Digital Commons Network^™

University Of Kentucky Libraries' Libqual+ Report 2024, Julene L. Jones

Library Faculty and Staff Publications

Report of University of Kentucky's 2024 LibQUAL+ results

Decentralized Clinical Trials For Medications To Reduce The Risk Of Dementia: Consensus Report And Guidance, Leanne Howard, Carla Abdelnour, Erin Abner, Ricardo F. Allegri, Hiroko H. Dodge, Serge Gauthier, Camilla M. Hoyos, Gregory Jicha, Patrick G. Kehoe, Catherine J. Mummery, Adesola Ogunniyi, Nikolaos Scarmeas, Xiaoying Chen, Jodie R. Titiner, Christopher R. Weber, Ruth Peters

Neurology Faculty Publications

INTRODUCTION: Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated with decentralized medication trials, but we currently lack specific recommendations for their delivery in the dementia field.

METHODS: A modified Delphi method engaged an expert panel to develop recommendations for the conduct of decentralized medication trials in dementia prevention. A working group of researchers and clinicians with expertise in dementia trials further refined the recommendations.

RESULTS: Overall, the recommendations support the delivery of decentralized trials in dementia prevention …

Type-2 Diabetes, Pancreatic Amylin, And Neuronal Metabolic Remodeling In Alzheimer's Disease, Noah Leibold, James R. Bain, Florin Despa

Neurology Faculty Publications

Type-2 diabetes raises the risk for Alzheimer’s disease (AD)-type dementia and the conversion from mild cognitive impairment to dementia, yet mechanisms connecting type-2 diabetes to AD remain largely unknown. Amylin, a pancreatic 𝜷-cell hormone co-secreted with insulin, participates in the central regulation of satiation, but also forms pancreatic amyloid in persons with type-2 diabetes and synergistically interacts with brain amyloid 𝜷 (A𝜷) pathology, in both sporadic and familial Alzheimer’s disease (AD). Growing evidence from studies of tumor growth, together with early observations in skeletal muscle, indicates amylin as a potential trigger of cellular metabolic reprogramming. Because the blood, cerebrospinal fluid, …

Β-Aminopropionitrile Induces Distinct Pathologies In The Ascending And Descending Thoracic Aortic Regions Of Mice, Michael K. Franklin, Hisashi Sawada, Sohei Ito, Deborah A. Howatt, Naofumi Amioka, Ching Ling Liang, Nancy Zhang, David B. Graf, Jessica J. Moorleghen, Yuriko Katsumata, Hong S. Lu, Alan Daugherty

Biostatistics Faculty Publications

BACKGROUND: β-aminopropionitrile (BAPN) is a pharmacological inhibitor of LOX (lysyl oxidase) and LOXLs (LOX-like proteins). Administration of BAPN promotes aortopathies, although there is a paucity of data on experimental conditions to generate pathology. The objective of this study was to define experimental parameters and determine whether equivalent or variable aortopathies were generated throughout the aortic tree during BAPN administration in mice. METHODS: BAPN was administered in drinking water for a period ranging from 1 to 12 weeks. The impacts of BAPN were first assessed with regard to BAPN dose, and mouse strain, age, and sex. BAPN-induced aortic pathological characterization was …

Ceramide-Mediated Orchestration Of Oxidative Stress Response Through Filopodia-Derived Small Extracellular Vesicles, Zainuddin Quadri, Ahmed Elsherbini, Simone M. Crivelli, Salim S. El-Amouri, Priyanka Tripathi, Zhihui Zhu, Xiaojia Ren, Liping Zhang, Stefka D. Spassieva, Mariana N. Nikolova‑Karakashian, Erhard Bieberich

Markey Cancer Center Faculty Publications

Extracellular vesicles (EVs) are shed from the plasma membrane, but the regulation and function of these EVs remain unclear. We found that oxidative stress induced by H 2 O 2 in Hela cells stimulated filopodia formation and the secretion of EVs. EVs were small (150 nm) and labeled for CD44, indicating that they were derived from filopodia. Filopodia-derived small EVs (sEVs) were enriched with the sphingolipid ceramide, consistent with increased ceramide in the plasma membrane of filopo- dia. Ceramide was colocalized with neutral sphingomyelinase 2 (nSMase2) and acid sphingomyelinase (ASM), two sphingomyelinases generating ceramide at the plasma membrane. Inhibition of …

Diffuse Reflectance Spectroscopy For Optical Characterizations Of Orthotopic Head And Neck Cancer Models In Vivo, Pranto Soumik Saha, Jing Yan, Caigang Zhu

Markey Cancer Center Faculty Publications

We demonstrated an easy-to-build, portable diffuse reflectance spectroscopy device along with a Monte Carlo inverse model to quantify tissue absorption and scattering-based parameters of orthotopic head and neck cancer models in vivo. Both tissue-mimicking phantom studies and animal studies were conducted to verify the optical spectroscopy system and Monte Carlo inverse model for the accurate extraction of tissue optical properties. For the first time, we reported the tissue absorption and scattering coefficients of mouse normal tongue tissues and tongue tumor tissues. Our in vivo animal studies showed reduced total hemoglobin concentration, lower tissue vascular oxygen saturation, and increased tissue scattering …

The Influence Of Light On The Succession Of Calcareous Grassland Using A Gis As An Instrument For Analysis, G Spatz, Th Fricke

IGC Proceedings (1977-2023)

The change of light transmission along a gradient from shrub center to open grassland and its correlation to vegetation composition has been studied in two shrub surroundings on abandoned calcareous grassland. Light measurements were made at soil surface locations in high density and later interpolated to area maps. Low-growing plants were mapped in plots within the shrub area and their shapes subsequently digitized. Using SPANS GIS an overlay of maps representing light transmission, distance to shrub center and apearance of low-growing plants was made by calculating averages in a specified grid to create data sets for a statistical evaluation. The …

Improvement Of Forage And Seed Yields In Orchardgrass In Western Canada, Joanna Fraser, Surya N. Acharya

IGC Proceedings (1977-2023)

Trials on orchard grass (Dactylis glomerata L.) were conducted on spaced plants in 1992 and 1993 in Lethbridge, Alberta to identify components that could be used for improvement of winterhardiness and seed yields in this species. Results showed that seed yield/plant was significantly higher in Kay than Chinook orchard grass but only in 1992. Seed yields were significantly correlated in each year with visual scoring for forage yield potential, seed yield potential, vegetative height, panicle length and panicle number/plant. Higher yielding plants were taller and had larger numbers of panicles/plant and longer panicles than lower yielding plants. A large …

Manitoba’S Forage/Livestock Technology Transfer System, A F. Stewart, K H. Ominski

IGC Proceedings (1977-2023)

There have been significant advances in forage/livestock technology systems in Western Canada in the past fifty years, including the introduction of new forage species and varieties, as well as new advances in harvesting, storage and cattle production systems. Adoption of new technology in Manitoba has been expedited by an extension system that involves all sectors of the agricultural community from primary producers and researchers to extension personnel and members of the agribusiness community all of whom are working together to find solutions to the local and regional challenges facing forage and livestock producers.

Manitoba Green Gold- An Extension Project Linking High Quality Hay With High Profits, Dennis Joosse

IGC Proceedings (1977-2023)

Improving the quality of harvested forage is seen as an important step in improving the productivity of Manitoba’s beef, dairy and cash hay operations. One of the most important determinants of forage quality is stage of maturity when harvested. Timely cutting is particularly important during first cut because it represents a major portion of the total harvest, and forage quality drops rapidly during this period.

Networking Advisory Groups And Electronic Media To Transfer Information On Forage Management, J J. Mullahey, R M. Muchovej, K U. Hill

IGC Proceedings (1977-2023)

The objective of this paper is to discuss a coordinated multi-county extension program in forages through the involvement of a beef/ forage advisory committee and technology transfer or information dissemination using electronic media.

Farmer Participation In The Development And Implementation Of A New Technology: Introduction Of Lucerne (Medicago Sativa L.), A Perennial Legume, Into South-West Western Australia, L J. Blacklow, P Cocks

IGC Proceedings (1977-2023)

Australia since its demise due to insect attack in the 1970s. With new insect resistant varieties lucerne is once again becoming a viable pasture option for farmers. There is however, a slow rate of adoption of lucerne for a number of social and economic factors. The main limitations to the adoption of lucerne by farmers are past negative experience, farm systems dominated by annual pastures, changing wool and wheat commodity prices and perceived establishment and management difficulties. To overcome these socio-economic limitations a Model of Lucerne Adoption was developed in which the target group for the technology, the farmer, took …

Case Studies- A Useful Tool For Integrating Socio-Economic Data Into Grazing Systems Research, N D. Macleod

IGC Proceedings (1977-2023)

Grazing systems research and development (R&D) projects can provide important information on which to base management principles to integrate conservation management into grazing production systems. However, the adoption of these principles into practice remains largely unfulfilled. Most grazing experiments give limited attention to the socio-economic context of pastoral management. The paper suggests that one way of incorporating R&D findings and presenting them within a context that is more acceptable to decision-makers is via a case study approach. That is, use the considerable communication potential of the approach.

Forage Information System On The World Wide Web, D B. Hannaway, S Griffith, P Hoagland, M Runyon, R Fisher

IGC Proceedings (1977-2023)

The Forage Information System on the World Wide Web (FIS WWW) is a global forage information resource envisioned to become a comprehensive information system for all aspects of forages. WWW technologies provide an opportunity to link people and information in a work-sharing and access-on-demand environment via interlinking of computers. The FIS is a collection of Internet-based forage information linked and accessible via WWW access software programs (browsers), like NetscapeR. Browsers provide a unified interface for information on the Internet. They make it possible to access formatted text, color pictures, sound, and video. The “superstructure” for FIS WWW is being developed …

Separate Harvest Of Leaves From The Stems Of Lucerne Stands, L Schmidt

IGC Proceedings (1977-2023)

Lucerne leaves have significantly higher crude protein and lower crude fibre contents than the stems. The present methods for separating the leaves from the stems have serious deficiencies. Early harvesting, for example, weakens the lucerne stand, and sifting after artificial drying impairs quality. Above that, preparation of leaf protein concentrates is rather expensive. Field trials with a pronged cylinder which strips the leaves from the stems produced leaf yields of ž 80 % with a stem portion of £ 15 % (containing ž 26 % crude protein and £ 18 % crude fibre in the dry matter). Lucerne leaves can …

The Role Of Seeds Rate In Higher Persistence On Newly Established Meadows, P Golinski, S Kozlowski

IGC Proceedings (1977-2023)

The paper presents results of a 7-year experiment concerning four mixtures applied for the renewal of meadows using the method of conventional tillage. The increase of the seed rate guarantees that the final composition of the obtained sward resembles the composition of species used in the sowing mixture and, what is equally important, this composition remains unchanged for a long period of utilization of meadows subjected to this method of renovation. Denser sowing restricts the appearance in the sward of species not used in the sowing mixture. Furthermore, it allows the development of a much more compact sward with a …

Restoration Of Degraded Coastal Grasslands In The Falkland Island, J A. Kerr

IGC Proceedings (1977-2023)

In the Falkland Islands the coastal grasslands are the most valuable for wool production and important habitats for wildlife. Tussac grass (Parodiochloa flabellata Lam.) and sandy areas which support an Ammophilia - Elymus association have been degraded by overgrazing, burning and invasion by alien flora and fauna. Traditional approaches to restoration, mainly by replanting, have had limited success. Research on

Monitoring Kinetics Of Readily Available Fermentable Components By Means Of In-Vitro Gas Production, G Pichard, G Jaurena, M A. Bruni

IGC Proceedings (1977-2023)

In vitro rumen incubations were used for measuring substrate disappearance and gas production dynamics. Samples were neutral detergent extracts of alfalfa and orchardgrass with or without added glucose. A logistic multi-pool model was used for describing feed fractions with distinct kinetic parameters, namely pools A, B1, B2 and C that represent fractions of increasing refractoriness. This technique based on gas measurement allowed to monitor early fermentation kinetics of readily available substrates thus overcoming the limitations encountered in traditional in vitro substrate disappearance. Pools A, B1 and B2 showed specific rates near 0.14 , 0.08 and 0.02 and lags of zero, …

Quantifying The Effect Of Grasses On Soil Physical Quality Of Fine Sandy Loams In Prince Edward Island, M R. Carter

IGC Proceedings (1977-2023)

Grasses are considered to be beneficial for soil structure but little quantifiable data is available. The objective of this study was to characterize the soil pore size distribution of a fine sandy loam under long-term perennial grass, compared to an adjacent cultivated area, in Prince Edward Island. Differentiating soil porosity into functional classes important to root growth, based on pore size, indicated that the soil structural form under timothy (Phleum pratense L.) was superior than that developed under continuous cultivation. Under timothy, the volume of soil pores > 9 mm were generally greater, over the 8 to 24 cm soil …

Effects Of Inoculation With Lactobacillus Casei Subsp. Rhamnosus At Ensiling On Fermentation And Flora Of Lactic Acid Bacteria Of Grass Silages, T Masuko, F Kitajima, S Okada, T Uchimura

IGC Proceedings (1977-2023)

The purpose of this study was to determine whether the inoculation with Lactobacillus casei subsp. rhamnosus (L.c.r) at ensiling would improve the fermentation and affect the flora of lactic acid bacteria of orchardgrass (Dactylis glomerata L) and timothy (Phleum pratense L) silages. The fermentation quality of orchardgrass and timothy silages were improved by the addition of L.c.r and Lactobacillus casei subsp. casei (L.c.c) except orchardgrass silage stored at 15°C. In orchardgrass and timothy silages, the species of lactic acid bacteria in the control silages was different than the inoculated silages. At 15°C and 35°C, L.c.r was dominant in …

Increasing Grassland Biodiversity Within The Environmentally Sensitive Areas Scheme In The U.K, S Peel

IGC Proceedings (1977-2023)

The ESA scheme is the main vehicle in the UK for increasing biodiversity on agricultural land. It is voluntary, and payments are made to compensate for reduced profitability when prescribed practices are followed. These include conversion of cropping land to grassland, zero fertiliser use and late cutting for hay. The scheme is supported by an R & D programme aimed particularly at practical problems arising from the need to reconcile environmental targets with the need to maintain viable and profitable livestock systems. The paper cites examples of this R & D, including choice of seeds mixtures, the role of soil …

Genomic Cloning Of Fasciola Hepatica Excretory-Secretory Antigenic Genes In E. Coli, Xu Heng, Zheng Li, Liu Shigui, Shen Bin, Wu Fend

IGC Proceedings (1977-2023)

A complementary DNA (cDNA) library was constructed from the mRNA of adult worms of Fasciola hepatica in the expression vector gt11, the size of the library contained approximately 2.4 x 105 recombinants and the recombinant efficiency was 85%. The library was directedly screened with a rabbit antisera raised against a excretory-secretory (ES) antigen of Fasciola hepatica. Two positive clones of strong signal were selected from a group of 200 positive clones, named FH3 and FH7. The length of external fragments of two recombinants were 0.85Kb (FH3) and 1.15Kb (FH7). The E.coli 1089 host was infected by recombinants FH3 and FH7 …

Responses Of Red Clover To Inoculation With Endophytic Bacteria From Root Nodules, A V. Sturz, B R. Christie, B G. Matheson, J Nowak

IGC Proceedings (1977-2023)

The aim of this study was to identify endophytic bacteria isolated from the nodules of healthy red clover plants (Trifolium pratense L.) and to assess their effects, alone and in combination with Rhizobium, on the growth and development of red clover seedlings. Clover root nodules were host to 12 bacteria species other than rhizobia. In root bacterization experiments, root nodule bacteria often promoted in vitro growth and nodulation of red clover when applied in combination with R. leguminosarum BV trifolii. Instances of growth depression were fewer in mixed than in individual bacterial applications. Single isolate applications of Rhizobium species to …

X-Ray Stereoscopic Radiographs Of Macropore Structures Formed By The Roots In Grassland Soils, K Sato, T Moroizumi

IGC Proceedings (1977-2023)

The objective of this study was to examine the morphology of macropores with respect to drainage and water-retention in the root zones under grassland soils. Soil samples were taken in Japan, the U.K. and China. The structures of macropores were studied threedimensionally by examining the macropore morphology using Xrays and contrast media. The pore morphology studied in grassland soils indicate that the shapes of most macropores in drainage and water-retention pores were formed by roots. The pores formed by grass roots were found to play an important part in the macropore forms found in grassland soils.

Effect Of Defoliation Intensity On The Absolute And Relative Growth Rates Of 'Grasslands Puna' Chicory, G D. Li, P D. Kemp, J Hodgson

IGC Proceedings (1977-2023)

The response of absolute and relative growth of 'Grasslands Puna' chicory (Cichorium intybus L.) to defoliation intensity was examined in a glasshouse. Five defoliation intensities (0, 50, 100, 150 and 200 mm above media level), at 3 week intervals with 4 replications were arranged in a completely randomised design. The aboveground relative growth rate of Puna chicory increased exponentially as defoliation intensity increased, resulting in defoliation intensity not decreasing average absolute growth rate until weeks 9-12. However, there were significant differences in belowground mass between defoliation intensities from week 6 onwards. Defoliation above 150 mm, with 3 week intervals, is …

Rhizobial And Nutritional Responses Of Desmanthus Clay Soils Of Queensland, N J. Brandon, R A. Date, R M. Jones, R L. Clem, G A. Bahnisch, P R. Spies, A Becerra, B A. Robertson, T.W G. Graham

IGC Proceedings (1977-2023)

The objective of these studies was to determine the reasons for chlorosis of desmanthus observed at some sites in southeast Queensland. Inoculation with Rhizobium increased growth of desmanthus in 2 of 4 soils in the field and 4 of 8 soils in pots. Greatest responses occurred in soils with few or no effective native Rhizobium. Most soils however, contained native strains that were effective. Omission of sulphur significantly reduced dry weight of desmanthus grown in pots in 5 of 7 soils by 30-51% relative to plants supplied with all nutrients. Omission of P and Mo resulted in similar yield reductions …

Effect Of Nitrogen And Potash Fertilization On Dry Matter Yield And Mineral Composition Of Pangolagrass, J B. Andrade, C L. Justo, J.L. V. Coutinho, R M. Peres, E Ferrari Junior, V T. Paulino, W Henrique, J C. Werner, H B. Mattos

IGC Proceedings (1977-2023)

The effect of nitrogen and potash fertilizations on dry matter and protein yields and chemical composition of pangolagrass (D. decumbens Stent.) was studied in a randomized block design with four replications using a 2 x 2 factorial arrangement. Nitrogen and potash were applied after each cut as an equivalent to 3 and 2% of dry matter (65°C) yield, respectively. There were great increases in dry matter and protein yields when nitrogen alone or combined with potash was used. Potash fertilization alone had no effect on the variables described above. Nitrogen fertilization improved forage pangolagrass composition, being particularly effective on crude …

Effectivity Of Arbuscular Mycorrhizas In Sustainable Grassland Agriculture Following Conversion From Intensive Management, W R. Eason, J Scullion, E P. Scott

IGC Proceedings (1977-2023)

With increased interest in sustainable agriculture, attention has focused on the role of arbuscular mycorrhiza (AM) in the productivity of agricultural systems. AM spores were taken from grassland and grass-arable systems with either a history of high-input, conventional, or low-input, organic management, and used as a source of inoculum in host plants (Allium amelioprasum, Trifolium repens and Lolium perenne). Spores from organic management systems produced a greater yield response than those from conventional systems. Where various spore inoculum produced differences in host growth responses, it was observed that the infected root of these host plants also produced similar …

This Be The Beloved Curse: Learning To Love Ever-Evolving Born-Digital Description, Ruth E. Bryan, Megan M. Mummey, Andrew Mcdonnell

Library Presentations

The title of the presentation, “This be the beloved curse” is taken from Philip Larkin’s poem “This be the curse.” In it, Larkin describes the cycle of life where children are messed up by their parents, who, with the best intentions, “...fill you with the faults they had/and add some extra, just for you.” He goes on to explain, though, that our parents, in their turn, were equally messed up “...by fools in old-style hats and coats…”, handing on what Larkin terms “misery” from one generation to another.

As archivists, and especially as archivists working with digital formats, our “beloved …

Small Island Risks: Research Reflections For Disaster Anthropologists And Climate Ethnographers, Crystal A. Felima

UK CARES Faculty Publications

Disasters and climate-related events, including tropical storms, droughts, coastal erosion, and ocean acidification, threaten small island nations. Given the urgency of reducing disaster risks and the effects of climate change on vulnerable populations, this reflection essay pursues three objectives. First, it highlights the role of anthropology, ethnography, and multi-sited research in exploring disaster impacts, climate crises, and public policy in island communities. It then highlights national planning and inter-regional activities to build awareness of various risk reduction efforts by island nations and multi-governmental organizations. This article concludes with discussion prompts to engage researchers, scholars, students, and practitioners studying and working …