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Physical Conditions Including Magnetic Fields In Several Star Forming Regions Of The Galaxy, Matt Lykins

University of Kentucky Doctoral Dissertations

This document describes studies of two independent regions of the interstellar medium (ISM). These studies have the common element that both pertain to regions in our Galaxy that are known to be associated with present-day star formation. These studies aim to help us understand the ISM, star formation, and ultimately where we came from, since, after all, our star, the Sun, is itself the product of star formation 4.5 billion years ago. The first project measured the Zeeman Effect on the 21 cm H I absorption line in order to create a map of the line of sight magnetic fields …

Characterization Of Soil Carbon Stabilization In Long-Term Row-Cropped Agro-Ecosystems, Soraya Patricia Alvarado-Ochoa

University of Kentucky Doctoral Dissertations

Soil organic matter (SOM) is a dynamic soil property, sensitive and responsive to many factors. The possibility of increasing soil carbon (C) sequestration by changing land use and management practices has been of great interest recently due to concerns with global changes in the atmospheric carbon dioxide (CO₂) balance. Nonetheless, as a result of the complex dynamics of SOM, there is still the need for SOM characterization procedures capable of monitoring SOM stabilization, taking into account all the factors involved.

This study characterized SOM stabilization as affected by management practices in three long-term field experiments, considering physical, chemical …

Opioid-Cannabinoid Codrugs With Enhanced Analgesic And Pharmacokinetic Profile, Harpreet Kaur Dhooper

University of Kentucky Doctoral Dissertations

The central hypothesis of the dissertation is that “the design and synthesis of a codrug of an opiate and a cannabinoid can be achieved which is stable in the gastrointestinal tract and shows a superior pharmacological and pharmacokinetic profile when compared to a physical mixture of the two parent drugs.” To prove the hypothesis, a series of novel codrugs were prepared by conjugation of the opiate drug codeine with Δ⁹-tetrahydrocannabinol (Δ⁹-THC), cannabidiol, abn-cannabidiol and an opiate prodrug 3-O-acetylmorphine with Δ⁹-THC. Codeine-cannabinoid codrugs were evaluated for analgesic activity in the rat after oral administration. The …

Evolution And The End Of A World, David Edward Long

University of Kentucky Doctoral Dissertations

This dissertation examines college student understanding and attitudes toward biological evolution. In ethnographic work, I followed a cohort of 31 students through their required introductory biology class. In interviews, students discuss their life history with the concept - in school, at home, at church, and in their communities. For some Creationist students, confronting evolution in class has meant confronting existential issues regarding both the basis of science and the basis of faith. For other Creationist students, claims of evolution's theoretical strength are eschewed for its direct challenge to their worldview. For most students, science holds minimal interest against other values …

Whole Farm Modeling Of Precision Agriculture Technologies, Jordan Murphy Shockley

University of Kentucky Doctoral Dissertations

This dissertation investigated farm management concerns faced by grain producers due to the acquisition of various precision agriculture technologies. The technologies evaluated in the three manuscripts included 1) auto-steer navigation, 2) automatic section control, and 3) autonomous machinery. Each manuscript utilized a multifaceted economic model in a whole-farm decision-making framework to determine the impact of precision agriculture technology on machinery management, production management, and risk management. This approach allowed for a thorough investigation into various precision agriculture technologies which helped address the relative dearth of economic studies of precision agriculture and farm management. Moreover, the research conducted on the above …

LP Bounded Point Evaluations For Polynomials And Uniform Rational Approximation, Erin Militzer

University of Kentucky Doctoral Dissertations

A connection is established between uniform rational approximation, and approximation in the mean by polynomials on compact nowhere dense subsets of the complex plane C. Peak points for R(X) and bounded point evaluations for H^p(X, dA), 1 ≤ p < ∞, play a fundamental role.

Development Of Novel Ahr Antagonists, Hyosung Lee

University of Kentucky Doctoral Dissertations

Aryl hydrocarbon receptor (AHR) is a sensor protein, activated by aromatic chemical species for transcriptionally regulating xenobiotic metabolizing enzymes. AHR is also known to be involved in a variety of pathogenesis such as cancer, diabetes mellitus, cirrhosis, asthma, etc. The AHR signaling induced by xenobiotics has been intensively studied whereas its physiological role in the absence of xenobiotics is poorly understood. Despite a number of ligands of AHR have been reported thus far, further applications are still hampered by the lack of specificity and/or the partially agonistic activity. Thus, a pure AHR antagonist is needed for deciphering the AHR cryptic …

Novel Approaches In Structured Light Illumination, Yongchang Wang

University of Kentucky Doctoral Dissertations

Among the various approaches to 3-D imaging, structured light illumination (SLI) is widely spread. SLI employs a pair of digital projector and digital camera such that the correspondences can be found based upon the projecting and capturing of a group of designed light patterns. As an active sensing method, SLI is known for its robustness and high accuracy. In this dissertation, I study the phase shifting method (PSM), which is one of the most employed strategy in SLI. And, three novel approaches in PSM have been proposed in this dissertation. First, by regarding the design of patterns as placing points …

Nonparametric Estimation Of Derivatives With Applications, Benjamin Hall

University of Kentucky Doctoral Dissertations

We review several nonparametric regression techniques and discuss their various strengths and weaknesses with an emphasis on derivative estimation and confidence band creation. We develop a generalized C(p) criterion for tuning parameter selection when interest lies in estimating one or more derivatives and the estimator is both linear in the observed responses and self-consistent. We propose a method for constructing simultaneous confidence bands for the mean response and one or more derivatives, where simultaneous now refers both to values of the covariate and to all derivatives under consideration. In addition we generalize the simultaneous confidence bands to account for heteroscedastic …

Building Sustainable Societies: Exploring Sustainability Policy And Practice In The Age Of High Consumption, Cindy Isenhour

University of Kentucky Doctoral Dissertations

This dissertation is an attempt to examine how humans in wealthy, post-industrial urban contexts understand sustainability and respond to their concerns given their sphere of influence. I focus specifically on sustainable consumption policy and practice in Sweden, where concerns for sustainability and consumer-based responses are strong. This case raises interesting questions about the relative strength of sustainability movements in different cultural and geo-political contexts as well as the specific factors that have motivated the movement toward sustainable living in Sweden.

The data presented here supports the need for multigenic theories of sustainable consumerism. Rather than relying on dominant theories of …

Palinspastic Reconstruction Around A Thrust Belt Recess: An Example From The Appalachian Thrust Belt In Northwestern Georgia, Brian Stephen Cook

University of Kentucky Doctoral Dissertations

In a well-defined subrecess in the Appalachian thrust belt in northwestern Georgia, two distinct regional strike directions intersect at approximately 50°. Fault intersections and interference folds enable tracing of both structural strikes. Around the subrecess, tectonically thickened weak stratigraphic layers—shales of the Cambrian Conasauga Formation—accommodated ductile deformation associated with the folding and faulting of the overlying Cambrian–Ordovician regional competent layer. The structures in the competent layer are analogous to those over ductile duplexes (mushwads) documented along strike to the southwest in Alabama.

The intersection and fold interference exemplify a long-standing problem in volume balancing of palinspastic reconstructions of sinuous thrust …

Real-Time Model Predictive Control Of Quasi-Keyhole Pipe Welding, Kun Qian

University of Kentucky Doctoral Dissertations

Quasi-keyhole, including plasma keyhole and double-sided welding, is a novel approach proposed to operate the keyhole arc welding process. It can result in a high quality weld, but also raise higher demand of the operator. A computer control system to detect the keyhole and control the arc current can improve the performance of the welding process. To this effect, developing automatic pipe welding, instead of manual welding, is a hot research topic in the welding field.

The objective of this research is to design an automatic quasi-keyhole pipe welding system that can monitor the keyhole and control its establishment time …

A Continuous Mathematical Model Of The One-Dimensional Sedimentation Process Of Flocculated Sediment Particles, Sebastian Fernando Torrealba

University of Kentucky Doctoral Dissertations

A new continuous one-dimensional sedimentation model incorporating a new continuous flocculation model that considers aggregation and fragmentation processes was derived and tested. Additionally, a new procedure to model sediment particle size distribution (PSD) was derived. Basic to this development were three different parametric models: Jaky, Fredlund and the Gamma probability distribution (GPD) were chosen to fit three different glass micro-spheres PSDs having average particle sizes of 7, 25 and 35 microns. The GPD provided the best fit with the least parameters. The bimodal GPD was used to fit ten sediment samples with excellent results (< 5% average error). A continuous flocculation model was derived using the method of moments for solving the continuous Smoluchowski coagulation equation with fragmentation. The initial sediment PSD was modeled using a bimodal GPD. This new flocculation model resulted in a new general moments’ equation that considers aggregation and fragmentation processes, which is represented by a system of ordinary differential equations. The model was calibrated using a genetic algorithm with initial and flocculated PSDs of four sediment samples and four anionic polyacrylamides flocculants. The results show excellent correlation between predicted and observed values (R² > 0.9878). A new continuous …

Progress Towards The Synthesis Of Type B Polycyclic Polyprenylated Acylphloroglucinol 7-Epi-Clusianone, Pushpa Suresh Jayasekara Mudiyanselage

University of Kentucky Doctoral Dissertations

Plants of the family Guttiferae produce polycyclic polyprenylated acylphloroglucinols (PPAPs), which have interesting biological activities including anticancer and antibacterial properties. The main structural features of PPAPs comprise of bicyclo[3.3.1]nonane-2,4,9-triketone with one acyl group together with prenyl, geranyl, or other C₁₀H₁₇ groups. 7-epi-Clusianone, a type B PPAP with C-7 endo stereochemistry, is being approached by establishing the cis relationship with C(4) allyl group and C(2) methyl ester in the early stage of the synthesis. Then C(2) methyl ester is converted to alkyne aldehyde and syn reduction followed by intramolecular aldol reaction to give bicyclo[3.3.1]nonane structure with …

Immobilization Of Mercury And Arsenic Through Covalent Thiolate Bonding For The Purpose Of Environmental Remediation, Lisa Y. Blue

University of Kentucky Doctoral Dissertations

Mercury and arsenic are widespread contaminants in aqueous environments throughout the world. The elements arise from multiple sources including mercury from coal-fired power plants and wells placed in natural geological deposits of arseniccontaining minerals. Both elements have significant negative health impacts on humans as they are cumulative toxins that bind to the sulfhydryl groups in proteins, disrupting many biological functions. There are currently no effective, economical techniques for removing either mercury or arsenic from aqueous sources. This thesis will demonstrate a superior removal method for both elements by formation of covalent bonds with the sulfur atoms in N,N’-Bis(2-mercaptoethyl)isophthalamide (commonly called …

Integration Of The Regression-Based Land Use Model And The Combined Trip Distribution-Assignment Transportation Model, Meiwu An

University of Kentucky Doctoral Dissertations

Regional growth caused the emergence of traffic congestion and pollution in the past few decades, which have started to affect small urban areas. These problems are not only related to transportation system design but also to land use planning. There has been growing recognition that the relationship between land use and transportation needs to be understood and analyzed in a consistent and systematic way. Integrated urban models have recently been introduced and implemented in several metropolitan areas to systematically examine the relationship between land use and transportation. The general consensus in the field of integrated urban models is that each …

Stimuli-Responsive Hydrogel Microdomes Integrated With Genetically Engineered Proteins For High-Throughput Screening Of Pharmaceuticals, Sylvia Daunert, Sapna K. Deo, Jason Douglas Ehrick, Tyler William Browning, Leonidas G. Bachas

Chemistry Faculty Patents

A hydrogel microdome that can swell in response to a stimuli or target molecule is formed by polymerizing a mixture comprising a monomer capable of forming a hydrogel with a biopolymer. An array of hydrogel microdomes can be formed on a substrate by microspotting the mixture and polymerizing. The array can be used for high-throughput screening of analytes as well as for use as an actuator and biosensor using the swelling property of the hydrogel.

Brazilian Adolescents Infected By Hiv: Epidemiologic Characteristics And Adherence To Treatment, Julia K. C. Machado, Maria J. C. Sant'anna, Veronica Coates, Flavia J. Almeida, Eitan N. Berezin, Hatim A. Omar

Pediatrics Faculty Publications

Over the last 3 decades since the first AIDS cases appeared, we have witnessed great progress in therapeutic methodologies that have transformed the evolution of the disease from debilitating and fatal, into chronic and controllable. HIV-infected children are arriving at adolescence and bringing specific challenges, not only to themselves, but also to their families and caregivers. This retrospective study sets forth epidemiological and treatment characteristics of 46 HIV-infected adolescents followed in a specialized university service relating said characteristics to therapy adherence assessed through a combination of three indirect methods. Therapy adherence did not reveal any association with either epidemiologic characteristics …

Interactions Between Connected Half-Sarcomeres Produce Emergent Mechanical Behavior In A Mathematical Model Of Muscle, Kenneth S. Campbell

Physiology Faculty Publications

Most reductionist theories of muscle attribute a fiber's mechanical properties to the scaled behavior of a single half-sarcomere. Mathematical models of this type can explain many of the known mechanical properties of muscle but have to incorporate a passive mechanical component that becomes approximately 300% stiffer in activating conditions to reproduce the force response elicited by stretching a fast mammalian muscle fiber. The available experimental data suggests that titin filaments, which are the mostly likely source of the passive component, become at most approximately 30% stiffer in saturating Ca2+ solutions. The work described in this manuscript used computer modeling to …

Dusty Structure Around Type-I Active Galactic Nuclei: Clumpy Torus Narrow-Line Region And Near-Nucleus Hot Dust, Rivay Mor, Hagai Netzer, Moshe Elitzur

Physics and Astronomy Faculty Publications

We fitted Spitzer/IRS ~ 2-35 μm spectra of 26 luminous quasi-stellar objects in an attempt to define the main emission components. Our model has three major components: a clumpy torus, dusty narrow-line region (NLR) clouds, and a blackbody-like dust. The models utilize the clumpy torus of Nenkova et al. and are the first to allow its consistent check in type-I active galactic nuclei (AGNs). Single torus models and combined torus-NLR models fail to fit the spectra of most sources, but three-component models adequately fit the spectra of all sources. We present torus inclination, cloud distribution, covering factor, and …

Photo Highlights Of The 10th Kentucky Grazing Conference, Kentucky Grazing Conference

Kentucky Grazing Conference

No abstract provided.

Forage Spokesman Information, Tom Flowers, Vince Rawe, Caldwell Willig

Kentucky Grazing Conference

No abstract provided.

Animal Welfare--Animal Rights: Role Of Grazing, Roy Burris

Kentucky Grazing Conference

The care and handling of farm animals has drawn a lot of media attention lately. Some well-publicized events have given our industry the proverbial black-eye and led to a chain of events that has left livestock producers feeling very vulnerable to negative attacks. Although these events have been very isolated, they have had some very farreaching effects. Could they have been prevented? How? What do we do now?

Extended Grazing And Reduced Stored Feed, Edward N. Ballard

Kentucky Grazing Conference

Feed costs represent the major cost in most livestock production systems. A recently completed analysis of 225 Standardized Performance Analysis (SPA) Beef Cow Records on herds in Illinois and Iowa showed that feed cost was the overriding factor determining profitability, explaining over 57 percent of the herd-to-herd variation. Typically the cost of supplying nutrients to ruminant livestock is much greater using harvested feedstuffs as opposed to grazing pastures or crop residues. The primary function of a grassland farm is to convert solar energy to marketable livestock products in the most efficient manner. The fewer steps between the animal product and …

Stored Feed Needs: How Much? What Quality?, Jeff Lehmkuhler

Kentucky Grazing Conference

Feed resources are the largest variable expense in beef production systems outside the initial investment in the livestock. When we look at Standardized Performance Analysis (SPA) information from Texas and Minnesota, states that are at the extreme from an environment stance, the projected costs for maintaining a beef cow are strikingly similar. It is important to note that these costs include all expenses and opportunity costs. Getting back to the SPA information, in 2007 the annual cost to maintain a cow in Texas was determined to be roughly $590 while the Minnesota value was near $610 or only about $20/cow …

Tall Fescue Grazing Research, Glen Aiken

Kentucky Grazing Conference

‘Kentucky-31’ tall fescue, like it or hate it, covers 5 million acres of Kentucky and if you do not have it on your farm, it is likely that one of your bordering neighbors does! Tall fescue owes its persistence and productivity in large part to a fungal endophyte that infects most plants. This endophyte produces an array of alkaloids that benefit the plant in tolerating heat, drought, and grazing. Unfortunately, the endophyte also produces ergot alkaloids that can cause “fescue toxicosis” in cattle. Cattle inflicted with toxicosis have reduced dry matter intake, elevated body temperature, and often retain their winter …

Weed Control Options For Pastures, Jon Doran

Kentucky Grazing Conference

What is a weed? A pasture or hayfield “weed” is any plant that you deem as being out of place and/or a plant that is decreasing your desired forage production. Weeds may be classified in several ways including broadleaf weeds, woody plants, and undesirable grasses. Besides decreasing forage, weeds can also interfere with forage utilization, grazing distribution, etc. There are several methods available to control weeds and increase production of and access to desirable forages. The three main methods are cultural, mechanical, and chemical. The cultural method is quite simple-a thriving grass stand is an excellent form of weed control …

Our Experiences With Eastern Gamagrass, Tommy R. Yankey

Kentucky Grazing Conference

As livestock producers try to reduce their cost of production, many look at ways to reduce their feed costs. Feed costs have been identified as the largest single cost of livestock production, making up 50 to 70% of the total cost of production. Grazing is the cheapest way to feed cattle on a cost per pound of nutrient basis.

New Developments In Grazing Species And Varieties, S. Ray Smith

Kentucky Grazing Conference

During the last 10 years there have been several new forage species that have emerged as useful in grazing systems and many new varieties have been released of traditional species. Plant breeders continue to make improvement in our traditional pasture species like tall fescue, orchardgrass, and red and white clover. In the following paragraphs, I will focus more on some of the forage species that you may not be as familiar with and highlight the advancements occurring in developing new varieties for grazing. There are many sources of information on this subject. I especially encourage you to read the new …

Why Should I Improve My Grazing Program?, Garry D. Lacefield

Kentucky Grazing Conference

Grazing represents the cheapest way to feed ruminants on a cost per pound of nutrient basis. Stored feed is usually the single largest item in livestock budgets and cost or amount of stored feed is usually the best prediction of potential profitability in most beef cattle operations.