Digital Commons Network^™

Communities That Heal Intervention And Mortality Including Polysubstance Overdose Deaths: A Randomized Clinical Trial, Bridget Freisthler, Rouba A. Chahine, Jennifer Villani, Redonna Chandler, Daniel J. Feaster, Svetla Slavova, Jolene Defiore-Hyrmer, Alexander Y. Walley, Sarah Kosakowski, Arnie Aldridge, Carolina Barbosa, Sabana Bhatta, Candace Brancato, Carly Bridden, Mia Christopher, Tom Clarke, James David, Lauren D'Costa, Irene Ewing, Soledad Fernandez, Erin Gibson, Louisa Gilbert, Megan E. Hall, Sarah Hargrove, Timothy Hunt, Elizabeth N. Kinnard, Lauren Larochelle, Aaron Macoubray, Shawn R. Nigam, Edward V. Nunes, Carrie B. Oser, Sharon Pagnano, Peter J. Rock, Pamela Salsberry, Aimee Shadwick, Thomas J. Stopka, Sylvia Tan, Jessica L. Taylor, Philip M. Westgate, Elwin Wu, Gary A. Zarkin, Sharon L. Walsh, Nabila El-Bassel, T. John Winhusen, Jeffrey H. Samet, Emmanuel A. Oga

Biostatistics Faculty Publications

IMPORTANCE: The HEALing Communities Study (HCS) evaluated the effectiveness of the Communities That HEAL (CTH) intervention in preventing fatal overdoses amidst the US opioid epidemic.

OBJECTIVE: To evaluate the impact of the CTH intervention on total drug overdose deaths and overdose deaths involving combinations of opioids with psychostimulants or benzodiazepines.

DESIGN, SETTING, AND PARTICIPANTS: This randomized clinical trial was a parallel-arm, multisite, community-randomized, open, and waitlisted controlled comparison trial of communities in 4 US states between 2020 and 2023. Eligible communities were those reporting high opioid overdose fatality rates in Kentucky, Massachusetts, New York, and Ohio. Covariate constrained randomization stratified …

Integrin Α6Β4 Upregulates Ptprz1 Through Uchl1-Mediated Hif-1Α Nuclear Accumulation To Promote Triple-Negative Breast Cancer Cell Invasive Properties, Min Chen, Parvanee A. Karimpour, Andrew Elliott, Daheng He, Teresa Knifley, Jinpeng Liu, Chi Wang, Kathleen L. O’Connor

Markey Cancer Center Faculty Publications

Integrin α6β4 drives triple-negative breast cancer (TNBC) aggressiveness through the transcriptional regulation of key genes. Here, we investigated how integrin α6β4 regulates protein tyrosine phosphatase receptor type Z1 (PTPRZ1). Using stable re-expression of integrin β4 (ITGB4) in cells naturally devoid of integrin α6β4 or knockdown or knockout (KO) of ITGB4, we found that integrin α6β4 regulates PTPRZ1 expression. To gain mechanistic insight, we focused on Hif-1α due to the impact of integrin α6β4 on a hypoxia-associated signature. We found that nuclear localization of Hif-1α, but not Hif-2α, was substantially enhanced with integrin α6β4 signaling. Hif-1α knockdown by shRNA or chemical …

Predicting The Pathway Involvement Of All Pathway And Associated Compound Entries Defined In The Kyoto Encyclopedia Of Genes And Genomes, Erik D. Huckvale, Hunter Moseley

Markey Cancer Center Faculty Publications

Background/Objectives: Predicting the biochemical pathway involvement of a compound could facilitate the interpretation of biological and biomedical research. Prior prediction approaches have largely focused on metabolism, training machine learning models to solely predict based on metabolic pathways. However, there are many other types of pathways in cells and organisms that are of interest to biologists. Methods: While several publications have made use of the metabolites and metabolic pathways available in the Kyoto Encyclopedia of Genes and Genomes (KEGG), we downloaded all the compound entries with pathway annotations available in the KEGG. From these data, we constructed a dataset where each …

The Absence Of Cxcl10 Activity Does Not Affect The Capability Of Cd8+ T Cells To Migrate And Eliminate The Tissue Cysts Of Toxoplasma Gondii From The Brains Of Chronically Infected Mice, Rajesh Mani, Yasuhiro Suzuki

Markey Cancer Center Faculty Publications

Toxoplasma gondii forms tissue cysts in neurons and astrocytes in the brain to establish chronic infection, and astrocytes express the CXCL10 chemokine in chronically infected mice. Since chemokines mediate the migration of T cells to attack their targets, and since CXCL10 plays key roles in T cell-mediated control of the proliferation of tachyzoites (the acute stage form) of T. gondii during the acute stage of infection, we examined whether CXCL10 is involved in recruiting anti-cyst CD8+ cytotoxic T cells to eliminate the cysts in their brains. We employed adoptive transfer of CD8+ immune T cells to infected, T cell-deficient SCID …

The Impact Of Pdcd4, A Translation Inhibitor, On Drug Resistance, Qing Wang, Hsin-Sheng Yang

Markey Cancer Center Faculty Publications

Programmed cell death 4 (Pdcd4) is a tumor suppressor, which has been demonstrated to efficiently suppress tumorigenesis. Biochemically, Pdcd4 binds with translation initiation factor 4A and represses protein translation. Beyond its role in tumor suppression, growing evidence suggests that Pdcd4 enhances the chemosensitivity of several anticancer drugs. To date, numerous translational targets of Pdcd4 have been identified. These targets govern important signal transduction pathways, and their attenuation may improve chemosensitivity or overcome drug resistance. This review will discuss the signal transduction pathways regulated by Pdcd4 and the potential mechanisms through which Pdcd4 enhances chemosensitivity or counteracts drug resistance.

2024 Kentucky Water Resources Annual Symposium, Kentucky Water Research Institute

Kentucky Water Resources Annual Symposium

The program and proceedings contains details of the 2024 Kentucky Water Resources Symposium, including presentations, award winners, and poster presentations.

This symposium was planned and conducted as a part of the state water resources research institute annual program that is supported by Grant/Cooperative Agreement Number G21AP10631-02 from the United States Geological Survey (USGS). The contents of this proceedings document and the views and conclusions presented at the symposium are solely the responsibility of the individual authors and presenters and do not represent the official views of the USGS or of the symposium organizers and sponsors. This publication is produced with …

2024 Kentucky Water Resources Annual Symposium, Kentucky Water Research Institute

Kentucky Water Resources Annual Symposium

No abstract provided.

Evaluating The Effects Of Climate Changes On Grasslands, Robert G. Woodmansee, William E. Riebsame

IGC Proceedings (1977-2023)

Determining the effects of climate change on cold region grasslands requires the integration of knowledge from the biological, physical and social sciences. That integration is dependent on new methods, technologies and facilitation techniques ! that allow evaluation and management of complexity rather than focusing on simplification. Specifically, grassland response can be defined as the interaction of 10 basic sectors: (I) wenther and climate (Including chemical factors}, (2) winter, (3) soil properties, (4) assemblages of organisms, (5) energy, (6) economic viability, (7) individual human behavior, (8) cultural and community viability, (9) organisational penalty, and (10) political, legal, policy, and regulatory Influences. …

The Integrated Screening Programme: Patterns Of Ecological Specialization In British Species, K Thompson, J P. Grime, R Colasanti

IGC Proceedings (1977-2023)

The Integrated Screening Programme (ISP), a major part of the UCPB research programme during the period 1987-1994, applies standardised procedures for the ecological, physiological and biochemical characterisation of plant species, populations or cultivars. The objectives are: (1) to establish the range of variation in selected plant attributes; (2) to recognise recurring patterns of ecological and evolutionary specialisation; (3) to devise a functional classification of plants relevant to the analysis of communities and ecosystems and the management of vegetation .. To date, the programme has been confined largely to the herbaceous species from central northern Britain. Later, and in particular as …

From Research Findings To Decision Tools: Supporting Local Choices, Margo Gustina

Library Research Seminar 8: Telling Library Stories

No abstract provided.

The Danger Of Retelling Family Stories: The Story Of The "Conjure" Chest, Deana Thomas

Library Research Seminar 8: Telling Library Stories

No abstract provided.

Public Librarians' Roles In Natural Disasters: Stories Of Leadership And Resilience, Denise Lyons, April Hobbs, Feili Tu-Keefner, Denise Gomez, Marcia A. Mardis

Library Research Seminar 8: Telling Library Stories

No abstract provided.

Sharing The Story Of Public Library Programming For Young Children With Disabilities Or Developmental Delays, Denice Adkins, Maria Cahill, Alicia Long, Bobbie Sartin Long, Derek Daskalakes

Library Research Seminar 8: Telling Library Stories

No abstract provided.

An Introduction To Infophilia, A Positive Psychology Of Information, Anita S. Coleman

Library Research Seminar 8: Telling Library Stories

This paper will tell some of the stories of infophilia, a positive psychology of information, avant-garde research. The goal of Brenda Dervin’s ground-breaking research was not just to develop the sense-making theory, framework, and tools, but also to “invent communication alternatives and assess their utility.” One of the ‘practice communication inventions’ of Brenda Dervin was the ‘Good news newsletter’ where she developed infosheets for doctors, schools, and medical clinics (Neill, 1992, p. 6). I am no Brenda Dervin. But I am a strongly interdisciplinary scholar who has been a tenured librarian, LIS school faculty, library director, publisher for the voiceless, …

Family Engagement In Public Libraries: Protective Factors And Play, Tammie Benham

Library Research Seminar 8: Telling Library Stories

No abstract provided.

The Public Library Routines Project, Darin Freeburg, Katie Klein

Library Research Seminar 8: Telling Library Stories

No abstract provided.

Audio Diaries In Identity Research, Darin Freeburg, Katie Klein

Library Research Seminar 8: Telling Library Stories

No abstract provided.

Measuring Library Co-Production With Mediation Models, Margo Gustina

Library Research Seminar 8: Telling Library Stories

No abstract provided.

Beyond The Numbers: Capturing Impactful Patron Interactions In Library Data, Jenica Ibarra, Triveni Kuchi, Julie Still

Library Research Seminar 8: Telling Library Stories

No abstract provided.

Our Mythic Potential: The Hero's Journey And The Library's Story, Sarah Beth Nelson, Andra Matthews

Library Research Seminar 8: Telling Library Stories

No abstract provided.

The Future Of Sustainable Agriculture In The United States, Dennis R. Keeney

IGC Proceedings (1977-2023)

In the United States, sustainable agriculture remains complicated and controversial as a concept, particularly to define and apply in terms of practices and policies to achieve sustainability. Many consider current agricultural practices to be sustainable in the near term with regard to the dependable, affordable supply of food and fibre, but unsustainable in terms of environmental quality and social costs. Production agriculture hos been linked to soil erosion and water pollution, and the emphasis on efficiency has contributed to the loss of many farmers and increasing instability in rural communities. Many of agriculture's dilemmas can be linked to policies of …

Lessons Learned From Developing Dashboards To Support Decision-Making For Community Opioid Response By Community Stakeholders: Mixed Methods And Multisite Study., Naleef Fareed, Ramona G. Olvera, Yiting Wang, Michael Hayes, Elizabeth Liz Larimore, Peter Balvanz, Ronald Langley, Corinna A. Noel, Peter J. Rock, Daniel Redmond, Jessica Neufeld, Sarah Kosakowski, Daniel R. Harris, Marc Larochelle, Timothy R. Huerta, Lashawn Glasgow, Emmanuel Oga, Jennifer Villani, Elwin Wu

Center on Drug and Alcohol Research Faculty Publications

BACKGROUND: Data dashboards are published tools that present visualizations; they are increasingly used to display data about behavioral health, social determinants of health, and chronic and infectious disease risks to inform or support public health endeavors. Dashboards can be an evidence-based approach used by communities to influence decision-making in health care for specific populations. Despite widespread use, evidence on how to best design and use dashboards in the public health realm is limited. There is also a notable dearth of studies that examine and document the complexity and heterogeneity of dashboards in community settings.

OBJECTIVE: Community stakeholders engaged in the …

Association Between Obesity And Risk Of Total And Obesity-Related Cancer In People With Incident Cardiovascular Disease., Sarah Malik, Avirup Guha, Xiaoling Wang, Neal L. Weintraub, Ryan Harris, Biplab Datta, Justin Moore, Priyanshu Nain, Sagar A. Patel, Steven Coughlin, Elizabeth Polter, Anna Prizment, Anne Blaes, Roberta Florido, Shelby Kutty, Alvaro Alonso, Corinne E. Joshu, Elizabeth A. Platz

Markey Cancer Center Faculty Publications

BACKGROUND: Cardiovascular disease (CVD) and cancer frequently co-occur due to shared risk factors such as obesity, which is linked to CVD and 14 cancer types. This study explores whether CVD pathophysiologies, combined with obesity, increase cancer risk, impacting clinical management.

METHODS AND RESULTS: Data from the ARIC (Atherosclerosis Risk in Communities) study, spanning 28 years, were analyzed. The cohort included 5127 participants with incident CVD (myocardial infarction, stroke, heart failure, coronary heart disease), of whom 1511 developed a first primary cancer. Follow-up began at CVD diagnosis after Visit 1. Obesity was assessed using body mass index, waist circumference, and waist-to-hip …

2024 Safety Belt Usage Survey In Kentucky, Erin Lammers-Staats, Derek Young, Kenneth R. Agent

Kentucky Transportation Center Research Report

No abstract provided.

Microfiltration Membrane Pore Functionalization With Primary And Quaternary Amines For Pfas Remediation: Capture, Regeneration, And Reuse, Sam Thompson, Angela Gutierrez, Jennifer Bukowski, Dibakar Bhattacharyya

UK CARES Faculty Publications

The widespread production and use of multi-fluorinated carbon-based substances for a variety of purposes has contributed to the contamination of the global water supply in recent decades. Conventional wastewater treatment can reduce contaminants to acceptable levels, but the concen- trated retentate stream is still a burden to the environment. A selective anion-exchange membrane capable of capture and controlled release could further concentrate necessary contaminants, mak- ing their eventual degradation or long-term storage easier. To this end, commercial microfiltration membranes were modified using pore functionalization to incorporate an anion-exchange moiety within the membrane matrix. This functionalization was performed with primary and …

Axonal Injury, Sleep Disturbances, And Memory Following Traumatic Brain Injury, Emma M. Tinney, Goretti España-Irla, Aaron E. L. Warren, Lauren N. Whitehurst, Alexandra N. Stillman, Charles H. Hillman, Timothy P. Morris, Alzheimer’S Disease Neuroimaging Initiative

Neurology Faculty Publications

Objectives: Traumatic brain injury (TBI) is associated with sleep deficits, but it is not clear why some report sleep disturbances and others do not. The objective of this study was to assess the associations between axonal injury, sleep, and memory in chronic and acute TBI. Methods: Data were acquired from two independent datasets which included 156 older adult veterans (69.8 years) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) with prior moderate- to-severe TBIs and 90 (69.2 years) controls and 374 (39.6 years) from Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) with a recent mild TBI (mTBI) and 87 controls …

Planetary Health Learning Objectives: Foundational Knowledge For Global Health Education In An Era Of Climate Change, Kathryn H. Jacobsen, Caryl E. Waggett, Pamela Berenbaum, Brett R. Bayles, Gail L. Carlson, René English, Carlos A Faerron Guzmán, Meredith L. Gartin, Liz Grant, Thomas L. Henshaw, Lora L. Iannotti, Philip J. Landrigan, Nina Lansbury, Hao Li, Maureen Y. Lichtveld, Ketrell Mcwhorter, Jessica E. Rettig, Cecilia J. Sorensen, Eric J. Wetzel, Dawn Michele Whitehead, Peter J. Winch, Keith Martin

Earth and Environmental Sciences Faculty Publications

Planetary health is an emerging field that emphasises that humans depend on a healthy Earth for survival and, conversely, that the sustainability of Earth systems is dependent on human behaviours. In response to member demands for resources to support teaching and learning related to planetary health, the Consortium of Universities for Global Health (CUGH) convened a working group to develop a set of planetary health learning objectives (PHLOs) that would complement the existing ten CUGH global health learning objectives. The eight PHLOs feature Earth system changes, planetary boundaries, and climate change science; ecological systems and One Health; human health outcomes; …

Coal Ash Triggers An Elevated Temperature Landfill Development: Lessons From The Bristol Virginia Solid Waste Landfill Neighboring Community, Reagan Patton Witt, Marcelo I. Guzman

UK CARES Faculty Publications

Landfills for disposing of solid waste are designed, located, managed, and monitored facili- ties expected to comply with government regulations to prevent contamination of the surrounding environment. After the average life expectancy of a typical landfill (30 to 50 years), a large investment in the construction, operation, final closure, and 30-year monitoring of a new site is needed. In this case study, we provide a holistic explanation of the unexpected development of elevated temperature landfills (ETLFs), such as that in the city of Bristol (United States) on the border of the states of Virginia and Tennessee, including the initial role …

Kentucky Surficial Geologic Map Compilation Database (Version 1), Matthew Massey

Research Data--KGS

The Kentucky Geological Survey (KGS), a state-supported independent research center within the University of Kentucky, is committed to providing accurate and unbiased geologic information on natural resources, environmental issues, and natural hazards in Kentucky. While Kentucky boasts complete coverage by 1:24,000-scale geologic bedrock maps, surficial materials have been largely overlooked, except in regions with thick deposits obscuring the bedrock. Given the increasing trends in economic development and urbanization, detailed surficial geologic mapping has become crucial for supporting geotechnical planning, environmental management, and hazard assessment. In response, KGS has prioritized new, detailed surficial geologic mapping since 2004, specifically targeting areas anticipated …

Spot, Zone And Overcoat Painting Of Steel Bridges, Christopher Goff, Sudhir Palle

Kentucky Transportation Center Research Report

Over the past 25 – 30 years, the Kentucky Transportation Cabinet (KYTC) has replaced lead-based coatings on many bridges, often with zinc-based systems. But many of these coating systems are now degrading and reaching the ends of their service lives. Historically, KYTC has relied entirely on remove-and-replace painting, however, given the programmatic costs associated with remove-and-replace painting and constraints imposed by limited funding, the agency needs to explore more economical options, such as spot, zone, and overcoat painting. This report discusses use cases for spot, zone, and overcoat painting and lays out guidelines staff can use to determine what method …