath

Theses and Dissertations--Civil Engineering

The United States Road Assessment Program (usRAP) was designed to rate highways for their ability to protect road users and to make recommendations to engineers and policy makers for investments to enhance road safety. The program is heavily dependent on local road data or characteristics. Pre-populating usRAP requires coders to evaluate sixty-six attributes at 100-meter intervals along a subject highway. In this thesis, methods for obtaining and assuring the quality of some of the usRAP data elements are proposed. Kentucky Transportation Cabinet Highway Information System (HIS) data are used as “ground truth” for roadway grade and curvature. Methods of using …

Clustering States To Improve The Strategic Highway Safety Plan, Victoria Cambron

Theses and Dissertations--Civil Engineering

Each update to a Strategic Highway Safety Plan (SHSP) can require a large amount of time, resources, and funding. From the requirements in U.S.C.148(a)(13)(E-F), in the SHSP update process states must consider the results of other transportation planning processes and develop a list of strategies to reduce or eliminate fatal and serious injury crashes (United States, 2023). To fulfill these requirements more efficiently and to gain the largest amount of benefit from said research, this thesis asks the question: how do we select other state transportation plans to study for ideas on improving our own SHSP? In this thesis, a …

Value Propositions, Adoption Factors, And Implementation Considerations: Building A Path Towards Construction Innovation, Makram Bou Bou Hatoum

Theses and Dissertations--Civil Engineering

The construction industry has been influenced by a wave of technological advancements and trends that were introduced by the fourth industrial revolution or Industry 4.0. Mapped as Construction 4.0, these technologies are disrupting the way projects are designed, planned, constructed, delivered, and operated. While existing research has predominantly focused on technology adoption and use cases across the project lifecycle, limited attention has been given to the organizational perspective and explored Construction 4.0 as a transformative vision. As such, there is a significant need for decision science research to support decision-makers in understanding the value of Construction 4.0, gaining leadership buy-in, …

Creating Change In Pediatric Health Disparities: Utilizing Systemsbased Thinking To Overcome Disparities Affecting Pediatric Type 1 Diabetes In Kentucky, Sydney Speed

Lewis Honors College Thesis Collection

Healthcare disparities are perpetuated and upheld for patients with type 1 diabetes (T1D) in rural and underserved urban areas of Kentucky. By adopting systems-based thinking, we can identify areas of the healthcare system to change to eliminate these disparities. Namely, key leverage points of this system include distribution and utilization of resources, finances and the movement of money, and communication pathways. To address the disparities surrounding pediatric T1D in Kentucky, a state-wide medical event called Kentucky Diabetes Family Day (KDFD) was hosted. The focus of this event was to lessen the effects of these specific healthcare disparities by altering key …

Early Childhood Language And Literacy Development Programs For Autism Spectrum Disorder And D/Deaf And Hard-Of-Hearing Students, Mayson Spillman

Lewis Honors College Thesis Collection

This paper examines several popular approaches in the United States for enhancing early childhood literacy and language development in two special education populations— d/Deaf or hard-of-hearing (d/DHH) students and students with autism spectrum disorder (ASD). In addition to examining the effectiveness of these approaches, I adopt an educational equity lens to describe how variability in implementation can impact outcomes for these children. Based on my critical reading of the literature, I offer three broad recommendations for school psychologists: (1) Carefully consider dosage and fidelity of implementation, (2) Use caution when modifying existing interventions for these populations, and (3) Increase in-service …

Evaluation Of Academic Detailing To Educate Clinicians Regarding Childhood Lead Poisoning Prevention: A Pilot Study, Nicholas C. Newman, Jacqueline M. Knapke, Rachael Kiniyalocts, John Belt, Erin N. Haynes

UK CARES Faculty Publications

Context: Environmental exposures are associated with approximately 19% of disease globally, and exposure to neurotoxic chemicals is estimated to cost the United States $50 billion per year. Despite calls from the Institute of Medicine to increase training for clinicians regarding environmental health since the 1990s, there is still little instruction in environmental health for clinicians. This leaves gaps in knowledge that need to be bridged through outreach and education to practicing clinicians. Academic detailing (AD) is an educational intervention associated with improved prescribing practices in healthcare professionals but has not been applied to preventive or environmental health. Childhood lead exposure …

Evaluating Trends In K-12 Teachers’ Well-Being And Career Plans Throuhgout The Covid-19 Pandemic, Madeline Dunfee

Theses and Dissertations--Epidemiology and Biostatistics

The COVID-19 pandemic has had far reaching effects on school communities, which will continue to affect the teaching profession for years to come. As K-12 teachers worked to meet the educational, social, emotional and health needs of students and families, their personal well-being was taxed. It is critical to understand the experiences of K-12 teachers during the COVID-19 pandemic and to leverage this understanding to develop effective strategies for supporting K-12 teachers in the future. This research leveraged data from the School Staff Health and Wellness Study to examine teachers’ well-being and career outlook during the COVID-19 pandemic. The central …

The Future Is Electric: Nuclear Energy’S Role In Combating Climate Change And The Regulatory Measures To Enable Its Advancement, Autumn Clark

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

An Agricultural Plastic Crisis: How Federally Endorsed Biodegradable Plastics Could Liberate The Industry In The Eleventh Hour, Samantha Davenport

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Is The Russian-Ukrainian Conflict Finally The Tipping Point For Criminal Liability When The Environmental And Natural Resources Are Weaponized In Armed Conflict? An Analysis Of The Karachun Dam Attack, Mary Jocelyn

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Changing The Conversation Around Big Oil Climate Commitments, Hannah Thompson

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

A Legislative Call-To-Action: Applying Capture Theory To Combat The Risk Of Private Industry’S Excess Influence Over The Fda’S Regulation Of Livestock Antibiotics, Nathaniel Richey

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Examining A Blood Biomarker Approach To Blood-Brain Barrier Disruption, Samantha Ford

Theses and Dissertations--Medical Sciences

Blood-brain barrier disruption has been identified to associate with the pathogenesis several neurological diseases such as dementia [1, 2], multiple sclerosis[3, 4], acute or chronic cerebral ischemia[5], brain trauma[5], meningitis[5], encephalitis[5], stroke[6], and seizures[7]. Being able to effectively identify blood-brain barrier disruption is limited in methodology. The current standard is using a cerebrospinal fluid (CSF) albumin to serum albumin index, which requires the use of a lumbar puncture. A novel method of identifying blood-brain barrier disruption utilizing blood biomarkers is proposed in this study. Participants in this study had previously collected blood and CSF samples, which were analyzed to compare …

A Phenomenological Study Of Inclusive And Equitable Teaching Practices Among Faculty At A Research-Intensive Institution, Adeola Christianah Ogunade

Theses and Dissertations--Education Sciences

The increasing enrollment of diverse students in the US higher education institutions has given rise to discussions on how to meet the academic needs of minority students. Non-faculty members have implemented programs and initiatives that indirectly improve minority students' educational outcomes. Less explored is the role of faculty in ensuring that minority students thrive academically. This phenomenological qualitative study explores the general orientation of faculty toward inclusive and equitable teaching (IET). Specifically, it looked at how faculty define and experience IET, factors that motivated their use of IET, and barriers to implementing IET in higher education. Eight faculty from different …

How Principals Foster A Culture Of Student Voice, Anne Stewart Demott

Theses and Dissertations--Education Sciences

Student voice is a key component of educational leadership, yet school leaders remain confounded about how to succinctly define student voice, how to offer opportunities for students that position them as decision-makers in their schools, and how to integrate student voice into their daily practice, much less transform school cultures into vibrant, student-centered communities of learning. The purpose of this study was to develop an understanding of how high school principals define student voice, the opportunities they provide for student voice in their schools, and the strategies they implement to foster cultures of student voice.

The study uses a sequential …

Inclusion For Students With Intellectual Disabilities: A Philosophical Reconstruction Of The Student To Expand Access And Its Benefits, Derek Thomas Myles Daskalakes

Theses and Dissertations--Education Sciences

This dissertation attempts a philosophical rethinking of the concept of the student in educationally relevant disability law for the sake of expanding access to general education settings for students with intellectual disabilities (ID), without committing to the approach known as full inclusion. I show that students with ID receive significantly less access to general education settings in comparison to other student populations, and that empirical studies show this to be harmful to their learning and developmental outcomes. Discussion of this problem in the inclusion literature assumes one of two positions that separately support either maintaining the status quo regarding the …

A Laboratory And Numerical Investigation Of The Strength Of Irregularly Shaped Pillars, Zachary Wedding

Theses and Dissertations--Mining Engineering

Underground mining operations utilize the room-and-pillar mining method that extracts the orebody and creates ‘rooms’ and leaves the remaining in-situ material as ‘pillars’ to support the overburden. Room-and-pillar mines are traditionally designed in square or rectangular-shaped pillars. This work presents laboratory experiments testing the compressive strengths of specimens modeled after square and parallelogram-shaped pillars and numerical models of square and -parallelogram-shaped pillar systems. The uniaxial compressive strength of the specimens’ shape and the observations of the extent of the specimen core post-failure were analyzed. There was insufficient evidence from the laboratory experiments to conclude that there is a difference in …

Gauging The Mass Of Metals In The Gas Phase Of Galaxies From The Local Universe To The Epoch Of Reionization, K. E. Heintz, Alice E. Shapley, Ryan L. Sanders, M. Killi, D. Watson, G. Magdis, F. Valentino, M. Ginolfi, D. Narayanan, T. R. Greve, J. P. U. Fynbo, D. Vizgan, S. N. Wilson

Physics and Astronomy Faculty Publications

The chemical enrichment of dust and metals are vital processes in constraining the star formation history of the universe. These are important ingredients in the formation and evolution of galaxies overall. Previously, the dust masses of high-redshift star-forming galaxies have been determined through their far-infrared continuum, however, equivalent, and potentially simpler, approaches to determining the metal masses have yet to be explored at z ≳ 2. Here, we present a new method of inferring the metal mass in the interstellar medium (ISM) of galaxies out to z 8, using the far-infrared [C II]- 158† μm emission line as a proxy. …

Measurementus Magnetic Moment To 0.20 Ppm Of The Positive Muon Anomalo, The Muon G − 2 Collaboration

Physics and Astronomy Faculty Publications

We present a new measurement of the positive muon magnetic anomaly, aμ(gμ-2)/2, from the Fermilab Muon g-2 Experiment using data collected in 2019 and 2020. We have analyzed more than 4 times the number of positrons from muon decay than in our previous result from 2018 data. The systematic error is reduced by more than a factor of 2 due to better running conditions, a more stable beam, and improved knowledge of the magnetic field weighted by the muon distribution, p′, and of the anomalous precession frequency corrected for beam dynamics effects, ωa. From the ratio ωa/p′, together with precisely …