Digital Commons Network^™

Electrophysiological And Imaging Calcium Biomarkers Of Aging In Male And Female 5×Fad Mice, Adam O. Ghoweri, Lara Ouillette, Hilaree N. Frazier, Katie L. Anderson, Ruei-Lung Lin, John C. Gant, Rachel Parent, Shannon Moore, Geoffrey G. Murphy, Olivier Thibault

Pharmacology and Nutritional Sciences Faculty Publications

BACKGROUND: In animal models and tissue preparations, calcium dyshomeostasis is a biomarker of aging and Alzheimer's disease that is associated with synaptic dysfunction, neuritic pruning, and dysregulated cellular processes. It is unclear, however, whether the onset of calcium dysregulation precedes, is concurrent with, or is the product of pathological cellular events (e.g., oxidation, amyloid-β production, and neuroinflammation). Further, neuronal calcium dysregulation is not always present in animal models of amyloidogenesis, questioning its reliability as a disease biomarker.

OBJECTIVE: Here, we directly tested for the presence of calcium dysregulation in dorsal hippocampal neurons in male and female 5×FAD mice on …

Manf Is Neuroprotective Against Ethanol-Induced Neurodegeneration Through Ameliorating Er Stress, Yongchao Wang, Wen Wen, Hui Li, Marco Clementino, Hong Xu, Mei Xu, Murong Ma, Jacqueline A. Frank, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Fetal alcohol spectrum disorders (FASD) are a spectrum of developmental disorders caused by prenatal alcohol exposure. Neuronal loss or neurodegeneration in the central nervous system (CNS) is one of the most devastating features in FASD. It is imperative to delineate the underlying mechanisms to facilitate the treatment of FASD. Endoplasmic reticulum (ER) stress is a hallmark and an underlying mechanism of many neurodegenerative diseases, including ethanol-induced neurodegeneration. Mesencephalic astrocyte-derived neurotrophic factor (MANF) responds to ER stress and has been identified as a protein upregulated in response to ethanol exposure during the brain development. To investigate the role of MANF in …

Pregabalin-Induced Myopathy In A Double Lung Transplant Recipient, Vishwajit Hegde, Nidhi Shekar, Filip G. Garrett, Maher A. Baz, Michael I. Anstead

Internal Medicine Faculty Publications

Pregabalin is a gamma-aminobutyric acid (GABA) derivative that was commercially approved by the Food and Drug Administration (FDA) in 2004. It is commonly used in the treatment of diabetic neuropathy, peripheral neuropathy, and spinal cord injury. We present the case of a 36-year-old Caucasian male double lung transplant recipient who presented with an 18-month history of fatigue and muscle weakness. He had elevated creatinine kinase level and his muscle biopsy showed evidence of drug-induced myopathy that improved after the cessation of pregabalin. We present a case of drug-induced myopathy as a rare complication of pregabalin therapy in a double lung …

Utilisation Of Near Infrared Spectroscopy To Optimise Productivity Of Grazing Animals In The Western Australian Rangelands, Peter Mccafferty, Gaye Krebs, Kevin Ho, Ken Dods, Kumara Mahipala

IGC Proceedings (1977-2023)

No abstract provided.

Intake And Apparent Digestibility Of Silages Obtained From Four Sunflower (Helianthus Annuus) Genotypes, Rogerio M. Mauricio, N. M. Rodriguez, L. C. Gonçalves, D. G. Jayme, J. A. S. Rodrigues, L. F. Sousa, W. G. Faria, G. O. Ribeiro

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of Defoliation Frequency And Severity During Winter On Herbage Regrowth And Water‐Soluble Carbohydrate Content Of Perennial Ryegrass (Lolium Perenne L.) Dominant Swards, Julia M. Lee, D. J. Donaghy, P. Sathish, J. R. Roche

IGC Proceedings (1977-2023)

No abstract provided.

Evaluation Of The Productivity And Grazing Capacity Of Cool Season Grasses, H. A. Lardner, C. Ward, L. Froehlich, L. Zemlak

IGC Proceedings (1977-2023)

No abstract provided.

Comparison Of Ewe Lamb Growth On Herb Based And Ryegrass Based Pastures, K. P. Golding, Paul R. Kenyon, Stephen T. Morris, Peter D. Kemp

IGC Proceedings (1977-2023)

No abstract provided.

Literature Review: Global Neonicotinoid Insecticide Occurrence In Aquatic Environments, Josephus F. Borsuah, Tiffany L. Messer, Daniel D. Snow, Steve D. Comfort, Aaron R. Mittelstet

Biosystems and Agricultural Engineering Faculty Publications

Neonicotinoids have been the most commonly used insecticides since the early 1990s. Despite their efficacy in improving crop protection and management, these agrochemicals have gained recent attention for their negative impacts on non-target species such as honeybees and aquatic invertebrates. In recent years, neonicotinoids have been detected in rivers and streams across the world. Determining and predicting the exposure potential of neonicotinoids in surface water requires a thorough understanding of their fate and transport mechanisms. Therefore, our objective was to provide a comprehensive review of neonicotinoids with a focus on their fate and transport mechanisms to and within surface waters …

Nutritional Parameters Of Grazing Calves In Milking Phase 2: Protein Metabolism, H. J. Fernandes, A. A. Rocha, J. Cavali, A. G. Silva, M. F. Paulino, L. M. Paiva, M. O. Porto, J. C. De Souza

IGC Proceedings (1977-2023)

No abstract provided.

Nutritional Parameters Of Grazing Nursing Calves 1: Rumen Microbial Production, H. J. Fernandes, J. Cavali, A. G. Silva, M. F. Paulino, A. A. Rocha, M. O. Porto, L. M. Paiva

IGC Proceedings (1977-2023)

No abstract provided.

Forage News [2020-12], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

Syphilis Hepatitis Presenting As A Mimic Of Primary Biliary Cholangitis, Cody Kern, Ahmed Elmoursi, Caroline Blake, Andrew Hoellein

Internal Medicine Faculty Publications

Syphilis hepatitis is a rare cause of acute liver injury. Primary biliary cholangitis (PBC) is a progressive autoimmune disease characterized by the typical presentation of a cholestatic liver injury and the presence of antimitochondrial antibodies (AMAs). We present a case of syphilis hepatitis that presented as a mimic to PBC with positive AMA. The eradication of syphilis led to the resolution of the liver injury and down trending of the antibody level. We recommend excluding syphilis in patients with high-risk behaviors presenting with a cholestatic liver injury and positive AMA before the diagnosis of PBC.

The Hydration Status Of Female Collegiate Soccer Players Over Consecutive Training And Match Days, Holly E. Clarke, Rebekah S. Carpenter, Katie Spain-Mansmann, James Kyle Taylor, Matthew M. Schubert

Kinesiology and Health Promotion Graduate Research

Purpose: Hydration has been shown to play a pivotal role in sport. Soccer is a team sport in which the integrity of all players is vital for team performance; thus, individual player hydration status is important. The primary aim of this study was to investigate the hydration status of female collegiate soccer players during regular season.

Methods: Sixteen collegiate female soccer players (age: 20.4 ± 0.8 years; height: 163.6 ± 6.9 cm; weight: 65.3 ± 12 kg) provided urine over 9 days to monitor their hydration status. Hydration was determined by urine specific gravity (U_sg). U_sg was …

Multicultural Competencies Of Healthcare Professionals And Disability-Inclusive In Telehealth During The Covid-19 Pandemic, Si-Yi Chao, Keith B. Wilson, Carrie L. Acklin

Early Childhood, Special Education, and Counselor Education Faculty Publications

There is evidence that people with disabilities are more likely to be discriminated against and to have disproportionate health care disparities compared to people who are able-bodied during the devastating COVID-19 pandemic. In light of COVID-19, telehealth has been transformed to the primary health care delivery due to social restrictions of most, globally. Disability-inclusive telehealth design can promote culturally diverse groups access and more accurate COVID-19 information, knowledge, public health measures, and guidelines of preventive strategies for acquiring COVID-19. Applying multicultural competencies is required for healthcare providers to maximize health engagement and outcomes of PWD. In many areas of health …

Milk Intake Improves Outcomes For Young Lambs With Continuous Exposure To Gastrointestinal Parasites In Pasture‐Based System, Robyn A. Dynes, Ray A. Moss, R. W. Mcanulty, Alec D. Mackay

IGC Proceedings (1977-2023)

No abstract provided.

Urinary‐Nitrogen Output By Dairy Cows In Conventional And Organic Grazing Systems, I. M. Brookes, David J. Horne, A. R. Thatcher

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of Community Grazing Regulation On Degraded Grasslands In Inner Mongolia, Ian Auldist, Zihong Chen, E. Erdun Baolige

IGC Proceedings (1977-2023)

No abstract provided.

Supplementary Feed To Improve The Production Of Dairy Cattle Under Zero Grazing Condition In Bangladesh, M. A. S. Khan, M. A. Islam

IGC Proceedings (1977-2023)

No abstract provided.

Tackle Epithelial-Mesenchymal Transition With Epigenetic Drugs In Cancer, Bo Dong, Zhaoping Qiu, Yadi Wu

Pharmacology and Nutritional Sciences Faculty Publications

Epithelial-mesenchymal Transition (EMT) is a de-differentiation process in which epithelial cells lose their epithelial properties to acquire mesenchymal features. EMT is essential for embryogenesis and wound healing but is aberrantly activated in pathological conditions like fibrosis and cancer. Tumor-associated EMT contributes to cancer cell initiation, invasion, metastasis, drug resistance and recurrence. This dynamic and reversible event is governed by EMT-transcription factors (EMT-TFs) with epigenetic complexes. In this review, we discuss recent advances regarding the mechanisms that modulate EMT in the context of epigenetic regulation, with emphasis on epigenetic drugs, such as DNA demethylating reagents, inhibitors of histone modifiers and non-coding …

Effect Of High And Low Pasture Allowance During Pregnancy On Ewe Lamb Pregnancy Performance, Paul R. Kenyon, F. J. Mulvaney, Stephen T. Morris, D. M. West

IGC Proceedings (1977-2023)

No abstract provided.

Lamb Growth On Leaf Turnips, White Clover And Pasture In Summer, C. L. Lindsay, Peter D. Kemp, Paul R. Kenyon, Stephen T. Morris, A. J. Wall

IGC Proceedings (1977-2023)

No abstract provided.

Response Of Plantain And Chicory To Frequency And Intensity Of Cutting, Y. Yu, M. X. Long, D. W. Zhou, Peter D. Kemp

IGC Proceedings (1977-2023)

No abstract provided.

Production System Elements Related To Fat Distribution In Beef Steers, J. W. Holloway, E. K. Bumpus, J. Sawyer, B. G. Warrington, R. R. Scott, T. D. A. Forbes

IGC Proceedings (1977-2023)

No abstract provided.

Rumen And Serum Metabolomes In Response To Endophyte-Infected Tall Fescue Seed And Isoflavone Supplementation In Beef Steers, Taylor B. Ault-Seay, Emily A. Melchior-Tiffany, Brooke A. Clemmons, Juan F. Cordero, Gary E. Bates, Michael D. Flythe, James L. Klotz, Huihua Ji, Jack P. Goodman, Kyle J. Mclean, Phillip R. Myer

Kentucky Tobacco Research and Development Center Faculty Publications

Fescue toxicosis impacts beef cattle production via reductions in weight gain and muscle development. Isoflavone supplementation has displayed potential for mitigating these effects. The objective of the current study was to evaluate isoflavone supplementation with fescue seed consumption on rumen and serum metabolomes. Angus steers (n = 36) were allocated randomly in a 2 × 2 factorial arrangement of treatments including endophyte-infected (E+) or endophyte-free (E−) tall fescue seed, with (P+) or without (P−) isoflavones. Steers were provided a basal diet with fescue seed for 21 days, while isoflavones were orally administered daily. Following the trial, blood and rumen …

The Challenges Of Cropping And Forestry Intensification On Grasslands Livestock Production Systems: The Uruguayan Case, Fabio Montossi, Walter Ayala, R. Díaz

IGC Proceedings (1977-2023)

No abstract provided.

Grand Challenge In Animal Nutrition, David L. Harmon

Animal and Food Sciences Faculty Publications

No abstract provided.

Forming Mechanism And Classification Standard Of "Black-Soil-Type" Degraded Grassland In Yangtze And Yellow River Headwater Region Of Qinghai-Tibetan Plateau, Y. S. Ma, Q. M. Dong, S. H. Yang, J. J. Shi, L. Sheng, Y. L. Wang, X. D. Sun

IGC Proceedings (1977-2023)

No abstract provided.

Regression-Derived Ileal Endogenous Amino Acid Losses In Broiler Chickens And Cannulated Pigs Fed Corn Fiber, Wheat Bran, And Pectin, Sunday A. Adedokun, Olayiwola Adeola

Animal and Food Sciences Faculty Publications

The objective of these studies was to determine the effect corn fiber (CF), wheat bran (WB) and pectin (PEC) on basal ileal endogenous amino acid (EAA) losses in broiler chickens (Exp. 1) and cannulated pigs (Exp. 2) using the regression method. Semi-purified diets containing 100 g/kg of CF, WB, or PEC (broiler chickens) and CF or PEC (pigs) were fed to replicate cages consisting of eight birds per cage of 21-d-old broiler chickens and six replicates of pigs consisting of one pig per pen. Ileal endogenous His, Glu, and Pro losses were higher (p < 0.05) for CF and WB compared with birds fed diets containing PEC. Contrasts between CF and WB showed higher (p < 0.05) ileal endogenous nitrogen, total amino acid, His, Ile, Met, Glu, Pro, and Tyr losses in birds fed the CF diets (Exp. 1). Contrasts of EAA losses between birds fed the WB and PEC diets showed higher (p < 0.05) losses for His, Glu, and Pro. In the cannulated pigs, CF resulted in higher (p < 0.05) ileal endogenous His, Leu, and Tyr losses. In summary, CF induced higher ileal EAA losses in broiler chickens and cannulated pigs.

The Landscape Of Connected Cancer Symptom Management In Rural America: A Narrative Review Of Opportunities For Launching Connected Health Interventions, Ming-Yuan Chih, Anna Mccowan, Sadie Whittaker, Melinda Krakow, David K. Ahern, Eliah Aronoff-Spencer, Bradford W. Hesse, Timothy W. Mullett, Robin C. Vanderpool

Journal of Appalachian Health

Background: The 2016 President’s Cancer Panel called for projects focusing on improving cancer symptom management using connected health technologies (broadband and telecommunications). However, rural communities, like those in Appalachia, may experience a “double burden” of high cancer rates and lower rates of broadband access and adoption necessary for connected health solutions.

Purpose: To better understand the current landscape of connected health in the management of cancer symptoms in rural America.

Methods: A literature search was conducted using four academic databases (PubMed, CINAHL, MEDLINE, and PsycINFO) to locate articles published from 2010 to 2019 relevant to connected cancer symptom management in …