Digital Commons Network^™

The Role Of Endoplasmic Reticulum Stress In Ethanol-Induced Neurodegeneration, Yongchao Wang

Theses and Dissertations--Pharmacology and Nutritional Sciences

Heavy ethanol use causes neurodegeneration manifested by neuronal loss and dysfunction. It is becoming imperative to delineate the underlying mechanism to promote the treatment of ethanol-induced neurodegeneration. Endoplasmic reticulum (ER) stress is a hallmark and an underlying mechanism of many neurodegenerative diseases. This study aims to investigate the role of ER stress in ethanol-induced neurodegeneration. In experimental design, adult mice were exposed to binge ethanol drinking by daily gavage for 1, 5, or 10 days and the response of ER stress was examined. We found the induction of ER stress appeared at 5 days and remained at 10 days. Moreover, …

Pathological Tau As A Cause, And Consequence, Of Cellular Dysfunction, Shelby Meier

Theses and Dissertations--Physiology

Tauopathies are a group of neurodegenerative diseases characterized by the abnormal deposition of the protein tau, a microtubule stabilizing protein. Under normal physiological conditions tau is a highly soluble protein that is not prone to aggregation. In disease states alterations to tau lead to enhanced fibril formation and aggregation, eventually forming neurofibrillary tangles (NFTs). The exact cause for NFT deposition is unknown, but increased post-translational modifications and mutations to the tau gene can increase tangle formation.

Tauopathic brains are stuck in a detrimental cycle, with cellular dysfunction contributing to the development of tau pathology and the development of tau pathology …

An Evaluation Of The Performance Of Leggings Based On A Consumer Survey, Virginia Elizabeth Groppo

Theses and Dissertations--Retailing and Tourism Management

The purpose of this research was to identify the legging features that athleisure consumers desire and the performance problems they frequently encounter. A non-probability sample (n=133) of college students who identified as female and wore leggings for non-athletic purposes were surveyed. The questionnaire was designed based upon examination of online product reviews and current complaints with legging products. The results of the survey were used to design and complete a laboratory evaluation. Laboratory samples and methods were then chosen to assess the performance qualities desired when purchasing leggings and the problems encountered when wearing leggings by the surveyed consumers. Three …

Effects Of Pituitary Pars Intermedia Dysfunction And Prascend® Treatment On Endocrine And Immune Function In Senior Horses, Ashton B. Miller

Theses and Dissertations--Veterinary Science

Pituitary pars intermedia dysfunction (PPID) is one of the most common endocrine diseases affecting senior horses. PPID causes abnormally high concentrations of adrenocorticotropic hormone (ACTH) in the plasma and a very distinct, long, shaggy haircoat (hypertrichosis). At present, the recommended treatment for PPID is daily oral administration of pergolide mesylate. Due to the increased ACTH levels associated with PPID, it is commonly thought that these horses are immunosuppressed and at increased risk of opportunistic infections, although current research in this area is sparse. Additionally, it is not well-understood how treatment with Prascend^® (pergolide tablets) affects endocrine measures other than …

Effects Of A Systemic High Urea Concentration On The Endometrial And Embryonic Transcriptomes Of The Mare, Yatta Linhares Boakari

Theses and Dissertations--Veterinary Science

Pregnancy loss remains a major source of economic cost to the equine industry. Frequently, the exact causes of pregnancy loss remain unknown. It has been shown, in other species, that increased dietary protein leading to elevated blood urea nitrogen concentrations (BUN) can be a factor in decreased survival of the early embryo. Our studies provided novel information regarding the effects of elevated BUN on endometrium and embryos from mares as well as insights on changes in their gene expression. Our first objective was to develop an experimental model to elevate BUN during diestrus using intravenous urea infusion. We analyzed the …

A Comparison Of Body Composition Estimates Between The Norland Dxa, The Idxa, And The Bodpod® In Overweight To Obese Adults, Jalyn Mason

Theses and Dissertations--Nutrition and Food Systems

Background: Body composition measures include fat mass (FM), fat free mass (FFM), and percent body fat (%BF), which are markers of health status and disease risk. Accurate body composition assessment is needed to evaluate an individual’s health and the efficacy of treatment strategies. Objective: Compare body composition estimates obtained from the Norland DXA, BodPod®, and iDXA before and after a 12-week exercise intervention. Subjects/setting: Overweight to obese (BMI 25–35 kg/m²) sedentary men and women (n=30) aged 18 to 40 years were recruited from central KY. Main outcome measure: Agreement in FM, FFM, and %BF between Norland DXA, iDXA, …

A Closer Look At Internet Addiction, Jakub Mikuška

Theses and Dissertations--Family Sciences

Based on a sample of 1,012 late adolescents and young adults (ages 18-26), the current three interrelated studies tested a series of specific questions and hypotheses focused on understanding Internet Addiction.

Study 1 sought to directly compare psychometric properties of four of the most widely used Internet addiction scales based on citation metrics (Internet Addiction Test, Problematic Internet Use Questionnaire, Generalized Problematic Internet Use Scale 2 and Chen Internet Addiction Scale), and to aggregate the best items across all scales into a new measure using bifactor IRT analyses. The resulting 10-item Aggregated Internet Addiction Scale (AIAS) consists of the best …

Beyond Telling: A Phenomenology Of Adoptive Parents' Adoption Communication Openness With Early Adolescents, Jane D. Samuel

Theses and Dissertations--Family Sciences

Despite calls for increased Adoption Communication Openness (ACO) within the adoptive family, research indicates that families still struggle to accomplish the recommended elements and levels of openness. What could be holding families back from this key process? Three focus groups comprised of 17 adoptive parents of early adolescents (aged 10-14) who were age 0-2 at the time of placement were thematically coded. This inductive analysis revealed the complexity rooted in being —sometimes successfully and sometimes not—communicatively open. Four key themes emerged painting a vivid and rich picture of: a) the breadth and depth of this experience; b) the work entailed; …

Promotion Of Fruit And Vegetable Intake Through Recipe Card Distribution And Sampling At Farmers’ Markets Throughout Kentucky, Umaima Sidra Afsheen Syeda

Theses and Dissertations--Nutrition and Food Systems

The Center for Disease Control and Prevention (CDC) reports indicate that 8% and 6.3% of Kentuckians consume enough fruits and vegetables, respectively. The Plate It Up! Kentucky Proud (PIUKP) project is a recipe-development project that aims to boost produce consumption by incorporating local fruits and vegetables. The purpose of this study was to implement promotional strategies using PIUKP recipes at farmers’ markets and determine their effects on consumers’ intent of purchasing and preparing the produce. The study was conducted at nine farmers’ markets across Kentucky (n=300) in collaboration with Cooperative Extension agents/assistants.

The consumers’ impression of the sample was positively …

The Interactive Effect Of A Text Message Intervention And Connectivity Among Rural Adolescents, Kara Coldiron

Theses and Dissertations--Nutrition and Food Systems

Social cohesion among peers profoundly influences decision making during adolescence. Despite this, the current research is very limited concerning the association of social cohesion and intimacy among rural adolescent peers with dietary intake and weight outcomes. This is problematic because social cohesion could be an unknown contributing factor in obesity among rural adolescents. The purpose of this study was to investigate how social cohesion and intimacy among rural adolescents in Kentucky and North Carolina affects the outcomes of a text message intervention aimed at improving fruit, vegetable, fast food and sugar sweetened beverage intake. Additionally, to determine if social cohesion …

Pilot Study Of Text Message Nudges As A Way To Improve Weight Loss Outcomes, Madison Copher

Theses and Dissertations--Nutrition and Food Systems

Weight loss programs for women are on the rise, including both face to face and online programs. However, current research is limited on the process measures and content which produce adherence and the largest outcomes. With obesity on the rise in the United States, it is important to understand out health coaches can strengthen their programs to better support the obese population in their weight loss journey. The purpose of this pilot study was to develop and test the acceptability of text message nudges among women participating in an online weight loss program; determine how dose may be associated with …

The Utilization Of Technology As An Approach To Improve Meal Planning And Dietary Intake, Alexa Lauren Kuziel

Theses and Dissertations--Nutrition and Food Systems

The prevalence of obesity is rising in the United States and one factor that contributes to it is the lack of cooking at home and planning out meals. Since text messaging is now a main avenue of communication, it could be used to motivate people to plan out their meals and cook at home instead of consuming fast food. Current research on how weekly nudges might relate to peoples’ goals about meal preparation and dietary intake is very limited. The purpose of this study was to examine if sending weekly nudges, focusing on specific dietary goals, improves meal planning and …

An Analysis Of Kentucky School Activity Fund Requirements For Internal Controls And Segregation Of Duties Compared With National Standards And Requirements In Surrounding States, Marla J. Carnes

MPA/MPP/MPFM Capstone Projects

Across the United States, K-12 school systems receive and disburse a significant amount of funds at the school level. These funds are classified as school activity funds and may be broken into two distinct categories: 1) student activity funds and 2) district activity funds. Student activity funds are generally derived from fundraising activities of students to support a particular student group or organization such as the Y-Club, senior class, or student council. District activity funds are generated in the normal course of school business and may include funds such as locker fees, parking permit fees, school picture sales, or vending …

Procure-To-Pay Software In The Digital Age: An Exploration And Analysis Of Efficiency Gains And Cybersecurity Risks In Modern Procurement Systems, Drew Lane

MPA/MPP/MPFM Capstone Projects

Procure-to-Pay (P2P) softwares are an integral part of the payment and procurement processing functions at large-scale governmental institutions. These softwares house all of the financial functions related to procurement, accounts payable, and often human resources, helping to facilitate and automate the process from initiation of a payment or purchase, to the actual disbursal of funds. Often, these softwares contain budgeting and financial reporting tools as part of the offering. As such an integral part of the financial process, these softwares obviously come at an immense cost from a set of reputable vendors. In the case of government, these vendors mainly …

Martin School Alumni Survey, Carl Sims

MPA/MPP/MPFM Capstone Projects

The Martin School of Public Policy and Administration is subject to reaccreditation from the Network of Schools of Public Policy, Affairs, and Administration (NASPAA) every seven years. To initiate the reaccreditation process, the Martin School must conduct a programmatic self-study that analyzes the program’s mission, governance, faculty, students, competencies, resources, and communication. The self-study is beneficial not only for the purpose of reaccreditation but also can better inform the school’s strategic planning process

To assist in providing the self-study relevant data, the Martin School can solicit information from its alumni. Alumni data can be used to establish how well the …

Everybody’S Working (But The Weakened): An Assessment Of Medicaid Work Requirements And Their Administrative Burdens, Samuel Misleh

MPA/MPP/MPFM Capstone Projects

Although Medicaid work requirements are currently halted in both Arkansas and Kentucky, this analysis utilizes the data available to make an assessment and estimate of what Kentucky’s Medicaid enrollment will look like if work requirements similar to those Arkansas had are ever implemented. The relative severity of the administrative burden of such requirements provide a tool for comparison, and a difference-in-differences analysis of the change in Medicaid enrollment between Arkansas and West Virginia, a state that has not implemented and currently has no plans to implement Medicaid work requirements, provide the bases for this estimate. After coding the work requirements …

Long-Term Land Management Practices And Their Effect On Soil Health And Crop Productivity, Thomas Joseph Muratore Jr.

Theses and Dissertations--Plant and Soil Sciences

Agricultural intensification reliant on monocrops could change soil health in a way that does not support maximum crop productivity. Twenty-nine-year-old no-till field plots at the University of Kentucky Spindletop research farm showed a significant reduction in corn yields from continuous corn plots compared to those from plots in various types of rotation. The objective of this study was to determine what role soil microbes might play in yield reduction and how management and time effects microbial community structure. Samples were collected from the following treatments: continuous corn (CC), continuous soybean (SS), a 2-year corn/soybean rotation (CCSS), Corn in rotation with …

Effects Of Abiotic Stresses On Sorbitol And Ribitol Accumulation And Sorbitol Biosynthesis And Metabolism In Tomato [Solanum Lycopersicum L.], Afaf Almaghamsi

Theses and Dissertations--Plant and Soil Sciences

Abiotic stresses are responsible for limiting crop production worldwide. Among diverse abiotic stresses, drought and salinity are the most challenging. Plants under these conditions have diverse strategies for tolerating stress. Osmotic adjustment and osmoprotection occur in plants during salinity and drought stress through accumulation of compatible solutes to a high level without interfering with cellular metabolism. Polyols (sugar alcohols) including sorbitol and ribitol are one such class of compatible solutes. Using plants of wild-type (WT) and three genetically-modified lines of tomato (Solanum lycopersicum cv. ‘Ailsa Craig’), an empty vector line ‘TR22’, and 2 sdh anti-sense lines ‘TR45’, and ‘TR49’ …

Two Cultures, One Identity: Biculturalism Of Young Mexican Americans, Janela Aida Salazar

Theses and Dissertations--Community & Leadership Development

The purpose of this study was to explore the daily life of the younger generation of Mexican Americans through a phenomenology design. Specifically, in regard to how the culture-sharing pattern of biculturalism is reflected in their lives and the way they construct their bicultural identity. The study utilized rich qualitative data to paint a clear and descriptive picture of the internal process of biculturalism within eight Mexican American college students. Ultimately, the data analysis aimed to collect and reflect their voices and the stories. This was done through three distinct data methods that complemented each other: interviews (oral), photo elicitation …

Application Of Boolean Logic To Natural Language Complexity In Political Discourse, Austin Taing

Theses and Dissertations--Computer Science

Press releases serve as a major influence on public opinion of a politician, since they are a primary means of communicating with the public and directing discussion. Thus, the public’s ability to digest them is an important factor for politicians to consider. This study employs several well-studied measures of linguistic complexity and proposes a new one to examine whether politicians change their language to become more or less difficult to parse in different situations. This study uses 27,500 press releases from the US Senate between 2004–2008 and examines election cycles and natural disasters, namely hurricanes, as situations where politicians’ language …

Metadata-Based Image Collecting And Databasing For Sharing And Analysis, Xi Wu

Theses and Dissertations--Computer Science

Data collecting and preparing is generally considered a crucial process in data science projects. Especially for image data, adding semantic attributes when preparing image data provides much more insights for data scientists. In this project, we aim to implement a general-purpose central image data repository that allows image researchers to collect data with semantic properties as well as data query. One of our researchers has come up with the specific challenge of collecting images with weight data of infants in least developed countries with limited internet access. The rationale is to predict infant weights based on image data by applying …

Rule Mining And Sequential Pattern Based Predictive Modeling With Emr Data, Orhan Abar

Theses and Dissertations--Computer Science

Electronic medical record (EMR) data is collected on a daily basis at hospitals and other healthcare facilities to track patients’ health situations including conditions, treatments (medications, procedures), diagnostics (labs) and associated healthcare operations. Besides being useful for individual patient care and hospital operations (e.g., billing, triaging), EMRs can also be exploited for secondary data analyses to glean discriminative patterns that hold across patient cohorts for different phenotypes. These patterns in turn can yield high level insights into disease progression with interventional potential. In this dissertation, using a large scale realistic EMR dataset of over one million patients visiting University of …

Learning To Map The Visual And Auditory World, Tawfiq Salem

Theses and Dissertations--Computer Science

The appearance of the world varies dramatically not only from place to place but also from hour to hour and month to month. Billions of images that capture this complex relationship are uploaded to social-media websites every day and often are associated with precise time and location metadata. This rich source of data can be beneficial to improve our understanding of the globe. In this work, we propose a general framework that uses these publicly available images for constructing dense maps of different ground-level attributes from overhead imagery. In particular, we use well-defined probabilistic models and a weakly-supervised, multi-task training …

Experiencing Displacement And Statelessness: Forced Migrants In Anse-À-Pitres, Haiti, Daniel Joseph

Theses and Dissertations--Anthropology

In 2013, the Dominican state ruled to uphold a 2010 constitutional amendment that stripped thousands of Dominicans of Haitian origin of their citizenship and forced them to leave the country during summer 2015. About 2,200 of these people became displaced in Anse-à-Pitres, where most took up residence in temporary camps. I use the term forced migrants or displaced persons interchangeably to refer to these people. Many endure challenges in meeting their daily survival needs in Haiti, a country with extreme poverty, considerable political instability, and still in the process of rebuilding itself from the devastating earthquake of 2010. Drawing on …

Evaluating The After Effects Of Successful Hazard Mitigation: Calculating The Social Benefit Of London, Kentucky’S Post-Mitigation Creation Of Public Park Space, Christopher Greyson Evans

MPA/MPP/MPFM Capstone Projects

After receiving FEMA hazard mitigation grants to improve weather and water management infrastructure, many communities are able to complete additional capital improvement projects that would not have been possible without the improvements facilitated by FEMA grants. FEMA projects often convert tracts of land to greenspace, or stabilize flood-damaged lands. Many communities then build public parks on such lands as a direct result. Although these parks or greenspaces create a benefit for their communities, FEMA’s methods for post-project evaluation, known as “Loss Avoidance Studies,” do not typically take the costs and benefits of new parks or greenspaces into consideration. From 2011-2015, …

Analyzing Public Relations As A Strategic Management Function At Sec Universities, Whitney Harder

MPA/MPP/MPFM Capstone Projects

A changing higher education landscape – rising costs, competition and skepticism – coupled with a changing media and communications landscape – a 24/7 news cycle with fewer local journalists, new technology and the expectation of instant and constant communication – have pushed universities to try to become more effective and efficient in telling their institutional stories to multiple stakeholder groups. Institutional leaders are concerned about how higher education and their institutions present public value and communicate their impact on both the students they graduate and their communities. But how are they using public relations and communications to deliver solutions for …

Female Disparity And Political Participation In The Kentucky State Legislature; The Presence Of Female Legislative Candidates And Their Effect On Voter Turnout In The Kentucky Electorate, Trenton K. Patrick

MPA/MPP/MPFM Capstone Projects

Female disparity in the political process in the state of Kentucky follows the same distinct pattern of female disparity all across state legislatures in the United States, and in the federal legislative branch. Female representation and parity in the political process is vital to the success of governmental bodies due to the benefits that the female perspective offers to governmental processes. After extensive review of the existing literature, it is clear that there is a gap in the literature when it comes to understanding how the presence of a female candidate effects the total turnout rate, female turnout rate, and …

Women Into Advanced Manufacturing: Can Community College Open This Door?, Carissa Bradley Schutzman

Theses and Dissertations--Educational Policy Studies and Evaluation

Women still rarely choose to seek employment in advanced manufacturing. Lack of familiarity with manufacturing jobs and education programs, lack of role models, and too few experiential opportunities contribute to women not choosing manufacturing jobs as well as other jobs traditionally held by men (Reha, Lufkin, & Harrison, 2009; St. Rose & Hill, 2013; Starobin & Laanan, 2008). Nontraditional jobs for women often provide higher wages and more opportunity for advancement than traditional jobs for women. This study is a qualitative thematic narrative analysis of factors that influenced women who chose an advanced manufacturing program at a community college to …

The Influence Of Patient-Provider Interaction, Self-Concept, And The Socio-Physical Environment On Pelvic Exam Seeking Behavior, Anxiety, And The Health Care Experience, Julie Lasslo

Theses and Dissertations--Education Sciences

Regular gynecological screenings are critical for women in promotion of health and preventing diseases like cervical cancer. Despite the importance of such examinations, many women fail to adhere to recommended screening protocols. As a result, women experience an increased disease risk. The current study examined the relationship between patient-provider communication quality, skill, and empathy on pelvic exam seeking behavior and exam-related anxiety and satisfaction. Additionally, negative self-concept, perceived poor genital self-image, and various elements of the socio-physical clinic environment were explored to better understand their impact on a women’s care seeking behavior.

A total of 350 women 19 through 80 …

A Leadership Perspective On Family Engagement: Qualitative Content Analysis Of Secondary Data, Stephanie Anderson

Theses and Dissertations--Education Sciences

The purpose of the study was to explore the leadership actions and activities that contributed to the implementation of a schoolwide family engagement initiative in a school. A qualitative content analysis of secondary data design was used to investigate the intentional actions and activities of a school leadership team during the implementation of a family engagement initiative within an elementary school. The Coherence Framework (Fullan & Quinn, 2016) provided a lens for which to investigate schoolwide change across drivers and sub-drivers.

The findings of this study describe intentional leadership actions and activities when communicating with families, conducting formal assessments, and …