Digital Commons Network^™

The Use Of A Whole Genome Scan To Find A Genetic Marker For Degenerative Suspensory Ligament Desmitis In The Peruvian Paso Horse, Diane I. Strong

University of Kentucky Master's Theses

Degenerative suspensory ligament desmitis (DSLD) is a debilitating disease of connective tissues seen in many breeds but has become prevalent in the Peruvian Pasohorse. DSLD is believed to be a genetic disorder caused by one primary founder and most likely has a recessive mode of inheritance although a dominant or co-dominant mode of inheritance has not been ruled out.

A genome scan using 259 microsatellite markers was used to test for linkage disequilibrium between one or more markers and DSLD. Two groups of Peruvian Pasohorses were selected from one population including the US and Canada. The only difference between the …

Cfd Modeling Of Heat Recovery Steam Generator And Its Components Using Fluent, Veera Venkata Sunil Kumar Vytla

University of Kentucky Master's Theses

Combined Cycle power plants have recently become a serious alternative for standard coal- and oil-fired power plants because of their high thermal efficiency, environmentally friendly operation, and short time to construct. The combined cycle plant is an integration of the gas turbine and the steam turbine, combining many of the advantages of both thermodynamic cycles using a single fuel. By recovering the heat energy in the gas turbine exhaust and using it to generate steam, the combined cycle leverages the conversion of the fuel energy at a very high efficiency. The heat recovery steam generator forms the backbone of combined …

The Intersection Of Filial Piety And Cultural Dissonance: Intergenerational Exchanges Among Khmer Families In The United States, Denise Clark Lewis

University of Kentucky Doctoral Dissertations

In this thesis I describe Khmers negotiations of circumstances surrounding the disassembly, reconstruction, and redefinition of Khmer identity from their homeland in Cambodia to a traditional Khmer village recreated in the United States. Using a framework derived from a constructivist perspective, I have placed processes of negotiation and identity transformation within the lived context of Khmers lives. Thus, a holistic understanding of the interrelatedness of multiple changes in Khmerness is made possible. Ethnographic data collected between 1997 and 1999, through participant-observation and interviews, inform this study. Findings from this study reveal three levels of identity transformation as told by members …

Tsc2 Modulates Actin Cytoskeleton And Focal Adhesion Through Tsc1-Binding Domain And The Rac1 Gtpase, Elena Goncharova, Dmitry Goncharov, Daniel J. Noonan, Vera P Krymskaya

Molecular and Cellular Biochemistry Faculty Publications

Tuberous sclerosis complex (TSC) 1 and TSC2 are thought to be involved in protein translational regulation and cell growth, and loss of their function is a cause of TSC and lymphangioleiomyomatosis (LAM). However, TSC1 also activates Rho and regulates cell adhesion. We found that TSC2 modulates actin dynamics and cell adhesion and the TSC1-binding domain (TSC2-HBD) is essential for this function of TSC2. Expression of TSC2 or TSC2-HBD in TSC2-/- cells promoted Rac1 activation, inhibition of Rho, stress fiber disassembly, and focal adhesion remodeling. The down-regulation of TSC1 with TSC1 siRNA in TSC2-/- cells activated Rac1 and induced loss of …

Monitoring Heart Rate In Drosophila Larvae By Various Approaches, Sameera Dasari, Robin L. Cooper

Biology Faculty Publications

No abstract provided.

Monitoring Activity Of Drosophila Larvae: Impedance & Video Microscopy Measures, Ann Simone Cooper, Robin L. Cooper

Biology Faculty Publications

No abstract provided.

Methods And Apparatus For In Vivo Identification And Characterization Of Vulnerable Atherosclerotic Plaques, Pedro Moreno, Robert A. Lodder, William O'Connor, James E. Muller

Internal Medicine Faculty Patents

Methods and apparatus for analyzing the chemical composition of vulnerable plaques with an intravascular catheter having a near-infrared light source, a fiber-optic probe, a mechanism for directing the light from the light source into a blood vessel, and detectors for detecting light reflected or scattered by the tissue. The light source may be a tunable laser, and may transmit an incident beam having a wavelength ranging from 1400 to 4100 nm. A computer may be included to receive and process the spectral data in the analysis of the vulnerable plaques. A catheter system may be configured to provide near-IR spectrometric …

A Subset Of Liver Nk T Cells Is Activated During Leishmania Donovani Infection By Cd1d-Bound Lipophosphoglycan, Joseph L. Amprey, Jin S. Im, Salvatore J. Turco, Henry W. Murray, Petr A. Illarionov, Gurdyal S. Besra, Steven A. Porcelli, Gerald F. Späth

Molecular and Cellular Biochemistry Faculty Publications

Natural killer (NK) T cells are activated by synthetic or self-glycolipids and implicated in innate host resistance to a range of viral, bacterial, and protozoan pathogens. Despite the immunogenicity of microbial lipoglycans and their promiscuous binding to CD1d, no pathogen-derived glycolipid antigen presented by this pathway has been identified to date. In the current work, we show increased susceptibility of NK T cell–deficient CD1d^−/− mice to Leishmania donovani infection and Leishmania-induced CD1d-dependent activation of NK T cells in wild-type animals. The elicited response was Th1 polarized, occurred as early as 2 h after infection, and was independent from …

Southeastern Law Librarian Fall 2004, Seaall

Newsletters

No abstract provided.

Similar Promotion Of Abeta1-42 Fibrillogenesis By Native Apolipoprotein E Epsilon3 And Epsilon4 Isoforms, David Sweeney, Ralph Martins, Harry Levine, Jonathan D. Smith, Sam Gandy

Sanders-Brown Center on Aging Faculty Publications

The apolipoprotein E epsilon4 allele contributes to the genetic susceptibility underlying a large proportion (~40-60%) of typical, sporadic Alzheimer disease. Apolipoprotein E deficient mice made transgenic for human apolipoprotein E epsilon4 accumulate excess cerebral amyloid when compared to similarly prepared mice expressing human apolipoprotein E epsilon3. Therefore, it is important to search for relevant interactions(s) between apolipoprotein E epsilon4 and Abeta in order to clarify the biological role for apolipoprotein E epsilon4 in Alzheimer disease. Using a thioflavine T (ThT)-based assay, we have investigated the effects of native human apolipoprotein E isoforms on the kinetics of Abeta fibrillogenesis. No obvious …

Developing An Intelligent Transportation Systems (Its) Architecture For The Kipda Region, Joseph D. Crabtree, Jennifer R. Walton

Kentucky Transportation Center Research Report

This report describes the development of a regional Intelligent Transportation Systems (ITS) Architecture for the five-county urban area under the auspices of the Kentuckiana Regional Planning and Development Agency (KIPDA). The architecture development process included the following steps: (1) Preliminary Architecture Work; (2) Inventory of Existing and Planned Projects; (3) Assessment of Regional Needs; (4) Development of Preliminary Architecture; (5) Review and Revision of Architecture; and (6) Delivery of Final Architecture and Documentation. Principal tools used in the development included the National ITS Architecture (version 4.0) and the Turbo Architecture software (version 2.0). Deliverables included the architecture database (created using …

"Competing Conceptions Of Globalization" Revisited: Relocating The Tension Between World-Systems Analysis And Globalization Analysis, Thomas Clayton

Linguistics Faculty Publications

No abstract provided.

Bubble Column Apparatus For Separating Wax From Catalyst Slurry, James K. Neathery, Burtron H. Davis

Center for Applied Energy Research Faculty Patents

Novel methods and devices for production of liquid hydrocarbon products from gaseous reactants are disclosed. In one aspect, a method for separating a liquid hydrocarbon, typically a wax, from a catalyst containing slurry is provided, comprising passing the slurry through at least one downcomer extending from an overhead separation chamber and discharging into the bottom of a slurry bubble column reactor. The downcomer includes a cross-flow filtration element for separating a substantially particle-free liquid hydrocarbon for downstream processing. In another aspect, a method for promoting plug-flow movement in a recirculating slurry bubble column reactor is provided, comprising discharging the recirculating …

Anticipating Artistic Behavior: New Research Tools For Art Historians, Robert Jensen

Art and Visual Studies Faculty Publications

The author applies David Galenson's work on the life cycles of modern artists to the study of the paintings of old masters, from about the early fifteenth to the late seventeenth centuries. Both the potential use of technical examination of paintings and the role of drawings for preconceiving compositions are explored as means for interpreting artistic behavior among premodern artists. Using a study of illustrations in texts to establish a list of canonical painters and the relative dates in which they are believed to have contributed their most important paintings, the author then analyzes a series of old master painters' …

Evaluation Of Kentucky’S “Buckle Up Kentucky: It’S The Law And It’S Enforced” 2004 Campaign, Kenneth R. Agent, Eric R. Green

Kentucky Transportation Center Research Report

The objective of this report was to document the results of the “Buckle Up Kentucky: It’s the Law & It’s Enforced” 2004 campaign in Kentucky. The campaign involved a combination of earned media, paid media, and enforcement. The earned media started two weeks prior to Memorial Day 2004 and continued through the enforcement period. The paid media started one week prior to Memorial Day. The enforcement period was a two-week period including the week before and the week of Memorial Day.

The evaluation of the campaign included documenting the activities associated with the program (publicity and enforcement) and evaluating the …

Marketing Assistance Available For Tourism Businesses In Kentucky, Rick Bates

Community and Leadership Development

No abstract provided.

Compositions And Methods For Enhancing Fiber Digestion, Juan Tricárico, Karl A. Dawson

Animal and Food Sciences Faculty Patents

Methods and enzyme supplements for enhancing fiber digestion in mammals and birds are described. The supplement comprises an effective amount of acetyl esterase, formulated for feeding to animals consuming significant percentages of forages in the diet. The compositions of this invention improve dry matter and neutral detergent fiber disappearance rates, and are useful dietary supplements for improving fiber digestion. The compositions of this invention may be utilized alone or in combination with known exogenous fibrolytic enzyme supplement to improve fiber digestion in mammals and birds. The acetyl esterase advantageously used in the compositions and methods of the present invention is …

Kentucky Highway User Survey 2004, Ronald E. Langley, Ted Grossardt

Kentucky Transportation Center Research Report

The purpose of this study was to continue the efforts begun in 1997 to monitor Kentucky public opinion regarding the quality of highway systems, including a portion to measure satisfaction with current drivers’ license and registration renewal processes. Kentucky’s 2004 public opinion is compared to data colleted in previous years to gauge the state’s progress.

Methods To Impair Hematologic Cancer Progenitor Cells And Compounds Related Thereto, Craig Jordan

Internal Medicine Faculty Patents

Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leukemia (CLL). Interleukin-3 receptor alpha chain (IL-3Rα or CD123) is strongly expressed on progenitor hematologic cancer cells, but is virtually undetectable on normal bone marrow cells. The present invention provides methods of impairing progenitor hematologic cancer (e.g., leukemia and lymphomic) cells by selectively targeting cells expressing CD123. These methods are useful in the detection and treatment of leukemias and malignant lymphoproliferative disorders. Also provided are compounds useful …

The Influence Of Environmental Temperature And Substrate Initial Moisture Content On Aspergillus Niger Growth And Phytase Production In Solid−State Cultivation, Seaborn B. Carter, Sue E. Nokes, Czarena L. Crofcheck

Biosystems and Agricultural Engineering Faculty Publications

Aspergillus niger is being used commercially for phytase production utilizing solid-state cultivation; however, no studies have been published that investigated the optimal environmental temperature and initial substrate water content to maximize fungal growth and/or phytase production. Solid-state cultivations of Aspergillus niger on wheat bran and soybean meal were conducted at three temperatures (25°C, 30°C, and 35°C) and three initial moisture contents (50%, 55%, and 60% wet basis) in a split-plot full-factorial experimental design. Fermentations were conducted for 0, 24, 48, 72, and 120 h. The containers were sampled destructively and assayed for phytase activity and glucosamine concentration as an estimate …

Global Wars And Writing Warrior Culture: Disclosure Interviews Anthony Swofford, Anna Froula, Danny Mayer, Jonathan Vincent, Keith Woodward

disClosure: A Journal of Social Theory

No abstract provided.

3/19, A View From My Porch, Doreen Lamantia Maloney

disClosure: A Journal of Social Theory

No abstract provided.

Rethinking Politics, Scholarship, And Economics: Disclosure Interviews David F. Ruccio, Tina Mangieri, Matt Mccourt, Natalia Ruiz-Junco, Jeff West

disClosure: A Journal of Social Theory

No abstract provided.

Book Review: Serge Gruzinski, Trans. Deke Dusinberre, The Mestizo Mind. New York: Routledge, 2002., Frankie Finley

disClosure: A Journal of Social Theory

No abstract provided.

Book Review: Fantasy And Desire In The Age Of Terrorism: Verso's Series On September 11th, Ben Smith

disClosure: A Journal of Social Theory

No abstract provided.

Geographies Of Globalization: Disclosure Interviews Neil Smith, Jamie Gillen, Ben Smith, David Walker

disClosure: A Journal of Social Theory

No abstract provided.

Globalization, Or The Vanishing Present Of Postcolonialism? (And The Figuration Of The Comprador-Intellectuai), Saikat Majumdar

disClosure: A Journal of Social Theory

No abstract provided.

Editors' Introduction And Acknowledgments, Danny Mayer, Keith Woodward

disClosure: A Journal of Social Theory

No abstract provided.

Nonparametric Control Chart For The Range, Arnold J. Stromberg

Statistics Faculty Patents

The method comprises establishing the number of subsets of a dataset that have a range of the difference between any two datapoints within the dataset, and computing a control chart for the range based thereon. In another aspect, a software program for accomplishing the method of the present invention is provided. The method of the invention allows monitoring variability of a product being produced by a particular piece of machinery, of a process conducted by the machinery, or of a product stream generated thereby, accurately detecting changes in variability in real time. The true distribution of the data is reflected, …

Prosecutorial Misconduct In Capital Cases In The Commonwealth Of Kentucky: A Research Study 1976-2000, Roberta M. Harding, Bankole Thompson

Law Faculty Scholarly Articles

The prosecutor wields tremendous power within the American criminal justice system. When that power is misused-particularly in capital cases-tremendous injustices are perpetrated. Yet, occurrences of prosecutorial misconduct seem to occur with distressing regularity. An exhaustive study covering appeals from 1973-95 revealed that two-thirds of overturned death penalties in the United States resulted from overzealous police and prosecutors who withheld exculpatory evidence. Our study covered 55 Kentucky cases from 1976-2000 and found evidence of prosecutorial misconduct in nearly one-half of them, often with several instances per case.