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Articles 121 - 150 of 26340
Full-Text Articles in Entire DC Network
Social Determinants Of Sleep Health Inequities Among Rural Appalachian Adults, Mairead E. Moloney, Emily Slade, Joon Chung, Maliha Mehnaz Mitu, Michael A. Grandner, Daniela C. Moga
Social Determinants Of Sleep Health Inequities Among Rural Appalachian Adults, Mairead E. Moloney, Emily Slade, Joon Chung, Maliha Mehnaz Mitu, Michael A. Grandner, Daniela C. Moga
Sociology Faculty Publications
No abstract provided.
Patients' Attitudes Towards Deprescribing And Associations With Patient-Related Factors Across Two Hospital Settings, Louise Westberg Strejby Christensen, Iman El Gamah, Amina Osman Ismail Barre, Daniela Claudia Moga, Anissa Aharaz, Olivia Bornæs, Rikke Lundsgaard Nielsen, Aino Leegaard Andersen, Esben Iversen, Kim Peder Dalhoff, Ove Andersen, Helle Gybel Juul-Larsen, Morten Baltzer Houlind
Patients' Attitudes Towards Deprescribing And Associations With Patient-Related Factors Across Two Hospital Settings, Louise Westberg Strejby Christensen, Iman El Gamah, Amina Osman Ismail Barre, Daniela Claudia Moga, Anissa Aharaz, Olivia Bornæs, Rikke Lundsgaard Nielsen, Aino Leegaard Andersen, Esben Iversen, Kim Peder Dalhoff, Ove Andersen, Helle Gybel Juul-Larsen, Morten Baltzer Houlind
Epidemiology and Environmental Health Faculty Publications
Medication deprescribing is a targeted strategy to reduce inappropriate polypharmacy. Patients in primary care settings have reported high willingness to discontinue medications, but this phenomenon is less well studied in hospital settings. In this explorative post hoc analysis of two previously described clinical trials, we assessed patients' attitudes towards deprescribing in two hospital-based cohorts: acutely admitted older medical patients (≥ 65 years) in the emergency department at Copenhagen University Hospital Hvidovre (October 2018–April 2021) and multimorbid patients (≥ 18 years) referred to an outpatient clinic at Copenhagen University Hospital Amager (March 2019–December 2019). Among 104 and 72 patients in each …
Multi-Jurisdictional Hazard Mitigation Plan For Landslides For The Kentucky River Area Development District, Kentucky, Hudson J. Koch, Matt M. Crawford, Jason M. Dortch
Multi-Jurisdictional Hazard Mitigation Plan For Landslides For The Kentucky River Area Development District, Kentucky, Hudson J. Koch, Matt M. Crawford, Jason M. Dortch
Contract Reports--KGS
Landslides are a widespread and complex geologic hazard that affects people and infrastructure. The Kentucky River Area Development District, Kentucky, sustains relatively high landslide activity that impacts several municipalities in eastern Kentucky. This hazard mitigation planning project outlines landslide hazard and risk assessments for the Kentucky River Area Development District, with information needed for each community in the region to develop mitigation strategies that will support infrastructure and development needs, land-use planning, situational awareness, and response and recovery actions for the communities.
Avoiding Misleading Estimates Of Among-Individual Variance Caused By Non-Random Sampling Of Individuals In A Changeable Environment, Denis Réale, Hassen Allegue, Yimen G. Araya-Ajoy, Ned A. Dochtermann, Shinichi Nakagawa, Joel L. Pick, Holger Schielzeth, David F. Westneat, Niels J. Dingemanse
Avoiding Misleading Estimates Of Among-Individual Variance Caused By Non-Random Sampling Of Individuals In A Changeable Environment, Denis Réale, Hassen Allegue, Yimen G. Araya-Ajoy, Ned A. Dochtermann, Shinichi Nakagawa, Joel L. Pick, Holger Schielzeth, David F. Westneat, Niels J. Dingemanse
Biology Faculty Publications
Animal ecologists frequently quantify variance in hierarchically structured traits in wild populations. Importantly, phenotypic plasticity within the period of measurement can modify the trait of interest in response to various unmeasured, temporally or spatially changeable, environmental conditions. Non-random sampling among units of the random effect (e.g. individuals) regarding the environment at issue may lead to estimates of the variance among ((Formula presented.)) or within ((Formula presented.)) such units that conflate several types of processes. This mixing of underlying biology can affect interpretations of the random effect variance. Here, we explore the conditions leading to this situation and assess potential solutions …
Muscle Atrophy After Acl Reconstruction Involves Molecular Mechanisms Beyond Unloading, Alexander R. Keeble, Gonzalez Velez Sara, Nicholas T. Thomas, Allison M. Owen, Austin V. Stone, Darren L. Johnson, Julián Candia, Luigi Ferrucci, Marco Narici, Esther E. Dupont-Versteegden, Brian Noehren, Martino V. Franchi, Christopher S. Fry
Muscle Atrophy After Acl Reconstruction Involves Molecular Mechanisms Beyond Unloading, Alexander R. Keeble, Gonzalez Velez Sara, Nicholas T. Thomas, Allison M. Owen, Austin V. Stone, Darren L. Johnson, Julián Candia, Luigi Ferrucci, Marco Narici, Esther E. Dupont-Versteegden, Brian Noehren, Martino V. Franchi, Christopher S. Fry
Physiology Faculty Publications
Anterior cruciate ligament reconstruction (ACLR) leads to profound muscle atrophy and weakness that remain resistant to rehabilitation. Although early recovery typically involves a brief period of limb unloading, the degree to which disuse alone accounts for muscle pathology after ACLR remains unclear. Here, we leveraged publicly available RNA-seq datasets of muscle biopsies from vastus lateralis obtained 7 days after ACLR or 10 days after unilateral lower limb suspension (ULLS), each with matched control limbs, to directly compare disuse-driven and ACLR-specific early transcriptional responses. Despite similar periods of reduced loading, substantial transcriptomic divergence was identified using both intersection and interaction bioinformatic …
The Association Between Apoe Ε4 Carrierships And The Detection Of Amyloid Positivity Using An Alzheimer's Disease Proteomic Blood Test In Asymptomatic Down Syndrome, Lubnaa Badriyyah Abdullah, Fan Zhang, Melissa Petersen, James Hall, Benjamin L. Handen, Mark Mapstone, Brad Christian, Elizabeth Head, Sigan Harley, Howard Andrews, Joseph H. Lee, Dana Tudorascu, Christy Hom, Shahid Zaman, Adam M. Brickman, Diana Rosas, Annie Cohen, Jordan P. Harp, Frederick Schmitt, Lauren Ptomey, Jeffrey M. Burns, Ira T. Lott, Florence Lai, Charles Laymon, Carlos Cruchaga, Sid O'Bryant, Beau M. Ances
The Association Between Apoe Ε4 Carrierships And The Detection Of Amyloid Positivity Using An Alzheimer's Disease Proteomic Blood Test In Asymptomatic Down Syndrome, Lubnaa Badriyyah Abdullah, Fan Zhang, Melissa Petersen, James Hall, Benjamin L. Handen, Mark Mapstone, Brad Christian, Elizabeth Head, Sigan Harley, Howard Andrews, Joseph H. Lee, Dana Tudorascu, Christy Hom, Shahid Zaman, Adam M. Brickman, Diana Rosas, Annie Cohen, Jordan P. Harp, Frederick Schmitt, Lauren Ptomey, Jeffrey M. Burns, Ira T. Lott, Florence Lai, Charles Laymon, Carlos Cruchaga, Sid O'Bryant, Beau M. Ances
Neurology Faculty Publications
INTRODUCTION: This study evaluates plasma-based proteomic profiles for predicting amyloid positivity in adults with Down syndrome (DS) and examines the impact of apolipoprotein E ε4 (APOE ε4) on test performance. METHODS: Cross-sectional data from 290 adults with DS were analyzed using single molecule array (SIMOA) technology to measure plasma amyloid beta (Aβ)42, Aβ40, neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), tau phosphorylated at threonine 181, and total tau. Amyloid burden was quantified using Pittsburgh Compound B and (18)F-florbetapir Aβ positron emission tomography. Support vector machine analyses were conducted with biomarkers as predictors and age, sex, and APOE ε4 …
Information-Content-Informed Kendall-Tau Correlation Methodology, Robert M. Flight, Praneeth S. Bhatt, Hunter N.B. Moseley
Information-Content-Informed Kendall-Tau Correlation Methodology, Robert M. Flight, Praneeth S. Bhatt, Hunter N.B. Moseley
Markey Cancer Center Faculty Publications
Background: Almost all correlation measures currently available are unable to directly handle missing values. Typically, missing values are either ignored completely by removing them or are imputed and used in the calculation of the correlation coefficient. In either case, the correlation value will be impacted based on the perspective that the missing data represents no useful information. However, missing values occur in real datasets for a variety of reasons. In metabolomics datasets a major reason for missing values is that a specific measurable phenomenon falls below the detection limits of the analytical instrumentation (left-censored values). These missing data are not …
Mapping The Polar Neuro-Interactome Of Garcinia Mangostana Against The Ad-Pd-Als Nexus, Rahni Hossain, Sirirat Surinkaew, Pradoldej Sompol, Nasmah K. Bastaki, Rifat Jafrin, Nazim Sekeroglu, Jitbanjong Tangpong
Mapping The Polar Neuro-Interactome Of Garcinia Mangostana Against The Ad-Pd-Als Nexus, Rahni Hossain, Sirirat Surinkaew, Pradoldej Sompol, Nasmah K. Bastaki, Rifat Jafrin, Nazim Sekeroglu, Jitbanjong Tangpong
Markey Cancer Center Faculty Publications
Background/Objectives: Neurodegenerative diseases like Alzheimer’s, Parkinson’s, and Amyotrophic lateral sclerosis (ALS) share common molecular pathways, including neuroinflammation and oxidative stress, which complicate the effectiveness of single-target treatments. Garcinia mangostana L. (mangosteen) has shown neuroprotective properties, but previous studies focused on lipophilic xanthones, which have poor bioavailability and uncertain blood–brain barrier permeability. Methods: In the current study, polar metabolites from G. mangostana peel aqueous extract (GMPE) were assessed for potential multi-target interactions via UHPLC-QTOF-MS-based metabolomics, systems pharmacology, and molecular docking analysis. Further, in silico ADMET screening and network-based analyses assessed for overlap between GMPE compounds and genes associated with neurodegeneration (AD, …
Systemic Consequences Of Chronic Ethanol Intake, Muni Swamy Ganjayi, Thomas A. Krauss, Gage E. Demster, Sehyung Park, Garrett B. Anspach, Sarah R. Anthony, Shaohua Wang, Michael Tranter, Robert N. Helsley, Cory W. Baumann
Systemic Consequences Of Chronic Ethanol Intake, Muni Swamy Ganjayi, Thomas A. Krauss, Gage E. Demster, Sehyung Park, Garrett B. Anspach, Sarah R. Anthony, Shaohua Wang, Michael Tranter, Robert N. Helsley, Cory W. Baumann
Markey Cancer Center Faculty Publications
Chronic ethanol (EtOH) consumption is a major contributor to multi-organ dysfunction, yet its systemic effects remain incompletely understood. To address this, we utilized a physiologically relevant long-term mouse model, administering 20% EtOH in drinking water for 60 weeks, to investigate the integrated consequences of chronic exposure. EtOH-consuming mice (0.4–0.5 mL/day) exhibited > 30% reductions in chow and fluid intake, resulting in a 12% decrease in total caloric intake compared to controls (p < 0.001). Body mass remained similar until Week 52, after which EtOH-treated mice had lower body mass due to reductions in both lean and fat mass (p ≤ 0.004). Functional assessments revealed impaired treadmill endurance (−17%) and grip strength (−11%) (p ≤ 0.037), while motor coordination remained unaffected (p = 0.203). Chronic EtOH exposure significantly altered gut microbiota composition, reducing Lactobacillus and enriching Faecalibaculum, Clostridium, and Bifidobacterium at the genus level. These changes were accompanied by marked depletion of short-chain fatty acids (p ≤ 0.05). Indirect markers of gut permeability (serum LPS & zonulin) and liver injury (serum ALT & AST, hepatic amyloid content) were elevated, alongside increased total cholesterol and > 62% upregulation of hepatic TNFα, IL-6 & serum amyloid A (p ≤ 0.046). EtOH also induced dyslipidemia and glucose intolerance (p ≤ 0.041), although transcriptomic changes in white adipose …
National Trends And In-Hospital Outcomes Of Valve-In-Valve Transcatheter Aortic Valve Replacement With Cerebral Embolic Protection, Ammar A. Hasnie, Avneet Hans, Emad A. Chishti, Joseph Leith, Hannah Murphy, Alyssa H. Harris, Kory Heier, Kristen Mcquerry, Steve W. Leung, Islam Y. Elgendy
National Trends And In-Hospital Outcomes Of Valve-In-Valve Transcatheter Aortic Valve Replacement With Cerebral Embolic Protection, Ammar A. Hasnie, Avneet Hans, Emad A. Chishti, Joseph Leith, Hannah Murphy, Alyssa H. Harris, Kory Heier, Kristen Mcquerry, Steve W. Leung, Islam Y. Elgendy
Radiology Faculty Publications
No abstract provided.
Oral Health In People With Schizophrenia, Leire Urien, Ainara Arnaiz, Xabier Marichalar-Mendia, Unax Lertxundi, Jose De Leon, Agate Txurruka, Nerea Jauregizar, Teresa Morera-Herreras
Oral Health In People With Schizophrenia, Leire Urien, Ainara Arnaiz, Xabier Marichalar-Mendia, Unax Lertxundi, Jose De Leon, Agate Txurruka, Nerea Jauregizar, Teresa Morera-Herreras
Psychiatry Faculty Publications
Aim This study aimed to assess the oral health status of individuals with schizophrenia and explore its association with behavioural and pharmacological factors, with particular focus on long-term antipsychotic treatment and cumulative anticholinergic burden. Methods A total of 153 adults with schizophrenia (18–65 years) from the Mental Health Network of Bizkaia (Spain), all under antipsychotic treatment for ≥12 months, were evaluated and compared with 153 controls from the general population. Data on socio-demographic variables, tobacco use and oral hygiene habits were collected. Oral health was assessed using the Decayed, Missing and Filled Teeth (DMFT) index and the Community Periodontal Index …
Generative Models And Synthetic Data In Clinical Prediction Models, Anthony A. Mangino, Taha Ahmed, Vincent L. Sorrell
Generative Models And Synthetic Data In Clinical Prediction Models, Anthony A. Mangino, Taha Ahmed, Vincent L. Sorrell
Radiology Faculty Publications
Introduction: Reproducibility, consistency, and transparency are essential to responsible and ethical scientific inquiry, though practices supporting these qualities are often neglected. However, in many cases data are confidential or otherwise unable to be shared publicly. This tutorial describes a method utilizing generative adversarial networks (GANs) to create synthetic data that are sufficiently similar to the original dataset in such cases where the source data cannot be shared or where the source data are too sparse as to internally validate results. Methods: Utilizing an exemplar study that aimed to create a clinical prediction model employing a novel echocardiographic measurement to differentiate …
The Supreme Court's Goldilocks: Why The Major Questions Doctrine Is The Ideal Compromise Between Two Unattractive Extremes, Bradley P. Simpson
The Supreme Court's Goldilocks: Why The Major Questions Doctrine Is The Ideal Compromise Between Two Unattractive Extremes, Bradley P. Simpson
Kentucky Law Journal
No abstract provided.
Exposing Car Dealerships' Final Hidden Sales Con: A Call For The Disclosure Of Interest Rate Markups When "Helping" Buyers With Indirect Financing, John C. Simms
Kentucky Law Journal
No abstract provided.
Congress's Mistaken Ip Power And Our Hybrid Constitutionalism, Barry P. Mcdonald
Congress's Mistaken Ip Power And Our Hybrid Constitutionalism, Barry P. Mcdonald
Kentucky Law Journal
No abstract provided.
The Brave New World Of Judicial Elections, Charles Gardner Geyh
The Brave New World Of Judicial Elections, Charles Gardner Geyh
Kentucky Law Journal
No abstract provided.
A Tale Of Two Landlords, Christopher J. Ryan Jr.
A Tale Of Two Landlords, Christopher J. Ryan Jr.
Kentucky Law Journal
No abstract provided.
The Case For Lgbtq+ Adoption Rights In The Post-Roe Era, Tate Craft
The Case For Lgbtq+ Adoption Rights In The Post-Roe Era, Tate Craft
Kentucky Law Journal
No abstract provided.
Domestic Guestworkers: A Call To End The H-2b Program And Empower American Workers, Preston Huennekens
Domestic Guestworkers: A Call To End The H-2b Program And Empower American Workers, Preston Huennekens
Kentucky Law Journal
No abstract provided.
Impeachment Can Be Based On Non-Criminal Misconduct: Corpus-Linguistic And Historical Evidence, Clark D. Cunningham, Ute Römer-Barron
Impeachment Can Be Based On Non-Criminal Misconduct: Corpus-Linguistic And Historical Evidence, Clark D. Cunningham, Ute Römer-Barron
Kentucky Law Journal
No abstract provided.
Party Over Country: The Inability For Congress To Check The Executive, Jordin A. Dickerson
Party Over Country: The Inability For Congress To Check The Executive, Jordin A. Dickerson
Kentucky Law Journal
No abstract provided.
Federal Prosecution In The Shadows Of Constitutional Immunity, J. Richard Broughton
Federal Prosecution In The Shadows Of Constitutional Immunity, J. Richard Broughton
Kentucky Law Journal
No abstract provided.
President Biden's Influence On The Use Of Executive Privilege, Mitchel A. Sollenberger, Mark J. Rozell
President Biden's Influence On The Use Of Executive Privilege, Mitchel A. Sollenberger, Mark J. Rozell
Kentucky Law Journal
No abstract provided.
Executive Immunity, Corruption, And The Rule Of Law: Death By A Thousand Cuts, Kimberly Breedon
Executive Immunity, Corruption, And The Rule Of Law: Death By A Thousand Cuts, Kimberly Breedon
Kentucky Law Journal
No abstract provided.
The Removal Responsibility, Kevin Frazier
Somebody's Watching Me: Modern Abusers Use Modern Methods Of Control, Savannah Molyneaux
Somebody's Watching Me: Modern Abusers Use Modern Methods Of Control, Savannah Molyneaux
Kentucky Law Journal
No abstract provided.
Happy Belated Iep: How A Notice Of Procedural Safeguards Fails Children With Specific Learning Disabilities, Chrystal Clodomir
Happy Belated Iep: How A Notice Of Procedural Safeguards Fails Children With Specific Learning Disabilities, Chrystal Clodomir
Kentucky Law Journal
No abstract provided.
Dred Scott, Military Enslavement, And The Case For Reparations, Hugh Mcclean
Dred Scott, Military Enslavement, And The Case For Reparations, Hugh Mcclean
Kentucky Law Journal
No abstract provided.
Building Jerusalem: Commercial Law And Ethics Of The Benefit Corporation, Jeff Lingwall, Susan Park
Building Jerusalem: Commercial Law And Ethics Of The Benefit Corporation, Jeff Lingwall, Susan Park
Kentucky Law Journal
No abstract provided.
Campus Coverage: How Biden's Title Ix Regulations Threaten Free Speech, Academic Freedom, And University Liability, Alex Drury
Kentucky Law Journal
No abstract provided.