Digital Commons Network^™

Strategic Alignment Of Lexington Public Library And Art Community, Jonnisa Ferguson, Samantha Metzger-Elder

MPA/MPP/MPFM Capstone Projects

Amidst the evolving economic, political, religious, social, and technological landscape of the United States, one enduring element across communities has been the presence and importance of public libraries. Despite the decreasing number of genuinely public spaces in America, public libraries remain accessible and welcoming to all (Howard, 2019). Modern public libraries unite people and are "rewriting common assumptions of what people think a library does" (Carlson, 2024). Going far beyond books, libraries are serving as a "trusted public common for social innovation and civic engagement," partnering with community organizations to address daily living issues (i.e., food insecurities and professional development), …

Lfucg: Assessing Homeownership Initiatives Through Document Analysis, Matthew D. Hallock, Dakota Hensley, Jordan G. Salem

MPA/MPP/MPFM Capstone Projects

The Lexington, Kentucky Vice Mayor’s Office is exploring ways to expand access to homeownership as a means to facilitate wealth creation for its citizens. This paper outlines literature highlighting the issues surrounding the shortage of housing and past discriminatory policies which negatively affected Lexington. Specific criteria were used to identify cities that resemble Lexington to see what housing programs those cities have implemented and to see what can be reasonably applied to Lexington. Descriptions and themes of the identified programs are provided to provide the Lexington Vice Mayor’s Office with policy options to increase avenues to first-time homeownership.

Ensuring A Future For The Past: Balancing Heritage Tourism And Historic Preservation, Kyra Frew Sexauer

MPA/MPP/MPFM Capstone Projects

Savannah’s historic city plan, Charleston’s colonial architecture, and New Orleans’ Creole and Cajun culture and cuisine all have a commonality: they tangibly and intangibly connect the past to the present. Each city has a distinct and recognizable landscape, shaped by its built environment, history, and culture, which is listed as a National Historic Landmark District (NHLD) – the most prestigious recognition a historic district can receive in the United States. Heritage tourists are drawn to these places by their history, culture, and authenticity. In 2022, a combined 42,320,000 million tourists poured into the streets of Savannah, Charleston, and New Orleans. …

A Comparative Study Of State-Level Fast Programs To Identify Best Practices For Kentucky, Alana Morgan

MPA/MPP/MPFM Capstone Projects

This capstone project examines best practices among state-level innovation programs participating in the U.S. Small Business Administration’s Federal and State Technology (FAST) Partnership Program, with a specific focus on the Kentucky Science and Engineering Foundation (KSEF). As a key player in Kentucky’s innovation ecosystem, KSEF supports small businesses and entrepreneurs in pursuing federal Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) funding. This study evaluates KSEF’s current program effectiveness and identifies strategies from similar states that could strengthen Kentucky’s outcomes in securing federal innovation funding.

Using a qualitative comparative research design, this study analyzes interviews with program …

Sex-Specific Roles Of The Adipocyte Mineralocorticoid Receptor In Obesity And Early Life Stress, Meghan B. Turner

Theses and Dissertations--Pharmacology and Nutritional Sciences

Obesity is a burgeoning health epidemic caused by chronic overnutrition and exacerbated by genetic, environmental and developmental factors. The adipocyte mineralocorticoid receptor (MR), a transcriptionally active nuclear receptor, is speculated to contribute to metabolic dysfunction in the obese state. MR expression is increased in obese adipose tissue, and MR modulates the expression of fat-derived hormones such as leptin and adiponectin. In women, obesity can be exacerbated by early life stress, such as adverse childhood experiences (ACEs). Studies show that women display a positive association between cumulative ACE exposures and increased body mass index. Previously, we demonstrated that maternal separation and …

Nothing Short Of Superheroic: A Quantitative Study Of Lifetime Exposure To Superhero Comic Book Media As A Predictor Of Attitudes Towards Diversity, Equity, And Inclusion, Michael Nguyen

Theses and Dissertations--Educational Leadership Studies

This dissertation examined the relationship between lifetime exposure to superhero comic book media and attitudes toward diversity, equity, and inclusion (DEI). Drawing on theories of identity formation—transitional objects, parasocial relationships, and cultivation theory—it investigated whether engagement with superhero narratives predicted DEI attitudes. Using quantitative methods, data from 499 U.S. adults were collected via Qualtrics. Two instruments were used: the Lifetime Superhero Comic Book Media Exposure Scale (LSES) and the Intolerant Schema Measure (ISM), which assessed prejudice across race, gender, sexuality, class, age, and religion. Multiple linear regression revealed that superhero media exposure significantly predicted ISM scores (B = 0.118, …

Comparison Of Machine Learning Models For Colon Cancer Survival: Predictive Modeling Approach, Reuben Adatorwovor, Motolani E. Ogunsanya, Bin Huang, Richard Charnigo, Olufunmilola Abraham

Biostatistics Faculty Publications

Background: Colon cancer is a leading cause of cancer-related deaths worldwide, with survival influenced by risk factors, treatment type, and patient characteristics. Traditional statistical models, such as Kaplan-Meier curves, have been widely used to estimate survival probabilities. However, these models often have difficulty handling complex interactions, covariates, and nonlinear relationships between risk factors. Recently, machine learning (ML) techniques have emerged as promising tools for improving survival prediction by handling large covariates and capturing complex patterns.

Objective: This study compares several ML models to accurately estimate colon cancer survival by leveraging data from the Kentucky Cancer Registry. By identifying key risk …

Minority In Baroque Trumpet Repertoire: Minor-Key Literature For Baroque Trumpet, Wing Heng Victor Yuen

Theses and Dissertations--Music

The repertoire for trumpet in the Baroque era is overwhelmingly in major keys for obvious reasons. As natural trumpet is limited by design to play the notes of the harmonic series, most players have little access to sonorities outside the major scale and arpeggios within the series without the help of technical innovations such as the slide, and much later, vent-holes. Baroque trumpet makers built valveless natural trumpets, which are limited by design to play the notes of the harmonic series. Since the fundamental physics limit the musical notes available to the natural trumpet, minor key is not an essentially …

Examples Of Storytelling In Tan Dun’S The Banquet Piano Sonata, Ni Zhan

Theses and Dissertations--Music

The Banquet is a 2006 Chinese martial arts film directed by Feng Xiaogang. Chinese-American composer Tan Dun was invited to create the film's original soundtrack. In 2016, Tan adapted the music from the soundtrack into a four-movement piano sonata, also titled The Banquet, using melodies from the original film score. This document examines The Banquet Piano Sonata’s connection to the film’s narrative. It explores ways in which the storytelling of the film is used in the sonata; this is accomplished through three key aspects depicted in the music: culture, atmosphere, and inner emotions.

Teacher Perceptions Of A Mindful-Based Social Emotional Group Drumming Curriculum: A Collective Case Study, Kristin Lewis

Theses and Dissertations--Music

Educational researchers have discovered a connection between educator and student well-being. Educators need to cultivate these skills to effectively model social emotional learning (SEL). However, there is a shortage of resources for elementary general music educators that intentionally embed social emotional competencies in tandem with adhering to the National Core Arts Standards.

Therefore, the purpose of this study was to examine elementary music educators’ perceptions of a Mindfulness-Based Social Emotional Learning (MBSEL) group drumming curriculum and its impact on their own and their students’ social emotional competencies (SECs). The research questions were: (1) What are elementary music educators’ perceptions of …

A Performance Pracitce Guide To Selected Cornet/Trumpet Excerpts From Wind Band Marches, Adiel P. Najera

Theses and Dissertations--Music

This dissertation seeks to illuminate a long-overlooked area in music and education. Wind band marches are part of a genre that has perhaps received less scholarly treatment when compared to the trumpet parts of orchestral, jazz, and popular music. This guide aims to fill the gap in information available for cornet/trumpet players in wind band settings.

This treatise will provide knowledge including a brief background information, marches in teaching and performing, insights from interviews with current and retired military trumpeters & current and retired music educators. Additionally, the document features excerpts with detailed performance practice and a list of renowned …

Hardcore And Metal Music In Music Therapy: A Functional Guide For Music Therapists And Music Therapy Students, Caroline Nc Wood

Theses and Dissertations--Music

Hardcore and metal music have long been misrepresented, stigmatized, and dismissed in music academia, and overlooked in music therapy literature and education. However, these genres hold significant emotional, cultural, and therapeutic value for many listeners, offering unique opportunities for connection, expression, catharsis, and healing. This thesis presents a practical, introductory guide to help music therapists and music therapy students gain an understanding of why, when, and how to effectively and authentically incorporate hardcore and metal music into clinical practice. The project explores the historical development of these genres; sociocultural associations and considerations, including stigmatization, sensationalism, and the juxtaposing sociopolitical dynamics …

A Comparison Of Informal Choral Singing Experiences, Christopher Powell

Theses and Dissertations--Music

A traditional choir relies on the interest and participation of the population in communal singing. However, drawing willing participants into a traditional choir program can often prove challenging to music educators, community choir directors, and leaders of religious music programs. One of the most prevalent informal singing groups in the USA is Sacred Harp. Sacred Harp “singings” have been around since the early years of The Sacred Harp itself. These singings occur regularly in multiple locations across the country and around the world. These events have an open atmosphere and, despite the mostly Christian material, have no expectation of a …

Professional Experiences Of Disabled Music Therapists: An Adapted Multiple Case Study, August Lily Tuggle

Theses and Dissertations--Music

Literature about disability often focuses on disabled people as recipients of professional services and there is scant literature about disabled professionals. Although music therapists work primarily with disabled individuals, there is little research on or from the perspectives of disabled music therapists. A growing body of qualitative research, grey literature, and media platforms provides perspectives from the disability community regarding music therapy. Disabled individuals both within and outside the profession critique common music therapy attitudes and practices that conflict with the expressed needs of the disability community. However, much of this literature contains the perspectives of one individual or a …

Analysis Of State And Local Requirements For Special Taxing District Fiduciary Managers And How Kentucky Could Improve, Zach Waller

MPA/MPP/MPFM Capstone Projects

This paper examines the oversight and training requirements for fiduciary managers within Special Purpose Government Entities (SPGEs), comparing practices in Kentucky with those in a select group of peer states. The analysis highlights notable deficiencies in fiduciary training, enforcement, and accountability standards in Kentucky, which lead to ongoing issues of financial mismanagement. A review of exemplary practices from other states highlights the importance of mandatory training, robust oversight frameworks, and effective enforcement measures in enhancing fiduciary outcomes. Recommended actions involve implementing mandatory fiduciary training programs, strengthening enforcement authority, and improving transparency mechanisms.

To evaluate Kentucky’s oversight of SPGEs compared to …

Managing Kentucky's Coal Severance Tax Decline: Lessons From Other States, Ryan Reed

MPA/MPP/MPFM Capstone Projects

Governments levy severance taxes on the extraction of natural resources such as coal, oil, and natural gas. This can be a substantial source of revenue for these entities, but overreliance on this has led to what is now known through extensive research as the so-called ‘resource curse’. This has been observed to create political instability, corruption, and repression within resource-rich areas. Additionally, it cripples the ability of the area to pursue future non-resource related economic development after the resource is depleted. A Sovereign Wealth Fund has been touted as one such solution to bridge this gap as an intergenerational wealth …

Targeted Federal Advocacy For Financial Stability: Recommendations For United Way Of The Bluegrass, Jefferson Abney, Lou Hurst

MPA/MPP/MPFM Capstone Projects

Advocacy refers to activities undertaken with the intent of influencing policy change. For nonprofit organizations, advocacy can be a critical aspect of furthering their mission. Successful advocacy requires a comprehensive, dynamic understanding of the needs and priorities of stakeholders, as well as an understanding of the political context in which the organization operates and the challenges and opportunities that context poses for its institutional goals. A policy agenda helps nonprofit organizations identify and communicate the most pertinent policy needs for consideration when making decisions around advocacy.

For this project, in response to a request from United Way of The Bluegrass …

Public University Gift Management Policies: Building A Best Practice Guide, Cristin Costello

MPA/MPP/MPFM Capstone Projects

Currently, no consistent standards exist for how institutions of higher education should manage their non-endowed gift revenue. Good stewardship of gift funds is vital to ensuring the maintenance of donor relationships to create unions that bring further financial opportunities to universities for years to come. Public institutions, as recipients of government dollars, are especially vulnerable to the negative repercussions that could come with the scandal of misappropriated gift dollars. Overall cash donations to higher education have significantly increased in the past few decades as state appropriations fall short and the need to keep tuition rates stable increases. It is more …

Boys & Girls Clubs Of Greater Cincinnati Strategic Plan, Emily Yellman

MPA/MPP/MPFM Capstone Projects

After-school organizations nationwide, such as Boys & Girls Clubs, provide youth with out-of-school opportunities for academic and social-emotional learning. Strategic plans can help after-school organizations maximize their impact. This paper outlines a strategic plan for Boys & Girls Clubs of Greater Cincinnati, specifically to increase the number of members they serve on an average daily basis. The plan addresses both Club member recruitment and retention techniques, and includes specific action items, communication, and monitoring plans.

Improvement Of Cellular Pattern Organization And Clarity Through Centrifugal Force, Lauren E. Mehanna, James D. Boyd, Shelley Remus-Williams, Nicole M. Racca, Dawson P. Spraggins, Martha E. Grady, Brad J. Berron

Chemical and Materials Engineering Faculty Publications

Rapid and strategic cell placement is necessary for high throughput tissue fabrication. Current adhesive cell patterning systems rely on fluidic shear flow to remove cells outside of the patterned regions, but limitations in washing complexity and uniformity prevent adhesive patterns from being widely applied. Centrifugation is commonly used to study the adhesive strength of cells to various substrates; however, the approach has not been applied to selective cell adhesion systems to create highly organized cell patterns. This study shows centrifugation as a promising method to wash cellular patterns after selective binding of cells to the surface has taken place. After …

Treating Social Media Addiction In Adolescents: A Scoping Review With Implications For Music Therapy Practice, Roman D. Swain

Theses and Dissertations--Music

With the rapid expansion of online connectivity, concerns have emerged regarding the influence of digital interactions on adolescents’ real-world relationships and mental health. Social media use can expose adolescents to harmful content and disrupt the brain’s pleasure centers, increasing the risk of developing addictive patterns of use. Such disruptions may interfere with daily functioning and contribute to negative mental health outcomes. Given the impact of music on the brain’s reward system, music therapy may offer a beneficial approach for helping adolescents develop mindfulness of social media use and strengthen offline social connections. This thesis presents a scoping review of current …

Unveiling Secrecy: A Qualitative Analysis Of The Breonna Taylor Grand Jury Proceedings, Taylor Bettis

Theses and Dissertations--Psychology

Grand juries have faced heightened scrutiny in recent decades following high-profile cases involving police use of lethal force against Black civilians. In 2020, Police officers killed Breonna Taylor while executing a search warrant at her home. Despite widespread public outcry, it remains unclear how prosecutors failed to indict the officers involved on charges directly related to her death. Guided by critical race theory, procedural justice, and theories of authority, the current project used reflexive thematic analysis to examine the Breonna Taylor grand jury proceedings. We identified two main themes: structural influences and narrative influences. Structural influences examine how prosecutorial authority, …

Distinct Odorant Receptor Response Patterns To Aliphatic Odorants In Freely Behaving Mice, Claire A. De March, Patrick Breheny, William B. Titlow, Hiroaki Matsunami, Timothy S. Mcclintock

Physiology Faculty Publications

In mammals, odors are encoded by a combinatorial code determined by the pattern of responses across hundreds of odorant receptors expressed monogenically and monoallelically in olfactory sensory neurons. The compositions of these receptor response patterns are largely unknown and overlap between them has yet to be explored. Activity-dependent reporter gene expression in freely behaving S100a5-tauGFP mice allowed capture of activated olfactory sensory neurons and identified 168 receptors responsive to moderate concentrations of 1 or more of 12 aliphatic (5 to 8 carbons) ketones, alcohols, and carboxylic acids. These 12 response patterns are remarkably different, with only 19% of the receptors …

Programmable Scanning Diffuse Speckle Contrast Imaging Of Cerebral Blood Flow, Faezeh Akbari, Xuhui Liu, Fatemeh Hamedi, Mehrana Mohtasebi, Li Chen, Lei Chen, Guoqiang Yu

Physiology Faculty Publications

Significance: Cerebral blood flow (CBF) imaging is crucial for diagnosing cerebrovascular diseases. However, existing large neuroimaging techniques with high cost, low sampling rate, and poor mobility make them unsuitable for continuous and longitudinal CBF monitoring at the bedside. Aim: We aimed to develop a low-cost, portable, programmable scanning diffuse speckle contrast imaging (PS-DSCI) technology for fast, high-density, and depth-sensitive imaging of CBF in rodents. Approach: The PS-DSCI employed a programmable digital micromirror device (DMD) for remote line-shaped laser (785 nm) scanning on tissue surface and synchronized a 2D camera for capturing boundary diffuse laser speckle contrasts. New algorithms were developed …

Neuro293, Joshua T. Moses, Fahad B. Shah, Nicholas M. Mcvay, Dylan E. Capes, Christopher C. Bosse-Joseph, Jocelyn Salazar, Victoria K. Slone, John E. Eberth, Jonathan Satin, Andrew N. Stewart

Physiology Faculty Publications

Efficient interrogation of neurobiology remains bottlenecked by obtaining mature neurons. Immortalized cell lines still require lengthy differentiation periods to obtain neuron-like cells, which may not efficiently differentiate and are challenging to transfect with plasmids relative to other cell lines such as HEK-293's. To overcome challenges with limited access to cells that express mature neuronal proteins, we knocked out the RE1-silencing transcription factor (REST) from HEK-293's to create a novel neuron-like cell, which we name Neuro293. RNA-sequencing and bioinformatics analyses revealed a significant upregulation of genes associated with neurobiology and membrane excitability including pre-/post-synaptic proteins, voltage gated ion channels, neuron-cytoskeleton, as …

S6k1 Is A Targetable Vulnerability In Tumors Exhibiting Plasticity And Therapy Resistance, Saptadwipa Ganguly, Ravshan Burikhanov, Vitaliy M. Sviripa, Sally Ellingson, Jieyun Jiang, Christian M. Gosser, David Orren, Eva M. Goellner, Gautham G. Shenoy, Mahadev Rao, John D’Orazio, Christine F. Brainson, Chang Guo Zhan, Peter H. Spielmann, David S. Watt, Vivek M. Rangnekar

Physiology Faculty Publications

Background: Most tumors initially respond to treatment, yet refractory clones subsequently develop owing to resistance mechanisms associated with cancer cell plasticity and heterogeneity. Methods: We used a chemical biology approach to identify protein targets in cancer cells exhibiting diverse driver mutations and representing models of tumor lineage plasticity and therapy resistance. An unbiased screen of a drug library was performed against cancer cells followed by synthesis of chemical analogs of the most effective drug. The cancer subtype target range of the leading drug was determined by PRISM analysis of over 900 cancer cell lines at the Broad Institute, MA. RNA-sequencing …

Skeletal Muscle Stem Cell Mitochondria Are Transferred To Muscle Fibers In Response To A Hypertrophic Stimulus, Jensen Goh, Julia G. Williams, Sarah E. Ogle, Jai K. Joshi, Logan N. Scott, Benjamin Burke, Alex R. Keeble, Nicholas T. Thomas, Christopher S. Fry, Ahmed Ismaeel, John J. Mccarthy

Physiology Faculty Publications

The fusion of skeletal muscle stem cell (MuSC) to myofibers during hypertrophy has exclusively focused on the transfer of the MuSC nucleus, leaving the fate of other MuSC organelles, such as mitochondria, largely unexplored. The objective of this study was to determine whether MuSCs transfer their mitochondria upon myofiber fusion in response to a hypertrophic stimulus. To achieve this goal, we specifically labeled MuSC mitochondria with Dendra2 fluorescence by crossing the MuSC-specific CreER (Pax7^CreER/CreER) mouse with the Rosa26-Dendra2 mouse to generate the Pax7-Dendra2 mouse. To induce the fusion of MuSC to myofibers, Pax7-Dendra2 mice underwent synergist ablation surgery …

A Unionid Mussel Biodiversity Hotspot Experiencing Unexplained Declines: Evaluating The Influence Of Chemical Stressors Using Caged Juveniles, W. Aaron Wilson, Christine Bergeron, Jennifer Archambault, Jason M. Unrine, Jess Jones, Braven Beaty, Damian Shea, Peter R. Lazaro, Jody L. Callihan, Jennifer J. Rogers

Plant and Soil Sciences Faculty Publications

Unionid mussel populations in a section of the Clinch River in Virginia, USA, has declined substantially, but the causes of the decline remain unknown. To investigate this zone of decline (ZOD), we deployed juvenile freshwater mussels (Villosa iris in 2012 and Lampsilis fasciola in 2013) in both cages and silos at sites within the Clinch River System. We analyzed mussel tissues for trace element and organic contaminant concentrations, shells for trace elements, and environmental media (total water, dissolved water, particulate sediment, and bedload sediment) for both inorganic and organic contaminants. We found a few differences between mussels deployed in cages …

The Research Examining Factors Associated With The Opioid Crisis Among Urban Adults (Refocus), Mona K.M. Goggins, Paige Orphé, Jovonna Atkinson, Brittany Miller-Roenigk, Kaylee A. Palomino, Danelle Stevens-Watkins

Educational, School, and Counseling Psychology Faculty Publications

Introduction: Deaths due to opioid-related overdoses have increased across the United States. Specifically in the state of Kentucky, African Americans are the only population that continues to experience an increase in opioid-related deaths. Previous literature highlights African Americans having unique drug use patterns due to systematic barriers and how these barriers limit access to protective factors and substance use treatment. The current study aims to specify patterns of African American non-medical prescription opioid use (NMPOU) and how these patterns may differ based on biological sex and generational cohort. Also, this study plans on using this data on patterns to inform …

The Role Of Metabolic Gate Keepers In Cell Fate Decision Making, Brian Kelly

Theses and Dissertations--Biology

Maintaining cellular energy balance and redox stability is crucial to cell survival, with glutamine metabolism playing a central role. While extensively studied in cancer, where it supports biosynthesis and reduces oxidative stress to promote tumor growth, its function in non-cancerous contexts like tissue development and muscle regeneration remains less understood. A key aspect of stem cell biology is quiescence, a metabolically dormant state that preserves the stem cell pool, yet the mechanisms regulating this state are not fully clear. Here, we identify glutamine metabolism as a critical factor governing myoblast proliferation and quiescence through a metabolic program distinct from that …