Digital Commons Network^™

Colorectal Cancer Prevention In The North Slope Borough Of Alaska Utilizing The Flu-Fit Intervention, Jennifer Jenkins

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The intention of the Flu-FIT intervention is to increase colorectal cancer screening rates by combing two annual activities into one visit that doesn’t necessitate a doctors visit. The original study increased colorectal cancer screening rates by 14 percentage points and this program should be able to show similar results in the North Slope Borough of Alaska. The North Slope Borough has the highest incidence rate of colorectal cancer in the United States, and this proposed intervention could lead to a reduction in that rate by increasing screening and knowledge about colorectal cancer in the community.

Identifying Predictors Of Functional Limitations Associated With Depression, Anxiety, And Emotional Problems In Us Adults, Jillian Richardson

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Depressive disorders are characterized as sharing affected mood, and somatic (e.g. sleep pattern, appetite, and unintentional changes in weight) and cognitive alterations from previous normal daily functioning that are clinically significant. Anxiety disorders are characterized by excessive fear, general or specific anxiety, and related behavioral disturbances that are also clinically significant. This project attempts to identify risk factors that may predict what groups are most likely to be affected by depression and/or anxiety.

Sponsored by the CDC, the National Health Interview Survey collects general health information for non-institutionalized individuals living in the US. Variables for use in logistic regression model …

"Life Skills Training" Prescription Drug Abuse Prevention Among Youth In Bell County, Kentucky, Arveen Kaur

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Prescription Drug Abuse (PDA) has become a serious public health concern and a major epidemic in the United States (U.S.). According to the 2014 National Survey on Drug Use and Health (NSUDH), approximately 15 million people (aged 12 or older) used prescription drugs in the past year and 6.5 million in past month. Out of these, 2 million Americans (aged 12 or older) either abused prescription drugs or were dependant on them. Almost 5% of adolescents (1.1 million) between the age group 12-17 abused prescription painkillers in 2014. Nationally, Kentucky is among the top five states with highest age-adjusted overdose …

Are There Rural-Urban Differences In Dentist Supply?, Mutlaq Alotaibi

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The purpose of this project was to examine the supply of dentists in the Commonwealth of Kentucky at the county level. Counties with shortages in dentist supply were determined and associated factors were examined.

Several county-level variables were analyzed. These included total number of dentists, total county population, dentist to population ratio, dentist supply shortage, median household income, median age, percent of Medicaid enrollees, rurality, oral cancer crude incidence and mortality rates per 100,000 and percent of adults missing six or more teeth.

This project showed that 42 of the 120 counties in Kentucky had shortages in dentist supply. Also, …

Undiagnosed Hepatitis C Infection In An Urban Emergency Department, Naseem Ansari

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Aim: To evaluate the prevalence of previously undiagnosed hepatitis C virus and associated patient risk factors in an urban ED through a universal, integrated screening program, to contextualize results found in terms of gaps in existing HCV screening models and to inform future sustainable and effective screening models.

Methods: ED patients, ages 18-71, that were medically stable, hadn’t had a prior HCV test, and were having blood drawn as part of routine clinical care, were offered (n=2,726) an anti-HCV test, of whom 1,945 accepted. An assessment of correlates to anti-HCV positivity was completed using a binomial logistic regression …

Relative Reactivity Of Protein And Lipid To Oxidants In Different Bi-Phasic Systems And Its Implication In Sausage Quality, Jiayi Yang

Theses and Dissertations--Animal and Food Sciences

This study investigated the progression of protein and lipid oxidation in different bi-phasic model systems: simple aqueous dispersions, liposome, and oil-in-water (O/W) emulsions. Varied concentrations of isolated pork myofibrillar protein (MFP) were mixed with free fatty acids (C18:1, C18:2, C18:3), lecithin, or vegetable oil to construct different lipid-protein dispersion systems, then subjected to hydroxyl radical stress at 4 °C. Comparison of the evolution of lipid oxidation with protein modification markers in all dispersion systems showed noteworthy attenuation of tryptophan fluorescence, protein carbonyl formation, and extensive polymerization of myosin in 2 h. This process preceded lipid oxidation which exhibited notable accumulations …

Lifestyle Contributors To Cardiovascular Disease Risk, Adam J. Berrones

Theses and Dissertations--Kinesiology and Health Promotion

Aortic stiffness is an independent risk factor that has prognostic value regarding future cardiovascular disease (CVD) events such as myocardial infarction, strokes, and heart failure. Although death rates due to coronary heart disease have declined in recent years, the leading global killer remains CVD and prevalence is still high. Understanding lifestyle contributors associated with aortic stiffness would provide the public with insight into targeting key health-related behaviors.

The purpose of this observational study was to examine the association of physical activity, physical function, and dietary quality as independent factors contributing to aortic stiffness in apparently healthy middle aged men. Fifty-two …

The Effect Of Curcumin On Cardiovascular Health In Obese Men, Marilyn S. Campbell

Theses and Dissertations--Kinesiology and Health Promotion

Cardiovascular disease is the leading cause of death in the United States, and conventional treatment often emphasizes pharmaceutical approaches. Research has recently started exploring non-pharmaceutical approaches, including nutritional interventions. This research study was conducted to test the effectiveness of a novel nutritional approach, curcumin, on the improvement of cardiovascular health in young, obese males (BMI≥30 kg/m²). This study included 22 men, matched based on BMI and randomly assigned to the intervention (n=11) or placebo group (n=11). The intervention consisted of 12 weeks of curcumin supplementation (1.0 g/day) with fenugreek added to enhance the curcumin bioavailability; the placebo consisted …

The Role And Impact Of School Nurses And Intentions To Delegate Diabetes-Related Tasks Amidst Budget Cuts And Legislative Changes, Michelle J. Lineberry

Theses and Dissertations--Kinesiology and Health Promotion

As the percentage of school children with chronic conditions such as diabetes continues to rise, funding for school nurses to keep those students healthy and safe is decreasing. This dissertation includes three studies: (1) a systematic review of the literature on the role and impact of American elementary school nurses, (2) a focus group study that further examined the role of Kentucky school nurses and described their reaction to a new regulation that necessitates delegation of diabetes-related nursing tasks to unlicensed assistive personnel (UAP), and (3) a quantitative study that examined Kentucky school nurses’ past behaviors and future intentions regarding …

An Internal Evaluation Of A Health Program For Adults With Mild, Moderate, And Severe Intellectual Disabilities, Shelley C. Sellwood-Davis

Theses and Dissertations--Educational Policy Studies and Evaluation

Adults with intellectual disabilities are not only more likely to be obese, but they are also more prone to medical complications, including diabetes, cardiovascular disease, thyroid disorder and osteoporosis. Therefore, health programs targeting this population are becoming more frequent in nature, and learning what makes such programs effective will be important in serving this population. A health program for adults between the ages of eighteen and forty with mild, moderate, and severe intellectual disabilities was evaluated in order to learn how the individual health program could be improved and in what ways the program itself could serve as a model …

The Development, Implementation, And Evaluation Of A Campus-Based Culinary Nutrition Program For College Students, Jennifer Mcmullen

Theses and Dissertations--Education Sciences

College students, on average, do not consume enough fruits and vegetables. Contributing to poor eating habits is an overall decline in young adults’ cooking skills as compared to previous decades, with today’s college students often relying on ubiquitous convenience food options. The detriments associated with these food choices are linked to a number of chronic diseases, including obesity. Though programming for college students which incorporates both nutrition education and hands-on cooking opportunities is rare, programs which have been implemented have had positive outcomes associated with increased self-efficacy with cooking and eating healthfully, and improved eating behaviors.

This research utilized a …

Duae Orationes Paedagogicae Marci Antonii Mureti De Praestantia Litterarum Humaniorum In Universitate Saeculo Sexto Decimo, Laura A. Manning

Theses and Dissertations--Modern and Classical Languages, Literature and Cultures

Marcus Antonius Muretus, humanista aetatis renascentium artium et orator, qui floruit 1526-1585, dicitur fuisse inter optimos oratores suae aetatis. Orationes Mureti per multa saecula legebantur et magni aestimabantur. Haec editio duarum orationum Mureti de praestantia litterarum est apta ad usum discipulorum qui facultatem Latine legendi confirmare debeant, qui nondum satis multa de humanismo sciant, qui provehere litteras et Latinas et Graecas volunt. In praefatione huius commentarii vitam Mureti, humanismum, artes liberales, cultum civilem Europaeum qui tempore renascentium artium exstabat, ipsam orationem, litteras humaniores, et methodum commentarii parandi tractamus.

Marcus Antonius Muretus (1526-1585) was a Renaissance humanist acknowledged as the foremost …

The Role Of Sox4 In Regulating Choroid Fissure Closure And Retinal Neurogenesis, Wen Wen

Theses and Dissertations--Biology

The development of the vertebrate eye is tightly controlled by precise genetic regulations. From a single ocular primordium to bilateral eyes with complex structures and cell types, it requires intensive proliferation and migration for cells in both the ectoderm and mesoderm to accomplish ocular morphogenesis, and during this process cell differentiation and interaction takes place to establish the complex composition of ocular cell types and cellular connections. Genetic defects can lead to severe abnormalities in eye morphogenesis and cell differentiation during ocular development. A tremendous amount of work has been done to identify both intrinsic and extrinsic factors that regulate …

Freedom From Want: Famine Relief In The Horn Of Africa, Christian T. Ruth

Theses and Dissertations--History

The United States, during both the Jimmy Carter and Ronald Reagan administrations, pursued humanitarian relief in the Horn of Africa and East Africa with an eye towards Cold War politics. During the Carter administration the focus was on Ethiopia and the regime of Mengistu Haile Mariam, while during the Reagan administration the United States’ efforts were mainly targeted towards Sudan and the regime of Gaffar Nimeiry. In both instances, the United States was concerned with the politics of the Cold War, trying to create a more positive image of the U.S. abroad by relieving world hunger, while also propping up …

Identifying The Core Elements Of Developing Student Leaders In A College Ambassador Program, Megan Tennison

Theses and Dissertations--Community & Leadership Development

Within the university system, student organizations have historically had multiple positive influences on the students who choose to participate in them. This study looked at a particular banner organization in the College of Agriculture, Food and Environment at the University of Kentucky. Using the Social Change Model of Leadership Development theory as a backbone, a survey was created to evaluate the impact UK CAFE Ambassador Program has on its participants, as well as to identify avenues for improvement. This is a program that seeks to represent the college through recruitment and to develop student leaders through soft skill building. After …

Evaluation Of Flocculation, Sedimentation, And Filtration For Dewatering Of Algal Biomass, Nicholas A. Rhea

Theses and Dissertations--Biosystems and Agricultural Engineering

Algae can be used as a feedstock for agricultural fertilizers, livestock/poultry feeds, anaerobic digestion, and biofuel production. Regardless of the end product, water removal is necessary and difficult to do cost effectively. For each product the requirements for moisture content (or solids content) vary, such that a desirable water removal strategy would need to be adaptable to varying levels of water removal. Flocculation, with sedimentation and drying was evaluated as a possible strategy for algae dewatering. Anionic and nonionic flocculants are known to be ineffective at flocculating algal culture, which was confirmed for this case by electro-osmotic flow testing of …

Heat And Mass Transfer In Baled Switchgrass For Storage And Bioconversion Applications, Drew F. Schiavone

Theses and Dissertations--Biosystems and Agricultural Engineering

The temperature and moisture content of biomass feedstocks both play a critical role in minimizing storage and transportation costs, achieving effective bioconversion, and developing relevant postharvest quality models. Hence, this study characterizes the heat and mass transfer occurring within baled switchgrass through the development of a mathematical model describing the relevant thermal and physical properties of this specific substrate. This mathematical model accounts for the effect of internal heat generation and temperature-induced free convection within the material in order to improve prediction accuracy. Inclusion of these terms is considered novel in terms of similar biomass models.

Two disparate length scales, …

Physico-Chemical, Rheological And Baking Properties Of Proso Millet, Manjot Singh

Theses and Dissertations--Biosystems and Agricultural Engineering

Due to climate change, water scarcity, increasing population and rising food prices, agriculture and food security has been affected worldwide. Cereal grains being a major part of world food supply also act as important energy source in human diet. In order to counter food insecurity, alternative grains are being explored, and millet being drought-resistant has the potential to serve as an alternative grain due to its comparable nutritional composition with other major cereals and its gluten free proteins. The evidence that gluten sensitivity is one of the increasing food intolerances is driving an increasing demand for gluten-free foods. However, gluten …

The Impact Of Cash Transfers On Labor Force Participation And Household Consumption: Evidence From Post-Apartheid South Africa, Steve M. M. Muchiri

Theses and Dissertations--Economics

The Old Age Pension (OAP) program for elderly South Africans puts a significant cash transfer in the hands of many poor households. This dissertation investigates its impact on labor force participation and consumption of selected household items. In the first half of the dissertation, we take advantage of a policy reform that lowered men's OAP eligibility age from 65 to 60 for men to match that of women for estimation identification. Using the General Household Survey data, we first demonstrate that both men and women respond to the eligibility age by dropping from labor force participation at the eligibility age, …

Statistical Methods For Environmental Exposure Data Subject To Detection Limits, Yuchen Yang

Theses and Dissertations--Statistics

In this dissertation, we develop unified and efficient nonparametric statistical methods for estimating and comparing environmental exposure distributions in presence of detection limits. In the first part, we propose a kernel-smoothed nonparametric estimator for the exposure distribution without imposing any independence assumption between the exposure level and detection limit. We show that the proposed estimator is consistent and asymptotically normal. Simulation studies demonstrate that the proposed estimator performs well in practical situations. A colon cancer study is provided for illustration. In the second part, we develop a class of test statistics to compare exposure distributions between two groups by using …

Effects Of Obesity On United States Farmers: A Pilot Study, Sharon C. Hunsucker

Theses and Dissertations--Nursing

Previous research described the value farmers place on their ability to work. The impact of obesity on workers is an increasing concern in occupational health research; yet, knowledge regarding the impact of obesity on the performance of farm work is limited. Identifying the impact of obesity on farmer’s work ability can guide healthcare workers in promoting and motivating farmers to implement lifestyle changes to improve health and sustain longevity in their ability to work.

The purpose of this dissertation was to examine the impact of obesity on the work ability of U.S. farmers. Specific aims were to 1) examine the …

The Effect Of Nicotine Co-Administration On Alcohol-Induced Reactive Hippocampal Cell Proliferation During Abstinence In An Adolescent Model Of An Alcohol Use Disorder, Megan Heath

Theses and Dissertations--Pharmacy

A significant consequence of alcohol use disorders (AUDs) is hippocampal neurodegeneration. The hippocampus is responsible for learning and memory, and neurodegeneration in this brain region has been shown to result in cognitive deficits. Interestingly, some alcoholics demonstrate improvements in hippocampus-dependent functions, potentially due the phenomenon termed adult neurogenesis. Adult neurogenesis, the process by which neural stem cells (NSCs) proliferate, differentiate into neurons, migrate into the granule cell layer, and survive, occurs in two brain regions; however, this study examines only neurogenesis occurring in the subgranular zone of the hippocampal dentate gyrus. Four-day binge ethanol exposure in an animal model causes …

Maternal Allostatic Load During Pregnancy: Predicting Length Of Gestation, Molly E. M. Sayre

Theses and Dissertations--Social Work

Allostatic load, or the “wear and tear” on the body due to stress, is thought to have a negative impact on length of pregnancy and contribute to health disparities in preterm birth. However, the magnitude of the effect on birth outcomes is unknown, in part due to questions of timing of measurement of allostatic load during pregnancy. This study used linear regression analysis of data from 156 pregnant women to test whether allostatic load is a predictor of length of gestation in the study sample, finding that third trimester allostatic load predicted length of gestation among women with full-term births. …

The Role Of Fat Grafting And Adipose-Derived Stem Cells In Breast Reconstruction, Krishna S. Vyas

Theses and Dissertations--Clinical and Translational Science

Fat grafting is a common surgical procedure that involves the transfer of fat from one area of the body to another in order to improve contour deformities, such as in breast reconstruction. Advantages of the technique include using autologous tissue rather than a foreign body and the added benefit of having liposuction to remove fat from an undesirable location. Although adipose tissue could be the ideal soft tissue filler, fat grafting is plagued by tremendous variability in long-term retention, with volume survival rates of 20-80%, resulting in suboptimal outcomes and repetitive procedures.

The mechanisms contributing to long-term fat graft survival …

Deep Sleep, Cognition, Body Weight, Body Temperature, And Behavioral Distress Responses To New Onset Psychosocial Stressors Are Blunted With Age In Male F344 Rats, Kendra E. Hargis

Theses and Dissertations--Pharmacology and Nutritional Sciences

Complaints associated with aging, including cognitive deficits and sleep loss, are highly prevalent and negatively impact quality of life. Further, with increased age, humans are also more likely to experience new-onset psychosocial stressors, such as divorce, loss of a spouse, and social isolation. Stress has detrimental consequences that in many ways parallel the effects of aging on sleep and cognition. The long-standing stress/ glucocorticoid hypotheses of brain aging posit that stress exposure exacerbates aging symptoms, and extensive prior studies have shown that early life stress exposure does worsen phenotypic aging symptoms. However, despite its prevalence in aged humans, little basic …

The Role Of Pxr And Ikkβ Signaling In Cardiometabolic Disease, Robert N. Helsley

Theses and Dissertations--Pharmacology and Nutritional Sciences

Cardiovascular disease (CVD) is the leading cause of death worldwide and is partially attributed to perturbations in lipid metabolism. Xenobiotics, such as pharmaceutical drugs and environmental chemicals, have been associated with increased risk of CVD in multiple large-scale human population studies, but the underlying mechanisms remain poorly defined. We and others have identified several xenobiotics as potent agonists for the pregnane X receptor (PXR), a nuclear receptor that can be activated by numerous drugs as well as environmental and dietary chemicals. However, the role of PXR in mediating the pathophysiological effects of xenobiotic exposure in humans and animals remains elusive. …

The Role Of The Ace2/Ang-(1-7)/Masr Axis In The Development Of Obesity-Hypertension In Male And Female Mice, Yu Wang

Theses and Dissertations--Pharmacology and Nutritional Sciences

Obesity is strongly associated with hypertension and cardiovascular diseases. An activated renin-angiotensin system (RAS) has long been suggested as a critical contributor to elevated blood pressure with obesity. Angiotensin II (AngII), the main effector of an activated RAS, can be catabolized by angiotensin-converting enzyme 2 (ACE2) to form angiotensin-(1-7) (Ang-(1-7)), which, acting through the mas receptor (MasR), has been shown to oppose the effects of an activated RAS. Therefore, further understanding of the mechanisms of this counter-regulatory arm, called the ACE2/Ang-(1-7)/MasR axis, may lead to new therapies for obesity-induced hypertension. Previously, we demonstrated that differences in the regulation of ACE2 …

The Role Of Astrocytic Calcineurin Activation And Downstream Signaling In Neurodegenerative Diseases, Melanie M. Pleiss

Theses and Dissertations--Pharmacology and Nutritional Sciences

Calcineurin (CN) is a calcium (Ca²⁺)-sensitive serine/threonine protein phosphatase that plays a significant role in several cell signaling pathways, and has been implicated in many neurodegenerative diseases including Alzheimer’s disease (AD) and vascular cognitive impairment and dementia (VCID). Although normally found in neurons, CN also appears at high levels in activated astrocytes under conditions of injury and disease. To elucidate the role of astrocytic calcineurin signaling in neurodegenerative diseases, our lab has used primary rat astrocytes, transgenic and diet-induced mouse models of dementia, and human tissue biospecimens from confirmed AD and VCID cases.

To better understand mechanisms for …

Competitive Food Policy Implementation In Kentucky Schools, Paula Gisler

Theses and Dissertations--Nursing

This study was designed to explore the literature on competitive food policy implementation (CFPI); examines demographic and school factors associated with CFPI; and explores the experiences of school leaders and staff in CFPI using a proposed theoretical framework to guide the research. Competitive foods are those sold in vending machines, a la carte settings, fundraisers, class parties and other venues which compete with foods offered through the national school lunch and breakfast programs. Competitive foods have traditionally been of low nutritional value and high energy density. CFPI may be effective in reducing student calorie intake and BMI. However, evaluation of …

Molecular And Biochemical Signaling Underlying Arabidopsis-Bacterial/Virus/Fungal Interactions, Mohamed H. El-Shetehy

Theses and Dissertations--Plant Pathology

Systemic acquired resistance (SAR) is a form of inducible defense response triggered upon localized infection that confers broad-spectrum disease resistance against secondary infections. Several factors are known to regulate SAR and these include phenolic phytohormone salicylic acid (SA), phosphorylated sugar glycerol-3-phosphate (G3P), and dicarboxylic acid azelaic acid (AzA). This study evaluated a role for free radicals nitric oxide (NO) and reactive oxygen species (ROS) in SAR. Normal accumulation of both NO and ROS was required for normal SAR and mutations preventing NO/ROS accumulation and/or biosynthesis compromised SAR. A role for NO and ROS was further established using pharmacological approaches. Notably, …