Digital Commons Network^™

Computational Tools For Improving Route Planning In Agricultural Field Operations, Rodrigo S. Zandonadi

Theses and Dissertations--Biosystems and Agricultural Engineering

In farming operation, machinery represents a major cost; therefore, good fleet management can have a great impact on the producer’s profit, especially considering the increasing costs of fuel and production inputs in recent years. One of the tasks to be accomplished in order to improve fleet management is planning the path that the machine should take to cover the field while working. Information such as distance traveled, time and fuel consumption as well as agricultural inputs wasted due to off-target-application areas are crucial in the path planning process. Parameters such as field boundary size and geometry, machine total width as …

Blast-Induced Brain Injury: Influence Of Shockwave Components, Dexter V. Reneer

Theses and Dissertations--Neuroscience

Blast-induced traumatic brain injury (bTBI) has been described as the defining injury of Operations Enduring Freedom and Iraqi Freedom (OEF/OIF). Previously, most blast injury research has focused on the effects of blast on internal, gas filled organs due to their increased susceptibility. However, due to a change in enemy tactics combined with better armor and front-line medical care, bTBI has become one of the most common injuries due to blast. Though there has been a significant amount of research characterizing the brain injury produced by blast, a sound understanding of the contribution of each component of the shockwave to the …

Analysis Of Binary Data Via Spatial-Temporal Autologistic Regression Models, Zilong Wang

Theses and Dissertations--Statistics

Spatial-temporal autologistic models are useful models for binary data that are measured repeatedly over time on a spatial lattice. They can account for effects of potential covariates and spatial-temporal statistical dependence among the data. However, the traditional parametrization of spatial-temporal autologistic model presents difficulties in interpreting model parameters across varying levels of statistical dependence, where its non-negative autocovariates could bias the realizations toward 1. In order to achieve interpretable parameters, a centered spatial-temporal autologistic regression model has been developed. Two efficient statistical inference approaches, expectation-maximization pseudo-likelihood approach (EMPL) and Monte Carlo expectation-maximization likelihood approach (MCEML), have been proposed. Also, Bayesian …

A Systematic Study Of Transport, Magnetic And Thermal Properties Of Layered Iridates, Oleksandr B. Korneta

Theses and Dissertations--Physics and Astronomy

A unique feature of the 5d-iridates is that the spin-orbit interaction (SOI) and Coulomb interactions U are of comparable strength and therefore compete vigorously. The relative strength of these interactions stabilizes new exotic ground states that provide a fertile ground for studying new physics. SOI is proportional to Z^4 (Z is the atomic number), and it is now recognized that strong SOI can drive novel narrow-gap insulating states in heavy transition metal oxides such as iridates. Indeed, strong SOI necessarily introduces strong lattice degrees of freedom that become critical to new physics in the iridates. This dissertation thoroughly examines a …

Evaluating Retention In Medical Care And Its Impact On The Health Outcomes Of Individuals Living With Human Inmmunodeficiency Virus, Timothy N. Crawford

Theses and Dissertations--Epidemiology and Biostatistics

In the last few years, engagement in medical care among individuals living with HIV has become a major priority among HIV medical providers and public health researchers. Engagement in medical care is an important concept as it involves the process of linking newly diagnosed individuals into medical care and retaining those individuals in care throughout the course of their infection. Although there have been major advances in the management of HIV, like the advent of Highly Active Antiretroviral Therapy, morbidity and mortality due to HIV cannot be fully reduced if the individual does not optimally retain in care. Retention in …

Multiwall Carbon Nanotube Arrays For Thermal Interface Enhancement, Darrell Keith Etheredge

Theses and Dissertations--Mechanical and Aerospace Engineering

High performance/small package electronics create difficult thermal issues for integrated circuits. Challenges exist at material interfaces due to interfacial contact resistances. Multiwall carbon nanotube (MWCNT) arrays are considered to be excellent candidates for use as thermal interface materials (TIMs) due to outstanding thermal/mechanical properties. In this work, MWCNT array TIMs are analyzed in aluminum and carbon fiber composites via flash diffusivity analysis. The effect of TIM thickness, areal/bulk density, surface cleanliness, and volumetric packing fraction; along with the effect of substrate finish and interfacial contact pressure on thermal performance are analyzed. Trends show the best TIMs possess low thickness, high …

Simulation And Experimental Validation Of Airborne And Structure-Borne Noise Transmission In Hvac Plenums, Srinivasan Ramalingam

Theses and Dissertations--Mechanical and Aerospace Engineering

This research demonstrates the usage of numerical acoustics to model sound and vibrational energy propagation in HVAC ducts and plenums. Noise and vibration in HVAC systems propagates along three primary paths that can be classified as airborne direct, airborne indirect and structure-borne. The airborne direct path was simulated using acoustic FEM with special boundary conditions to handle the diffuse acoustic field loading and the baffled termination. The insertion loss for a number of different plenum geometries was compared to published measurement results. Results were in good agreement both below and above the cutoff frequency. Additionally, the airborne indirect path, often …

Cryogenic Machining And Burnishing Of Az31b Magnesium Alloy For Enhanced Surface Integrity And Functional Performance, Zhengwen Pu

Theses and Dissertations--Mechanical and Aerospace Engineering

Surface integrity of manufactured components has a critical impact on their functional performance. Magnesium alloys are lightweight materials used in the transportation industry and are also emerging as a potential material for biodegradable medical implants. However, the unsatisfactory corrosion performance of Mg alloys limits their application to a great extent. Surface integrity factors, such as grain size, crystallographic orientation and residual stress, have been proved to remarkably influence the functional performance of magnesium alloys, including corrosion resistance, wear resistance and fatigue life.

In this dissertation, the influence of machining conditions, including dry and cryogenic cooling (liquid nitrogen was sprayed to …

Specified Motion And Feedback Control Of Engineering Structures With Distributed Sensors And Actuators, Amirhossien Ghasemi

Theses and Dissertations--Mechanical and Aerospace Engineering

This dissertation addresses the control of flexible structures using distributed sensors and actuators. The objective to determine the required distributed actuation inputs such that the desired output is obtained. Two interrelated facets of this problem are considered. First, we develop a dynamic-inversion solution method for determining the distributed actuation inputs, as a function of time, that yield a specified motion. The solution is shown to be useful for intelligent structure design, in particular, for sizing actuators and choosing their placement. Secondly, we develop a new feedback control method, which is based on dynamic inversion. In particular, filtered dynamic inversion combines …

Simulation Of Whistle Noise Using Computational Fluid Dynamics And Acoustic Finite Element Simulation, Jiawei Liu

Theses and Dissertations--Mechanical and Aerospace Engineering

The prediction of sound generated from fluid flow has always been a difficult subject due to the nonlinearities in the governing equations. However, flow noise can now be simulated with the help of modern computation techniques and super computers. The research presented in this thesis uses the computational fluid dynamics (CFD) and the acoustic finite element method (FEM) in order to simulate the whistle noise caused by vortex shedding. The acoustic results were compared to both analytical solutions and experimental results to better understand the effects of turbulence models, fluid compressibility, and wall boundary meshes on the acoustic frequency response. …

A Filter-Forcing Turbulence Model For Large Eddy Simulation Incorporating The Compressible "Poor Man's" Navier--Stokes Equations, Joshua Strodtbeck

Theses and Dissertations--Mechanical and Aerospace Engineering

A new approach to large-eddy simulation (LES) based on the use of explicit spatial filtering combined with backscatter forcing is presented. The forcing uses a discrete dynamical system (DDS) called the compressible ``poor man's'' Navier--Stokes (CPMNS) equations. This DDS is derived from the governing equations and is shown to exhibit good spectral and dynamical properties for use in a turbulence model. An overview and critique of existing turbulence theory and turbulence models is given. A comprehensive theoretical case is presented arguing that traditional LES equations contain unresolved scales in terms generally thought to be resolved, and that this can only …

A New Metric-Based Lca Method For Assessing The Sustainability Performance Of Metallic Automotive Components, Xiangxue Zhang

Theses and Dissertations--Mechanical and Aerospace Engineering

This thesis presents a new metric-based Life-cycle Assessment (LCA) method for assessing the sustainability performance of metallic automotive components. The unique feature of this research work include the development and use of a metrics-based product sustainability index (ProdSI) methodology by considering the total life-cycle approach and the triple bottom line (TBL) with the 6R methodology. It has been shown that the manufactured product’s sustainability performance can be comprehensively assessed using this new methodology. The major focus of this research is the integration of the 6R activities (Reduce, Reuse, Recycle, Recover, Redesign and Remanufacture). Four life-cycle stages of the …

Finite Element Analysis Of Cancellous Bone, Lucas T. Wilkerson

Theses and Dissertations--Mechanical and Aerospace Engineering

A variety of pathologies exist which increase the likelihood of bone fracture. Present methods for determining the fracture risk of a specific patient are based exclusively on the amount of bone present. While the quantity of bone tissue is correlated with strength, it neglects to account for bone’s intricate microarchitecture. To assess the effect of bone quality on strength, a methodology was developed for the structural analysis of cancellous bone biopsies. Thirty biopsies were selected from a pre-existing biopsy bank, and scanned using a SCANCO µCT-40 at a resolution of 30 microns. Cortical bone was removed from the resulting three-dimensional …

Low Reynolds Number Flow Field Modification Via Travelling Wave Actuation Of A Vertically Aligned Wire Array Surface, John C. Calhoun

Theses and Dissertations--Mechanical and Aerospace Engineering

Experiments were conducted to observe the effects of an active wire surface on low-Reynolds number Poiseuille flow. The objective was to evaluate the feasibility of actuating piezoelectric nanowires into a travelling wave motion in order to reduce wall shear stress in turbulent flows. Studies have shown that travelling wave motions introduced into the bounding wall of turbulent flow can reduce wall shear stress by disrupting the formation of drag-inducing coherent vortical structures. A Reynolds number scaled flow facility was designed to represent the near-wall region of turbulent flow. A wire surface was installed in the bounding wall and dynamically actuated …

Applying Specific Arts Activities To Improve The Quality Of Life For Individuals With Alzheimer’S Disease And Dementia, Ann Christianson Tietyen

Theses and Dissertations--Art and Visual Studies

This study examined the effectiveness of a combination of seven different visual art activities, hat decoration, collage, embossing, painting, ceramics, photography, and printmaking, on quality of life for eight veterans with Alzheimer’s disease and dementia. The eight veterans were selected from the population of residents at the Thomson‐ Hood Veterans facility in Wilmore, Kentucky. These veterans were administered the seven art activities mentioned above, which ranged from less difficult to increasing difficulty. Three standard self‐reporting instruments, the Quality of Life‐AD, the Rosenberg Self‐Esteem Scale, and the Smiley‐Face Mood Assessment, as well as systematic observation and surveys were used to explore …

Localization And Functional Characterization Of Oatp4c1 Transporter In In Vitro Cell Systems And Human/Rat Tissues, Kuei-Ling Kuo

Theses and Dissertations--Pharmacy

The organic anion transporting polypeptide 4c1 (Oatp4c1) was previously identified as a novel uptake transporter predominantly expressed at the basolateral membrane in the rat kidney proximal tubules. Its functional role was suggested to be a vectorial transport partner of an apically-expressed efflux transporter for the efficient translocation of physiological substrates into urine, some of which were suggested to be uremic toxins. In vitro studies in polarized cell lines showed that upon transfection rat Oatp4c1 localizes at the apical membrane. The objectives of this project were to further validate the subcellular localization of Oatp4c1/OATP4C1 in rat and human tissues as well …

The Transmission Dynamics Of Equine Herpesvirus Type 1 (Ehv-1) Infection In Outbreaks Characterized Predominately By Neurologic Or Respiratory Illness, Barry Jay Meade

Theses and Dissertations--Veterinary Science

Formalized epidemiological field investigations were conducted to compare and contrast the transmission dynamics of EHV-1 neurological disease among horses stabled at Churchill Downs Racetrack, Louisville, Kentucky and of EHV-1 respiratory illness among horses stabled in the student barn at Murray State University. Differences were assessed by means of statistical and mathematical modeling techniques applied to survey and biological data collected over the course of the respective disease events.

Regression methods applied to survey data enabled the construction of a statistical model to predict a date of onset of illness for horses within each equine cohort. Comparisons of the epidemic curves …

Multihierarchical Documents And Fine-Grained Access Control, Neil Moore

Theses and Dissertations--Computer Science

This work presents new models and algorithms for creating, modifying, and controlling access to complex text. The digitization of texts opens new opportunities for preservation, access, and analysis, but at the same time raises questions regarding how to represent and collaboratively edit such texts. Two issues of particular interest are modelling the relationships of markup (annotations) in complex texts, and controlling the creation and modification of those texts. This work addresses and connects these issues, with emphasis on data modelling, algorithms, and computational complexity; and contributes new results in these areas of research.

Although hierarchical models of text and markup …

Characteristics Of Kentucky Agricultural Operations Participating In Nrcs Conservation Programs, Carmen T. Agouridis

MPA/MPP/MPFM Capstone Projects

The Natural Resource Conservation Service (NRCS) designs and promotes a wide variety of conservation practices and programs that enhance the environment by reducing soil erosion, improving water quality, and enhancing and creating wildlife habitat. The impact of these practices and programs is largely dependent on the voluntary participation of landowners. Thus, central to the success of the NRCS conservation programs is an understanding of the characteristics of landowners and operations participating in these programs.

Using operator and operation characteristics from the 1997, 2002, and 2007 Censuses of Agriculture and controlling for county fixed effects, this study 1) identifies significant characteristics …

Strategic Management And Job Satisfaction: Agency-Level Effects In The Federal Government, Tara Bopp

MPA/MPP/MPFM Capstone Projects

As strategic planning and human capital strategies become more regulated in the United States government, a decision must be made by federal agency heads. Will agencies fully participate and buy into the process of participative strategic planning and management or will they comply with regulations and reforms merely for the sake of compliance with little further effort? The intent of this study is to show that agencies that choose to do more than simply comply with GPRA and implement strategic planning and management can benefit from their increased effort in by increasing job satisfaction in their workforce.

The Government Performance …

Has The Emergence Of Charter Schools Affected Student Performance In Traditional Public Schools In Shared Markets? Recent Evidence From Public Schools In Ohio, Robert Akers

MPA/MPP/MPFM Capstone Projects

This paper addresses a key issue in the charter school debate, which is whether or not the existence of charter schools in a specific locality causes neighboring traditional public schools to improve their effectiveness. Measuring four student outcomes in Ohio counties where charter school enrollment represents at least five percent of the total public school-age population yielded mixed results. Standardized test scores in math and reading failed to keep pace with state averages but progress was made closing the gap in graduation rates and Performance Index Scores (the PIS is a weighted score given by the Ohio Department of Education …

Neuroinflammation In The Aging Down Syndrome Brain; Lessons From Alzheimer's Disease, Donna M. Wilcock

Physiology Faculty Publications

Down syndrome (DS) is the most genetic cause of mental retardation and is caused by the triplication of chromosome 21. In addition to the disabilities caused early in life, DS is also noted as causing Alzheimer's-disease-like pathological changes in the brain, leading to 50-70% of DS patients showing dementia by 60-70 years of age. Inflammation is a complex process that has a key role to play in the pathogenesis of Alzheimer's disease. There is relatively little understood about inflammation in the DS brain and how the genetics of DS may alter this inflammatory response and change the course of disease …

A Changing Perspective On The Role Of Neuroinflammation In Alzheimer's Disease, Donna M. Wilcock

Physiology Faculty Publications

Alzheimer's disease (AD) is a complex, neurodegenerative disorder characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain. Glial cells, particularly microglial cells, react to the presence of the amyloid plaques and neurofibrillary tangles producing an inflammatory response. While once considered immunologically privileged due to the blood-brain barrier, it is now understood that the glial cells of the brain are capable of complex inflammatory responses. This paper will discuss the published literature regarding the diverse roles of neuroinflammation in the modulation of AD pathologies. These data will then be related to the well-characterized macrophage phenotypes. The conclusion …

"Human Babesiosis": An Emerging Transfusion Dilemma, Helieh S. Oz, Karin N. Westlund

Physiology Faculty Publications

Babesiosis, a common disease of animals, can infect humans via vector "tick bite", particularly in endemic areas. The recent reports of fatal cases in Hepatitis C and postliver transplant patients resulting from transfusion of contaminated blood should alert the medical profession regarding this emerging dilemma in endemic as well as nonendemic areas and the need for accurate blood screening for transfusion. Here, we illustrate different stages of the parasite lifecycle, progression of babesiosis in animal model, some aspects of pathologic outcomes, ongoing therapeutic modalities, and a feasible Acridine Orange fluorescent methodology for the diagnostic evaluation of blood samples.

Nutrition, Inflammation, And Infectious Disease, Helieh S. Oz, Sung-Ling Yeh

Physiology Faculty Publications

No abstract provided.

Pegylated Arginine Deiminase Downregulates Colitis In Murine Models, Helieh S. Oz, Jian Zhong, Willem J. S. De Villiers

Physiology Faculty Publications

Arginine deiminase (ADI), an arginine-metabolizing enzyme involved in cell signaling, is dysregulated in multiple inflammatory diseases and cancers. We hypothesized that pegylated ADI (ADI-PEG) provide protection against colitis.

METHODS: Dextran sodium sulfate colitis was induced in IL-10-deficient and BALB/c (WT) mice. ADI-PEG was administered i.p., and inflammatory mediators and pathology were evaluated.

RESULTS: Acute colitis in mice was manifested by increases in inflammatory biomarkers, such as serum amyloid A (SAA, P < 0.001), IL-12 p40, and disease index (3-Fold). In contrast, ADI-PEG significantly decreased clinical disease index, SAA levels, and inflammatory cytokines in blood as well as in colonic explants. Animals developed moderate (2.2 ± 0.3 WT) to severe (3.6 ± 0.5 IL-10 deficient) colonic pathology; and ADI-PEG treatment significantly improved the severity of colitis (P < 0.05). Marked infiltration of CD68+ macrophages and iNOS expression were detected in colonic submucosa in colitic animals but not detected in ADI-PEG-treated animals.

CONCLUSION: ADI-PEG attenuated inflammatory responses by suppression of macrophage infiltration and iNOS expression in colitic animals. ADI-PEG can serve as a potential therapeutic value in IBD.

Mild Cognitive Impairment: Statistical Models Of Transition Using Longitudinal Clinical Data, Erin L. Abner, Richard J. Kryscio, Gregory E. Cooper, David W. Fardo, Gregory A. Jicha, Marta S. Mendiondo, Peter T. Nelson, Charles D. Smith, Linda J. Van Eldik, Lijie Wan, Frederick A. Schmitt

Sanders-Brown Center on Aging Faculty Publications

Mild cognitive impairment (MCI) refers to the clinical state between normal cognition and probable Alzheimer's disease (AD), but persons diagnosed with MCI may progress to non-AD forms of dementia, remain MCI until death, or recover to normal cognition. Risk factors for these various clinical changes, which we term "transitions," may provide targets for therapeutic interventions. Therefore, it is useful to develop new approaches to assess risk factors for these transitions. Markov models have been used to investigate the transient nature of MCI represented by amnestic single-domain and mixed MCI states, where mixed MCI comprised all other MCI subtypes based on …

Development And Deployment Of A Bioreactor For The Removal Of Sulfate And Manganese From Circumneutral Coal Mine Drainage, C. B. Mastin, J. D. Edwards, Christopher D. Barton, Anastasios D. Karathanasis, Carmen T. Agouridis, Richard C. Warner

Forestry and Natural Resources Faculty Publications

Surface mining, in the form of contour mining and mountain-top removal, is a common means for retrieving coal in the Appalachian Coal Belt region of Kentucky. Overburden or excess spoil generated by these two methods is placed in valley fills. Traditionally Constructed fills have been shown to adversely impact headwater ecosystems via stream burial and through alterations to the hydrology, sediment supply, water quality and biological composition of downstream reaches. Mine drainages emanating from the toe of valley fills often contain elevated levels of total dissolved solids and heavy metals. Drainage chemistry from Guy Cove, a valley fill located in …

Evaluation Of Algae Concentration In Manure Based Media, Maira Freire Pecegueiro Do Amaral

Theses and Dissertations--Biosystems and Agricultural Engineering

Algae can be used to treat wastewater and manure while producing a feedstock for renewable energy. Algae require nutrients to achieve their maximum growth and manure could provide those nutrients, thereby reducing the cost of algae production and the impact of manure treatment. Algae concentration during cultivation is a critical variable that is difficult to measure due to the high concentration of suspended solids present in manure. This dissertation addresses methods to measure algae concentration in the presence of manure solids.

Quantifying the algae concentration gravimetrically or by optical density was unreliable due to manure solids interfering with the measurement. …

Efficient Greedy-Face-Greedy Geographic Routing Protocols In Mobile Ad Hoc And Sensor Networks, Yan Sun

Theses and Dissertations--Computer Science

This thesis describes and develops two planarization algorithms for geographic routing and a geographic routing protocol for mobile ad hoc and sensor networks. As all nodes are mobile and there is no fixed infrastructure, the design of routing protocols is one of the most challenging issues in mobile ad hoc and sensor networks. In recent years, greedyface- greedy (GFG) geographic routing protocols have been widely used, which need nodes to construct planar graphs as the underlying graphs for face routing.

Two kinds of planarization algorithms have been developed, idealized and realistic planarization algorithms, respectively. The idealized planarization algorithms make the …