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Model Predictive Control Of 5l-Anpc Inverter Fed Coreless Afpm Motor With Mitigated Cmv In Electric Aircraft Propulsion, Farzad Y. Notash, Matin Vatani, Jiangbiao He, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper proposes a fast model predictive control (FMPC) method without weighting factors and mitigated common-mode voltage (CMV) for a five-level active neutral point clamped (5L-ANPC) inverter-fed electric aircraft propulsion system with a coreless axial flux permanent magnet (CAFPM) motor. This motor is specifically designed for electric aircraft propulsion through a combined electromagnetic and thermal evaluation, benefiting from a high specific power density, efficiency, and integrated thermal management system. The proposed method utilizes the deadbeat approach to calculate the reference voltage vector and compensate for the one-time interval delay between the predicted and applied switching commands. The angle and amplitude …

Analytical And Fe Modeling For The Design Of Coreless Axial Flux Machines With Halbach Array And Surface Pm Rotors, Matin Vatani, Yaser Chulaee, John F. Eastham, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper introduces a rapid analytical modeling approach for coreless axial flux permanent magnet (AFPM) machines featuring surface-mounted and Halbach PM array rotors. The methodology employs a 2D model at an arbitrary diameter of the machine and converts AFPM machines into an equivalent linear machine. Initially, equations for PM flux density, accounting for harmonic content, are developed for both rotor types. Subsequently, a force equation is derived for the 2D equivalent machine based on the Lorentz force equation and the stator winding factor. In the final step, a torque equation at an arbitrary diameter—specifically, the average diameter in this paper—is …

Multi-Disk Coreless Axial Flux Permanent Magnet Synchronous Motors With Surface Pm And Halbach Array Rotors For Electric Aircraft Propulsion, Matin Vatani, John F. Eastham, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper presents multiple single- and multi-disk coreless axial flux permanent magnet (AFPM) motors, focusing on specific power density and reliability for electric aircraft propulsion. Several 3D finite element analysis (FEA) parametric studies were conducted to assess the geometric impacts on a single-disk coreless AFPM motor featuring two separate stators and a double-sided Halbach array rotor configuration. These studies form the foundation for the design of both single and multi-disk machines. Single-disk coreless AFPM motors with rotor back iron embedded between the stators, offering magnetically decoupled stators, are subsequently introduced. The paper concludes by presenting four multi-disk coreless AFPM motor …

Multi-Wound Axial Flux Generators With Halbach Array Rotors, Matin Vatani, Yaser Chulaee, John F. Eastham, Xiaoze Pei, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper presents three coreless axial flux permanent magnet (AFPM) generator topologies that feature magnetically and electrically decoupled outputs using a single prime mover. The proposed topologies include: (1) two separate generators mounted on the same shaft, (2) a nested configuration with a smaller generator inside a larger one, and (3) a multi-wound generator with two sets of windings and different pole numbers for each rotor side. The multi-wound generator is selected for further investigation due to its superior power-to-volume ratio and the advantage of utilizing a single structure for stator cooling. The airgap magnetic flux density equation is derived …

Bacillus Thuringiensis Cry14a Family Proteins As Novel Anthelmintics Against Gastrointestinal Nematode Parasites, Duy Hoang, Kelly Flanagan, Qian Ding, Nicholas R. Cazeault, Hanchen Li, Stefani Díaz-Valerio, Florentina Rus, Esther A. Darfour, Elizabeth Kass, Katherine H. Petersson, Martin Krarup Nielsen, Heiko Liesegang, Gary R. Ostroff, Raffi V. Aroian

Veterinary Science Faculty Publications

Bacillus thuringiensis crystal (Cry) proteins have been expressed in commercial transgenic crops for nearly 30 years, providing safe and effective control of insect pests and significantly reducing the application of hazardous chemical pesticides. B. thuringiensis crystal proteins have also been shown to target parasitic nematodes, including plant parasitic nematodes. Recently, transgenic soybean crops expressing Cry14Ab have been shown to provide control against the soybean cyst nematode Heterodera glycines, marking the first time a crystal protein is being commercialized in transgenic crops for control of a nematode pest. However, apart from H. glycines and the free-living nematode, Caenorhabditis elegans, the breadth …

Communities That Heal Intervention And Mortality Including Polysubstance Overdose Deaths: A Randomized Clinical Trial, Bridget Freisthler, Rouba A. Chahine, Jennifer Villani, Redonna Chandler, Daniel J. Feaster, Svetla Slavova, Jolene Defiore-Hyrmer, Alexander Y. Walley, Sarah Kosakowski, Arnie Aldridge, Carolina Barbosa, Sabana Bhatta, Candace Brancato, Carly Bridden, Mia Christopher, Tom Clarke, James David, Lauren D'Costa, Irene Ewing, Soledad Fernandez, Erin Gibson, Louisa Gilbert, Megan E. Hall, Sarah Hargrove, Timothy Hunt, Elizabeth N. Kinnard, Lauren Larochelle, Aaron Macoubray, Shawn R. Nigam, Edward V. Nunes, Carrie B. Oser, Sharon Pagnano, Peter J. Rock, Pamela Salsberry, Aimee Shadwick, Thomas J. Stopka, Sylvia Tan, Jessica L. Taylor, Philip M. Westgate, Elwin Wu, Gary A. Zarkin, Sharon L. Walsh, Nabila El-Bassel, T. John Winhusen, Jeffrey H. Samet, Emmanuel A. Oga

Biostatistics Faculty Publications

IMPORTANCE: The HEALing Communities Study (HCS) evaluated the effectiveness of the Communities That HEAL (CTH) intervention in preventing fatal overdoses amidst the US opioid epidemic.

OBJECTIVE: To evaluate the impact of the CTH intervention on total drug overdose deaths and overdose deaths involving combinations of opioids with psychostimulants or benzodiazepines.

DESIGN, SETTING, AND PARTICIPANTS: This randomized clinical trial was a parallel-arm, multisite, community-randomized, open, and waitlisted controlled comparison trial of communities in 4 US states between 2020 and 2023. Eligible communities were those reporting high opioid overdose fatality rates in Kentucky, Massachusetts, New York, and Ohio. Covariate constrained randomization stratified …

Integrin Α6Β4 Upregulates Ptprz1 Through Uchl1-Mediated Hif-1Α Nuclear Accumulation To Promote Triple-Negative Breast Cancer Cell Invasive Properties, Min Chen, Parvanee A. Karimpour, Andrew Elliott, Daheng He, Teresa Knifley, Jinpeng Liu, Chi Wang, Kathleen L. O’Connor

Markey Cancer Center Faculty Publications

Integrin α6β4 drives triple-negative breast cancer (TNBC) aggressiveness through the transcriptional regulation of key genes. Here, we investigated how integrin α6β4 regulates protein tyrosine phosphatase receptor type Z1 (PTPRZ1). Using stable re-expression of integrin β4 (ITGB4) in cells naturally devoid of integrin α6β4 or knockdown or knockout (KO) of ITGB4, we found that integrin α6β4 regulates PTPRZ1 expression. To gain mechanistic insight, we focused on Hif-1α due to the impact of integrin α6β4 on a hypoxia-associated signature. We found that nuclear localization of Hif-1α, but not Hif-2α, was substantially enhanced with integrin α6β4 signaling. Hif-1α knockdown by shRNA or chemical …

Upregulation Of Fatty Acid Synthase Increases Activity Of Β-Catenin And Expression Of Notum To Enhance Stem-Like Properties Of Colorectal Cancer Cells, Courtney O. Kelson, Josiane Weber Tessmann, Mariah E. Geisen, Daheng He, Chi Wang, Tianyan Gao, B. Mark Evers, Yekaterina Y. Zaytseva

Markey Cancer Center Faculty Publications

Dysregulated fatty acid metabolism is an attractive therapeutic target for colorectal cancer (CRC). We previously reported that fatty acid synthase (FASN), a key enzyme of de novo synthesis, promotes the initiation and progression of CRC. However, the mechanisms of how upregulation of FASN promotes the initiation and progression of CRC are not completely understood. Here, using Apc/VillinCre and ApcMin mouse models, we show that upregulation of FASN is associated with an increase in activity of β-catenin and expression of multiple stem cell markers, including Notum. Genetic and pharmacological downregulation of FASN in mouse adenoma organoids decreases the activation of β-catenin …

Symbiotic Characterization Of Azide-Resistant Mutants Of Rhizobium Leguminosarum By Trifolii, Shashi Bhushan Sharma, K Sakadevan, R Corner

IGC Proceedings (1977-2023)

Azide-resistant mutants of Rhizobium legumnosarum bv, trifolii strain NZPS61 were isolated. Mutations conferring azide resistance appeared at a frequency of 1.6x t0·7 on minimal media containing 25 µglml sodium azide. Two classes of mutants were observed with respect to the nitrogen source in the growth media. Mutants in the first class showed azide resistance in the presence of both nitrate and ammonia whereas the mutants in the second class showed azide resistance only in the presence of nitrate. Eleven azide-resistant mutants were characterised for their symbiotic ability with white clover. All the mutants were similar to their parent strain NZPS61 …

First Results On Growth Rates Of The Endophytic Fungi Acremonium And Epichloe On Solid And Liquid Media, P Dapprich, A Klose, V H. Paul

IGC Proceedings (1977-2023)

Growth rates of the ·grass endophytes Acrenonium lolii Latch, Christensen and Samuels, A. coenoplrialiim Morgan-Jones lind Garns and Epichloe typhina' (Fries) Tulasne were measured on different solid media under various conditions and in liquid medium. A. coenophiallum and E. ryphina developed best vegetative growth at 25°C in the dark ori;pofato-dextrose-ilgar (PDA) and on minimal­medium (MM), respectively. A: lo/ii grew best at 2coenophialum and E. typhina produced 1.48 g and 6 g FW, respectively. Within 3 days the conductivit)'. reached constant values.· Osmolarity decreased with the increase of biomass. pH rose in cultures of A. lolii and E. typhina …

Tissue Culture Of Sainfoin, Nakashima Hiroshi, Yang Zhuomeng

IGC Proceedings (1977-2023)

The effecls of 1-napthaleneacetic acid (NAA) and 6-benzylamino purine (BAP) on callus induction, callus proliferation and plant regeneration were examined ip sainfojn (011ob1ycl1is viciifo/ia Scop.) from differen! ex plant. Then the effects of indole-3-butyric acid (IBA) on root formation from differentiated shoot from calli were examined. The combinations of 1-10 µM ofNAA an4 BAP were better for sainfoin culture. For callus induction, there was no significant difference among 3 explants, but Chere were interactions between explant and media. For plant regeneration, hypocotyl and root are ��ter explants than cotyledon. The effects of NAA and BAP showed less effective on callus …

Public Librarians' Roles In Natural Disasters: Stories Of Leadership And Resilience, Denise Lyons, April Hobbs, Feili Tu-Keefner, Denise Gomez, Marcia A. Mardis

Library Research Seminar 8: Telling Library Stories

No abstract provided.

Sharing The Story Of Public Library Programming For Young Children With Disabilities Or Developmental Delays, Denice Adkins, Maria Cahill, Alicia Long, Bobbie Sartin Long, Derek Daskalakes

Library Research Seminar 8: Telling Library Stories

No abstract provided.

An Introduction To Infophilia, A Positive Psychology Of Information, Anita S. Coleman

Library Research Seminar 8: Telling Library Stories

This paper will tell some of the stories of infophilia, a positive psychology of information, avant-garde research. The goal of Brenda Dervin’s ground-breaking research was not just to develop the sense-making theory, framework, and tools, but also to “invent communication alternatives and assess their utility.” One of the ‘practice communication inventions’ of Brenda Dervin was the ‘Good news newsletter’ where she developed infosheets for doctors, schools, and medical clinics (Neill, 1992, p. 6). I am no Brenda Dervin. But I am a strongly interdisciplinary scholar who has been a tenured librarian, LIS school faculty, library director, publisher for the voiceless, …

Our Mythic Potential: The Hero's Journey And The Library's Story, Sarah Beth Nelson, Andra Matthews

Library Research Seminar 8: Telling Library Stories

No abstract provided.

Stories From The Road: Embedding A Librarian With An Immersive Leadership Development Travel Experience, Eric Tans

Library Research Seminar 8: Telling Library Stories

No abstract provided.

Use Of Plant Height For Determining The Nutritive Value, Yield And The Optimal Use Span Of Lucerne, Lother Schmidt

IGC Proceedings (1977-2023)

Determining the ·cutting date is important for high yield, good forage quality and longevity of lucerne (Medicago media Pers.) stands. Most recommendations for the optimal use date are based on the development ,stage. The results of research conducted over 9 years show that forage quality and the dry matter (DM) yield of luccrne, at the same, developmental stage, vary considerably, depending on weather conditions during the growth period. A better criterion is the plant height of lucerne. There was a highly significant correlation between plant height and the content of crude fibre, crude protein and DM. We recommend the …

Impact Of Intermittent Clipping On Productivity, Forage Quality And Legume Persistence Of Reclaimed Mine Soils, M Collins, H B. Rice, R Turley, W O. Thom

IGC Proceedings (1977-2023)

The materials used as plant growth media during surface mine· reclamation are frequently low in available N, P and K and are drought­prone. Legumes are included in reclamation seeding mixtures . because of their symbiotic N2-fixation ability but competition may prevent establishment or reduce persistence. A field study was conducted to test the hypothesis that intermittent clipping of these sites would reduce grass competition and thereby maintain legume stands. In 1990 and· 1991, 4 clipping treatments were imposed, providing intervals of 2, 4; and 6 weeks between harvests. Clipping at the 2- or 4-week intervals gave equal yields that were …

Microfiltration Membrane Pore Functionalization With Primary And Quaternary Amines For Pfas Remediation: Capture, Regeneration, And Reuse, Sam Thompson, Angela Gutierrez, Jennifer Bukowski, Dibakar Bhattacharyya

UK CARES Faculty Publications

The widespread production and use of multi-fluorinated carbon-based substances for a variety of purposes has contributed to the contamination of the global water supply in recent decades. Conventional wastewater treatment can reduce contaminants to acceptable levels, but the concen- trated retentate stream is still a burden to the environment. A selective anion-exchange membrane capable of capture and controlled release could further concentrate necessary contaminants, mak- ing their eventual degradation or long-term storage easier. To this end, commercial microfiltration membranes were modified using pore functionalization to incorporate an anion-exchange moiety within the membrane matrix. This functionalization was performed with primary and …

Nitrate Removal By Floating Treatment Wetlands Under Aerated And Unaerated Conditions: Field And Laboratory Results, Jenna Mccoy, Matt Chaffee, Aaron Mittelstet, Tiffany L. Messer, Steve Comfort

Earth and Environmental Sciences Faculty Publications

Urban and storm water retention ponds eventually become eutrophic after years of receiving runoff water. In 2020, a novel biological and chemical treatment was initiated to remove accumulated nutrients from an urban retention pond that had severe algae and weed growth. Our approach installed two 6.1 m × 6.1 m floating treatment wetlands (FTWs) and two airlift pumps that contained slow-release lanthanum composites, which facilitated phosphate precipitation. Four years of treatment (2020–2023) resulted in median nitrate-N concentrations decreasing from 23 μg L−1 in 2020 to 1.3 μg L−1 in 2023, while PO4-P decreased from 42 μg L−1 to 19 μg …

Spot, Zone And Overcoat Painting Of Steel Bridges, Christopher Goff, Sudhir Palle

Kentucky Transportation Center Research Report

Over the past 25 – 30 years, the Kentucky Transportation Cabinet (KYTC) has replaced lead-based coatings on many bridges, often with zinc-based systems. But many of these coating systems are now degrading and reaching the ends of their service lives. Historically, KYTC has relied entirely on remove-and-replace painting, however, given the programmatic costs associated with remove-and-replace painting and constraints imposed by limited funding, the agency needs to explore more economical options, such as spot, zone, and overcoat painting. This report discusses use cases for spot, zone, and overcoat painting and lays out guidelines staff can use to determine what method …

Investigating Effectiveness Of Inverted Classroom In Undergraduate Statistics Education, Xin Ma, Jing Zhang, Petya Karkelanova, Michael C. Osborne, Anushka Karkelanova

Educational, School, and Counseling Psychology Faculty Publications

Data collected from an educational experiment were analyzed to investigate the effectiveness of an instructional reform referred to as the inverted classroom (learning activities traditionally taking place inside the classroom now take place outside the classroom and vice versa) in undergraduate statistics education. Students were taught the same statistics course in the inverted classroom (135 students) and the traditional classroom (135 students) over one semester. A small sample HLM (hierarchical linear modeling) approach was used to account for the data structure of students nested within 12 sections of the course and small sample sizes at both student and section levels. …

Depressive Symptoms And Sleep Quality Mediate The Relationship Between Race And Quality Of Life Among Patients With Heart Failure: A Serial Multiple Mediator Model, Jia-Rong Wu, Debra K. Moser, Chin-Yen Lin, Ambrose A. Chiang, Barbara Riegel

UK CARES Faculty Publications

Background: Black patients with heart failure (HF) report worse quality of life (QoL) than White patients. Few investigators have examined mediators of the association between race and QoL, but depressive symptoms and sleep quality are associated with QoL.

Objective: The aim of this study was to determine whether depressive symptoms and sleep quality are mediators of the relationship between race and QoL among patients with HF.

Methods: This was a cross-sectional study. We included 271 outpatients with HF. Self-reported race (White/Black), depressive symptoms (Patient Health Questionnaire), sleep quality (Pittsburgh Sleep Quality Index), and QoL (Kansas City Cardiomyopathy Questionnaire) were collected …

Determining The Key Education Priorities Related To Heart Failure Care In Nursing Homes: A Modified Delphi Approach, James Mcmahon, David R. Thompson, Christine Brown Wilson, Loreena Hill, Paul Tierney, Jan Cameron, Doris S. F. Yu, Debra K. Moser, Karen Spilsbury, Nittaya Srisuk, Jos M. G. A. Schols, Mariëlle Van Der Velden-Daamen, Gary Mitchell

UK CARES Faculty Publications

There is currently a limited understanding of what nurses in nursing homes view as the key education priorities to support their ability to provide the appropriate care for residents with heart failure (HF). A modified Delphi technique was utilized to gain a consensus on the key education priorities for nurses working in nursing homes in Northern Ireland. An initial list of items (n = 58), across 19 domains, was generated using the findings of a scoping review and stakeholder interviews, and a review of available clinical guidelines. Two rounds of surveys were undertaken. Items were presented using a 5-point Likert …

Evaluation Of Roadway Reconfigurations In Louisville, Kentucky, William Staats, Adam Kirk

Kentucky Transportation Center Research Report

In 2009, Louisville Metro Public Works undertook its first roadway reconfiguration project, converting a section of Eastern Parkway (US 60A) from a four-lane undivided road to a three-lane section with a two-way left-turn lane and one travel lane in each direction. Since this initial project, Louisville Metro Public Works and the Kentucky Transportation Cabinet (KYTC) have completed 40 roadway reconfigurations to reduce the number of through lanes and reassign existing right-of-way to other roadway users. Additionally, the agencies have 25 more planned or proposed reconfiguration projects. This report documents the safety and operational performance of reconfigured roads. Across all projects, …

Antimicrobial Resistance In Equines: A Growing Threat To Horse Health And Beyond-A Comprehensive Review., Ajran Kabir, Bibek Lamichhane, Tasmia Habib, Alexis Adams, Hossam El-Sheikh Ali, Nathan M Slovis, Mats H. T. Troedsson, Yosra A. Helmy

Veterinary Science Faculty Publications

The equine industry holds substantial economic importance not only in the USA but worldwide. The occurrence of various infectious bacterial diseases in horses can lead to severe health issues, economic losses, and restrictions on horse movement and trade. Effective management and control of these diseases are therefore crucial for the growth and sustainability of the equine industry. While antibiotics constitute the primary treatment strategy for any bacterial infections in horses, developing resistance to clinically important antibiotics poses significant challenges to equine health and welfare. The adverse effects of antimicrobial overuse and the escalating threat of resistance underscore the critical importance …

Challenges Of Spatially Resolved Metabolism In Cancer Research, Andrew N. Lane, Richard M. Higashi, Teresa W-M Fan

Markey Cancer Center Faculty Publications

Stable isotope-resolved metabolomics comprises a critical set of technologies that can be applied to a wide variety of systems, from isolated cells to whole organisms, to define metabolic pathway usage and responses to perturbations such as drugs or mutations, as well as providing the basis for flux analysis. As the diversity of stable isotope-enriched compounds is very high, and with newer approaches to multiplexing, the coverage of metabolism is now very extensive. However, as the complexity of the model increases, including more kinds of interacting cell types and interorgan communication, the analytical complexity also increases. Further, as studies move further …

Cow-Calf Production Response To Pasture Forage Species, J C. Kopp, W P. Mccaughey

IGC Proceedings (1977-2023)

To study cow-calf production on fragile soils, 32 ‘tester’ cow-calf pairs were grazed on fertilized and unfertilized meadow brome (Bromus biebersteinii Roem & Schult.) and alfalfa (Medicago sativa L.)/meadow brome pastures, to determine the effects of forage type and fertility on pasture yield and botanical composition; and on animal productivity including cow milk production, cow and calf average daily gain and total gain (per head and per hectare). Cow fertility may be depressed on alfalfa-based pastures, therefore, blood urea nitrogen (BUN) levels were also examined. Cow average daily gain (0.15 kg d-1) and milk production (4.82 kg d-1) …

Rhizobium Specificity In Leucaena, B F. Mullen, V E. Frank, R A. Date

IGC Proceedings (1977-2023)

Twenty-seven accessions of Leucaena, representing 20 species, were assessed for effective N-fixing symbioses in association with 13 strains of Rhizobium in N-free conditions in a glasshouse. Fifteen accessions formed effective symbioses with most strains of Rhizobium. Only 4 accessions required specific strains. Conversely, 9 of the strains of Rhizobium formed effective symbioses with most accessions of Leucaena. Only one strain was ineffective. Strains CB3060 and CB3126 were effective with 21 and 22 accessions of Leucaena, respectively.

Protease Expression In The Human And Rat Cumulus–Oocyte Complex During The Periovulatory Period: A Role In Cumulus–Oocyte Complex Migration, Ketan Shrestha, Muraly Puttabyatappa, Michelle Arelia Ann Wynn, Patrick R. Hannon, Linah Al-Alem, Katherine L. Rosewell, James Akin, Thomas E. Curry

UK CARES Faculty Publications

The migratory and matrix-invading capacities of the cumulus–oocyte complex have been shown to be important for the ovulatory process. In metastatic cancers, these capacities are due to increased expression of proteases, however, there is limited information on protease expression in the cumulus–oocyte complexes. The present study examined cumulus–oocyte complex expression of plasmins, matrix metalloproteases, and A Disintegrin and Metalloproteinase with Thrombospondin Motifs family members in the rat and human. In the rat, human chorionic gonadotropin (hCG) administration increased cumulus–oocyte complex expression of Mmp2, Mmp9, Mmp13, Mmp14, Mmp16, Adamts1, and the protease inhibitors Timp1, Timp3, and Serpine1 by 8–12 h. This …