Digital Commons Network^™

Social Space And Social Media: Analyzing Urban Space With Big Data, Ate Poorthuis

Theses and Dissertations--Geography

This dissertation focuses on the key role that big data can play in minimizing the perceived disconnect between social theory and quantitative methods in the discipline of geography. It takes as its starting point the geographic concept of space, which is conceptualized very differently in social theory versus quantitative methodology. Contrary to this disparity, an examination of the disciplinary history reveals a number of historic precedents and potential pathways for a rapprochement, especially when combined with some of the new possibilities of big data. This dissertation also proposes solutions to two common barriers to the adoption of big data in …

Campus Storytelling Networks And Student Retention Intent, Dale Howard Davis

Theses and Dissertations--Community & Leadership Development

In an effort to better understand retention, a survey was developed to ask students at a southern land-grant university how they communicate with each other. Communication Infrastructure Theory (CIT) was previously used to identify communication networks in urban neighborhoods. My thesis adapted this theory and networks to identify the strength of three communication techniques of college students and how it effects a student’s sense of belonging which can impact that student’s intent to stay in school.

Insights Into Perspectives On Environmental Sustainability, Amber R. Shobe

Theses and Dissertations--Community & Leadership Development

As scientists become more aware of the imposing threats associated with climate change, university leaders are encouraged to become familiar with the principles of sustainability. Abundant research already supports the relevance of environmental sustainability in higher education; however, there exists a gap in the literature which investigates an understanding of environmental sustainability and the implementation of its practices. By examining colleges at the University of Kentucky, this study identifies organizational barriers to recognizing a thorough understanding of environmental sustainability at the departmental level. The results indicate that out of the eight colleges selected, two have no existing environmental sustainability programs …

The Effects Of Inoculum Size, Airflow Rate, Bulk Density And Particle Size On The Scale-Up Of Phanerochaete Chrysosporium Pretreatment, Amanda N. Hickman

Theses and Dissertations--Biosystems and Agricultural Engineering

The following full-factorial study compared fungal activity on lignocellulosic biomass that was inoculated with three different amounts of fungus, and grown using three different airflow rates. These treatments were compared to a control which consisted of biomass that was not inoculated but was exposed to the same growth conditions in the environmental chamber. The objectives of the following experiment were to determine the inoculum density and airflow rate required to optimize Phanerochaete chrysosporium lignin degradation. Additionally, this study quantifies the saccharification yield from the pretreated switchgrass.

The impact of substrate bulk density and substrate particle size on fungal growth were …

Investigation Of Phanerochaete Chrysosporium And Clostridium Thermocellum For Improved Saccharification Of Lignocellulose Under Nonsterile Conditions, William E. Simon

Theses and Dissertations--Biosystems and Agricultural Engineering

Current research efforts are directed at developing competitive processes that can utilize lignocellulose as a feedstock for biorefineries. The purpose of this study was to investigate methods of processing lignocellulosic material so that its monosacharides can be more easily accessed for fermentation, the lack of which is hindering the economics and widescale adoption of lignocellulosic biorefining. The monosaccharides are of interest because they can be used by Clostridium beijerinckii downstream of P. chrysosporium and C. thermocellum in a sequential bioprocess to produce butanol. Butanol is an attractive biofuel because it can be utilized without modifying current transportation infrastructure. Butanol is …

The Influence Of Media Ingredients And Ph On The Growth Of Chloromonas Rosae Var. Psychrophila, Caoli Zheng

Theses and Dissertations--Biosystems and Agricultural Engineering

In order to utilize algae to fix CO2 and reduce Greenhouse gas emissions, large-scale, year-round algae cultivation will be required. This will require alga species that thrive in colder weather with media recipes based on commercially available fertilizers. The objectives of this study were to evaluate the effect of using commercial based media and the effect of pH when growing the cold-temperature algae Chloromonas rosae var. psychrophila. Commercial grade media ingredients urea, potash, triple superphosphate, and Sprint 330® were used to provide nitrogen, potassium, phosphorus, and EDTA with iron, respectively. The commercial grade media supported growth similar to the growth …

Up Regulation Of Heat Shock Protein 70b (Hsp70b) And Ssa1 In Chlamydomonas Reinhardtii Via Hsp70a-Rbcs2 And Psad Promoter, B. Kirtley Amos

Theses and Dissertations--Biosystems and Agricultural Engineering

Fabrication of effective algae cultivation systems adjacent to coal-fired power plants to fixate waste CO₂ would represent a sizable step towards achieving a carbon neutral energy cycle. However, emission gas would elevate the algal cultivation system temperature and decreases its pH without expensive preprocessing. Increased temperature and acidity constitutes a profound stress on the algae. Although stressed algae produce heat shock proteins (HSPs) that promote protein folding and protect against stress, the ordinary biological response is insufficient to protect against coal flue gas. Experimental upregulation of HSPs could make algae respond to the stress caused by high temperatures and …

The Role Of Batf2 In Lps/Ifnγ Polarized Macrophages, Marie A. Gehman

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Transcription factors regulate distinct macrophage functions by regulating gene expression in response to micro-environmental cues. This functional plasticity is critical for regulating innate and adaptive immune responses during infection and during chronic disease processes including inflammatory diseases and cancer. Microarray analysis of macrophages polarized to a pro-inflammatory (M1) phenotype with LPS and IFNγ revealed that basic leucine zipper transcription factor ATF-like 2 (Batf2), a member of the AP1 transcription factors, is selectively upregulated in M1 macrophages compared to anti-inflammatory IL-4-polarized (M2) macrophages. The initial hypothesis was that Batf2 is a master regulator of gene expression that orchestrates M1 polarization. To …

Dietary Selenium Supplementation: Effects On Neurodegeneration Following Traumatic Brain And Spinal Cord Injury, Carolyn A. Crowdus Meyer

Theses and Dissertations--Neuroscience

Traumatic brain and spinal cord injury continue to be substantial clinical problems with few available treatment strategies. Individuals who are at a greater risk for sustaining a central nervous system (CNS) injury, such as professional athletes and military personnel, may benefit from a prophylactic supplement that would intervene in the neurodegenerative pathways immediately following injury. The high demand for selenium within the central nervous system, as well as the synthesis of selenoproteins by neurons and astrocytes suggests a critical role of selenium within the brain and spinal cord. Studies were designed to test the efficacy of enriched dietary selenium status …

Target-Directed Biosynthetic Evolution: Redirecting Plant Evolution To Genomically Optimize A Plant’S Pharmacological Profile, Dustin Paul Brown

Theses and Dissertations--Neuroscience

The dissertation describes a novel method for plant drug discovery based on mutation and selection of plant cells. Despite the industry focus on chemical synthesis, plants remain a source of potent and complex bioactive metabolites. Many of these have evolved as defensive compounds targeted on key proteins in the CNS of herbivorous insects, for example the insect dopamine transporter (DAT). Because of homology with the human DAT protein some of these metabolites have high abuse potential, but others may be valuable in treating drug dependence. This dissertation redirects the evolution of a native Lobelia species toward metabolites with greater activity …

Zhx2 Regulation Of Lipid Metabolism And The Balance Between Cardiovascular And Hepatic Health, Kate Townsend Creasy

Theses and Dissertations--Pharmacology and Nutritional Sciences

The growing obesity epidemic in America carries with it numerous health risks, including diabetes, increased serum lipid levels, and excess fat accumulation in the liver. If these conditions persist or become exacerbated, they may lead to the development of cardiovascular disease, the current leading cause of death among Americans, or to nonalcoholic fatty liver disease (NAFLD) which can progress to hepatocellular carcinoma (HCC), one of the deadliest forms of cancer. Better understanding of the genes involved in these diseases can lead to improved identification of at-risk individuals and treatment strategies.

Our lab previously identified zinc fingers and homeoboxes 2 (Zhx2) …

Two Essays On Corporate Finance, Soohyung Kim

Theses and Dissertations--Finance and Quantitative Methods

This dissertation consists of two essays on corporate finance. The first essay investigates the relationship between dual-class shares and firm’s risk-taking. While costs associated with dual-class shares are widely documented, the benefits are seldom studied in the literature. We attempt to fill this gap and find that dual-class firms tend to have fewer business segments, higher volatilities in their cash flows, earnings, and investment opportunities compared to propensity-matched single-class firms. Business segments within a dual-class firm are also more positively correlated in their cash flows, earnings, or investment opportunities than those in single-class firms. The results are consistent with the …

Building Bridges: Church Women United And Social Reform Work Across The Mid-Twentieth Century, Melinda M. Johnson

Theses and Dissertations--History

Church Women United incorporated in December 1941 as an interdenominational and interracial movement of liberal Protestant women committed to social reform. The one hundred organizers represented ten million Protestant women across the United States. They organized with the express purposes of helping to bring peace on Earth and to develop total equality within all humanity.

Church Women United was the bridge between the First and Second Wave of Feminism and the bridge between the Social Gospel and Social Justice Movements. Additionally they connected laterally with numerous social and religious groups across American society. As such, they exemplify the continuity and …

Foreign Affairs: Policy, Culture, And The Making Of Love And War In Vietnam, Amanda C. Boczar

Theses and Dissertations--History

Foreign Affairs: Policy, Culture, and the Making of Love and War in Vietnam investigates the interplay between war and society leading to and during the Vietnam War. This project intertwines histories of foreign relations, popular culture, and gender and sexuality as lenses for understanding international power relations during the global Cold War more broadly. By examining sexual encounters between American service members and Vietnamese civilian women, this dissertation argues that relationships ranging from prostitution to dating, marriage, and rape played a significant role in the diplomacy, logistics, and international reception of the war. American disregard for South Vietnamese morality laws …

Social Capital At The Capitol: A Social Network Analysis Of Interest Group Influence In The 111th Congress, Steven A. Martin

Theses and Dissertations--Political Science

This dissertation builds on existing scholarship in political science and political sociology to explore the influence of interest groups in legislative action networks. The primary theoretical insight is that as the number of interest group affiliations between two members of Congress increases, so does the frequency with which they forge other sorts of social ties necessary to advance the interests of their interest group constituencies. In particular, the analysis looks at interest group donation strategies, legislative co-sponsorships, and roll-call votes during the 111^th Congress (2009-2010). The analysis uses social network analysis methods to create network models of 19 different …

Kinetics And Mechanisms Of Crystal Growth Inhibition Of Indomethacin By Model Precipitation Inhibitors, Dhaval D. Patel

Theses and Dissertations--Pharmacy

Supersaturating Drug Delivery Systems (SDDS) could enhance oral bioavailability of poorly water soluble drugs (PWSD). Precipitation inhibitors (PIs) in SDDS could maintain supersaturation by inhibiting nucleation, crystal growth, or both. The mechanisms by which these effects are realized are generally unknown. The goal of this dissertation was to explore the mechanisms underpinning the effects of model PIs including hydroxypropyl β-cyclodextrins (HP-β-CD), hydroxypropyl methylcellulose (HPMC), and polyvinylpyrrolidone (PVP) on the crystal growth of indomethacin, a model PWSD. At high degrees of supersaturation (S), the crystal growth kinetics of indomethacin was bulk diffusion-controlled, which was attributed to a high energy form deposited …

Design, Synthesis, And Pharmacological Evaluation Of Three Series Of Lobelane Analogs As Inhibitors Of The Vesicular Monoamine Transporter (Vmat2), John P. Culver

Theses and Dissertations--Pharmacy

Methamphetamine (METH) abuse is a serious problem in the United States and worldwide. The reward experienced by METH users is due to the increase in extracellular dopamine (DA) concentrations caused by an interaction between METH and the DA transporter (DAT) as well as the Vesicular Monoamine Transporter-2 (VMAT2). The reward felt by users of METH leads to further use of the drug and subsequent abuse. The current project examined the ability of three novel series of lobelane analogs to interact with a binding site on the Vesicular Monoamine Transporter-2 (VMAT2) in an attempt to inhibit the effects of METH. Lobelane …

Korean Anthracite Coal Cleaning By Means Of Dry And Wet Based Separation Technologies, Majid Mahmoodabadi

Theses and Dissertations--Mining Engineering

Korean coals are typically high rank anthracite characterized by high ash content and difficult cleaning characteristics. The main objective of the study was to evaluate the feasibility of treating various size fractions within the coal using an assortment of physical coal cleaning technologies. Dry cleaning is preferred due to the friability of the coal. As such, three pneumatic processes were tested including Ore Sorting for the plus 10 mm material, Air Table Separation for 10 x 1 mm fraction and Tribo-electric Separator for - 1 mm fraction. The Dense Medium Cyclone is known to be one of the most efficient …

Pilot Scale Demonstration And Evaluation Of Innovative Non-Deslimed Non-Classified Gravity-Fed Hm Cyclone, Yumo Zhang

Theses and Dissertations--Mining Engineering

Coal preparation plants are required in some cases to produce a high-grade product using a low specific gravity cut-point. For these situations, a second higher gravity separation would be desirable to generate a mid-grade product that can be utilized for electricity generation thereby maximizing coal recovery. A study was conducted to evaluate the potential of achieving efficient separations at two different density cut-points in a single stage using a three-product dense medium cyclone. Variations in density cut-point and process efficiency values were quantified as a function of the feed medium density, feed medium-to-coal ratio, and feed pressure using a three-level …

An Empirical Investigation Of Potential Relationships Between Organizational Culture Traits And Problem Solving Practices To Support Lean Transformations, Saket D. Fadnavis

Theses and Dissertations--Mechanical and Aerospace Engineering

Organizational culture can be defined as a set of values and behavior that contribute to the unique social and psychological environment of an organization. It is the major contributing factor in determining the progress of an organization towards the desired objectives. The importance of organizational culture for successful Lean transformation has been emphasized prior research.

Lean implementation is based on continuous improvement, the achievement of which is based on problem solving practices. For sustained continuous improvement, problem solving must be done in a repeatable and disciplined way. However, not many organizations follow a structured approach towards problem solving. Some preliminary …

Incorporating Dynamic Flame Behavior Into The Scaling Laws Of Wildland Fire Spread, Brittany A. Adam

Theses and Dissertations--Mechanical and Aerospace Engineering

A challenge for fire researchers is obtaining data from those fires that are most dangerous and costly. While it is feasible to instrument test beds, test plots, and small prescribed burns for research, it is uncommon to successfully instrument an active wildland fire. With a focus on very specific facets of wildland fire, researchers have created many unique models utilizing matchsticks, cardboard, liquid fuel, excelsior, plywood, live fuels, dead fuels, and wood cribs of different packing densities. Such scale models, however, only serve as valid substitutes for the full-scale system when all functional relations of the scale model are made …

Effect Of Heating And Ionization Of Four Atomizing Gases On The Spray Characteristics Of A High Volume Low Pressure Spray Atomizer, Anthony V. Adornato

Theses and Dissertations--Mechanical and Aerospace Engineering

The disintegration of a liquid jet emerging from a nozzle by a high speed gas stream has been under investigation of several decades. A result of the liquid jet disintegration is droplet formation. This process is referred to as atomization. Industrial applications use atomization as a method for applying coatings to substrates. It has been reported that the use of other atomizing gases instead of compressed plant air will positively affect paint droplet size distributions, spray patterns and finish qualities; furthermore, the ionization and heating of the atomizing gas was reported to positively affect finish qualities. Although ionization techniques have …

Cfd Modeling Of Multiphase Counter-Current Flow In Packed Bed Reactor For Carbon Capture, Li Yang

Theses and Dissertations--Mechanical and Aerospace Engineering

Packed bed reactors with counter-current, gas-liquid flows have been considered to be applicable in CO₂ capture systems for post-combustion processing from fossil-fueled power production units. However, the hydrodynamics within the packing used in these reactors under counter-current flow has not been assessed to provide insight into design and operational parameters that may impact reactor and reaction efficiencies. Hence, experimental testing of a laboratory-scale spherical ball, packed bed with two-phase flow was accomplished and then a meso-scale 3D CFD model was developed to numerically simulate the conditions and outcomes of the experimental tests. Also, the hydrodynamics of two-phase flow in …

High Temperature Flow Solver For Aerothermodynamics Problems, Huaibao Zhang

Theses and Dissertations--Mechanical and Aerospace Engineering

A weakly ionized hypersonic flow solver for the simulation of reentry flow is firstly developed at the University of Kentucky. This code is the fluid dynamics module of known as Kentucky Aerothermodynamics and Thermal Response System (KATS). The solver uses a second-order finite volume approach to solve the laminar Navier– Stokes equations, species mass conservation and energy balance equations for flow in chemical and thermal non-equilibrium state, and a fully implicit first-order backward Euler method for the time integration. The hypersonic flow solver is then extended to account for very low Mach number flow using the preconditioning and switch of …

Radiative Conductivity Analysis Of Low-Density Fibrous Materials, Nima Nouri

Theses and Dissertations--Mechanical and Aerospace Engineering

The effective radiative conductivity of fibrous material is an important part of the evaluation of the thermal performance of fibrous insulators. To better evaluate this material property, a three-dimensional direct simulation model which calculates the effective radiative conductivity of fibrous material is proposed. Two different geometries are used in this analysis.

The simplified model assumes that the fibers are in a cylindrical shape and does not require identically-sized fibers or a symmetric configuration. Using a geometry with properties resembling those of a fibrous insulator, a numerical calculation of the geometric configuration factor is carried out. The results show the dependency …

Clinical And Pathologic Significance Of Integrin Α6Β4 Expression In Human Malignancies, Rachel L. Stewart

Theses and Dissertations--Clinical and Translational Science

Integrins are cellular adhesion molecules that bind cells to the extracellular matrix. The integrin α6β4, a receptor for laminins, is predominantly expressed on epithelial cells where it is present at the basal surface adjacent to the basement membrane. This integrin plays a critical role in maintaining normal cellular functions, yet has also been implicated in promoting invasion and metastasis in human malignancies. While overexpression of the integrin α6β4 has been detected in select human cancers, the clinical significance of integrin α6β4 expression in a number of malignancies has not been determined. The purpose of this study was to examine integrin …

The Metabolomic Effects Of Metformin On Colon Cancer, Jennifer W. Harris

Theses and Dissertations--Clinical and Translational Science

Metformin is an oral biguanide that is prescribed to over 120 million people worldwide for the treatment of conditions including type II diabetes mellitus, polycystic ovarian syndrome, and gestational diabetes. This hypoglycemic agent is rapidly emerging as a potential cost-effective anti-oncogenic agent. Over the past decade multiple epidemiologic studies have consistently associated metformin with decreased cancer incidence and cancer-related mortality. More recently numerous preclinical and clinical studies have demonstrated anti-cancer effects of metformin, leading to the proposal of numerous clinical trials to better understand this drug and its mechanism of action.

Previously experts believed metformin primarily targeted AMP-activated protein kinase …

Parent/Caregiver Knowledge And Satisfaction Of Information And Referrals Related To Speech-Language Pathology Services For Children With Down Syndrome, Erin K. Salmons

Theses and Dissertations--Communication Sciences and Disorders

Down syndrome, also known as Trisomy 21, is the most commonly occurring chromosomal abnormality present at birth. The Centers for Disease Control and Prevention estimates that there are approximately 6,000 diagnoses of Down syndrome per year in the United States, further indicating that 1/700 infants are born with Down syndrome. A diagnosis of Down syndrome can be made either prenatally or postnatally. Early intervention services will be warranted to address underlying deficits associated with the syndrome, (i.e., speech-language/feeding/swallowing). Communicative disorders are among the most prominent concomitant deficits associated with Down syndrome. Therefore, it is critical that parents/caregivers of children with …

The Role Of Apob-Containing Lipoproteins In Abdominal Aortic Aneurysm, Jing Liu

Theses and Dissertations--Pharmacology and Nutritional Sciences

Abdominal aortic aneurysm (AAA) is a devastating disease that exhibits permanent lumen expansion typically in the infrarenal aorta. AAA is prevalent among aged population, especially in males. Despite the incidence in women is lower, studies indicate the tortuosity is more severe and aortic rupture risk is higher in women. In most patients, AAA remains asymptomatic until it ruptures leading to sudden and fatal hemorrhage.

To date, there is no proven medical therapy that can prevent the expansion or rupture. Human observational studies implicate the presence of AAA is associated with both high plasma low-density lipoprotein-cholesterol (HDL-C) and low plasma high-density …

Tumor-Derived Proteins And Mitochondrial Dysfunction In Lung Cancer-Induced Cachexia, Julie B. Mclean

Theses and Dissertations--Physiology

Lung tumors secrete multiple factors that contribute to cachexia, a severe wasting syndrome that includes loss of muscle mass, weakness, and fatigue. 80% of advanced lung cancer patients experience cachexia, which cannot be reversed by nutritional interventions, diminishes response to and tolerance of cancer treatments, and increases morbidity and mortality. Despite a multitude of clinical trials, there are currently no approved treatments. This deficiency suggests that not all of the factors that contribute to cachexia have been identified.

Cancer is frequently accompanied by an increase in cyclooxygenase-2 (COX-2), a hallmark of inflammation. Clinical trials for COX-2 inhibitors have resulted in …