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Voltage Modulated Infrared Reflectance Study Of Soluble Organic Semiconductors In Thin Film Transistors, Emily Geraldine Bittle

Theses and Dissertations--Physics and Astronomy

Soluble organic semiconductors have attracted interest due to their potential in making flexible and cheap electronics. Though their use is being implemented in electronics today, the conduction mechanism is still under investigation. In order to study the charge transport, this study examines the position, voltage, and frequency dependence of charge induced changes in far infrared absorption in soluble organic semiconductors in thin-film transistor structures. Measurements are compared to a simple model of a one-dimensional conductor which gives insight into the charge distribution and timing in devices. Main results of the study are dynamic measurements of charge taken by varying the …

Successfully Climbing The "Stairs": Surmounting Failed Translation Of Experimental Ischemic Stroke Treatments, Michael Kahle, Gregory J. Bix

Sanders-Brown Center on Aging Faculty Publications

The Stroke Therapy Academic Industry Roundtable (STAIR) provided initial (in 1999) and updated (in 2009) recommendations with the goal of improving preclinical stroke therapy assessment and to increase the translational potential of experimental stroke treatments. It is important for preclinical stroke researchers to frequently consider and revisit these concepts, especially since promising experimental stroke treatments continue to fail in human clinical trials. Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the selection and execution of the animal stroke model, drug/experimental treatment administration, and outcome measures to improve experimental validity and translation potential. …

Testing Diagnostics Of Nuclear Activity And Star Formation In Galaxies At Z > 1, Jonathan R. Trump, Nicholas P. Konidaris, Guillermo Barro, David C. Koo, Dale D. Kocevski, Stéphanie Juneau, Benjamin J. Weiner, S. M. Faber, Ian S. Mclean, Renbin Yan, Pablo G. Pérez-González, Victor Villar

Physics and Astronomy Faculty Publications

We present some of the first science data with the new Keck/MOSFIRE instrument to test the effectiveness of different AGN/SF diagnostics at z ~ 1.5. MOSFIRE spectra were obtained in three H-band multi-slit masks in the GOODS-S field, resulting in 2 hr exposures of 36 emission-line galaxies. We compare X-ray data with the traditional emission-line ratio diagnostics and the alternative mass-excitation and color-excitation diagrams, combining new MOSFIRE infrared data with previous HST/WFC3 infrared spectra (from the 3D-HST survey) and multiwavelength photometry. We demonstrate that a high [O III]/Hβ ratio is insufficient as an active galactic nucleus (AGN) indicator …

The Central Molecular Gas Structure In Liners With Low-Luminosity Active Galactic Nuclei: Evidence For Gradual Disappearance Of The Torus, F. Müller-Sánchez, M. A. Prieto, M. Mezcua, R. I. Davies, M. A. Malkan, Moshe Elitzur

Physics and Astronomy Faculty Publications

We present observations of the molecular gas in the nuclear environment of three prototypical low-luminosity active galactic nuclei (LLAGNs), based on VLT/SINFONI AO-assisted integral-field spectroscopy of H₂ 1-0 S(1) emission at angular resolutions of ~0.''17. On scales of 50-150 pc, the spatial distribution and kinematics of the molecular gas are consistent with a rotating thin disk, where the ratio of rotation (V) to dispersion (σ) exceeds unity. However, in the central 50 pc, the observations reveal a geometrically and optically thick structure of molecular gas (V/σ < 1 and N _H > 10²³ cm^{–2 …}

A Hunter Virus That Targets Both Infected Cells And Hiv Free Virions: Implications For Therapy, Cody Greer, Gisela García-Ramos

Biology Faculty Publications

The design of 'hunter' viruses aimed at destroying human immunodeficiency virus (HIV) infected cells is an active area of research that has produced promising results in vitro. Hunters are designed to target exposed viral envelope proteins in the membranes of infected cells, but there is evidence that the hunter may also target envelope proteins of free HIV, inducing virus-virus fusion. In order to predict the effects of this fusion on therapy outcomes and determine whether fusion ability is advantageous for hunter virus design, we have constructed a model to account for the possibility of hunter-HIV fusion. The study was based …

Economic Impacts Of The Kentucky Green Industry, Dewayne L. Ingram, Alan Hodges

Agriculture and Natural Resources Publications

The Green Industry has a significant impact on Kentucky’s economy. Green Industry enterprise owners, managers and employees should be aware of their economic impacts, and policy makers and other state leaders need to know the importance of this industry as potential laws, regulations and resource allocations are considered. This publication is intended to provide a brief summary of the 2007 economic impacts of the Green Industry in Kentucky.

Lack Of P53 Affects The Expression Of Several Brain Mitochondrial Proteins: Insights From Proteomics Into Important Pathways Regulated By P53, Ada Fiorini, Rukhsana Sultana, Eugenio Barone, Giovanna Cenini, Marzia Perluigi, Cesare Mancuso, Jian Cai, Jon B. Klein, Daret K. St. Clair, D. Allan Butterfield

Chemistry Faculty Publications

The tumor suppressor protein p53 has been described "as the guardian of the genome" for its crucial role in regulating the transcription of numerous genes responsible for cells cycle arrest, senescence, or apoptosis in response to various stress signals. Although p53 promotes longevity by decreasing the risk of cancer through activation of apoptosis or cellular senescence, several findings suggest that an increase of its activity may have deleterious effects leading to selected aspects of the aging phenotype and neurodegenerative diseases. There is the link between p53 and oxidative stress, the latter a crucial factor that contributes to neurodegenerative processes like …

Terrain Analysis For Locating Erosion Channels: Assessing Lidar Data And Flow Direction Algorithm, Adam Pike, Tom Muller, Eduardo Abel Rienzi, Surendran Neelakantan, Blazan Mijatovic, Anastasios D. Karathanasis, Marcos Rodrigues

Plant and Soil Sciences Faculty Publications

No abstract provided.

Two-Component Structure Of The HΒ Broad-Line Region In Quasars. I. Evidence From Spectral Principal Component Analysis, Chen Hu, Jian-Min Wang, Luis C. Ho, Gary J. Ferland, Jack A. Baldwin, Ye Wang

Physics and Astronomy Faculty Publications

We report on a spectral principal component analysis (SPCA) of a sample of 816 quasars, selected to have small Fe II velocity shifts with spectral coverage in the rest wavelength range 3500-5500 Å. The sample is explicitly designed to mitigate spurious effects on SPCA induced by Fe II velocity shifts. We improve the algorithm of SPCA in the literature and introduce a new quantity, the fractional-contribution spectrum, that effectively identifies the emission features encoded in each eigenspectrum. The first eigenspectrum clearly records the power-law continuum and very broad Balmer emission lines. Narrow emission lines dominate the second eigenspectrum. The …

Strategies To Minimize The Effects Of Drought, Gary Bates

Kentucky Grazing Conference

As this summer has shown, forage production from cool-season pasture and hay fields across the state can be dramatically affected by drought. Pastures that consist of cool-season grasses like tall fescue and orchardgrass have been severely overgrazed, and many may have lost some significant stand. Even if you have reseeded these fields, the question is how to prevent having the same problem next year. One of the best practices is to develop a forage program that doesn’t rely on cool-season grasses for summer production, but selects forage species that are better able to produce during periods of limited rainfall and …

Grassfed Beef From A Global Perspective, Glen Aiken

Kentucky Grazing Conference

Beef production and marketing has been shifting over the last few decades in response to unstable cattle markets, higher input costs, and a need to better meet market demands. Advancement of vertical integration of the production and marketing of beef calves through retained ownership from suckling calf to feedyard has certainly enhanced the genetics of the U.S. beef herd and improved the consistency of beef products. Another shift in production has been an increased number of grassfed cattle (grass finished) for marketing either organic or locally grown beef. These niche markets have developed primarily from concerns of urban consumers regarding …

The Cost Of Pasture Versus Hay, Kenneth H. Burdine

Kentucky Grazing Conference

Whenever I discuss the economics of grazing, I like to start by thinking about hay production costs. Regardless of which species we are talking about, a livestock producer should know what his / her most expensive feeding days are. In most cases, these will be winter feeding days, and that will generally consist of feeding either purchased or home-grown hay. So, I encourage producers to start by getting a solid feel for what their daily winter feeding costs are. For the purposes of this article, I am going to present some specific estimates for winter feeding costs, and other items, …

Pastures For Horses, Robert Coleman

Kentucky Grazing Conference

For horse owners, the use of pasture in the daily management of their horses provides both exercise for the horses, but also is a valuable source of nutrients. Horse feeding programs are based on forage and pasture is an excellent means to supply nutrients. To make effective use of the forage, horse owners need to manage both the horse and the grass.

Winter Annuals And Short Term Perennials For Grazing, S. Ray Smith

Kentucky Grazing Conference

During the last 5 years there has been a renewed interest in winter annual and short term perennials for grazing and for stored feed. There are many sources of information on this subject. I especially encourage you to read the new publication written by Dr. Garry Lacefield and colleagues, “Extending Grazing and Reducing Stored Feed Needs”. I have used information from this publication and other publications from the University of Kentucky Forage Website (www.uky.edu/Ag/Forage) in writing this article. This website contains many use publications on the subject of winter annuals and variety trial information on annual ryegrass and …

Novel Endophyte Tall Fescue, Garry D. Lacefield

Kentucky Grazing Conference

“Novel” endophyte is a term used to describe a “good” or “friendly” fungus (endophyte) in tall fescue as opposed to the endophyte that’s present if over eighty-five percent of the tall fescue in the Fescue Belt of the USA. This endophyte is costing beef producers an estimated $1 Billion dollars in losses from animal gains, reproduction and overall performance.

Forages On My Farm, Brent White

Kentucky Grazing Conference

No abstract provided.

Foreword And Kfgc Award Winners [2012], Garry D. Lacefield, Christi L. Forsythe

Kentucky Grazing Conference

No abstract provided.

Organics In Environmental Ices: Sources, Chemistry, And Impacts, V. F. Mcneill, A. M. Grannas, J. P. D. Abbatt, M. Ammann, P. Ariya, T. Bartels-Rausch, F. Domine, D. J. Donaldson, Marcelo I. Guzman, D. Heger, T. F. Kahan, P. Klán, S. Masclin, C. Toubin, D. Voisin

Chemistry Faculty Publications

The physical, chemical, and biological processes involving organics in ice in the environment impact a number of atmospheric and biogeochemical cycles. Organic material in snow or ice may be biological in origin, deposited from aerosols or atmospheric gases, or formed chemically in situ. In this manuscript, we review the current state of knowledge regarding the sources, properties, and chemistry of organic materials in environmental ices. Several outstanding questions remain to be resolved and fundamental data gathered before an accurate model of transformations and transport of organic species in the cryosphere will be possible. For example, more information is needed regarding …

Rat Brain Pro-Oxidant Effects Of Peripherally Administered 5 Nm Ceria 30 Days After Exposure, Sarita S. Hardas, Rukhsana Sultana, Govind Warrier, Mo Dan, Rebecca L. Florence, Peng Wu, Eric A. Grulke, Michael T. Tseng, Jason M. Unrine, Uschi M. Graham, Robert A. Yokel, D. Allan Butterfield

Chemistry Faculty Publications

The objective of this study was to determine the residual pro-or anti-oxidant effects in rat brain 30 days after systemic administration of a 5 nm citrate-stabilized ceria dispersion. A ∼4% aqueous ceria dispersion was iv-infused (0 or 85 mg/kg) into rats which were terminated 30 days later. Ceria concentration, localization, and chemical speciation in the brain was assessed by inductively coupled plasma mass spectrometry (ICP-MS), light and electron microscopy (EM), and electron energy loss spectroscopy (EELS), respectively. Pro- or anti-oxidant effects were evaluated by measuring levels of protein carbonyls (PC), 3-nitrotyrosine (3NT), and protein-bound-4-hydroxy-2-trans-nonenal (HNE) in the hippocampus, cortex, and …

The Great Recession And The Rhetorical Canons Of Law And Economics, Michael D. Murray

Law Faculty Scholarly Articles

The Great Recession of 2008 and onward has drawn attention to the American economic and financial system and has cast a critical spotlight on the theories, policies, and assumptions of the modern, neoclassical school of law and economics-often labeled the "Chicago School"-because this school of legal economic thought has had great influence on the American economy and financial system. The Chicago School's positions on deregulation and the limitation or elimination of oversight and government restraints on stock markets, derivative markets, and other financial practices are the result of decades of neoclassical economic assumptions regarding the efficiency of unregulated markets, the …

Kentucky Water Resources Research Institute Center Of Excellence For Watershed Management Watershed Summit Summary Report, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Research Reports

No abstract provided.

Pumping Up The [N I] Nebular Lines, Gary J. Ferland, W. J. Henney, C. R. O'Dell, R. L. Porter, P. A. M. Vanhoof, R. J. R. Williams

Physics and Astronomy Faculty Publications

The optical [N I] doublet near 5200 Å is anomalously strong in a variety of emission-line objects. We compute a detailed photoionization model and use it to show that pumping by far-ultraviolet (FUV) stellar radiation previously posited as a general explanation applies to the Orion Nebula (M42) and its companion M43; but, it is unlikely to explain planetary nebulae and supernova remnants. Our models establish that the observed nearly constant equivalent width of [N I] with respect to the dust-scattered stellar continuum depends primarily on three factors: the FUV to visual-band flux ratio of the stellar population, the optical properties …

Improved He I Emissivities In The Case B Approximation, R. L. Porter, Gary J. Ferland, P. J. Storey, M. J. Detisch

Physics and Astronomy Faculty Publications

We update our prior work on the case B collisional-recombination spectrum of He i to incorporate ab initio photoionization cross-sections. This large set of accurate, self-consistent cross-sections represents a significant improvement in He i emissivity calculations because it largely obviates the piecemeal nature that has marked all modern works. A second, more recent set of ab initio cross-sections is also available, but we show that those are less consistent with bound-bound transition probabilities than our adopted set. We compare our new effective recombination coefficients with our prior work and our new emissivities with those by other researchers, and we conclude …

An Empirical Examination Of The Associations Between Social Tags And Web Queries, Kwan Yi, Chan Yun Yoo

Journalism and Media Faculty Publications

Introduction. We aim to discover the associations between social tags for a Web page and Web queries that would retrieve the same Webpage in three major search engines.

Method. 4,827 query terms were submitted to the three major search engines to acquire search engine results pages. A series of Perl scripts were written to read search engine results pages and to identify, analyse, and extract organic links

Analysis. Web pages from the organic links in search engine results pages were examined to see whether and how they had been tagged in Delicious. Only the Webpages tagged by …

A Support Vector Machine Based Test For Incongruence Between Sets Of Trees In Tree Space, David C. Haws, Peter Huggins, Eric M. O'Neill, David W. Weisrock, Ruriko Yoshida

Statistics Faculty Publications

BACKGROUND: The increased use of multi-locus data sets for phylogenetic reconstruction has increased the need to determine whether a set of gene trees significantly deviate from the phylogenetic patterns of other genes. Such unusual gene trees may have been influenced by other evolutionary processes such as selection, gene duplication, or horizontal gene transfer.

RESULTS: Motivated by this problem we propose a nonparametric goodness-of-fit test for two empirical distributions of gene trees, and we developed the software GeneOut to estimate a p-value for the test. Our approach maps trees into a multi-dimensional vector space and then applies support vector machines (SVMs) …

Electromyographical Comparison Of Four Common Shoulder Exercises In Unstable And Stable Shoulders, Aaron Sciascia, Nina Kuschinsky, Arthur J. Nitz, Scott D. Mair, Tim L. Uhl

Physical Therapy Faculty Publications

This study examines if electromyographic (EMG) amplitude differences exist between patients with shoulder instability and healthy controls performing scaption, prone horizontal abduction, prone external rotation, and push-up plus shoulder rehabilitation exercises. Thirty nine subjects were categorized by a single orthopedic surgeon as having multidirectional instability (n = 10), anterior instability (n = 9), generalized laxity (n = 10), or a healthy shoulder (n = 10). Indwelling and surface electrodes were utilized to measure EMG activity (reported as a % of maximum voluntary isometric contraction (MVIC)) in various shoulder muscles during 4 common shoulder exercises. The exercises studied effectively activated the …

Residual Cooling And Persistent Star Formation Amid Active Galactic Nucleus Feedback In Abell 2597, G. R. Tremblay, C. P. O'Dea, S. A. Baum, T. E. Clarke, C. L. Sarazin, J. N. Bregman, F. Combes, M. Donahue, A. C. Edge, A. C. Fabian, Gary J. Ferland, B. R. Mcnamara, R. Mittal, J. B. R. Oonk, A. C. Quillen, H. R. Russell, J. S. Sanders, P. Salomé, G. M. Voit, R. J. Wilman, M. W. Wise

Physics and Astronomy Faculty Publications

New Chandra X-ray and Herschel Far-Infrared (FIR) observations enable a multiwavelength study of active galactic nucleus (AGN) heating and intracluster medium (ICM) cooling in the brightest cluster galaxy (BCG) of Abell 2597 (z= 0.0821). The new Chandra observations reveal the central ≲30 kpc X-ray cavity network to be more extensive than previously thought, and associated with enough enthalpy to theoretically inhibit the inferred classical cooling flow. Nevertheless, we present new evidence, consistent with previous results, that a moderately strong residual cooling flow is persisting at 4–8 per cent of the classically predicted rates in a spatially structured manner …

Modeling Of Pharmacokinetics Of Cocaine In Human Reveals The Feasibility For Development Of Enzyme Therapies For Drugs Of Abuse, Fang Zheng, Chang-Guo Zhan

Pharmaceutical Sciences Faculty Publications

A promising strategy for drug abuse treatment is to accelerate the drug metabolism by administration of a drug-metabolizing enzyme. The question is how effectively an enzyme can actually prevent the drug from entering brain and producing physiological effects. In the present study, we have developed a pharmacokinetic model through a combined use of in vitro kinetic parameters and positron emission tomography data in human to examine the effects of a cocaine-metabolizing enzyme in plasma on the time course of cocaine in plasma and brain of human. Without an exogenous enzyme, cocaine half-lives in both brain and plasma are almost linearly …

Creating Opportunities Or Building Barriers: Framing Policy For Placement Testing As An Impactful Part Of The First-Year Experience, Megan Beach, Karin Ann Lewis

Kentucky Journal of Higher Education Policy and Practice

Placement tests are an integral aspect of the first-year experience. As policymakers seek to raise high school standards and ensure that more students graduate prepared for the academic rigor of college, placement tests are being called upon to serve new purposes. Placement tests are touted for their ability to predict college success, but do these tests really measure student attainment of specific college readiness skills? How can they fit with or contribute to institutional initiatives?

Noninvasive Optical Quantification Of Absolute Blood Flow, Blood Oxygenation, And Oxygen Consumption Rate In Exercising Skeletal Muscle, Katelyn Gurley, Yu Shang, Guoqiang Yu

Biomedical Engineering Faculty Publications

This study investigates a method using novel hybrid diffuse optical spectroscopies [near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS)] to obtain continuous, noninvasive measurement of absolute blood flow (BF), blood oxygenation, and oxygen consumption rate (V̇O₂) in exercising skeletal muscle. Healthy subjects (n=9) performed a handgrip exercise to increase BF and V̇O₂ in forearm flexor muscles, while a hybrid optical probe on the skin surface directly monitored oxy-, deoxy-, and total hemoglobin concentrations ([HbO₂], [Hb], and THC), tissue oxygen saturation (S_tO₂), relative BF (rBF), and relative oxygen …