Digital Commons Network^™

Increasing Dry Cow And Bred Heifer Performance With Environmental Management, Stephen F. Higgins, Kylie Schmidt

Agriculture and Natural Resources Publications

Producing high-quality milk is a primary concern of dairy farmers, which is why the production herd often receives more attention than the dry cows and bred heifers. However, it is important that dairy producers not lose sight of the great value that their dry cows and bred heifers hold: the future of the milking herd. Environmental management practices such as rotational grazing, heavy-use area pads for feeding and watering, and shelter can be used to increase close-up cows’ future performance by preventing mastitis and other health disorders such as lameness.

Soybean Nutrient Management In Kentucky, Edwin L. Ritchey, Chad Lee, Carrie Ann Knott, John H. Grove

Agriculture and Natural Resources Publications

Soybean grows best on fertile soils. For decades, the University of Kentucky has conducted field studies to establish the relationship between soil nutrient supplies and soybean yield. Adequate soil fertility must be present so that yields are not limited. Soybean removes a large amount of nutrients in the seed relative to other annual crops. For each bushel of soybean produced, 3 lb N, 0.7 lb P₂O₅, and 1.1 lb K₂O will be removed in the seed, but considerably more is required to supply the leaves, stems and pods that are not removed during harvest …

Induced Transcriptional Profiling Of Phenylpropanoid Pathway Genes Increased Flavonoid And Lignin Content In Arabidopsis Leaves In Response To Microbial Products, Mohammad Babar Ali, David H. Mcnear

Plant and Soil Sciences Faculty Publications

BACKGROUND: The production and use of biologically derived soil additives is one of the fastest growing sectors of the fertilizer industry. These products have been shown to improve crop yields while at the same time reducing fertilizer inputs to and nutrient loss from cropland. The mechanisms driving the changes in primary productivity and soil processes are poorly understood and little is known about changes in secondary productivity associated with the use of microbial products. Here we investigate secondary metabolic responses to a biologically derived soil additive by monitoring changes in the phenlypropanoid (PP) pathway in Arabidopsis thaliana.

RESULTS: This study …

Bisphenol A Increases Atherosclerosis In Pregnane X Receptor-Humanized Apoe Deficient Mice, Yipeng Sui, Se-Hyung Park, Robert N. Helsley, Manjula Sunkara, Frank J. Gonzalez, Andrew J. Morris, Changcheng Zhou

Saha Cardiovascular Research Center Faculty Publications

BACKGROUND: Bisphenol A (BPA) is a base chemical used extensively in many consumer products. BPA has recently been associated with increased risk of cardiovascular disease (CVD) in multiple large-scale human population studies, but the underlying mechanisms remain elusive. We previously reported that BPA activates the pregnane X receptor (PXR), which acts as a xenobiotic sensor to regulate xenobiotic metabolism and has pro-atherogenic effects in animal models upon activation. Interestingly, BPA is a potent agonist of human PXR but does not activate mouse or rat PXR signaling, which confounds the use of rodent models to evaluate mechanisms of BPA-mediated CVD risk. …

From Blue To Green: The Development And Implementation Of A Horticultural Therapy Program For Residents Of A Battered Women’S Shelter, Claire M. Renzetti, Diane R. Follingstad, Diane Fleet

CRVAW Faculty Presentations

No abstract provided.

Strengthening The Science Of Public Health Delivery: Complexities In Implementation, Inference & Translation, Glen P. Mays

Health Management and Policy Presentations

Delivery systems for public health programs and policies are diffuse and heterogeneous across the U.S., reflecting wide variation in the capacity to implement population-level health improvement strategies. This lecture examines strategies for evaluating the causes and consequences of variation in public health delivery across the U.S., with a focus on identifying pathways for improving the health and economic effects of policy and practice.

Poster Session, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

1. Grading a Watershed? Patrick Creager, Eastern Kentucky University, Richmond, KY
2. Permeability Heterogeneity and Its Effects on Hyporheic Zone Exchange, Timothy Pryshlak and Audrey Sawyer, Department of Earth and Environmental Sciences, University of Kentucky, Lexington, KY
3. Effects of Atrazine on the Chemical Alarm Cue Response in Longear Sunfish (Lepomis megalottis), Ben M. Adams and Ben F. Brammell, Natural Sciences Department, Asbury University, Wilmore, KY
4. New Features Available on the Kentucky Groundwater Data Repository, Bart Davidson and others, Kentucky Geological Survey, University of Kentucky, Lexington, KY
5. Removal of Persistent Organic Pollutants from Contaminated Water Sources Utilizing Polyphenol- Functionalized Magnetic …

The Soldiers In Societies: Defense, Regulation, And Evolution, Li Tian, Xuguo Zhou

Entomology Faculty Publications

The presence of reproductively altruistic castes is one of the primary traits of the eusocial societies. Adaptation and regulation of the sterile caste, to a certain extent, drives the evolution of eusociality. Depending on adaptive functions of the first evolved sterile caste, eusocial societies can be categorized into the worker-first and soldier-first lineages, respectively. The former is marked by a worker caste as the first evolved altruistic caste, whose primary function is housekeeping, and the latter is highlighted by a sterile soldier caste as the first evolved altruistic caste, whose task is predominantly colony defense. The apparent functional differences between …

Soy Products With Reduced Levels Of Sulfite, Free Radicals And Methanethiol, William L. Boatright

Animal and Food Sciences Faculty Patents

Soy products or compositions are treated with a food grade iodate compound or a cystine compound to reduce levels of methanethiol, sulfites and sulfite free-radicals, sulfate free radicals and other free radicals generated from sulfite free radicals in the soy products or compositions by 1% to 95%.

Compositions And Methods For Selectively Targeting Cancer Cells Using A Thiaminase Compound, Jeffrey A. Moscow, Shuqian Liu, Younsoo Bae

Pharmaceutical Sciences Faculty Patents

Compositions and methods of treating cancer using a thiaminase compound are described. The presently-disclosed subject matter includes a method of treating cancer by administering a thiaminase compound and a thiamine-dependent enzyme inhibitor.

Public Health Services Most Commonly Provided By Local Health Departments In The United States, Gulzar H. Shah, Huabin Luo, Sergey Sotnikov

Frontiers in Public Health Services and Systems Research

The primary purpose of this research is to identify the most commonly performed public health services by local health departments (LHDs) and highlight variation by LHD characteristics. Data were drawn from the 2008 and 2010 National Profile of LHDs, conducted by the National Association of County and City Health Officials (NACCHO). The descriptive analysis aims to further the essential dialogue triggered by a recent Institute of Medicine (IOM) report about the standard minimum set of services that all LHDs should provide. This study identified a set of 22 activities performed by LHDs that are common in jurisdictions of all sizes. …

A Fresh Cow Health Monitoring System, Amanda E. Sterrett, Donna M. Amaral-Phillips, Jeffrey M. Bewley, Michelle Arnold

Agriculture and Natural Resources Publications

Calving causes cows to endure many physiological changes that require good nutrition, time, and adequate rest for recovery. Upon calving, cows are introduced into the lactating herd, where they consume high amounts of a new ration and have to adapt to a new feeding and milking routine. Lactation requires more support from the diet than pregnancy and weight maintenance, particularly in fresh cows calving in with a negative energy balance. Additionally, the social hierarchy within the herd is re-established every time a new cow enters the group, which can cause stress, especially for timid and weak cows. For these reasons, …

Spatiotemporal Expression Of Manf In The Developing Rat Brain, Haiping Wang, Zunji Ke, Alexander Alimov, Mei Xu, Jacqueline A. Frank, Shengyun Fang, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an evolutionarily conserved neurotrophic factor which exhibited neuroprotective properties. Recent studies suggested that MANF may play a role in the neural development of Drosophila and zebra fishes. In this study, we investigated the spatiotemporal expression of MANF in the brain of postnatal and adult rats. MANF expression appeared wide spread and mainly localized in neurons. In the cerebral cortex, neurons in layer IV and VI displayed particularly strong MANF immunoreactivity. In the hippocampus, intensive MANF expression was observed throughout the subfields of Cornu Amonis (CA1, CA2, and CA3) and the granular layer of the …

Nuclear Interaction Between Adr-Induced P65 And P53 Mediates Cardiac Injury In Inos (−/−) Mice, Marsha P. Cole, Jitbanjong Tangpong, Terry D. Oberley, Luksana Chaiswing, Kinsley K. Kiningham, Daret K. St. Clair

Toxicology and Cancer Biology Faculty Publications

Adriamycin (ADR) treatment causes an imbalance in the levels of nitric oxide (^•NO) and superoxide (O₂^•−) production leading to cardiac injury. Previously we demonstrated that mice lacking inducible nitric oxide synthase (iNOS) have increased oxidative stress and mitochondrial injury. The molecular events leading to increased mitochondrial injury in iNOS deficient mice is unknown. ADR in the absence of iNOS preferentially activates a proapoptotic pathway without a concurrent increase in prosurvival pathways. Treatment with ADR leads to an increase in DNA binding activity of nuclear factor kappa B (NFκB) and p53 in wildtype mice. Following ADR …

Aged Rats Are Hypo-Responsive To Acute Restraint: Implications For Psychosocial Stress In Aging, Heather M. Buechel, Jelena Popovic, Kendra Staggs, Katie L. Anderson, Olivier Thibault, Eric M. Blalock

Pharmacology and Nutritional Sciences Faculty Publications

Cognitive processes associated with prefrontal cortex and hippocampus decline with age and are vulnerable to disruption by stress. The stress/stress hormone/allostatic load hypotheses of brain aging posit that brain aging, at least in part, is the manifestation of life-long stress exposure. In addition, as humans age, there is a profound increase in the incidence of new onset stressors, many of which are psychosocial (e.g., loss of job, death of spouse, social isolation), and aged humans are well-understood to be more vulnerable to the negative consequences of such new-onset chronic psychosocial stress events. However, the mechanistic underpinnings of this age-related shift …

Human Papillomavirus Genotype Prevalence In Invasive Penile Cancers From A Registry-Based United States Population, Brenda Y. Hernandez, Marc T. Goodman, Elizabeth R. Unger, Martin Steinau, Amy Powers, Charles F. Lynch, Wendy Cozen, Maria Sibug Saber, Edward S. Peters, Edward J. Wilkinson, Glenn Copeland, Claudia Hopenhayn, Youjie Huang, Meg Watson, Sean F. Altekruse, Christopher Lyu, Mona Saraiya, The Hpv Typing Of Cancer Workgroup

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: Human papillomavirus (HPV) is estimated to play an etiologic role in 40-50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited.

METHODS: HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998-2005 within the catchment areas of seven U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review.

RESULTS: HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral …

Metrics Of The Gynecologic Oncology Literature Focused On Cited Utilization And Costs, Edward J. Pavlik, John Hoff, Dylan Woolum, Yuqing Liang, Christiaan Wijers, Melissa Schwartz, Jason Lefringhouse, Lauren Baldwin

Obstetrics and Gynecology Faculty Publications

OBJECTIVE: The newest findings on literature utilization relevant to gynecologic oncology were published by Thomson Reuters during June 2013 as determinants of journal standing. Our objective was to assess the different metrics reported for relative impact and cost for journals relevant to gynecologic oncology.

METHODS: 55 journals were evaluated for Impact Factor (IF), 5Year IF, Immediacy Index, Cited Half Life, Eigenfactor (EF) Score, Article Influence (AI) scores and subscription costs obtained from publisher information.

RESULTS: CA-A Cancer Journal for Clinicians had the highest IF (101.78) & AI (24.502). The top EF cancer-specific journals were the Journal of Clinical Oncology, Cancer …

Superoxide Signaling In Perivascular Adipose Tissue Promotes Age-Related Artery Stiffness, Bradley S. Fleenor, Jason S. Eng, Amy L. Sindler, Bryant T. Pham, Jackson D. Kloor, Douglas R. Seals

Graduate Center for Nutritional Sciences Faculty Publications

We tested the hypothesis that superoxide signaling within aortic perivascular adipose tissue (PVAT) contributes to large elastic artery stiffening in old mice. Young (4-6 months), old (26-28 months), and old treated with 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPOL), a superoxide scavenger (1 mm in drinking water for 3 weeks), male C57BL6/N mice were studied. Compared with young, old had greater large artery stiffness assessed by aortic pulse wave velocity (aPWV, 436 ± 9 vs. 344 ± 5 cm s(-1)) and intrinsic mechanical testing (3821 ± 427 vs. 1925 ± 271 kPa) (both P < 0.05). TEMPOL treatment in old reversed both measures of arterial stiffness. Aortic PVAT superoxide production was greater in old (P < 0.05 vs. Y), which was normalized with TEMPOL. Compared with young, old controls had greater pro-inflammatory proteins in PVAT-conditioned media (P < 0.05). Young recipient mice transplanted with PVAT from old compared with young donors for 8 weeks had greater aPWV (409 ± 7 vs. 342 ± 8 cm s(-1)) and intrinsic mechanical properties (3197 ± 647 vs. 1889 ± 520 kPa) (both P < 0.05), which was abolished with TEMPOL supplementation in old donors. Tissue-cultured aortic segments from old in the presence of PVAT had greater mechanical stiffening compared with old cultured in the absence of PVAT and old with PVAT and TEMPOL (both, P < 0.05). In addition, PVAT-derived superoxide was associated with arterial wall hypertrophy and greater adventitial collagen I expression with aging that was attenuated by TEMPOL. Aging or TEMPOL treatment did not affect blood pressure. Our findings provide evidence for greater age-related superoxide production and pro-inflammatory proteins in PVAT, and directly link superoxide signaling in PVAT to large elastic artery stiffness.

Red Meat And Our Health: Separating Scientific Fact From Politics, Emotion And Misinformation, Peter Ballerstedt

Forage Symposium at the Kentucky Cattlemen’s Convention

The 2010 Dietary Guidelines for Americans recommends restricting our intake of saturated fat to less than 7 percent of calories, and our cholesterol intake to less than 300 mg per day (less than two eggs). They promote the use of low-fat milk and lean meat, and the use of “meat substitutes” in school lunches. These recommendations are consistent with the official dietary policy that began in 1977 with the release of the first Dietary Goals for the United States by the United States Senate Select Committee on Nutrition and Human Needs. These guidelines were not justified by the then-available science. …

Animal Welfare--Animal Rights: "Protecting Animals Or A Threat To U.S. Food Production And Our Way Of Life?", W. Roy Burris

Forage Symposium at the Kentucky Cattlemen’s Convention

Cattle producers are accustomed to dealing with many forms of adversity. Adversity generally comes in the form of blizzards, droughts, floods and economic conditions but now we must deal with animal activists who have their own opinions of what we can and cannot do as it relates to animal welfare and animal rights.

Snap And Food Consumption, Hilary W. Hoynes, Leslie Mcgranahan, Diane W. Schanzenbach

University of Kentucky Center for Poverty Research Discussion Paper Series

In this paper we describe the relationship between SNAP and food consumption. We first present the neoclassical framework for analyzing in-kind transfers, which unambiguously predicts that SNAP will increase food consumption, and then describe the SNAP benefit formula. We then present new evidence from the Consumer Expenditure Survey on food spending patterns among households overall, SNAP recipients, and other subgroups of interest. We find that a substantial fraction of SNAP-eligible households spend an amount that is above the program’s needs standard. We also show that the relationship between family size and food spending is steeper than the slope of the …

The Rak/Frk Tyrosine Kinase Associates With And Internalizes The Epidermal Growth Factor Receptor, Ling Jin, Rolf J. Craven

Pharmacology and Nutritional Sciences Faculty Publications

Src is the founding member of a diverse family of intracellular tyrosine kinases, and Src has a key role in promoting cancer growth, in part, through its association with receptor tyrosine kinases. However, some Src-related proteins have widely divergent physiological roles, and these proteins include the Rak/Frk tyrosine kinase (Frk stands for Fyn-related kinase), which inhibits cancer cell growth and suppresses tumorigenesis. Rak/Frk phosphorylates and stabilizes the Pten tumor suppressor, protecting it from degradation, and Rak/Frk associates with the retinoblastoma (Rb) tumor suppressor. However, the role of Rak/Frk in receptor-mediated signaling is largely unknown. Here, we demonstrate that Rak/Frk associates …

Farmers' Market Use Is Associated With Fruit And Vegetable Consumption In Diverse Southern Rural Communities, Stephanie B. Jilcott Pitts, Alison A. Gustafson, Qiang Wu, Mariel Leah Mayo, Rachel K. Ward, Jared T. Mcguirt, Ann P. Rafferty, Mandee F. Lancaster, Kelly R. Evenson, Thomas C. Keyserling, Alice S. Ammerman

Dietetics and Human Nutrition Faculty Publications

Background

While farmers’ markets are a potential strategy to increase access to fruits and vegetables in rural areas, more information is needed regarding use of farmers’ markets among rural residents. Thus, this study’s purpose was to examine (1) socio-demographic characteristics of participants; (2) barriers and facilitators to farmers’ market shopping in southern rural communities; and (3) associations between farmers’ market use with fruit and vegetable consumption and body mass index (BMI).

Methods

Cross-sectional surveys were conducted with a purposive sample of farmers’ market customers and a representative sample of primary household food shoppers in eastern North Carolina (NC) and the …

Redox Pioneer: Professor Joe M. Mccord, David M. Schnell, Daret K. St Clair

Graduate Center for Nutritional Sciences Faculty Publications

Dr. Joe McCord (Ph.D. 1970) is recognized here as a Redox Pioneer because he has published at least three articles on antioxidant/redox biology as first/last author that have been cited over 1000 times and has published at least 37 articles each cited over 100 times. Dr. McCord is known for the monumental discovery of the antioxidant superoxide dismutase (SOD) while a graduate student under fellow redox pioneer Irwin Fridovich and demonstrating its necessity to aerobic life. Beyond this, McCord's career is distinguished for bridging the gap from basic science to clinical relevance by showing the application of SOD and superoxide …

Multiple Program Participation And The Snap Program, Robert A. Moffitt

University of Kentucky Center for Poverty Research Discussion Paper Series

Receipt of benefits from other traditional transfer programs by SNAP families is common, with 76 percent of those families receiving at least one other major benefit of that type, excluding Medicaid, in 2008. However, over half of these only received one other benefit and only a very small fraction received more than two others. Over the long-term, multiple benefit receipt among SNAP families has been falling, a result of declines in the TANF caseload offsetting rises in the SSI, SSDI, and WIC caseloads. Finally, the analysis shows that high marginal tax rates generated by multiple program receipt are relevant for …

Pb Neurotoxicity: Neuropsychological Effects Of Lead Toxicity, Lisa H. Mason, Jordan P. Harp, Dong Y. Han

Neurology Faculty Publications

Neurotoxicity is a term used to describe neurophysiological changes caused by exposure to toxic agents. Such exposure can result in neurocognitive symptoms and/or psychiatric disturbances. Common toxic agents include heavy metals, drugs, organophosphates, bacterial, and animal neurotoxins. Among heavy metal exposures, lead exposure is one of the most common exposures that can lead to significant neuropsychological and functional decline in humans. In this review, neurotoxic lead exposure's pathophysiology, etiology, and epidemiology are explored. In addition, commonly associated neuropsychological difficulties in intelligence, memory, executive functioning, attention, processing speed, language, visuospatial skills, motor skills, and affect/mood are explored.

Heritage Hog Carcass Yields: Ossabaw Hog, Bob Perry

Heritage Hog Carcass Yields

Average hot carcass weight 187.86 pounds with 3.49 inches of fat at the 1st rib and 2.53 inches at the 10th rib. The LEA (loin eye area) was 4.33 square inches and overall the average yield of lean muscle using the industry standard formula was 31%.

Heritage Hog Carcass Yields: Hereford Hog, Bob Perry

Heritage Hog Carcass Yields

The saleable yield of a Hereford Hog, cut in the American style, is 75%. The overall percentage of lean muscle using the industry formula based on backfat at 1st and 10th rib, loin eye area and hot carcass weight is 42%. Cut for Charcuterie, the saleable yield is 69%, not including bones, trim and backfat.

Heritage Hog Carcass Yields: Tamworth Hog, Bob Perry

Heritage Hog Carcass Yields

The saleable yield of a Tamworth Hog, cut in the American style, is 75%. The overall percentage of lean muscle using the industry formula based on backfat at 1st and 10th rib, loin eye area and hot carcass weight is 43%. Cut for Charcuterie, the saleable yield is 73%, not including bones, trim and backfat.

Heritage Hog Carcass Yields: Mulefoot Hog, Bob Perry

Heritage Hog Carcass Yields

The saleable yield of a Mulefoot Hog, cut in the American style, is 67%. The overall percentage of lean muscle using the industry formula based on backfat at 1st and 10th rib, loin eye area and hot carcass weight is 36%. Cut for Charcuterie, the saleable yield is 66%, not including bones, trim and backfat.