Digital Commons Network^™

Nalfurafine Promotes Myelination In Vitro And Facilitates Recovery From Cuprizone + Rapamycin-Induced Demyelination In Mice, Ross Van De Wetering, Rabia Bibi, Andy Biggerstaff, Sheein Hong, Bria Pengelly, Thomas E. Prisinzano, Anne C. La Flamme, Bronwyn M. Kivell

Markey Cancer Center Faculty Publications

The kappa opioid receptor has been identified as a promising therapeutic target for promoting remyelination. In the current study, we evaluated the ability of nalfurafine to promote oligodendrocyte progenitor cell (OPC) differentiation and myelination in vitro, and its efficacy in an extended, cuprizone-induced demyelination model. Primary mouse (C57BL/6J) OPC-containing cultures were treated with nalfurafine (0.6–200 nM), clemastine (0.01–100 μM), T3 (30 ng/mL), or vehicle for 5 days. Using immunocytochemistry and confocal microscopy, we found that nalfurafine treatment increased OPC differentiation, oligodendrocyte (OL) morphological complexity, and myelination of nanofibers in vitro. Adult male mice (C57BL/6J) were given a diet con- taining …

Ezh2 Inhibition Promotes Tumor Immunogenicity In Lung Squamous Cell Carcinomas, Tanner Ducote, Xiulong Song, Kassandra J. Naughton, Fan Chen, Daniel Plaugher, Avery R. Childress, Abigail R. Gellert, Erika M. Skaggs, Xufeng Qu, Jinze Liu, Jinpeng Liu, Fei Li, Kwok-Kin Wong, Christine F. Brainson

Markey Cancer Center Faculty Publications

Two important factors that contribute to resistance to immune checkpoint inhibitors (ICI) are an immune-suppressive microenvironment and limited antigen presentation by tumor cells. In this study, we examine whether in- hibition of the methyltransferase enhancer of zeste homolog 2 (EZH2) can increase ICI response in lung squamous cell carcinomas (LSCC). Our in vitro experiments using two-dimensional human cancer cell lines as well as three-dimensional murine and patient-derived organoids treated with two inhibitors of the EZH2 plus IFNγ showed that EZH2 inhibition leads to expression of both MHC class I and II (MHCI/II) expression at both the mRNA and protein levels. …

The Effect Of A Signal Peptidase Mutation On Protein Secretion By The Maize Anthracnose Pathogen Colletotrichum Graminicola, Renata Belisario

Theses and Dissertations--Plant Pathology

Colletotrichum graminicola infects maize during several phases of plant growth, resulting in anthracnose leaf blight, stalk rot, and top die-back diseases. This ubiquitous fungus has significant destructive potential and causes millions of dollars of losses annually in North America. Colletotrichum graminicola is hemibiotrophic and initially invades living host cells via biotrophic primary infection hyphae before switching to necrotrophy and inducing host cell death, host cell-wall degradation, and lesion development.

An insertional mutation in the 3’UTR region of a gene (Cpr1), which encodes a homolog of the noncatalytic SPC22/23 subunit of the endoplasmic reticulum associated signal peptidase complex, completely …

Crowdsourced Geospatial Data Is Reshaping Urban Sciences, Xiao Huang, Siqin Wang, Tianjun Lu, Yisi Liu, Leticia Serrano-Estrada

Earth and Environmental Sciences Faculty Publications

For many years, urban sciences relied heavily on traditional, authoritative data sources. However, a paradigm shift has occurred recently with the advent of citizen-driven data contribution. This evolution in data acquisition for urban science is attributable to advancements in positioning and navigation technologies, widespread use of digital devices, the rise of Web 2.0, enhanced broadband communications, and refined data management techniques. The significance of crowdsourced geospatial data in the realm of urban sciences is now widely acknowledged. A diverse array of novel data sources has been increasingly gaining prominence. These include, but are not limited to, social media platforms, street …

Crowdsourcing Geospatial Data For Earth And Human Observations: A Review, Xiao Huang, Siqin Wang, Di Yang, Tao Hu, Meixu Chen, Mengxi Zhang, Guiming Zhang, Filip Biljecki, Tianjun Lu, Lei Zou, Connor Y. H. Wu, Yoo Min Park, Xiao Li, Yunzhe Liu, Hongchao Fan, Jessica Mitchell, Zhenlong Li, Alexander Hohl

Earth and Environmental Sciences Faculty Publications

The transformation from authoritative to user-generated data landscapes has garnered considerable attention, notably with the proliferation of crowdsourced geospatial data. Facilitated by advancements in digital technology and high-speed communication, this paradigm shift has democratized data collection, obliterating traditional barriers between data producers and users. While previous literature has compartmentalized this subject into distinct platforms and application domains, this review offers a holistic examination of crowdsourced geospatial data. Employing a narrative review approach due to the interdisciplinary nature of the topic, we investigate both human and Earth observations through crowdsourced initiatives. This review categorizes the diverse applications of these data and …

Synthesis, Characterization, And Performance Assessment Of Reusable And Biodegradable Antimicrobial Polymeric Membranes For Aerosolized Pathogen Inactivation And Filtration, Ebuka Ogbuoji

Theses and Dissertations--Chemical and Materials Engineering

Air filtration technology has proven effective in purifying air by trapping particulates which can cause adverse health effects. High Efficiency Particulate Air (HEPA) filters, capable of capturing over 99.99% of PM_0.3, are recommended for critical applications. However, conventional non-woven HEPA filters rely on electrostatic interactions to trap smaller particles, which can deplete over time or after cleaning, reducing filtration efficiency and posing health risks. Additionally, these filters contribute to plastic waste.

This dissertation investigated the feasibility of using flat sheet polymeric membranes fabricated via nonsolvent-induced phase separation (NIPS) as reusable and biodegradable alternatives to commercially available non-biodegradable air …

From Policy Sources To Research Information Management Sources: Incorporating Multiple Bibliographic Data Sources Into Dashboard Analytics, Rachel Miles

Research Analytics Summit 2024

As the availability of bibliographic data becomes more diverse and unique, so do the complexities of those sources. As a result, it can be challenging and daunting to analyze such data, especially from a single research analytics service request. In this session, the presenter will demonstrate examples of building dashboards to analyze data for research outputs of a college using data from a research information management system, a policy database, and a bibliographic database. Attendees will learn about the advantages of using RIM systems to perform analytics as well as their shortcomings; they’ll also learn how to export data from …

Introducing A ‘Research Impact Roadmap’ In A Young University: Challenges And Opportunities, Roopa Rajashekar

Research Analytics Summit 2024

‘Research Impact’ as a defined concept is expanding and garnering more attention globally. What was once positioned more narrowly and often confused with basic outcomes reporting has since risen to a primary focus for sponsor agencies across all stages of R&D. Hence, building a comprehensive research impact framework provides a critical map for universities to strengthen the R&D ecosystems in which it engages in innumerable ways.

Khalifa University of Science and Technology (KU), located in Abu Dhabi, UAE, is a relatively a young university, by Times Higher Education definition). Even so, KU ranked 238 in the QS World University Rankings …

Generating Impact Narratives With Ai, Sean Newell, Charity Elifritz

Research Analytics Summit 2024

Senior academic leaders face mounting pressure to communicate academic impact to various stakeholders, including faculty, students, funding bodies, government agencies, and the media. However, assessing impact extends beyond traditional bibliometrics, encompassing influence on policy, culture, environment, and technology, making it complex to define and measure. Moreover, the interpretation of research impact can vary significantly depending on the perspective. In this discussion, we explore how Elsevier leverages AI to integrate quantitative metrics and qualitative narratives, offering a comprehensive approach to addressing the nuanced challenge of understanding and quantifying research impact. Through real-world examples, we demonstrate the efficacy of this approach and …

Flexible Attenuation Fields: Tomographic Reconstruction From Heterogeneous Datasets, Clifford S. Parker

Theses and Dissertations--Computer Science

Traditional reconstruction methods for X-ray computed tomography (CT) are highly constrained in the variety of input datasets they admit. Many of the imaging settings -- the incident energy, field-of-view, effective resolution -- remain fixed across projection images, and the only real variance is in the detector's position and orientation with respect to the scene. In contrast, methods for 3D reconstruction of natural scenes are extremely flexible to the geometric and photometric properties of the input datasets, readily accepting and benefiting from images captured under varying lighting conditions, with different cameras, and at disparate points in time and space. Extending CT …

“Your Legs Don’T Look All That Good” An Analysis Of Impoliteness And Politeness In Individuals With Traumatic Brain Injuries In The Workplace, Grace Kozal

Theses and Dissertations--Communication Sciences and Disorders

Background: Social communication disorders are a common outcome from traumatic brain injury (TBI). This social communication disorder can be seen through impolite speech acts during conversation. While politeness is a social norm for workplace discourse, instances of impoliteness may have poor consequences. This research explores the use of impoliteness in persons with TBI within computer generated work-based conditions.

Methods: Language samples from the Voicemail Elicitation Task (VET) and Feedback/Advice Spoken Task (FAST) were transcribed word-for-word. Transcripts from all 62 participants were coded for impoliteness using a developed Impoliteness Codebook and were analyzed to identify significant differences in the number of …

Knowledge, Experiences, And Perceptions Of Medications For Opioid Use Disorder Among Black Kentuckians, Paris B. Wheeler, Brittany Miller-Roenigk, Jasmine Jester, Danelle Stevens-Watkins

Educational, School, and Counseling Psychology Faculty Publications

Background: Opioid overdoses have continued to increase at higher rates among Black Americans compared to people from other racial groups. Despite demonstrated effectiveness of MOUD in reducing risk of opioid overdose, Black Americans face decreased access to and uptake of MOUD. the current study aimed to examine the knowledge, perceptions, and experiences with MOUD among a sample of Black adults who use prescription opioids nonmedically in order to inform tailored efforts to improve MOUD uptake.

Methods: Data were derived from a larger study assessing cultural and structural influences on drug use and drug treatment among people who use prescription opioids …

Two Perspectives On Immigrants In The Labor Market: The Immigration Act Of 1990, Shria Holla

Gaines Fellow Senior Theses

When evaluating the impact of immigration, extant economic literature has overwhelmingly focused on natives and men. The widely accepted methodology in the literature usually segments by education and by experience. Segmenting by education has been found to not be viable for immigrants due to immigrant downgrading, and experience is not conducive for women since it is calculated based on age. Through both an empirical analysis and an ethnography, this study takes the initial steps to include existent immigrants and women in the discussion. The economic empirical analysis evaluates the impact of immigration on existent immigrants, a growing portion of the …

A Sampling Strategy For Longitudinal And Cross-Sectional Analyses Using A Large National Claims Database, Timothy L. Mcmurry, Jennifer M. Lobo, Soyoun Kim, Hyojung Kang, Min-Woong Sohn

Health Management and Policy Faculty Publications

Importance: The United States (US) Medicare claims files are valuable sources of national healthcare utilization data with over 45 million beneficiaries each year. Due to their massive sizes and costs involved in obtaining the data, a method of randomly drawing a representative sample for retrospective cohort studies with multi-year follow-up is not well-documented.

Objective: To present a method to construct longitudinal patient samples from Medicare claims files that are representative of Medicare populations each year.

Design: Retrospective cohort and cross-sectional designs.

Participants: US Medicare beneficiaries with diabetes over a 10-year period.

Methods: Medicare Master Beneficiary Summary Files were used to …

"And I / Am The Arrow": The Narrative, Personae Construction, And Language Ideology Of Confessional Poets' Identity Performance, Madison Fuchs

Theses and Dissertations--Linguistics

This thesis argues for consideration of linguistic features in service of raising the postmodern confessionalist poet identity as an utterance and an act of loyalty to performance. The embodiment of the confessionalist identity, attributed to the features used to adhere to the confessional mode, is realized through the invention of confessional personae. These confessional personae merge the responsibilities of the speaker and the narrator to convey a pseudo-autobiographical utterance to a designated audience. In this thesis, I analyze a sequence of poems that either possess taboo subjects or utilize linguistic functions, like indexicality and audience design, that mark its mode. …

Quantitative Sustainable Design Of Urban Tree Soil Cells For Stormwater Management, Jamaya Wilson

Theses and Dissertations--Civil Engineering

Urban trees are critical assets to cities around the world. They act as a green infrastructure system to provide various environmental, economic and social benefits to their surrounding environments. However, the quality of life of urban trees is severely threatened by uncontrolled urbanization and climate change. The compaction of urban soils to meet the structural stability requirements for buildings and pavements directly restricts tree growth. Soil cells are green infrastructure placed in tree wells to transfer active and static loads to pavements. This allows for reduced soil compaction and increased tree root expansion. However, because the technology is still in …

Revolutionizing Our Understanding Of Specific Platelet-Pathogen Interactions, Hammodah Rawhi Hammodah Alfar

Theses and Dissertations--Molecular and Cellular Biochemistry

Aside from their classical role in maintaining hemostasis, platelets are considered first-line vascular guardians that influence both the innate and adaptive immune systems. This is mediated by either direct interactions with immune cells or through the release of pre-stored cytokines and chemokines upon interacting with pathogens such as viruses. While this establishes platelets as potential players in the response to pathogens, it remains unclear what platelets can do with pathogens and how important that is to immune responses, especially against viruses. Most systemic viremias, such as HIV-1, present with mild thrombocytopenia, which is mediated through several mechanisms such as a …

Wine, Other, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Wine, Red, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Wine, White, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.

Bringing Artificial Intelligence To Research Analytics Research Highlighter-Matchmaker At Suny Ualbany, Tianning Huang, Yuemin Li

Research Analytics Summit 2024

Research analytics has become an indispensable part in today’s higher education institutions’ organizational structure. It not only provides a mechanism or platform to present research awards and expenditures data to internal and external data users, but also serves a superior tool that enables data-driven strategic decision makings with more reliable, valid, and in-depth analysis. The development of Artificial Intelligence techniques could push the boundary of Research Analytics to an even higher level by incorporating the abundance of data scattered across the university. We propose to present one attempt adopted by University at Albany, State University of New York (UAlbany) to …

Collabnext -A Person-Focused Open Knowledge Graph For Collaborations With Emerging Researchers, Lew Lefton

Research Analytics Summit 2024

CollabNext is being developed as part of the NSF ProtoOKN (Prototype Open Knowledge Network) effort. This project originated as a partnership between Georgia Tech and the Atlanta University Center, and is now being developed jointly by Fisk University, Georgia Tech, Morehouse College, Texas Southern University, and University at Buffalo with support from the NSF TIP Directorate.

Our goal is to develop a knowledge graph based on people, organizations, and research topics. We are adopting an intentional design approach which initially prioritizes HBCUs and emerging researchers in a deliberate effort to counterbalance the Matthew effect, a naturally accumulated advantage of well-resourced …

Reaching Beyond Research How A Research Information Management System Can Empower Your Analytics And Energize Your Outreach, Jeff Agnoli, Alexandra Winzeler

Research Analytics Summit 2024

Expertise Finder Systems and Research Information Management System (RIMS) provides administrators and scholars the ability to collect, curate, and highlight their research activity, and the reporting tools to assist with strategic decisions and generate meaningful outreach.

Jeff Agnoli, Senior Liaison for Strategic Partnerships at the Ohio Innovation Exchange, shares his 10+ years of experience using these tools to connect industry partners and researchers across the State of Ohio and beyond. Alexandra Winzeler, Business Development Manager from Digital Science showcases the benefits and efficiencies of using Symplectic Elements to streamline research collection and promote collaboration.

See how built-in integration and automation …

The Semiotics Of Smell: Gender, Materiality, And The Language Of Fragrances, Kathryn Copeland

Theses and Dissertations--Linguistics

Fragrances have long been used in a variety of cultures to communicate or articulate perceptions of different types of people or personae (Classen, Howes, & Synnott; 1994); however, the meanings “articulated” by fragrances have rarely been studied through the analytical frameworks of indexicality, enregisterment, and materiality (Eckert, 2008; Johnstone, 2016; Miller, 2005; Silverstein, 2003).

To do this, I first conducted a quantitative corpus analysis of user-generated reviews of popular perfumes on the fragrance database Fragrantica to identify differences in how reviewers of “men’s” fragrances and “women’s” fragrances describe their experience with the fragrances, and what these patterns indicate about how …

De Historia Linguae Latinae In Columbia, Esteban Arango Casas

Theses and Dissertations--Modern and Classical Languages, Literature and Cultures

Abstract: Latin was the official language of ancient Rome, and consequently it saw its rise and fall. Nevertheless, it did not disappear after the Roman Empire fell. Latin continued thriving during the Middle Ages and the Renaissance, but it did not stay only in Europe. It went overseas and reached other continents like Asia, Africa, and finally America. Unfortunately, there were opinions that Latin in the Americas was of a lesser quality. For that reason, we thought important to show some of the most skillful Latin writers in Colombia. We selected three authors who were born in Colombia or who …

Can Temporary Signs Remind Who Should Yield At Uncontrolled Intersections? – A Driving Simulator Study, Kirti Mahajan, Saumik Sakib Bin Masud, Grace Savoie, Alexandra Kondyli

Kentucky Transportation Center Presentations

Background: A generic right of way (ROW) rule at uncontrolled intersections is to yield to the vehicle from the right, if not stated otherwise in the right-hand side driving countries such as the US. However, this rule is greatly neglected in practice, resulting in unsafe situations. This study investigated the effectiveness of using two proposed temporary yield signs: “Yield to Traffic on right” (Sign1_YT) and “Yield to Person on right” (Sign2_YP), to remind the drivers of ROW rule at uncontrolled intersections. Method: A driving simulator experiment was conducted with 20 drivers (aged 18-65 years), 50% males, recording observations for 198 …

The Power Of The Electorate Under State Constitutions, Joshua A. Douglas

Law Faculty Scholarly Articles

Voters are special. They are the foundation of our constitutional democracy. Everything starts with the voters.

State constitutions, too, are special, as the recent surge in scholarship on state constitutions demonstrates.

This Article bridges the gap between various strands of scholarship on state constitutions, the right to vote, and democracy, making several novel claims about the way in which state constitutions protect voters. First, this Article canvasses all fifty state constitutions to conclude that they contain multiple levels of protection for the right to vote through numerous clauses that, in combination, elevate the status of voters in the constitutional structure. …

The Fourth Estate's Estate, Ramsi Woodcock

Law Faculty Scholarly Articles

The news industry in the United States faces a funding crisis because the tech giants, particularly Google and Facebook, have acceded to the advertising monopolies once enjoyed by the newspaper industry itself. Breakup of these monopolies is unlikely to restore the news industry’s profits, however, because search and social media will remain better ad distribution channels than the news whether search and social media are competitive or monopolized. A better solution to the funding crisis would be for government to divide the advertising distribution market, reallocating to the news industry some of the ad impressions taken from it by the …

Ductus Exemplo: A Model Municipal Executive Order On Food Waste Reduction, Linda Breggin, Darby Hoover, Jessica Sugarman

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Pollution Discrimination: The Epa’S Utilization Of Title Vi Of The Civil Rights Act To Bring Justice To Overburdened African American Communities, Lindsay Bates

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.