Digital Commons Network^™

Structures, Roles And Relationships Within Public Health’S Response To The 2009-2010 H1n1 Outbreak: The Ties That Bind Public Information Officers And Emergency Risk Communication Efforts, Kathleen G. Vidoloff

University of Kentucky Doctoral Dissertations

Little is known about the role of public health public information officers (PIOs) during public health emergencies. This study uses interpretative methods to learn about the organizational structures that facilitate and constrain emergency risk communication efforts during public health emergencies. Interpretive thematic comparative analysis of PIOs experiences and reflections about their involvement in the 2009-2010 H1N1 response will be used to illustrate how social interactions between and among PIOs, public health staff, and representatives from other agencies create implicit and explicit structures that facilitate and constrain emergency risk communication. The application of three specific concepts from structuration theory, namely, agent, …

Atomic Force Microscopy Method Development For Surface Energy Analysis, Clare Aubrey Medendorp

University of Kentucky Doctoral Dissertations

The vast majority of pharmaceutical drug products are developed, manufactured, and delivered in the solid-state where the active pharmaceutical ingredient (API) is crystalline. With the potential to exist as polymorphs, salts, hydrates, solvates, and cocrystals, each with their own unique associated physicochemical properties, crystals and their forms directly influence bioavailability and manufacturability of the final drug product. Understanding and controlling the crystalline form of the API throughout the drug development process is absolutely critical. Interfacial properties, such as surface energy, define the interactions between two materials in contact. For crystal growth, surface energy between crystal surfaces and liquid environments not …

The Application Of Discontinuous Galkerin Finite Element Time-Domain Method In The Design, Simulation And Analysis Of Modern Radio Frequency Systems, Bo Zhao

University of Kentucky Doctoral Dissertations

The discontinuous Galerkin finite element time-domain (DGFETD) method has been successfully applied to the solution of the coupled curl Maxwell’s equations. In this dissertation, important extensions to the DGFETD method are provided, including the ability to model lumped circuit elements and the ability to model thin-wire structures within a discrete DGFETD solution. To this end, a hybrid DGFETD/SPICE formulation is proposed for high-frequency circuit simulation, and a hybrid DGFETD/Thin-wire formulation is proposed for modeling thin-wire structures within a three-dimensional problem space. To aid in the efficient modeling of open-region structures, a Complex Frequency Shifted-Perfectly Matched Layer (CFS-PML) absorbing medium is …

High Performance Piezoelectric Materials And Devices For Multilayer Low Temperature Co-Fired Ceramic Based Microfluidic Systems, Wenli Zhang

University of Kentucky Doctoral Dissertations

The incorporation of active piezoelectric elements and fluidic components into micro-electromechanical systems (MEMS) is of great interest for the development of sensors, actuators, and integrated systems used in microfluidics. Low temperature cofired ceramics (LTCC), widely used as electronic packaging materials, offer the possibility of manufacturing highly integrated microfluidic systems with complex 3-D features and various co-firable functional materials in a multilayer module. It would be desirable to integrate high performance lead zirconate titanate (PZT) based ceramics into LTCC-based MEMS using modern thick film and 3-D packaging technologies. The challenges for fabricating functional LTCC/PZT devices are: 1) formulating piezoelectric compositions which …

Role Of Pi3k-Akt Pathway In The Age Associated Decline In Tlr Mediated Activation Of Innate And Adaptive Immune Responses, Mosoka Papa Fallah

University of Kentucky Doctoral Dissertations

Immunosenescence results in reduced immune response to infections with Streptococcus pneumoniae as well as to pneumococcal polysaccharide vaccines. The antibody response to the capsular polysaccharide (CPS) provides protection against S. pneumoniae infection. CPS immunoresponse is T cell independent and needs the macrophage-derived cytokines such as IL-12, IL-6 and IL-1β to elicit an antibody response. We showed a cytokine dysregulation, i.e. a decrease in IL-12, IL-6 and TNF-α but an increase in IL-10, in the aged (18-24 months old comparable to >65 years in human) compared to young adult mouse (8-12 weeks less than 65 years old) splenic macrophages (SM) or …

Synthesis And Energy Applications Of Oriented Metal Oxide Nanoporous Films, Qingliu Wu

University of Kentucky Doctoral Dissertations

This dissertation mainly addresses the synthesis of well-ordered mesoporous titania thin films by dip coating with PEO-PPO-PEO triblock copolymer surfactant template P123. Because P123 is composed of poly(ethylene oxide) [PEO] and poly(propylene oxide) [PPO] blocks, concentrations of ingredients are adjusted to tune the films’ wall thickness, pore size and mesophase. Structural changes are consistent with partitioning of species among PEO blocks, PPO blocks, and the PEO/PPO interface. Titanates localize near PEO and increase wall thickness (by 5 nm to 7 nm). Depending on aging temperature, PPG either swells the PPO cores (when it is hydrophobic) or introduces large (>200 …

T-Phylloplanin And Cis-Abienol, Two Natural Products From Tobacco Have Broad Spectrum, Anti-Fungal Activities, Brian Christopher King

University of Kentucky Doctoral Dissertations

Tobacco phylloplanins (T-phylloplanin) are a group of closely-related glycoproteins that are formed and disposed at the interface between the plant aerial surface (the phylloplane) and the atmosphere. They are synthesized in short procumbent trichomes and are secreted to aerial surfaces where they are thought to serve the plant as a first line of defense against fungal pathogens. Here it is shown using in vitro and in planta assays that tobacco and sunflower phylloplanins have broad-spectrum antifungal activities against spores - and also hyphae for two species - of several true fungi. Field tests show that T-phylloplanin reduces diseases caused by …

Nationalism And Its Expression In Cuba’S Art Music: The Use Of Folklore In Mario Abril’S “Fantasia (Introduction And Pachanga)” For Clarinet And Piano, Nikolasa Tejero

University of Kentucky Doctoral Dissertations

In the centuries since the colonization of the New World, the people of Cuba created a strong musical tradition. Initially, their music mirrored the European composition canons of structural, melodic and harmonic order. The eventual confluence of its distinct cultural elements (i.e. the European, African, and, to a lesser extent, Amerindian) led to the emergence of a new, distinctly Cuban musical tradition.

The wars for independence that began in the United States and Europe in the eighteenth century created a surge towards political and cultural autonomy that swept across the Latin American colonies, generating a wave of nationalism during the …

Lavapiés, Madrid As Twenty-First Century Urban Spectacle, Matthew Isaiah Feinberg

University of Kentucky Doctoral Dissertations

Informed by the theories of Henri Lefebvre regarding the production of space and the theories of scale found in current scholarship in Cultural Geography, my methodology analyzes both dramatic texts and theater spaces to investigate how cultural production and capital converge in the “spectacle” of urban space. While employing this term “spectacle” to describe how dramatic texts, theater productions, and modern architecture transform the urban landscape into a metaphoric theater space for the production of local, national, and global identities, this project examines the relationship between theater and urban change in Lavapiés, an iconic, multicultural, and oftenunderserved neighborhood located in …

Seeing Subjects: Recognition, Identity, And Visual Cultures In Literary Modernism, George Micajah Phillips

University of Kentucky Doctoral Dissertations

Seeing Subjects plots a literary history of modern Britain that begins with Dorian Gray obsessively inspecting his portrait’s changes and ends in Virginia Woolf’s visit to the cinema where she found audiences to be “savages watching the pictures.” Focusing on how literature in the late-19^th and 20^th centuries regarded images as possessing a shaping force over how identities are understood and performed, I argue that modernists in Britain felt mediated images were altering, rather than merely representing, British identity. As Britain’s economy expanded to unprecedented imperial reach and global influence, new visual technologies also made it possible to …

Conditioning Democratization: Eu Membership Conditionality And Domestic Politics In Balkan Institutional Reforms, Ridvan Peshkopia

University of Kentucky Doctoral Dissertations

The uneven effects of EU membership conditionality on Eastern European reforms continue to puzzle the research community. Sometimes, the research focus has been too large, considering EU membership conditionality as a policy implemented uniformly across policy areas. Other efforts take a too narrow approach by trying to explain the effects of EU membership conditionality in single sectors. I suggest studying this phenomenon through a set of mid-level theories in a cross-country, cross-sectorial approach. I argue that both the intensity of EU membership conditionality and reform outcomes are contingent upon the policy sector context; hence, we should take a sectorial contextual …

Using Manual Defoliation To Simulate Soybean Rust: Effect On Growth And Yield Formation, Abdullah Mohammad Aqeel

University of Kentucky Doctoral Dissertations

Field experiments were conducted in Kentucky and Louisiana in 2008 and 2009 (split-plot in a randomized complete block design with four replications) to investigate it is possible to simulate with manual defoliation the effect of soybean rust (SBR) (Phakopsora pachyrhizi Syd. and P. Syd) injury on a healthy soybean [Glycine max, (L.) Merr.] canopy, understand how defoliation affects the growth dynamics and canopy light interception, and if defoliation affectsleaf senescence and nitrogen remobilization during the seed-filling period. Two manual defoliation treatments based on changes in effective leaf area index (ELAI) (calculated as the reduction in leaf area …

Efficacy Of Organically Certifiable Materials And Natural Compounds Against Foliar Hemibiotrophic And Necrotrophic Fungi In Cantaloupe And Tomato, Merari Feliciano-Rivera

University of Kentucky Doctoral Dissertations

Kentucky reported a solid 13.1% growth in certified organic land from 1997 to 2002. The relative lack of research on disease management practices in Kentucky consistent with organic regulations is an issue that needs to be addressed to provide more reliable information to local farmers. Thus, the first objective of this research was to investigate the potential disease control obtained with natural, organically certifiable spray materials against Colletotrichum orbiculare in vitro and in vivo. The second objective was to test certifiable spray materials in combinations to identify synergistic interactions. The third objective was to evaluate Organic Material Review Institute …

Defying The Modernist Canon: Mikhail Larionov’S Artistic Experience Beyond The Canvas, Ella Hans

University of Kentucky Master's Theses

In the contemporary art-historical vision, Mikhail Larionov is renowned as the author and the main figure in the polemical discourse of Neoprimitivism and the inventor of the Rayonism style. These aspects, although crucial to his career, are far from exhausting the artist’s legacy. During his most industrious period, from 1910 to 1915, he was equally, if not more, engaged in the development of new forms of art than in the practice of painting; in fact, the conventional cornerstone of the high art in the era of Modernism – a painting – lost its central position and receded to the status …

Mechanical Characterizations Of Environmentally Conditioned Shape Memory Polymers For Reconfigurable Aerospace Structures, Jared T. Fulcher

University of Kentucky Master's Theses

Shape memory polymers (SMPs) have been candidate materials for morphing applications. However, the SMPs have not been fully tested to work in relevant environments required for Air Force missions. In this study, an epoxy-based SMP was separately exposed to moisture, lubricating oil and UV radiation, which are simulated service environments designed to be reflective of anticipated performance requirements. The thermomechanical properties and shape memory effects were studied by using novel high-temperature nanoindentation technique. Results show that environmental conditions have affected the glass transition temperature and mechanical properties of the SMPs. In most cases, the conditioned SMPs exhibited higher elastic moduli …

“All Must Combine In The Struggle Against The Microbes” Global Biopolitics And Twentieth-Century Health Organizations, Patrick Kothe

University of Kentucky Master's Theses

The following paper explores the rise of global biopolitics by focusing on the League of Nations Health Organization (LNHO) and the World Health Organization (WHO) as pivot points around which an international system transitioned into a global system. The central thesis of the paper is that the LNHO served as the first true site of deployment for global discourses on health and hygiene, not as recent scholarship has suggested, the WHO. The purpose of the paper, however, is to provide an overview of the larger transformation of public health in the twentieth century, beginning with the proliferation of nineteenth-­‐century international …

Constructing The Real: The New Photography Of Crewdson, Gursky And Wall, Melissa A. Schwartz

University of Kentucky Master's Theses

A new class of photographs that relies on digital processes, best exemplified by the works of Gregory Crewdson, Andreas Gursky and Jeff Wall all exhibit a ‘not quite right’ quality that calls into question some of the most closely held truisms of photographic thought. Through novel technological processes combined with the elements of the new photography—new scale, fabulist imagery, and implied narrative—these images challenge the nature of photography as a documentary process and, beyond that, the nature of what we understand to be ‘the real’ that is supposedly documented. A visual analysis of these images through the lens of Roland …

Development Of Novel Electrophilic Ruthenium(Ii) And Iridium(Iii) Complexes And Their Applications As Homogeneous Catalysts, Ryan R. Ketcham

University of Kentucky Master's Theses

Our aim was to develop the synthetic potential and reaction chemistry of Ir³⁺ and Ru²⁺ electrophiles by preparing well-characterized complexes whose properties are controllable by modification of the ancillary ligand environment Specifically, we prepared a series of ruthenium complexes to serve as selective hydrogenation and hydrogenolysis catalysts of furan derivatives. We also expanded the synthesis of electrophilic Ir³⁺ di-thiolate complexes. These types of compounds could eventually serve as catalysts precursors for the addition of weak nucleophiles to alkynes and nitriles.

Becoming Bodies: How Preadolescent Girls Consume And Produce Media In 21St Century America, Margaret Louise Mcgladrey

University of Kentucky Master's Theses

This study investigates preadolescent girls’ interpretations of images of and messages about women’s bodies presented in both traditional and online media in the American cultural context. Using qualitative methods including in-depth interviews, email diaries, and digital photo collages, this study gives voice to girls aged nine to eleven from diverse racial and socioeconomic backgrounds so that they might tell their stories about interacting with media that is relevant to their relationships with their bodies. Employing objectification theory as well as concepts from the cultural studies tradition, the findings suggest that the process of becoming a female body in the 21 …

Constructing Coldstream: Sustainability And The Politics Of Local Economic Development, John Taylor Shelton

University of Kentucky Master's Theses

This thesis explores the evolution of the Coldstream Research Campus, a high-tech research park operated by the University of Kentucky. Conceived of in the late 1980s and built in 1992, Coldstream was expected to become the „economic engine‟ of central Kentucky through the commercialization of applied scientific and technological research coming out of the university. Twenty years later, with Coldstream having failed to live up to expectations, the university initiated the process of updating the Coldstream Master Plan to incorporate a decided emphasis on the concept of sustainability. Through a mix of archival research and semi-structured interviews, this thesis argues …

Bench-Scale, Multifilament Spinning Conditions Effect On The Structure And Properties Of Polyacrylonitrile Precursor Fiber, Elizabeth Ashley Morris

University of Kentucky Master's Theses

Due to its unique characteristics, carbon fiber is one of the leading materials for light weight, high strength and stiffness applications in composite materials. The development of carbon fibers approaching theoretical strengths and stiffness is a continuing process which has led to improved mechanical and physical properties over the recent years. Improvements in carbon fiber properties are directly dependent on the quality of the precursor fiber. Research and development of PAN precursor fiber requires extensive experimentation to determine how processing conditions affect the structure and properties of the precursor fibers. Therefore, it is the goal of this thesis to analyze …

“Obtuse Women”: Venereal Disease Control Policies And Maintaining A “Fit” Nation, 1920-1945, Evelyn Ashley Sorrell

University of Kentucky Master's Theses

Public health officials and social reformers grew concerned over the prevalence of gonorrhea and syphilis following World War I. The initiatives put in place by authorities to control the spread of venereal disease lacked any concern for women’s health and sought to control their newly found independence and mobility. This thesis examines public health policies related to venereal disease control from 1920-1945 and how these regulations affected women in the United States. Laws and social reform measures such as pre-marital blood tests, the Sheppard-Towner Maternity and Infancy Act, and the use of quarantining prostitutes during World War I and World …

“You’Re Surviving But I Don’T See How You’Re Living” Appalachian Women Talk About Tanf And Employment In Their Communities, Pon-Chu Tsou

University of Kentucky Master's Theses

This thesis studies qualitative data to examine the lived experiences of Kentucky Transitional Assistance Program (K-TAP) recipients in Appalachian Kentucky. This research suggests that PRWORA legislation utilize the importance of place-based analyses to implement and evaluate poverty policy. For women who are attempting to meet PRWORA’s goals, the local services available to the women and the barriers they face to employment highlight the role place has in this national policy discussion. Of the women interviewed, recipients who resided in economically distressed areas had fewer opportunities to participate in employment activities than women in at-risk or transitional areas. While many strived …

Nongovernmental Organizations And Sex Work In Cambodia: Development Perspectives And Feminist Agendas, Jessica Catherine Schmid

University of Kentucky Master's Theses

This project focuses on nongovernmental organizations (NGOs) in Cambodia that deal, either directly or indirectly, with sex work and sex workers. The NGOs outlined in this study have goals ranging from preventing Cambodian women from entering the commercial sex industry to empowering Cambodian sex workers through the formation of sex worker unions. Through the textual analysis of documents and web materials disseminated by these NGOs and from interviews with representatives from the NGOs, I seek to analyze how underlying assumptions about development and about the commercial sex industry shape the ways in which the personnel leading these NGOs think and …

Fate Of Stable Isotope Label During Predation Of 15N-Tagged Wild-Type Escherichia Coli By Protozoa, Ashley M. Barton

University of Kentucky Master's Theses

Currently, bacterial movement in karst aquifers is not well understood. Use of stable isotopes to label non-pathogenic Escherichia coli as a particulate groundwater tracer in karst systems has been examined in previous studies. Loss of the stable isotope signal is anticipated in traces greater than 500 m in length. Potential loss of ¹⁵N due to predation by protozoa was examined. Filter-sterilized water from Royal Spring in Georgetown, Kentucky, was inoculated with a mixture of either Tetrahymena pyriformis or Colpoda steinii and ¹⁵N-enriched E. coli and stored in the dark at 14°C. Samples were analyzed for their nitrogen isotope …

Cultivating Miracle Perceptions: Cultivation Theory And Medical Dramas, Rachael A. Record

University of Kentucky Master's Theses

This thesis reports the results of a study designed to investigate the influence of exposure to televised medical dramas on perceptions of medical miracles. Four hundred and eighty-one college students participated in a survey in which they responded to different questions about their medical drama viewership and their different beliefs with regard to medical miracles. Results found that heavy medical drama viewers perceived belief in medical miracles to be less normal than non-viewers. Similarly, heavy viewers perceived medical miracles to occur less often than non-viewers. Interestingly, heavy viewers perceived medical dramas to be less credible than non-viewers. In addition, this …

“What’S Happening” @Twitter: A Uses And Gratifications Approach, Corey Leigh Ballard

University of Kentucky Master's Theses

The uses and gratifications approach places power in the hands of the audience and is a helpful perspective when trying to understand media usage, exposure, and effects. However, while the uses and gratifications approach has been applied regularly to traditional media, research explaining why people use new social media networks as well as the gratifications they obtain from them is scarce at best. This thesis provides a comprehensive overview of the uses and gratifications approach as well as the current literature about social media networks. An argument is built within the thesis to study Twitter as one social media network …

Readers’ Knowledge Of Functional Devices, Hung-Tao Chen

University of Kentucky Master's Theses

Various writing devices are designed to serve specialized purposes or “functions” to aid readers in their processing of a text. For example, an index lists important topics in the book and allows the readers to quickly locate the pages relevant to a particular topic. The purpose of this study was to learn what mature readers know about various functional devices. Two experiments were conducted to learn what readers know about functional devices in texts. Experiment 1 investigated readers’ knowledge about functional writing devices and Experiment 2 examined readers’ beliefs about the relevance of functional writing devices in various reading situations. …

Mir-17* Suppresses Tumorigenicity Of Prostate Cancer By Inhibiting Mitochondrial Antioxidant Enzymes, Yong Xu, Fang Fang, Jiayou Zhang, Sajni Josson, William H. St. Clair, Daret K. St. Clair

Toxicology and Cancer Biology Faculty Publications

Aberrant micro RNA (miRNA) expression has been implicated in the pathogenesis of cancer. Recent studies have shown that the miR-17-92 cluster is overexpressed in many types of cancer. The oncogenic function of mature miRNAs encoded by the miR-17-92 cluster has been identified from the 5' arm of six precursors. However, the function of the miRNAs produced from the 3' arm of these precursors remains unknown. The present study demonstrates that miR-17* is able to suppress critical primary mitochondrial antioxidant enzymes, such as manganese superoxide dismutase (MnSOD), glutathione peroxidase-2 (GPX2) and thioredoxin reductase-2 (TrxR2). Transfection of miR-17* into prostate cancer PC-3 …

Cell Lines Having Enhanced Cell Longevity And Protein Expression, Bruce Allen Webb, Jeremy Kroemer

Entomology Faculty Patents

It is the object of the current invention to provide methods and compositions relating to the expression of vankyrin proteins in cell lines to increase their viability, longevity and capacity for protein production. The inventors have discovered that the expression of P-ank-1 and I²-ank-3 proteins in cell culture has increased the cells' longevity and capacity for endogenous and/or heterologous target protein production. Specifically, the present invention relates to the enhanced expression of endogenous and/or heterologous target proteins/polypeptides in recombinant cells that are also expressing P-ank-1 and/or I²-ank-3 protein compared to expression host cells that are not …