Digital Commons Network^™

China In Global Digital Trade Governance: Towards A Development-Oriented Agenda?, Yujia He, Ka Zeng

Patterson School of Diplomacy and International Commerce Faculty Publications

Existing literature on the behaviour of rising powers in global trade governance has yielded inconclusive evidence about their role and impact. This article contributes to this literature by examining China's role in global digital trade governance, an issue area which so far has not received sufficient scholarly attention. Specifically, it addresses the following question: as a self-proclaimed leader of the developing world in digital development, to what extent do its preferences and negotiation approach align with the interests of other developing countries? Analysing China's participation in three sets of negotiations using process tracing, the article argues that China's dual identity …

Predicting The Association Of Metabolites With Both Pathway Categories And Individual Pathways, Erik D. Huckvale, Hunter Moseley

Markey Cancer Center Faculty Publications

Metabolism is a network of chemical reactions that sustain cellular life. Parts of this metabolic network are defined as metabolic pathways containing specific biochemical reactions. Products and reactants of these reactions are called metabolites, which are associated with certain human-defined metabolic pathways. Metabolic knowledgebases, such as the Kyoto Encyclopedia of Gene and Genomes (KEGG) contain metabolites, reactions, and pathway annotations; however, such resources are incomplete due to current limits of metabolic knowledge. To fill in missing metabolite pathway annotations, past machine learning models showed some success at predicting the KEGG Level 2 pathway category involvement of metabolites based on their …

Perspectives On The Clinical Use Of Anti-Amyloid Therapy For The Treatment Of Alzheimer's Disease: Insights From The Fields Of Cancer, Rheumatology, And Neurology, Gregory Jicha, Erin Abner, Elif Pinar Coskun, Mark Huffmyer, Thomas Tucker, Peter T. Nelson

Neurology Faculty Publications

Introduction: The advent of disease-modifying therapies for Alzheimer’s disease (AD) has raised many questions and debates in the field as to the clinical benefits, risks, and costs of such therapies. The controversies have resulted in the perception that many clinicians are apprehensive about prescribing these medications to their patient populations. There also remains widespread uncertainty as to the economic impact, cost benefit ratio, and safety oversight for use of these medications in standard clinical care settings.

Methods: To contextualize such issues, the present study compared anti-amyloid biologic therapy (lecanemab) to four commonly used biologic agents in other fields, including trastuzumab …

Analysis Of The Thermal Aging Kinetics Of Tallow, Chicken Oil, Lard, And Sheep Oil, Yun-Chuan Hsieh, Hao Ouyang, Yulin Zhang, Donyau Chiang, Fuqian Yang, Hsin-Lung Chen, Sanboh Lee

Chemical and Materials Engineering Faculty Publications

Understanding the thermal aging kinetics of animal oils is of vital importance in the storage and applications of animal oils. In this work, we use four different techniques, including UV-Vis spectrometry, viscometry, impedance spectroscopy, and acid–base titration, to study the thermal aging kinetics of tallow, chicken oil, lard, and sheep oil in the temperature range from 120 ◦C to 180 ◦C. The evolutions of the UV-Vis absorbance, dynamic viscosity, electric impedance, and acid titration are discussed with the defect kinetics. The evolutions of the color centers, defects for dynamic viscosity, and electric dipoles follow second-order, first-order, and zero-order kinetics, respectively. …

Factors Associated With Child And Youth Mental Health Readmissions From A Us National Database, W. David Lohr, Kahir S. Jawad, Nichole Wood, Jennifer F. Le, Michelle D. Stevenson, Yana B. Feygin, Deborah Winders Davis

Biostatistics Faculty Publications

Objective: To describe and identify factors associated with mental health (MH) readmission rates for youth ages 5 to 17 years discharged between January 2019 and November 2019. Method: This retrospective, cross-sectional analysis using the 2019 Nationwide Readmissions Database identified hospitalizations for patients with a primary diagnosis of an MH condition using the Clinical Classification Software groupings, which are based on ICD-10-CM codes. Various patient characteristics including comorbidities were included in univariate and multivariate analysis to study their association with psychiatric readmission. Results: A 30-day readmission rate of 7.8% was found for the overall sample with significantly higher rates for youth …

Regenerating Family Member 3 Alpha Is Predictive Of Mortality Following Emergent Large Vessel Occlusion, Madison Sands, Christopher J. Mclouth, Jacqueline A. Frank, Benton Maglinger, Nathan Millson, Mais N. Al-Kawaz, Shivani Pahwa, David L. Dornbos, Douglas E. Lukins, Amanda L. Trout, Ann M. Stowe, Justin F. Fraser, Keith R. Pennypacker

Biostatistics Faculty Publications

Regenerating Family Member 3 Alpha (REG3A) is an antimicrobial protein secreted by the intestine and pancreas with additional immunomodulatory properties. Previously, we published that REG3A expression in ischemic stroke patient systemic blood, during mechanical thrombectomy (MT), is significantly associated with inflammatory cytokines and patient function on admission. This paper, however, did not investigate post-acute death rates. Therefore, we investigated plasma REG3A protein expression, during MT, in patients (n = 141) that survived or died within the end of the follow-up after MT. Subjects who died had significantly higher systemic plasma REG3A levels at the time of MT compared to survivors …

Growth And Faceting Of Tungsten And Oxides In Scandate Cathode Particles During In Situ Heating In The Scanning Electron Microscope, Huanhuan Bai, Thomas John Balk

Chemical and Materials Engineering Faculty Publications

Tungsten-based scandate dispenser cathodes are promising next-generation thermionic electron sources for vacuum electron devices, due to their excellent emission performance at tempera- tures lower than those required for conventional cathodes. There has been a significant recent effort to understand scandate cathode performance and to characterize the tungsten and other materials on the emitting surface, primarily via the study of cathodes before and after emission testing. Moreover, these scandate cathodes have typically been characterized at room temperature only. In situ obser- vations of scandate cathodes is challenging, as these devices are thermionic emitters that operate in a high-vacuum environment, and because …

Advancements In Apoe And Dementia Research: Highlights From The 2023 Aaic Advancements: Apoe Conference., Courtney M Kloske, Michael E Belloy, Elizabeth E Blue, Gregory R Bowman, Maria C Carrillo, Xiaoying Chen, Ornit Chiba-Falek, Albert A Davis, Gilbert Di Paolo, Francesca Garretti, David Gate, Lesley R. Golden, Jay W Heinecke, Joachim Herz, Yadong Huang, Costantino Iadecola, Lance A Johnson, Takahisa Kanekiyo, Celeste M Karch, Anastasia Khvorova, Sascha J Koppes-Den Hertog, Bruce T Lamb, Paige E Lawler, Yann Le Guen, Alexandra Litvinchuk, Chia-Chen Liu, Simin Mahinrad, Edoardo Marcora, Claudia Marino, Danny M Michaelson, Justin J Miller, Josh M. Morganti, Priyanka S Narayan, Michel S Naslavsky, Marlies Oosthoek, Kapil V Ramachandran, Abhirami Ramakrishnan, Ana-Caroline Raulin, Aiko Robert, Rasha N M Saleh, Claire Sexton, Nilomi Shah, Francis Shue, Isabel J Sible, Andrea Soranno, Michael R Strickland, Julia Tcw, Manon Thierry, Li-Huei Tsai, Ryan A Tuckey, Jason D Ulrich, Rik Van Der Kant, Na Wang, Cheryl L Wellington, Stacie C Weninger, Hussein N Yassine, Na Zhao, Guojun Bu, Alison M Goate, David M Holtzman

Physiology Faculty Publications

INTRODUCTION: The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex-dependent disease manifestations. Furthermore, ancestral background may significantly impact the link between APOE and AD, underscoring the need for more inclusive research.

METHODS: In 2023, the Alzheimer's Association convened multidisciplinary researchers at the "AAIC Advancements: APOE" conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates …

Enhancement Of High-Density Lipoprotein-Associated Protease Inhibitor Activity Prevents Atherosclerosis Progression, Maura Mobilia, Alexander A. Karakashian, Khaga R. Neupane, Olivia Hage, Callie Whitus, Abigail Carter, Clairity Voy, Lance A. Johnson, Gregory A. Graf, Scott M. Gordon

Saha Cardiovascular Research Center Faculty Publications

Background and aims: Inflammatory cells within atherosclerotic lesions secrete proteolytic enzymes that contribute to lesion progression and destabilization, increasing the risk for an acute cardiovascular event. Elastase is a serine protease, secreted by macrophages and neutrophils, that may contribute to the development of unstable plaque. We previously reported interaction of endogenous protease-inhibitor proteins with high- density lipoprotein (HDL), including alpha-1-antitrypsin, an inhibitor of elastase. These findings support a potential role for HDL as a modulator of protease activity. In this study, we test the hypothesis that enhancement of HDL-associated elastase inhibitor activity is protective against atherosclerotic lesion progression.

Methods: We …

Checklist And Key To Species Of Stink Bugs (Hemiptera, Heteroptera, Pentatomidae) Of Kentucky, United States Of America, Armando Falcon-Brindis, Raul Villanueva

Entomology Faculty Publications

Stink bugs (Heteroptera: Pentatomidae) have received a lot of attention as there are many economically important pest species. However, the status of species richness, distribution, and taxonomy remain overlooked and outdated in Kentucky (USA). Having such information at a regional scale is crucial to allow the development of suitable pest management and conservation programs. Here, the stink bug fauna of Kentucky was ex- amined from museum specimens, literature, and public online repositories. Overall, 42 species in 28 genera and three subfamilies (Asopinae, Podopinae, and Pentatominae) are listed from Kentucky. Thirteen species are new records for Kentucky, 10 species are considered …

Investigating Effectiveness Of Inverted Classroom In Undergraduate Statistics Education, Xin Ma, Jing Zhang, Petya Karkelanova, Michael C. Osborne, Anushka Karkelanova

Educational, School, and Counseling Psychology Faculty Publications

Data collected from an educational experiment were analyzed to investigate the effectiveness of an instructional reform referred to as the inverted classroom (learning activities traditionally taking place inside the classroom now take place outside the classroom and vice versa) in undergraduate statistics education. Students were taught the same statistics course in the inverted classroom (135 students) and the traditional classroom (135 students) over one semester. A small sample HLM (hierarchical linear modeling) approach was used to account for the data structure of students nested within 12 sections of the course and small sample sizes at both student and section levels. …

Therapeutics For Sickle Cell Disease Intravascular Hemolysis, Jianyao Xue, Xiang-An Li

Markey Cancer Center Faculty Publications

Sickle cell disease (SCD) is a genetic disorder predominantly affecting individuals of African descent, with a significant global health burden. SCD is characterized by intravascular hemolysis, driven by the polymerization of mutated hemoglobin within red blood cells (RBCs), leading to vascular inflammation, organ damage, and heme toxicity. Clinical manifestations include acute pain crises, hemolytic anemia, and multi-organ dysfunction, imposing substantial morbidity and mortality challenges. Current therapeutic strategies mitigate these complications by increasing the concentration of RBCs with normal hemoglobin via transfusion, inducing fetal hemoglobin, restoring nitric oxide signaling, inhibiting platelet-endothelium interaction, and stabilizing hemoglobin in its oxygenated state. While hydroxyurea …

Novel Psychoplastogen Dm506 Reduces Cue-Induced Heroin-Seeking And Inhibits Tonic Gaba Currents In The Prelimbic Cortex, Kassandra Looschen, Shailesh N. Khatri, Malabika Maulik, Colin Salisbury, Alaina F. Carman, Katilyn Corriveau, Colton Smith, Dina Manetti, Maria Novella Romanelli, Hugo R. Arias, Cassandra D. Gipson, Swarup Mitra

Markey Cancer Center Faculty Publications

Opioid use disorder is a major public health crisis that is manifested by persistent drug-seeking behavior and high relapse frequency. Most of the available treatments rely on targeting opioid receptors using small molecules that do not provide sustained symptom alleviation. Psychoplastogens are a novel class of non-opioid drugs that produce rapid and sustained effects on neuronal plasticity, intended to produce therapeutic benefits. Ibogalogs are synthetic derivatives of iboga alkaloids that lack hallucinogenic or adverse side effects. In the current study, we examine the therapeutic potential of DM506, a novel ibogalog lacking any cardiotoxic or hallucinogenic effects, in cue-induced seeking behavior …

Covid-19 And Rates Of Cancer Diagnosis In The Us, Todd Burus, Feitong Lei, Bin Huang, Jay W. Christian, Pamela C. Hull, Amanda R. Ellis, Svetla Slavova, Thomas Tucker, Krystle A. Lang Kuhs

Markey Cancer Center Faculty Publications

IMPORTANCE US cancer diagnoses were substantially lower than expected during the COVID-19 pandemic in 2020. A national study on the extent to which rates recovered in 2021 has not yet been conducted.

OBJECTIVE To examine observed vs expected cancer rate trends for January 2020 to December 2021.

DESIGN, SETTING, AND PARTICIPANTS This cross-sectional, population-based study of cancer incidence trends used the Surveillance, Epidemiology, and End Results 22 (SEER-22) Registries Database, which covers 47.9% of the US population. Included individuals were those with an invasive cancer diagnosis reported to registries included in SEER-22 between January 1, 2000, and December 31, 2021. …

Depressive Symptoms And Sleep Quality Mediate The Relationship Between Race And Quality Of Life Among Patients With Heart Failure: A Serial Multiple Mediator Model, Jia-Rong Wu, Debra K. Moser, Chin-Yen Lin, Ambrose A. Chiang, Barbara Riegel

UK CARES Faculty Publications

Background: Black patients with heart failure (HF) report worse quality of life (QoL) than White patients. Few investigators have examined mediators of the association between race and QoL, but depressive symptoms and sleep quality are associated with QoL.

Objective: The aim of this study was to determine whether depressive symptoms and sleep quality are mediators of the relationship between race and QoL among patients with HF.

Methods: This was a cross-sectional study. We included 271 outpatients with HF. Self-reported race (White/Black), depressive symptoms (Patient Health Questionnaire), sleep quality (Pittsburgh Sleep Quality Index), and QoL (Kansas City Cardiomyopathy Questionnaire) were collected …

Linkage Facilitation For Opioid Use Disorder In Criminal Legal System Contexts: A Primer For Researchers, Clinicians, And Legal Practitioners, Milan F. Satcher, Steven Belenko, Anthony Coetzer-Liversage, Khirsten J. Wilson, Michael R. Mccart, Tess K. Drazdowski, Amanda Fallin-Bennett, Nickolas Zaller, Alysse M. Schultheis, Aaron Hogue, Noel Vest, Ashli J. Sheidow, Brandon Del Pozo, Dennis P. Watson, Patrick F. Hibbard, Randy Stevens, L. A. R. Stein

Nursing Faculty Publications

At the intersection of drug policy, the opioid crisis, and fragmented care systems, persons with opioid use disorder (OUD) in the United States are significantly vulnerable to contact with the criminal legal system (CLS). In CLS settings, provision of evidence-based treatment for OUD is variable and often secondary to punitive approaches. Linkage facilitation at every touch point along the CLS Sequential Intercept Model has potential to redirect persons with OUD into recovery-oriented systems of care, increase evidence-based OUD treatment connections, and therefore reduce CLS re-exposure risk. Research in this area is still nascent. Thus, this narrative review explores the state …

Evaluating The Effectiveness Of A Student-Run Clinic On Reducing Cigarette Smoking In A Homeless Population, Briana Taormina, Bryson Jones, Kiah Gledhill Md, Audrey Darville Phd, Aprn, Cpaha-Tt

ePublications of Emerging Medical Research Scholars

Objective

Cigarette smoking remains a major health crisis in the United States, claiming the lives of hundreds of thousands of tobacco users each year. Access to evidence-based smoking cessation remains a challenge for many people that use tobacco products. Prior research demonstrates that the homeless population is exceedingly vulnerable to cigarette smoking and faces more barriers to quitting than their domiciled counterparts. This study explores the effectiveness of a free Smoking Cessation Clinic (SCC) within a homeless shelter for women and children, run by a nurse practitioner and a clinical nurse specialist trained as Tobacco Treatment Specialists, along with two …

Rehabilitation On Public Rangelands In Idaho, Usa: A Change In Emphasis From Grass Monocultures, Mike Pellant, Stephen B. Monsen

IGC Proceedings (1977-2023)

Since the 1940s the Bureau of Land Management has reseeded 485 830 ha of public rangelands in southern Idaho. Introduced wheatgrasses were seeded on most rehabilitation projects, often resulting in monoculture plant communities. Introduced wheatgrasses were relatively inexpensive to seed, established well, excluded weedy annuals and provided additional livestock forage. Concern about extensive shrubland losses after wildfires prompted BLM managers to begin reseeding native shrubs in the early 1980s. Use of different herbaceous plants on rehabilitation projects is increasing. Seed mixtures now include up to 10 species (grass, forb and shrubs) that, when established, meet multiple use resource objectives.

Diverse Book Finders: Diversifying A Children’S Picture Book Collection By Integrating Acquisitions Into A Classroom Experience, Mitchell Scott, Melanie E. Hughes, Niyetta Williams-Hill, Cathy Johnson

Library Faculty and Staff Publications

Two recent trends in collection development include finding new ways to bring patron voices into collection development and developing strategies for increasing the diversity and representation within collections. Indiana University Southeast (IU Southeast) Library recently developed a project that combined these two strategic directions by embedding an acquisition experience that used students enrolled in a sophomore block elementary education course to use the Diverse Book Finder (DBF) to select diverse picture books for the IU Southeast collection. While diversification strategies and projects around children’s picture book collections in academic libraries are nothing new, IU Southeast’s project is unique in its …

In-Clinic Versus Online Recruitment Of Women With A History Of Cervical Intraepithelial Neoplasia Or Cervical Cancer To A Smoking Cessation Trial: A Post Hoc Comparison Of Participant Characteristics, Study Retention, And Cessation Outcomes., Bethany Shorey Fennell, Sarah R. Jones, Steven K. Sutton, Charles E. Hoogland, Cherell Cottrell-Daniels, David W. Wetter, Ya-Chen Tina Shih, Vani N. Simmons, Yesenia P. Stephens, Damon J. Vidrine, Jennifer I. Vidrine

Markey Cancer Center Faculty Publications

INTRODUCTION: Recruiting special populations to smoking cessation trials is challenging and approaches beyond in-clinic recruitment may be beneficial. This secondary analysis of data from a smoking cessation RCT for individuals with a history of cervical cancer or cervical intraepithelial neoplasia (CIN) explored differences associated with in-clinic vs. online recruitment.

AIMS AND METHODS: Participants were recruited from clinics within a university-based NCI-designated cancer center (n = 87) and online nationally via Facebook (n = 115). Baseline measures included sociodemographics, smoking history, and cancer or CIN history. Study retention and smoking abstinence were assessed 12 months post-baseline. Group differences in baseline characteristics …

Writing For The Journal: A Guide For Community-Based Organizations, Randy Wykoff, Rachel E. Dixon

Journal of Appalachian Health

The Journal of Appalachian Health welcomes submissions from a variety of stakeholders interested in and contributing to improvement of health across the Appalachian Region. This editorial provides basic guidelines for those working in community settings who may with to make JAH (or any other journal) their publication home.

Morphological Changes In Three Clover (Trifolium Repens L.) Cultivars Under Continuous Stocking, M Fothergill, D A. Davies

IGC Proceedings (1977-2023)

Individual plant morphology of 3 white clover (Trifolium repens L.) cultivars was studied during 1990 and 1991. Seasonal shifts were demonstrated by all cultivars towards a higher proportion of less complex plants from winter to mid summer. Over the latter half of the year the population tended lo return towards its original distribution. Seasonal fluctuations in stolon dry weight/plant and root number/plant were also identified, with the small-leaved Ac3351 maintaining a greater stolon OW/plant than Aberystwyth S184 and Grasslands Huia during 1990. Ac3351 and S184 also maintained a larger root number/plant over this period. However, no significant differences were detected …

Establishing And Sharing Collections Of Valuable Global Resource, R Reid

IGC Proceedings (1977-2023)

The conservation of forage plant genetic resources has attracted growing public and scientific interest in recent times. The number of genebanks has risen significantly with a concomitant increase in the total number of accessions. Competition for funds and some duplication of effort has led to an increasing need for co-operation between the curators if the full potential of the germplasm is to be realised. International organisations such as PAO, the mandated CGIAR Centres and IBPGR, have played a major role in establishing sustainable forage genetic resource programmes; and despite the restrictions of limited funding, have made some significant achievements in …

Plant List Of Accepted Nomenclature, Taxonomy And Symbols, J S. Peterson

IGC Proceedings (1977-2023)

The Plant List of Accepted Nomenclature, Taxonomy & Symbols (PLANTS) is a dynamic database providing scientific and vernacular names, distributional, growth form, origin, symbols and bibliographic standardised botanical data to US federal agencies. PLANTS encompasses the vascular plant, moss, lichen and liverwort flora of North America, north of the Mexico border, including US states and territories.

Characterisation Of Us Collection Of Clover And Special Purpose Legume Germplasm, R R. Smith, K H. Quesenberry

IGC Proceedings (1977-2023)

Systematic collection of forage legume germplasm by the USA from the centers of origin was initiated in the 1890s. Since then over 11 000 accessions of clover and special-purpose legume species have been introduced into the US. These accessions are catalogued and maintained by the National Plant Germplasm System with working collections located at 4 locations in the US. Appropriate passport and evaluation data are available in the US Germplasm Resources Information Network (GRIN). The Clover and Special Purpose Legume Crop Advisory Commitlee is responsible for providing advice to the National Plant Germplasm System on the collection, mnintenance, evaluation and …

Use Of Ecogeographical Factors For Sampling A Core Collection Of Perennial Ryegrass, F Balfourier, G Charmet, C Grand-Ravel

IGC Proceedings (1977-2023)

In order to set up a core collection of wild populations of pei:ennial ryegra11 {Lolium perenne L.), 3 different criteria have been combined lo make a choice of populations: similarities between populations, geographic location and ecological characteristics of their original sites. Different multivariate analysis and clustering methods, introducing a geographic contiguity CXJnstnint were used to sample, among a set of 550 Prench wild populations, 114 populations 111 representative as po11ible of the whole variability.

Control Rumex Obtusifolius L. By Manipulating Grass Seeding Rate For Re-Establishment Of Pasture, M Nashiki, R Meguro, T Suyama

IGC Proceedings (1977-2023)

For the renovation of deteriorated pastures O\\'ing to the invasion of Rumex obtusifollus L. sprout, manipulation of seeding rate of pasture plants was Investigated to reduce R. obtusifolius. In an autumn-sown sward, Loilum perenne L. was sown at 100, 300, 600, 1000 and 2000 g/a, Dactylis glomerata L. at 600 gta, and a mixture of 6 species were sown together with SO g/a of R, obtusifolius. Plant density and dry weight of R. obtusifolius declined clearly at high rates (1000 and 2000 g/a) of L. perenne compared with low rates, though this difference was likely to disappear …

Plant Improvement: The Evaluation And Extension Processes, A S. Laidlaw, K.F M. Reed

IGC Proceedings (1977-2023)

Registration and evaluation systems throughout the world range from voluntary registration to compulsory schemes involving assessment of taxonomic and agronomic characteristics. Evaluation can be confined to agronomic tests simulated under grazing management or extended to feeding-value trials. Criteria include adaptation to climate and soils, persistence and seasonal growth, annual dry matter production, resistance to pests and diseases, and association with beneficial organisms. The need for stress (e.g. drought, low nutrients, acidity, salinity, heat or cold) to be given more emphasis in programmes in specific localities is suggested. In developing regions the emphasis is screening a wide range of grasses and …

Achievements And Perspectives In The Breeding Of Forage Grasses And Legumes, A.J P. Van Wijk, J G. Boonman, W Rumball

IGC Proceedings (1977-2023)

Successful breeding progrnmmes on forage grasses and legumes have in common that they made seed and plant material of superior genetic and physical quality available to the end-user at competitive prices. This was achieved by government- and privately-funded breeding programmes. A distinction between these two types of breeding organisations is made and discussed. Achievements in various areas are presented and the constraints the breeder is faced with ore given. It is felt that highly advanced genetic designs are not directly applicable, but that progress can continue to be made by applying classical procedures at a greater level of efficiency.

The Product Of Science, Rolf A.E Mueller

IGC Proceedings (1977-2023)

The relationships between agricultural science, invention, production and consumption are conventionally considered in a hierarchical model with consumption at the basis and science at the pinnacle of the hierarchy. -Two important shortcomings of that model as a basis for organising and manag\ng agricultural research are identified. First, the model does not specify how the direction and intensity of research Is guided in the absence of markets for the outputs from research. Second, the model does not identify the flows of specific information from the consumption and agricultural production sphere to the research sphere where such information is crucial for the …