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Insulin-Resistant Subjects Have Normal Angiogenic Response To Aerobic Exercise Training In Skeletal Muscle, But Not In Adipose Tissue, R. Grace Walton, Brian S. Finlin, Jyothi Mula, Douglas E. Long, Beibei Zhu, Christopher S. Fry, Philip M. Westgate, Jonah D. Lee, Tamara Bennett, Philip A. Kern, Charlotte A. Peterson

Clinical and Translational Science Faculty Publications

Reduced vessel density in adipose tissue and skeletal muscle is associated with obesity and may result in decreased perfusion, decreased oxygen consumption, and insulin resistance. In the presence of VEGFA, Angiopoietin-2 (Angpt2) and Angiopoietin-1 (Angpt1) are central determinants of angiogenesis, with greater Angpt2:Angpt1 ratios promoting angiogenesis. In skeletal muscle, exercise training stimulates angiogenesis and modulates transcription of VEGFA, Angpt1, and Angpt 2. However, it remains unknown whether exercise training stimulates vessel growth in human adipose tissue, and it remains unknown whether adipose angiogenesis is mediated by angiopoietin signaling. We sought to determine whether insulin-resistant subjects would display an impaired angiogenic …

Amyloid Peptide Inactivating Enzyme To Treat Alzheimer's Disease Peripherally, Louis B. Hersh, Hanjun Guan

Molecular and Cellular Biochemistry Faculty Patents

Methods for treatment and/or prevention of Alzheimer's disease comprising inactivating peripheral AP in serum to a reduce A(3 in the brain. Methods comprise expression of amyloid peptide inactivating enzyme on bone marrow cells; and coupling of amyloid peptide inactivating enzyme to hematopoietic cells.

Pannexin1 Channels Dominate Atp Release In The Cochlea Ensuring Endocochlear Potential And Auditory Receptor Potential Generation And Hearing, Jin Chen, Yan Zhu, Chun Liang, Jing Chen, Hong-Bo Zhao

Otolaryngology--Head & Neck Surgery Faculty Publications

Pannexin1 (Panx1) is a gap junction gene in vertebrates whose proteins mainly function as non-junctional channels on the cell surface. Panx1 channels can release ATP under physiological conditions and play critical roles in many physiological and pathological processes. Here, we report that Panx1 deficiency can reduce ATP release and endocochlear potential (EP) generation in the cochlea inducing hearing loss. Panx1 extensively expresses in the cochlea, including the cochlear lateral wall. We found that deletion of Panx1 in the cochlear lateral wall almost abolished ATP release under physiological conditions. Positive EP is a driving force for current through hair cells to …

Forage News [2015-06], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• National Forage Week
• Stewardship with Herbicides
• Set Disc Mowers High to Prolong Grass Hay Stands
• Warm Season Grass Professional Workshop
• Updated Compendium of Alfalfa Diseases and Pests now Available
• UK Ag Weather

The Archaeology Of Disjuncture: Classic Period Disruption And Cultural Divergence In The Tuxtla Mountains Of Mexico, Wesley D. Stoner, Christopher A. Pool

Anthropology Faculty Publications

Reconstructing human interaction systems has been a major objective of archaeological research, but we have typically examined the topic in a conceptually limited manner. Most studies have—intentionally or unintentionally—focused on how trade, communication, conquest, and migration foster cultural similarities over long distances. It has largely been a positivistic endeavor that exclusively features groups linked through a single network but glosses over how alternative networks intersect with the former through common nodes. Models of long-distance interaction have largely ignored variation in how external influences are negotiated across space within the receiving region. We adapt Arjun Appadurai’s concept of disjuncture to conceptualize …

The Biosynthesis Of Capuramycin-Type Antibiotics: Identification Of The A-102395 Biosynthetic Gene Cluster, Mechanism Of Self-Resistence, And Formation Of Uridine-5'-Carboxamide, Wenlong Cai, Anwesha Goswami, Zhaoyong Yang, Xiaodong Liu, Keith D. Green, Sandra Barnard-Britson, Satoshi Baba, Masanori Funabashi, Koichi Nonaka, Manjula Sunkara, Andrew J. Morris, Anatol P. Spork, Christian Ducho, Sylvie Garneau-Tsodikova, Jon S. Thorson, Steven Van Lanen

Pharmaceutical Sciences Faculty Publications

A-500359s, A-503083s, and A-102395 are capuramycin-type nucleoside antibiotics that were discovered using a screen to identify inhibitors of bacterial translocase I, an essential enzyme in peptidoglycan cell wall biosynthesis. Like the parent capuramycin, A-500359s and A-503083s consist of three structural components: a uridine-5'-carboxamide (CarU), a rare unsaturated hexuronic acid, and an aminocaprolactam, the last of which is substituted by an unusual arylamine-containing polyamide in A-102395. The biosynthetic gene clusters for A-500359s and A-503083s have been reported, and two genes encoding a putative non-heme Fe(II)-dependent α-ketoglutarate:UMP dioxygenase and an l-Thr:uridine-5'-aldehyde transaldolase were uncovered, suggesting that C-C bond formation during assembly of …

Cellular And Deafness Mechanisms Underlying Connexin Mutation-Induced Hearing Loss - A Common Hereditary Deafness, Jeffrey C. Wingard, Hong-Bo Zhao

Otolaryngology--Head & Neck Surgery Faculty Publications

Hearing loss due to mutations in the connexin gene family, which encodes gap junctional proteins, is a common form of hereditary deafness. In particular, connexin 26 (Cx26, GJB2) mutations are responsible for ~50% of non-syndromic hearing loss, which is the highest incidence of genetic disease. In the clinic, Cx26 mutations cause various auditory phenotypes ranging from profound congenital deafness at birth to mild, progressive hearing loss in late childhood. Recent experiments demonstrate that congenital deafness mainly results from cochlear developmental disorders rather than hair cell degeneration and endocochlear potential reduction, while late-onset hearing loss results from reduction of active …

Macrophage Migration Inhibitory Factor Mediates Par-Induced Bladder Pain., Dimitrios E. Kouzoukas, Katherine L. Meyer-Siegler, Fei Ma, Karin N. Westlund, David E. Hunt, Pedro L. Vera

Physiology Faculty Publications

INTRODUCTION: Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is constitutively expressed in urothelial cells that also express protease-activated receptors (PAR). Urothelial PAR1 receptors were shown to mediate bladder inflammation. We showed that PAR1 and PAR4 activator, thrombin, also mediates urothelial MIF release. We hypothesized that stimulation of urothelial PAR1 or PAR4 receptors elicits release of urothelial MIF that acts on MIF receptors in the urothelium to mediate bladder inflammation and pain. Thus, we examined the effect of activation of specific bladder PAR receptors on MIF release, bladder pain, micturition and histological changes.

METHODS: MIF release was measured …

A Cost Analysis Of The 1-2-3 Pap Intervention, Kristina M. Rabarison, Rui Li, Connie L. Bish, Robin C. Vanderpool, Richard A. Crosby, Mehran S. Massoudi

Frontiers in Public Health Services and Systems Research

Background: Cervical cancer places a substantial economic burden on our healthcare system. The three-dose human papillomavirus (HPV) vaccine series is a cost-effective intervention to prevent HPV infection and resultant cervical cancer. Despite its efficacy, completion rates are low in young women aged 18 through 26 years. 1-2-3 Pap is a video intervention tested and proven to increase HPV vaccination completion rates.

Purpose: To provide the full scope of available evidence for 1-2-3 Pap, this study adds economic evidence to the intervention’s efficacy. This study tested the economies of scale hypothesis that the cost of 1-2-3 Pap intervention per number of …

Building The Capacity For Community Food Work: The Geographic Distribution Of Usda Community Food Projects Competitive Grant Program Grantees, Keiko Tanaka, Erica Indiano, Graham T. Soley, Patrick H. Mooney

Community & Leadership Development Faculty Publications

Projects Competitive Grants Program, or USDA CFPCGP, supports community efforts to address food system issues. Over the last 15 years the program has funded diverse community-based projects across the nation, including youth education programs on healthy eating, farm-to-table initiatives, and community food assessments. In this initial study, we endeavor to understand the contribution of the CFPCGP in building a community's capacity to address its own challenges for food security. To analyze funding patterns of the CFPCGP program between 1996 and 2012, we used the websites of the CFPCGP and the WhyHunger Network to identify 420 competitive grant applications successfully funded …

Common Sense Solutions For Management Of Global Carbon Emissions, Kimery Vories

World of Coal Ash Proceedings

No abstract provided.

Perils Of Constructing A Gypsum Stack On Top Of An Ash Pond Tva Bull Run Fossil (Brf) Plant Gypsum Disposal Area 2, Rachel Combs, Hugo Aparicio, Will Mattingly, Charla Barnes

World of Coal Ash Proceedings

No abstract provided.

System-Wide Life Cycle Benefits Of Recycled Materials, Angela Pakes Ahlman, Tuncer Edil, Bharat Natarajan

World of Coal Ash Proceedings

No abstract provided.

In-Situ Coal Combustion Products Impoundment Closure/Remediation Strategy, Tim Silar, John Magee, Christopher Robb, Glenn Luke

World of Coal Ash Proceedings

No abstract provided.

Implementing The Proposed Ccr Rule And Groundwater Corrective Measures, Sean Rome

World of Coal Ash Proceedings

No abstract provided.

Options To Stabilize And Utilize Tomorrow’S Fly Ash: Approaches And Initial Results, Sharon Sjostrom, Ken Baldrey, Kirk Ellison

World of Coal Ash Proceedings

No abstract provided.

Occurrence And Distribution Of Rare Earths With Different Coal Power Plants Ash And Recovery Of Critical Rare Earths From Coal Ash For Simultaneous Utilization Of Co2, Ji Wahn Ahn, Thenepalli Thriveni, Yujin Jegal

World of Coal Ash Proceedings

No abstract provided.

Sequestration Of Halides From Fgd Wastewater Through Lime Stabilization Of Fly Ash, Shubhashini Oza, Vincent Ogunro, John Daniels, Kirk Ellison

World of Coal Ash Proceedings

No abstract provided.

Chemical Treatment Of Coal Ash For Beneficial Use Applications / By-Product Treatment Via Calcium Polysulfide, James Easton, James Papp, Guy Wojtowicz

World of Coal Ash Proceedings

No abstract provided.

Assessment Of Emergent Springs At A Fly Ash Impoundment, Bruce Sass, Ryan Fimmen, Marvin Leedy, John Massey-Norton

World of Coal Ash Proceedings

No abstract provided.

Framework For Evaluating The Relative Impacts Of Surface Impoundment Closure Options, Ari Lewis, Andrew Bittner, Kurt Herman, Eric Dube

World of Coal Ash Proceedings

No abstract provided.

The Effect Of Sulphuric Acid Concentration On The Removal Of Reactive Aluminium From South African Coal Fly Ash, Mathibela Aphane, Elizabet Merwe, Frederic Doucet, Leslie Petrik

World of Coal Ash Proceedings

No abstract provided.

Rare Earth Element Geochemistry Of Late Paleozoic Coals In Taiyuan And Shanxi Formation, North China, Deyu Yan, Wenhui Huang, Tinghao Wang, Bei Liu

World of Coal Ash Proceedings

No abstract provided.

Compressive Strength Of Chemically And Mechanically Activated Aluminosilicate Systems, Grizelda Du Toit, Elizabet Van Der Merwe, Elsabe Kearsley, Mike Mcdonald

World of Coal Ash Proceedings

No abstract provided.

The Five Fundamentals For Successful Restoration Of Coal Ash Sites, Marc Theisen

World of Coal Ash Proceedings

No abstract provided.

Geochemical Characterization Of Coal-Combustion Byproducts And Numerical Simulations Of Their Long-Term Effects As Capping Materials At Coal Mine Reclamation Sites, Qian Zhang, Greg Olyphant, Tracy Branam, Hind Ghanem

World of Coal Ash Proceedings

No abstract provided.

Wet Impoundment Stabilization, Consolidation, And Landfill Development: The Best Alternative To Dig And Haul Propositions Is In-Situ Stabilization And Vertical Expansion, Russell Stapp

World of Coal Ash Proceedings

No abstract provided.

Binder Stabilization With Beneficial Use Of Ccr In Closure – Remediation / Corrective Actions Of Coal Ash Impoundments, Vito Schifano

World of Coal Ash Proceedings

No abstract provided.

The Next Time The World Is Going Downhill: America And The 1983 Ethiopian Famine, Bethany Sharpe

disClosure: A Journal of Social Theory

In 1983, a massive famine struck Ethiopia. Bred by a complex array of factors, thousands of men, women, and children experienced the painful effects of this humanitarian disaster as bodies weakened and widespread death took place. Throughout the famine, an unlikely partnership took place between the Communist leader Chairman Mengistu Haile Mariam and the staunchly anti-Communist White House.[1] The partnership allowed each nation to pursue strategic foreign policy goals; the United States sought to undermine the socialist PMGSE through humanitarian aid while Mengistu attempted to salvage his government’s international reputation. Soon, global attention swirled around the issue and unlikely …

Gold Mining And Unequal Exchange In Western Amazonia: A Theoretical Photo Essay, Gordon L. Ulmer

disClosure: A Journal of Social Theory

I combine fieldwork photography and ethnographic documentation of gold mining in Madre de Dios, Peru, to examine the localized material, social, environmental, and health outcomes of the global gold boom. This 'theoretical photo essay’ examines how local and global forces coalesce around gold mining and influence peoples and environments in Western Amazonia. I use embodiment theory in anthropology, ecological economics, and theories of underdevelopment to understand local consequences of the global gold trade and to elucidate how opulence and the machinations of capital accumulation in economic centers of the world occur at the expense of human lives and environments in …