Digital Commons Network^™

Engineered Surface Properties Of Porous Tungsten From Cryogenic Machining, Julius M. Schoop

Theses and Dissertations--Chemical and Materials Engineering

Porous tungsten is used to manufacture dispenser cathodes due to it refractory properties. Surface porosity is critical to functional performance of dispenser cathodes because it allows for an impregnated ceramic compound to migrate to the emitting surface, lowering its work function. Likewise, surface roughness is important because it is necessary to ensure uniform wetting of the molten impregnate during high temperature service. Current industry practice to achieve surface roughness and surface porosity requirements involves the use of a plastic infiltrant during machining. After machining, the infiltrant is baked and the cathode pellet is impregnated. In this context, cryogenic machining is …

Association Of Molecular Pathology V. Myriad Genetics, Inc.: Determining The Scope Of The Supreme Court's Holding For Patentable Subject Matter, Ashley Winkler

Kentucky Law Journal

No abstract provided.

A Uniform Test Isn't Here Right Now, But Please Leave A Message: How Altering The Spence Symbolic Speech Test Can Better Meet The Needs Of An Expressive Society, Caitlin Housley

Kentucky Law Journal

No abstract provided.

50,000 Voices Can't Be Wrong, But Courts Might Be: How Chevron's Existence Contributes To Retrenching The Higher Education Act, Twinette L. Johnson

Kentucky Law Journal

No abstract provided.

Crowd Crush: How The Law Leaves American Crowds Unprotected, Tracy Hresko Pearl

Kentucky Law Journal

Crowd-related injuries and deaths are startlingly common both in the United States and worldwide. They occur in a wide range of situations and at a vast array of venues: at music concerts, sporting events, retail holiday sales, in and around airports, subway plaorms, and parking lots, among other locations. These "crowd crush" incidents, however, are extremely underreported and rarely litigated, masking the seriousness of this issue and making it difficult for the few victims who pursue legal recourse to recover damages. Given that there is virtually no statutory law in the United States pertaining to crowd management and control, crowd …

Rectifying These Mean Streets: Percent-For-Art Ordinances, Street Furniture, And The New Streetscape, Asmara M. Tekle

Kentucky Law Journal

No abstract provided.

Persecution: How Much Is Enough?, Hillary R. Chambers

Kentucky Law Journal

No abstract provided.

Federal Reverse Preemption Of Uninsured And Underinsured Motorist Coverage Offering In The Digital Age: E-Sign And Ueta Have Not Had A Significant Impact On State Offering Or Rejection Requirements, Steven Plitt, Daniel Maldonado, John Wittwer

Kentucky Law Journal

No abstract provided.

Effects Of Headings On Processing Of Audio Texts, Hung-Tao Chen

Theses and Dissertations--Psychology

Text-to-speech devices often do a poor job of translating signals such as headings from visual into audio mode. Previous research studies have attempted to address this problem but these studies have mainly used heading detection tasks. The current study seeks to investigate 1) whether listeners find the presence of audio headings useful in natural learning tasks, and 2) the type of heading rendering that is most useful in natural learning tasks. The three learning tasks in this study include note-taking, cued recall, and knowledge transfer. Results from this study reveal that listeners find audio headings useful in the note-taking task. …

Delicious Justice: Schadenfreude Toward Atheists Bound For Hell, Maxine Najle

Theses and Dissertations--Psychology

In the wake of the death of a prominent atheist figure in 2011, an especially unsavory side of anti-atheist prejudice became evident as many celebrated the death of a prominent atheist, rejoicing that he would be in hell. The current study explores how these attitudes reveal a sense of schadenfreude in anti-atheist prejudice previously unexplored in the literature. Potential origins of this schadenfreude are discussed, and a study to experimentally explore this phenomenon was carried out. Using the repeated taste-test paradigm, this study gave participants atheist primes and hell primes between identical drinks and measure perceived taste after these manipulations, …

Parenting Behaviors Of Sleepy Parents: Associations With Emotion Regulation And Stress, Lauren R. Gilbert

Theses and Dissertations--Psychology

Over the last decade, the topic of sleep has garnered a great deal of interest from psychologists, due to the physiological, emotional, and behavioral outcomes associated with its deprivation. However, questions remain to be answered regarding sleep's influence in the day-to-day life of families. The current study examines the importance of sleep deprivation for parents’ parenting behaviors during problem solving discussions with their children; emotion regulation and stress reactivity are examined as mediators of these associations. Participants were 196 families with a child between the ages of 6-11. Parents filled out diaries for 7 days prior to their in-lab visit, …

Gαq-Associated Signaling Promotes Neuroadaptation To Ethanol And Withdrawal-Associated Hippocampal Damage, Anna R. Reynolds

Theses and Dissertations--Psychology

Prolonged, heavy consumption of alcohol produces marked neuroadaptations in excitatory neurotransmission. These effects are accelerated following patterns of intermittent heavy drinking wherein periods of heavy consumption are followed by periods of abstinence. Studies have shown that neuroadaptive changes in the glutamatergic N-methyl-D-aspartate (NMDA) receptor produces excitotoxicity during periods of withdrawal; however, upstream targets were not adequately characterized. The present studies sought to identify these targets by assessing the role of group 1 metabotropic glutamate receptors (mGluR) and intracellular calcium in promoting cytotoxicity of hippocampal cell layers in vitro. It was hypothesized that ethanol-induced activity of mGluR1-and-5 contributes to hippocampal …

On A(Pe)Theism: Religious Dehumanization Of Atheists And Other Outgroups, Ben Kok Leong Ng

Theses and Dissertations--Psychology

Research on the dark side of religion has recently found evidence that anti-atheist prejudice is embedded in distrust (Gervais et al, 2011). Anti-atheist prejudice though old in its form, has only been systemically researched on over the last couple of years. This study seeks to extend on research in anti-atheist prejudice by examining religious dehumanization of atheists in comparison with other religious outgroups – gays and Muslims. Study 1 utilized a two factor model of dehumanization (Haslam, 2006) to examine dehumanization. Study 2 serves as a conceptual replication and extension using two different measures of dehumanization. Study 1 failed to …

The Effects Of Alcohol And Hypoxia Exposure In The Developing Brain, Megan L. Carter

Theses and Dissertations--Psychology

Exposure to alcohol (ethanol (ETOH)) during fetal development results in a variety of cognitive/behavioral deficits. The effects of fetal ETOH exposure vary across individuals and numerous studies have shown that ETOH’s interaction with other variables can affect outcome in offspring. These studies investigated the effects of developmental ETOH and hypoxia. It was hypothesized that a history of ETOH during development alters the response to a subsequent hypoxic challenge, such as that which may occur during parturition; this results in central nervous system (CNS) damage and behavioral deficits.

The first study determined if developmental ETOH and hypoxia exposure produced behavioral deficits …

R-Bpidi, An Α6Β2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release And Nicotine Reinforcement, Joshua S. Beckmann, Andrew C. Meyer, Marharyta Pivavarchyk, David B. Horton, Guangrong Zheng, Andrew M. Smith, Thomas E. Wooters, J. Michael Mcintosh, Peter A. Crooks, Michael T. Bardo, Linda P. Dwoskin

Psychology Faculty Publications

α6β2* nicotinic acetylcholine receptors (nAChRs) expressed by dopaminergic neurons mediate nicotine-evoked dopamine (DA) release and nicotine reinforcement. α6β2* antagonists inhibit these effects of nicotine, such that α6β2* receptors serve as therapeutic targets for nicotine addiction. The present research assessed the neuropharmacology of 1,10-bis(3-methyl-5,6-dihydropyridin-1(2H)-yl)decane (r-bPiDI), a novel small-molecule, tertiary amino analog of its parent compound, N,N-decane-1,10-diyl-bis-3-picolinium diiodide (bPiDI). bPiDI was previously shown to inhibit both nicotine-evoked DA release and the reinforcing effects of nicotine. In the current study, r-bPiDI inhibition of [³H]nicotine and [³H]methyllycaconitine binding sites was evaluated to assess interaction with the recognition binding sites on …

Influence Of Student Engagement On The Career Transition Of Division I Football Student-Athletes, Ronnie Riley

Theses and Dissertations--Kinesiology and Health Promotion

College’s revenue sports, football and men’s basketball, fuel the billion dollar intercollegiate athletics industry. Historically, those same two sports have maintained the lowest grade point average among all student-athletes. This inverse relationship begs the question, “what academic sacrifices are being made at the expense of college’s revenue sports?”

Student engagement into educationally purposeful activities has been widely acknowledged as having influence on desirable college outcomes. The full extent of student engagement’s effect has yet to be determined. The purpose of this study was to conduct exploratory, qualitative research into the role of student engagement in educationally purposeful activities on the …

Cardiovascular Disease Risk Factors In Structural Firefighters, Nicholas W. Trubee

Theses and Dissertations--Kinesiology and Health Promotion

This dissertation is composed of two manuscripts assessing cardiovascular disease (CVD) risk in structural firefighters. Study 1 compared traditional CVD risk factors and health-related behaviors between professional and volunteer firefighters. Online questionnaires were sent to approximately 4000 firefighters in the state of Kentucky. The results indicated that 90% of volunteer and 58% of professional firefighters were classified as moderate-to-high CVD risk. Volunteer firefighters were significantly (p < 0.001) older and more likely (p = 0.026) to be current cigarette smokers. The mean body mass index among all firefighters in the sample was 30.8 kg·m^-2. Nearly 60% of volunteer firefighters were obese. Obese firefighters were more likely (p < 0.05) to have been diagnosed as diabetic or pre-diabetes compared to overweight and normal weight firefighters. These results indicate that volunteer firefighters may be at a greater CVD risk compared to professional firefighters.

Study 2 investigated the association of cardiorespiratory fitness (CRF) and body fat with arterial stiffness in professional firefighters. Forty-six …

Regulation Of The Pay Television Market: Why A La Carte Cable Is Not The Solution But Giving The Fcc More Power Is, Jacob Moak

Kentucky Law Journal

No abstract provided.

That's Unfair! Or Is It? Big Data, Discrimination And The Ftc's Unfairness Authority, Dennis D. Hirsch

Kentucky Law Journal

No abstract provided.

Surveillance At The Source, David Thaw

Kentucky Law Journal

Contemporary discussions concerning surveillance focus predominantly on government activity. These discussions are important for a variety of reasons, but they generally ignore a critical aspect of the surveillance--harm calculus--the source from which government entities derive the information they use. The source of surveillance data is the information "gathering" activity itself which is where harms like "chilling" of speech and behavior begin.

Unlike the days where satellite imaging, communications intercepts, and other forms of information gathering were limited to advanced law enforcement, military, and intelligence activities, private corporations now play a dominant role in the collection of information about individuals' activities. …

One Minute To Midnight: Amending The War Powers Resolution To Confront The Coming Cyber Wars, Benjamin L. Monarch

Kentucky Law Journal

No abstract provided.

Sudden Death, Aortic Rupture In Horses, Literature Review, Case Studies Reported And Risk Factors, Abelardo Morales Briceño, Aniceto Mendez, Kimberly Brewer, Charlie Hughes, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Sudden deaths of horses in multiple equestrian disciplines have been attributed to acute and chronic respiratory and cardiovascular diseases. The aim of this study was to perform a review of aortic rupture in horses analyzing, case studies and assessing risk factors. The literature has reported a total of 137 cases of aortic rupture in horses for 28 years (1986-2014), with approximately five horses dying of aortic rupture per year. Histopathologically, there are observed discrete macroscopic degenerative changes in the intima layer only in the aorta. The histological evaluation in the beginning portion of the aorta of the heart evidenced degenerative …

Health Communication As A Public Health Training And Workforce Development Issue, Nancy L. Winterbauer, Ann P. Rafferty, Katherine A. Jones, Mary Tucker-Mclaughlin, Colleen Bridger

Frontiers in Public Health Services and Systems Research

Effective communication is one of the core competencies for public health professionals and is required for local health department (LHD) accreditation. Public health communication specialists play a critical role as conduits of health information, particularly with regard to managing relationships with media and the message that is ultimately represented by news outlets. However, capacity for engagement with traditional media in community health improvement at the local level has not been well-described. As part of a larger study examining the use and impact of the County Health Rankings in North Carolina, LHD media staffing and interaction with traditional media were examined …

Interfacial Polymerization For Colorimetric Labeling Of Protein Expression In Cells, Jacob L. Lilly, Phillip R. Sheldon, Liv J. Hoversten, Gabriela Romero, Vivek Balasubramaniam, Brad J. Berron

Chemical and Materials Engineering Faculty Publications

Determining the location of rare proteins in cells typically requires the use of on-sample amplification. Antibody based recognition and enzymatic amplification is used to produce large amounts of visible label at the site of protein expression, but these techniques suffer from the presence of nonspecific reactivity in the biological sample and from poor spatial control over the label. Polymerization based amplification is a recently developed alternative means of creating an on-sample amplification for fluorescence applications, while not suffering from endogenous labels or loss of signal localization. This manuscript builds upon polymerization based amplification by developing a stable, archivable, and colorimetric …

Enzymes From Fungal And Plant Origin Required For Chemical Diversification Of Insecticidal Loline Alkaloids In Grass-Epichloë Symbiota, Juan Pan, Minakshi Bhardwaj, Padmaja Nagabhyru, Robert B. Grossman, Christopher L. Schardl

Chemistry Faculty Publications

The lolines are a class of bioprotective alkaloids that are produced by Epichloë species, fungal endophytes of grasses. These alkaloids are saturated 1-aminopyrrolizidines with a C2 to C7 ether bridge, and are structurally differentiated by the various modifications of the 1-amino group: -NH₂ (norloline), -NHCH₃ (loline), -N(CH₃)₂ (N-methylloline), -N(CH₃)Ac (N-acetylloline), -NHAc (N-acetylnorloline), and -N(CH₃)CHO (N-formylloline). Other than the LolP cytochrome P450, which is required for conversion of N-methylloline to N-formylloline, the enzymatic steps for loline diversification have not yet been established. …

Mitochondria Dysfunction In Lung Cancer-Induced Muscle Wasting In C2c12 Myotubes, Julie B. Mclean, Jennifer S. Moylan, Francisco H. Andrade

Physiology Faculty Publications

Aims: Cancer cachexia is a syndrome which results in severe loss of muscle mass and marked fatigue. Conditioned media from cachexia-inducing cancer cells triggers metabolic dysfunction in skeletal muscle, including decreased mitochondrial respiration, which may contribute to fatigue. We hypothesized that Lewis lung carcinoma conditioned medium (LCM) would impair the mitochondrial electron transport chain (ETC) and increase production of reactive oxygen species, ultimately leading to decreased mitochondrial respiration. We incubated C2C12 myotubes with LCM for 30 min, 2, 4, 24 or 48 h. We measured protein content by western blot; oxidant production by 2′,7′-dichlorofluorescin diacetate (DCF), 4-amino-5-methylamino-2′,7′-difluorofluorescein diacetate (DAF), and …

Gender, Smoking And Tobacco Reduction And Cessation: A Scoping Review, Joan L. Bottorff, Rebecca Haines-Saah, Mary T. Kelly, John L. Oliffe, Iris Torchalla, Nancy Poole, Lorraine Greaves, Carole A. Robinson, Mary H. H. Ensom, Chizimuzo T.C. Okoli, J. Craig Phillips

Nursing Faculty Publications

Considerations of how gender-related factors influence smoking first appeared over 20 years ago in the work of critical and feminist scholars. This scholarship highlighted the need to consider the social and cultural context of women's tobacco use and the relationships between smoking and gender inequity. Parallel research on men's smoking and masculinities has only recently emerged with some attention being given to gender influences on men's tobacco use. Since that time, a multidisciplinary literature addressing women and men's tobacco use has spanned the social, psychological and medical sciences. To incorporate these gender-related factors into tobacco reduction and cessation interventions, our …

2015-2016 Burley And Dark Tobacco Production Guide, Robert C. Pearce, William A. Bailey, Lowell P. Bush, Jonathan D. Green, Anne M. Jack, Robert D. Miller, William M. Snell, Lee H. Townsend, Mark A. Purschwitz, Larry D. Swetnam, John H. Wilhoit, Eric Walker, Steve Bost, Neil Rhodes, David Reed, Chuck Johnson, Loren Fisher, Matthew Vann, Scot Whitley, Mina Mila

Agriculture and Natural Resources Publications

Burley and dark tobacco growers in the U.S. make hundreds of decisions every growing season that impact the yield and quality of the crops that they produce. These decisions may include choosing appropriate varieties, planning effective pest control measures or perhaps deciding the best time to top or harvest a crop. Increasingly, tobacco growers are being required by the industry to record and justify their management decisions and actions. The most comprehensive example of this is the U.S. Tobacco Good Agricultural Practices (GAP) program that was initiated during the 2013 growing season and expanded in 2014. Under …

“The Personal Has Become Political”: A Secondary Teacher’S Perceptions Of Her Body In The Classroom, Christine A. Mallozzi

Curriculum and Instruction Faculty Publications

The purpose of this paper is to examine how a secondary English teacher considered her body a personal and political matter within her professional settings. Discourse analysis of the participant’s narrative evidences that women teachers are pressured to present certain feminine and heterosexual bodies and present a similar personal life within their pedagogy. The risk in not following suit is being pushed out of the profession, a matter that can be problematic especially when a teacher undergoes personal changes counter to professional expectations. Teacher education responsibility in preparing teacher candidates for a variable professional trajectory is noted.

First Proof Of Concept Of Sustainable Metabolite Production From High Solids Fermentation Of Lignocellulosic Biomass Using A Bacterial Co-Culture And Cycling Flush System, Wanying Yao, Sue E. Nokes

Biosystems and Agricultural Engineering Faculty Publications

To improve the lignocellulose conversion for ABE in high solids fermentation, this study explored the feasibility of cycling the process through the cellulolytic or/and solventogenic phases via intermittent flushing of the fermentation media. Five different flushing strategies (varying medium ingredients, inoculum supplement and cycling through phases) were investigated. Flushing regularly throughout the cellulolytic phase is necessary because re-incubation at 65 °C significantly improved glucose availability by at least 6-fold. The solvents accumulation was increased by 4-fold using corn stover (3-fold using miscanthus) over that produced by flushing only through the solventogenic phase. In addition, cycling process was simplified by re-incubating …