Digital Commons Network^™

Towards Omni-Tomography -- Grand Fusion Of Multiple Modalities For Simultaneous Interior Tomography, Ge Wang, Jie Zhang, Hao Gao, Victor Weir, Hengyong Yu, Wenxiang Cong, Xiaochen Xu, Haiou Shen, James Bennett, Mark Furth, Yue Wang, Michael Vannier

Radiology Faculty Publications

We recently elevated interior tomography from its origin in computed tomography (CT) to a general tomographic principle, and proved its validity for other tomographic modalities including SPECT, MRI, and others. Here we propose "omni-tomography", a novel concept for the grand fusion of multiple tomographic modalities for simultaneous data acquisition in a region of interest (ROI). Omni-tomography can be instrumental when physiological processes under investigation are multi-dimensional, multi-scale, multi-temporal and multi-parametric. Both preclinical and clinical studies now depend on in vivo tomography, often requiring separate evaluations by different imaging modalities. Over the past decade, two approaches have been used for multimodality …

Lipopolysaccharide Impairs Amyloid Β Efflux From Brain: Altered Vascular Sequestration, Cerebrospinal Fluid Reabsorption, Peripheral Clearance And Transporter Function At The Blood-Brain Barrier, Michelle A. Erickson, Pehr E. Hartvigson, Yoichi Morofuji, Joshua B. Owen, D. Allan Butterfield, William A. Banks

Chemistry Faculty Publications

BACKGROUND: Defects in the low density lipoprotein receptor-related protein-1 (LRP-1) and p-glycoprotein (Pgp) clearance of amyloid beta (Aβ) from brain are thought to contribute to Alzheimer's disease (AD). We have recently shown that induction of systemic inflammation by lipopolysaccharide (LPS) results in impaired efflux of Aβ from the brain. The same treatment also impairs Pgp function. Here, our aim is to determine which physiological routes of Aβ clearance are affected following systemic inflammation, including those relying on LRP-1 and Pgp function at the blood-brain barrier.

METHODS: CD-1 mice aged between 6 and 8 weeks were treated with 3 intraperitoneal injections …

Synthetic Approaches To Organometallic Complexes For Electronics Applications, Ilya V. Vinogradov

Kaleidoscope

No abstract provided.

Effects Of Mining Reclamation On Sediment Yield And Organic Carbon Flux In First Order Watersheds, Zoe E. Bezold

Kaleidoscope

No abstract provided.

Systems And Methods For Detecting Defects In Coatings Utilizing Color-Based Thermal Mismatch, Richard Alloo, Kozo Saito, Belal Gharaibeh, Keng Hoo Chuah, Nelson Kudzo Akafuah, Ahmad Salaimeh

Mechanical Engineering Faculty Patents

A method of analyzing a thermal image of a coated substrate to determine the presence of defects includes determining a defect temperature range based on a color of the coated substrate and the maximum temperature of the coated substrate in the thermal image. Thereafter, the thermal image is processed by determining a signal value of a pixel of interest based on a temperature of the pixel of interest, temperatures of pixels in a kernel of pixels surrounding the pixel of interest, and the color of the coated substrate. The signal value of the pixel of interest is then compared to …

Concentration Effects And Ion Properties Controlling The Fractionation Of Halides During Aerosol Formation, Marcelo I. Guzman, Richa R. Athalye, Jose M. Rodriguez

Chemistry Faculty Publications

During the aerosolization process at the sea surface, halides are incorporated into aerosol droplets, where they may play an important role in tropospheric ozone chemistry. Although this process may significantly contribute to the formation of reactive gas phase molecular halogens, little is known about the environmental factors that control how halides selectively accumulate at the air-water interface. In this study, the production of sea spray aerosol is simulated using electrospray ionization (ESI) of 100 nM equimolar solutions of NaCl, NaBr, NaI, NaNO(2), NaNO(3), NaClO(4), and NaIO(4). The microdroplets generated are analyzed by mass spectrometry to study the comparative enrichment of …

The Nuclear Infrared Emission Of Low-Luminosity Active Galactic Nuclei, R. E. Mason, E. Lopez-Rodriguez, C. Packham, A. Alonso-Herrero, N. A. Levenson, J. Radomski, C. Ramos Almeida, L. Colina, Moshe Elitzur, I. Aretxaga, P. F. Roche, N. Oi

Physics and Astronomy Faculty Publications

We present high-resolution mid-infrared (MIR) imaging, nuclear spectral energy distributions (SEDs), and archival Spitzer spectra for 22 low-luminosity active galactic nuclei (LLAGNs; L_bol ≲ 10⁴² erg s^–1). Infrared (IR) observations may advance our understanding of the accretion flows in LLAGNs, the fate of the obscuring torus at low accretion rates, and, perhaps, the star formation histories of these objects. However, while comprehensively studied in higher-luminosity Seyferts and quasars, the nuclear IR properties of LLAGNs have not yet been well determined. We separate the present LLAGN sample into three categories depending on their Eddington ratio and radio …

Multi-Dimensional Modeling Of Charring Ablators, Haoyue Weng, Huaibao Zhang, Ovais U. Khan, Alexandre Martin

Mechanical Engineering Faculty Publications

Re-entry of a spacecraft occurs at the hypersonic regime where the flow field is extremely complex: high temperature gradients occurring in the shock-layer region ionize and dissociate the air. Even if a large portion of heat generated during this process is convected away in the surrounding air, a fraction of it is still transferred to the vehicle. Therefore, it is important to protect the vehicle with a suitable kind of shielding. Of the many techniques available today, use of ablative material is gaining popularity. The basic idea behind an ablating heat shield is that the energy incident on the spacecraft …

Bctcblue+ Program: A Joint Enrollment/Joint Admissions Program Supporting Transfer Student Success At The University Of Kentucky, Randolph Hollingsworth

Undergraduate Education White Papers

This paper outlines the purpose and goals of the BCTCblue+ Program, its impact on student success and how it relates to the University of Kentucky’s mission. The findings from the review of the Program show that it supports a more intentional admissions and transfer process for incoming UK students. In addition, the Program addresses a critical role in transitioning UK’s reverse transfer population back into a baccalaureate degree program for successful graduation.

Applied Microeconomics: Consumption, Production And Markets, David L. Debertin

Agricultural Economics Textbook Gallery

This is a microeconomic theory book designed for upper-division undergraduate students in economics and agricultural economics. This is a free pdf download of the entire book. As the author, I own the copyright. Amazon markets bound print copies of the book at amazon.com at a nominal price for classroom use. The book can also be ordered through college bookstores using the following ISBN numbers:

• ISBN‐13: 978‐1475244342
• ISBN-10: 1475244347

Basic introductory college courses in microeconomics and differential calculus are the assumed prerequisites. The last, tenth, chapter of the book reviews some mathematical principles basic to the other chapters. All of the …

Qualitative Evaluation Of Project P.A.T.H.S.: An Integration Of Findings Based On Program Participants, Daniel T. L. Shek, Rachel C. F. Sun

Pediatrics Faculty Publications

An integration of the qualitative evaluation findings collected in different cohorts of students who participated in Project P.A.T.H.S. (Positive Adolescent Training through Holistic Social Programmes) (n = 252 students in 29 focus groups) was carried out. With specific focus on how the informants described the program, results showed that the descriptions were mainly positive in nature, suggesting that the program was well received by the program participants. When the informants were invited to name three metaphors that could stand for the program, positive metaphors were commonly used. Beneficial effects of the program in different psychosocial domains were also voiced by …

Ebookmobile: Delivering Subject-Specific Ebooks To Your Inbox, Kathryn Lybarger

Library Presentations

Today's users are overloaded by the massive amount of information available to them, even within their own library's collection. Ebooks cataloged in batches of hundreds (or thousands) make a generic new ebook shelf prohibitively large and mostly uninteresting to a subject researcher. The Ebookmobile helps researchers become aware of new ebooks in the library collection in their specific area of interest, so they can start using them immediately. Ebookmobile checks the Voyager database daily for newly cataloged ebooks and creates feeds for ranges in a classification scheme. Researchers can choose to receive a daily e-mail or subscribe to an RSS …

Families Or Unrelated: The Evolving Debate In Genetic Association Studies, David W. Fardo, Richard Charnigo, Michael P. Epstein

Biostatistics Faculty Publications

To help uncover the genetic determinants of complex disease, a scientist often designs an association study using either unrelated subjects or family members within pedigrees. But which of these two subject recruitment paradigms is preferable? This editorial addresses the debate over the relative merits of family- and population-based genetic association studies. We begin by briefly recounting the evolution of genetic epidemiology and the rich crossroads of statistics and genetics. We then detail the arguments for the two aforementioned paradigms in recent and current applications. Finally, we speculate on how the debate may progress with the emergence of next-generation sequencing technologies.

Improving Woody Biomass Estimation Efficiency Using Double Sampling, David L. Parrott, John M. Lhotka, Songlin Fei, B. Scott Shouse

Forestry and Natural Resources Faculty Publications

Although double sampling has been shown to be an effective method to estimate timber volume in forest inventories, only a limited body of research has tested the effectiveness of double sampling on forest biomass estimation. From forest biomass inventories collected over 9,683 ha using systematic point sampling, we examined how a double sampling scheme would have affected precision and efficiency in these biomass inventories. Our results indicated that double sample methods would have yielded biomass estimations with similar precision as systematic point sampling when the small sample was ≥ 20% of the large sample. When the small to large sample …

The Use Of High-Solids Loadings In Biomass Pretreatment – A Review, Alicia A. Modenbach, Sue E. Nokes

Biosystems and Agricultural Engineering Faculty Publications

The use of high‐solids loadings (≥ 15% solids, w/w) in the unit operations of lignocellulose conversion processes potentially offers many advantages over lower‐solids loadings, including increased sugar and ethanol concentrations and decreased production and capital costs. Since the term lignocellulosic materials refers to a wide range of feedstocks (agricultural and forestry residues, distillery by‐products, and dedicated energy crops like grasses), the term “solids loading” here is defined by the amount of dry material that enters the process divided by the total mass of material and water added to the material. The goal of this study is to provide a consolidated …

Genetic Association Studies Of Copy-Number Variation: Should Assignment Of Copy Number States Precede Testing?, Patrick Breheny, Prabhakar Chalise, Anthony Batzler, Liewei Wang, Brooke L. Fridley

Biostatistics Faculty Publications

Recently, structural variation in the genome has been implicated in many complex diseases. Using genomewide single nucleotide polymorphism (SNP) arrays, researchers are able to investigate the impact not only of SNP variation, but also of copy-number variants (CNVs) on the phenotype. The most common analytic approach involves estimating, at the level of the individual genome, the underlying number of copies present at each location. Once this is completed, tests are performed to determine the association between copy number state and phenotype. An alternative approach is to carry out association testing first, between phenotype and raw intensities from the SNP array …

Evidence-Based Medicine Versus Personalized Medicine: Are They Enemies?, Jose De Leon

Psychiatry Faculty Publications

No abstract provided.

Enlivening Election Law, Joshua A. Douglas

Law Faculty Scholarly Articles

Election law cases are often lengthy and include complex discussion of constitutional doctrines. Moreover, there is rarely a clear-cut answer to a tricky election law question. The field is full of balancing tests, competing interests to weigh, and ever-shifting standards. A challenge for Election Law teachers, then, is to ensure that the long judicial opinions and difficult constitutional doctrines undergirding the field of election law do not bury the vibrancy of the topic. One way to keep an Election Law course student-friendly is to make frequent use of electronic media. Election law is well-suited to the adoption of images, videos, …

Oxidative Stress In Hpv-Driven Viral Carcinogenesis: Redox Proteomics Analysis Of Hpv-16 Dysplastic And Neoplastic Tissues, Federico De Marco, Elona Bucaj, Cesira Foppoli, Ada Fiorini, Carla Blarzino, Kozeta Filipi, Alessandra Giorgi, Maria Eugenia Schininà, Fabio Di Domenico, Raffaella Coccia, D. Allan Butterfield, Marzia Perluigi

Chemistry Faculty Publications

Genital infection by high risk Human Papillomavirus (HR-HPV), although recognized as the main etio-pathogenetic factor of cervical cancer, is not per se sufficient to induce tumour development. Oxidative stress (OS) represents an interesting and under-explored candidate as a promoting factor in HPV-initiated carcinogenesis. To gain insight into the role of OS in cervical cancer, HPV-16 positive tissues were collected from patients with invasive squamous cervical carcinoma, from patients with High Grade dysplastic HPV lesions and from patients with no clinical evidence of HPV lesions. After virological characterization, modulation of proteins involved in the redox status regulation was investigated. ERp57 and …

Conquests Of The Imagination: The Manipulation Of Myth In Iberian Conquest Literatures, Daniel Arbino, Michael Arnold

Nomenclatura: aproximaciones a los estudios hispánicos

No abstract provided.

The Curious Conundrum Regarding Sulfur Abundances In Planetary Nebulae, R. B. C. Henry, Angela Speck, Amanda I. Karakas, Gary J. Ferland, Mason Maguire

Physics and Astronomy Faculty Publications

Sulfur abundances derived from optical emission line measurements and ionization correction factors (ICFs) in planetary nebulae are systematically lower than expected for the objects' metallicities. We have carefully considered a large range of explanations for this "sulfur anomaly," including: (1) correlations between the size of the sulfur deficit and numerous nebular and central star properties, (2) ICFs which undercorrect for unobserved ions, (3) effects of dielectronic recombination on the sulfur ionization balance, (4) sequestering of S into dust and/or molecules, and (5) excessive destruction of S or production of O by asymptotic giant branch stars. It appears that all but …

Poster Session, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Western Kentucky Deep Saline Reservoir CO₂ Storage Test: Shallow Groundwater Monitoring Results, E. Glynn Beck and others, Kentucky Geological Survey
• Baseline Soil Properties of a Central Kentucky Riparian Buffer, Amanda Gumbert and others, Dept of Plant and Soil Science, UK
• The Kentucky Water Well Driller’s Certification Program, Scotty E. Robertson and David A. Jackson, Kentucky Division of Water, Frankfort, KY
• Influences of Cladophora Bloom on the Diets of Amblema plicata and Elliptio dilatata in the Upper Green River, Kentucky, Jennifer M. Yates and others, Dept of Biology, Western Kentucky University
• Using Electrical Resistivity to Locate …

Session 2c, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• The Developing Need for the Regulation of Geothermal Closed Loop Borehole Installations, David A. Jackson, Kentucky Division of Water, Frankfort, KY
• Strategies for Effective Management and Mitigation of Nonpoint Source Pollution within Wellhead Protection Areas, Jessica Moore and others, Kentucky Division of Water, Frankfort, KY
• Status and Early Findings at the Kentucky Horse Park Monitoring Station, James C. Currens and others, Kentucky Geological Survey
• Fluid Evolution in Cambrian-Ordovician Knox Group Reservoirs, Marty Parris and M.W. Bradley, Kentucky Geological Survey and USGS, Tennessee Water Science Center, Nashville, TN
• Simulating Long-Term Fate of CO₂ for a Western …

Session 2b, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Agriculture Producer Responses to Government-Funded Conservation Programs to Address Water Quality, Wuyang Hu and others, Dept of Agricultural Economics, UK
• Abatement Costs for Agricultural Non-Point Source Polluters, Jack Schieffer and others, Dept of Agricultural Economics, UK
• Point Source Polluters in the Kentucky River Watershed and the Potential for Water Quality Trading, Ron Childress and others, Dept of Agricultural Economics, UK
• Point Source Abatement Costs and Preferences for Trading Market Mechanisms in the Kentucky River Watershed, Andrew McLaughlin and others, Dept of Agricultural Economics, UK

Session 2a, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• The Potential for Using a P Loss Model to Improve the Accuracy of the Kentucky Phosphorus Index, Carl H. Bolster, USDA-ARS, Bowling Green, KY
• Additive State Space Model – A Promising Approach to Water- Quality-Related Treatment Experiments in Heterogeneous Landscapes, Ole Wendroth, Dept of Plant and Soil Sciences, UK
• Development and Application of Numeric Interpretations of Kentucky’s Narrative Water Quality Standards for Nutrients, Lara Panayotoff, Kentucky Division of Water, Frankfort, KY
• Arsenic Removal in Reactor Systems, Aniruddha Dastidar and Y.T. Wang, Watershed Management Branch and Dept of Civil Engineering, UK
• Trends in Water Quality Issues for …

Session 1c, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• The Effects of Prescribed Fire on Amphibian and Reptile Diversity in an Oak-Grassland Restoration Area, Robert Knopp and Howard Whiteman, Dept Biological Sciences and Watershed Studies, Murray State University
• Results of a Data Evaluation to Establish Priority Remediation Areas for Dry Weather Fecal Contamination in a Karst Influenced Watershed, Steve Evans and others, Third Rock Consultants, Lexington, KY
• Development of In-House Methods for High-Throughput DNA Extraction, Kimberly L. Cook and LorraBelle Hill, USDA-ARS, Bowling Green, KY
• Validation of the Sanitary Category Value Model (SCV) for the Identification of Leaking Sewer Lines: A Study of the West Hickman …

Session 1b, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• University – Habitat for Humanity Green Infrastructure Demonstration Project, Nancy Givens and Terry Wilson, WKU Center for Environmental Education and Sustainability, Bowling Green, KY
• Effectiveness of Pollutant Removal in the McConnell Springs Stormwater Quality Wetland Pond and the Gainesway Pond Retrofit Project, Year Two, David J. Price and Susan L. Plueger, Lexington-Fayette Urban County Government
• Coca-Cola Stormwater Replenish Project, Eric Dawalt and Russ Turpin, Ridegewater, LLC and EcoGro, Lexington, KY
• ITEST and LFUCG Stormwater Professional Development, Brian Radcliffe and Carol D. Hanley, Tracy Farmer Institute for Sustainability and the Environment, UK

Session 1a, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• A Regionally-Calibrated Critical Flow for Stream Channel Protection, Bob Hawley and others, Sustainable Streams LLC, Louisville, KY
• Monitoring Wetland Restoration Success at North Fork of Irish Creek, Brian C. Reeder, Center for Environmental Education and Institute for Regional Analysis and Public Policy, Morehead State University
• NC2D Open Channel Flow Model: Development and Applications for Stream Restoration Design in Kentucky, Brian J. Belcher, Beaver Creek Hydrology LLC, Lexington, KY
• Using Remote Sensing Tools to Target Stream Protection and Wastewater Treatment BMPs in Rural Kentucky, Catherine Carter and others, Tetra Tech, Research Triangle Park, NC
• Improving Water Quality …

Plenary Session: Water Research Needs In Kentucky, Alan E. Fryar, Peter T. Goodmann, Michael S. Griffin, James A. Kipp

Kentucky Water Resources Annual Symposium

Four panelists were invited to present their visions/predictions of current and future water research needs in Kentucky in an opening plenary session at the 2012 Kentucky Water Resources Annual Symposium. The requested overall general focus was ground water research needs.

Proceedings Of 2012 Kentucky Water Resources Annual Symposium, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

This symposium was planned and conducted as a part of the state water resources research institute annual program that is supported by Grant/Cooperative Agreement Number G11AP20081 from the United States Geological Survey. The contents of this proceedings document and the views and conclusions presented at the symposium are solely the responsibility of the individual authors and presenters and do not necessarily represent the official views of the USGS or of the symposium organizers and sponsors. This publication is produced with the understanding that the United States Government is authorized to reproduce and distribute reprints for government purposes.