Digital Commons Network^™

Consuming Appalachia: An Archaeology Of Company Coal Towns, Zada Komara

Theses and Dissertations--Anthropology

Material culture is an understudied aspect of social life in Appalachian Studies, the multi- disciplinary investigation of social life in the Appalachian region. Historically, material culture in the region has been largely studied for its semiotic properties, decoded as a tangible symbol of “a region apart,” lagging behind the rest of America in terms of moral, mental, economic, and social development. Critical material studies from archaeology and other disciplines paint a different picture, however, and construct a region as American as any other. This study utilizes discourse analysis of material rhetoric about Appalachia and archaeological and oral historical data from …

The Wages Of Precarious Work: An Ethnography Of Upstate South Carolina’S Reserve Army Of The Laboring, Henry Bundy

Theses and Dissertations--Anthropology

The proliferation of precarious work represents a sea change in the opportunity structure of the new economies of the American South. As the role of the State has shifted from guarantor of rights and services to anxious custodian of economic liberalization, Americans have been enjoined to shoulder ever-larger shares of the responsibilities and risks associated with wage labor. As a result, the working poor have been left to weather the vicissitudes of the unfettered market with the increasingly paltry social membership guaranteed through waged employment. Among the risks now frequently assumed by individuals, are the responsibilities of health.

In the …

Making Experts: An Ethnographic Study Of “Makers” In Fablabs In Japan, Vaughn M. Krebs

Theses and Dissertations--Anthropology

“Makers” around the world cohere in a digital and physical network of technology hobbyists. “Makers" are open-source hardware enthusiasts who use machines like 3D printers and laser cutters - manufacturing tools that have only recently become accessible to laypeople - to make things. “Makers" share a vision for a world where everyone would be able to make almost anything, supplanting top-down economic systems and channels of production. This ethnographic research examines a subset of the “maker” community: “makers” in “FabLabs” in Japan. These “FabLabs” are small workshops that house the machines that “makers” need and make them open to the …

Patient-Centered Medical Homes In Community Oncology Practices: Changes In Spending And Care Quality Associated With The Come Home Experience, Teresa M. Waters, Cameron M. Kaplan, Ilana Graetz, Mary M. Price, Laura A. Stevens, Barbara L. Mcaneny

Health Management and Policy Faculty Publications

PURPOSE:

We examined whether the Community Oncology Medical Home (COME HOME) program, a medical home program implemented in seven community oncology practices, was associated with changes in spending and care quality.

PATIENTS AND METHODS:

We compared outcomes from elderly fee-for-service Medicare beneficiaries diagnosed between 2011 and 2015 with breast, lung, colorectal, thyroid, or pancreatic cancer, lymphoma, or melanoma and served by COME HOME practices before and after program implementation versus similar beneficiaries served by other geographically proximate oncologists. Difference-in-differences analysis compared changes in outcomes for COME HOME patients versus concurrent controls. Propensity score matching and regression methods were adjusted for …

Deterioration Modelling Of Bridges On Brm 5.2.3, Sudhir Palle, Theodore Hopwood Ii

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) initiated the study KYSPR 17-532, “Deterioration Modelling of Bridges on BrM 5.2.3,” so it could receive assistance identifying and employing bridge deterioration and cost forecast modeling for its bridge maintenance program. The Kentucky Transportation Center (KTC) was to help coordinate KYTC in adapting BrM 5.2.3’s deterioration and cost modelling features and update the existing guide material to reflect all changes for BrM 5.2.3. This study included acquiring access and becoming familiar with AASHTO Bridge Management (BrM 5.2.3) software. It was also to explore opportunities for any training on BrM and BrM 5.2.3’s deterioration and cost …

Investigating The Use Of In-Place Lateral Pull Off Tests To Determine The Compressive Strength Of Structural Concrete, Charlie Sun

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet’s current practice for determining the compressive strength of structural concrete consists of two methods. Both methods require that samples be delivered to an off-site facility for testing. Accordingly, affected parties on the project site must wait for the delivery of samples to the off-site facility, the performance of tests and analysis of test data, and the return of test results to the project site. Analysis of existing structural concrete requires core samples to be taken from the structural element in question. As a result, sample locations must be patched and repaired. Sampling can also potentially damage …

The Field Trip Project: Using Environmental Education To Bridge Science Learning Across Formal And Informal Kindergarten Settings, Meg Gravil

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

The Field Trip Study was conducted in direct response to the emergence of scientific thinking as it relates to children’s cognitive abilities. The purpose of the study was to evaluate the effects of nature-based, experiential activities on children’s acquisition of science knowledge. A multiple treatments and controls with pretest research design was utilized to compare science knowledge acquisition between kindergarten children in four instructional conditions: 1) nature-based field trip plus extension activities from an environmental education curriculum, and corresponding book reading and activities, 2) nature-based field trips plus extension activities from an environmental education curriculum, 3) nature-based field trips plus …

Gz-11608, A Vesicular Monoamine Transporter-2 Inhibitor, Decreases The Neurochemical And Behavioral Effects Of Methamphetamine, Na-Ra Lee, Guangrong Zheng, Markos Leggas, Venumadhav Janganati, Justin R. Nickell, Peter A. Crooks, Michael T. Bardo, Linda P. Dwoskin

Psychology Faculty Publications

Despite escalating methamphetamine use and high relapse rates, pharmacotherapeutics for methamphetamine use disorders are not available. Our iterative drug discovery program had found that R-N-(1,2-dihydroxypropyl)-2,6-cis-di-(4-methoxy-phenethyl)piperidine hydrochloride (GZ-793A), a selective vesicular monoamine transporter-2 (VMAT2) inhibitor, specifically decreased methamphetamine’s behavioral effects. However, GZ-793A inhibited human-ether-a-go-go-related gene (hERG) channels, suggesting cardiotoxicity and prohibiting clinical development. The current study determined if replacement of GZ-793A’s piperidine ring with a phenylalkyl group to yield S-3-(4-methoxyphenyl)-N-(1-phenylpropan-2-yl)propan-1-amine (GZ-11608) diminished hERG interaction while retaining pharmacological efficacy. VMAT2 inhibition, target selectivity, and mechanism of GZ-11608-induced inhibition of methamphetamine-evoked vesicular dopamine release were determined. We used GZ-11608 doses that decreased methamphetamine-sensitized …

Effects Of Methamphetamine Isomers On D-Methamphetamine Self-Administration And Food-Maintained Responding In Male Rats, Michael T. Bardo, Emily D. Denehy, Lindsey R. Hammerslag, Linda P. Dwoskin, B. E. Blough, A. Landavazo, Jack Bergman, S. J. Kohut

Psychology Faculty Publications

Rationale Methamphetamine (METH) abuse is generally attributed to the d-isomer. Self-administration of l-METH has been examined only in rhesus monkeys with a history of cocaine self-administration or drug-naïve rats using high toxic doses.

Objectives In this study, the ability of l-METH and, for comparison, d-METH to engender self-administration in experimentally naïve rats, as well as to decrease d-METH self-administration and food-maintained responding, was examined.

Methods Male Sprague-Dawley rats were used in 3 separate experiments. In experiment 1, the acquisition of l- or d-METH self-administration followed by dose-response determinations was studied. In experiment 2, rats were trained to self-administer d-METH (0.05 …

Factors That Influence Maternal Feeding Decisions For Toddlers: Extending The Theory Of Planned Behavior, Elizabeth Lucas Combs

Theses and Dissertations--Kinesiology and Health Promotion

Establishing healthy eating behaviors is vital in the early years to help combat the development of obesity and other chronic diseases. Mothers play an invaluable role in shaping their children's eating habits through controlling what and when children eat as well as the overall food environment, which is why a better understanding of what influences mothers’ decisions about these behaviors is important.

The purpose of the dissertation was to gain a better understanding of what impacts maternal feeding decisions regarding toddler nutrition behaviors. This was a two-phased mixed methods study. The aim of the initial study was to explore, using …

The Effects Of The Usda Summer Food Service Program On Rural Adolescents’ Nutrition Attitudes, Knowledge, Behavioral Intentions And Nutrition Behaviors, Mary Rachel Harrington

Theses and Dissertations--Kinesiology and Health Promotion

Rural adolescents suffer from poor nutrition, increasing their risk for obesity and other chronic diseases. The Summer Food Service Program (SFSP), an off-shoot of the National School Lunch Program, provides meals to qualifying children, including low-income, rural adolescents, under the age of 18. The purpose of this study was to: 1) examine the impact of the SFSP on the nutrition–related knowledge, self-reported fruit and vegetable (SRFV) consumption, and the constructs of the Theory of Planned Behavior (attitudes, subjective norms, perceived behavioral control, and behavioral intentions) of rural, low-income adolescents; and 2) examine the relationship between nutrition behaviors (quality food selection …

Chronic Low Intensity Continuous And Interval Training Prevent Heart Failure-Related Coronary Artery Stiffness, An Ouyang

Theses and Dissertations--Kinesiology and Health Promotion

Heart failure (HF) induced by aortic pressure over-load is associated with increased coronary artery stiffness. Perivascular adipose tissue (PVAT) and advanced glycation end products (AGE) both promote arterial stiffness. However, the mechanisms by which coronary PVAT promotes arterial stiffness and the efficacy of exercise to prevent coronary stiffness are unknown. The present study hypothesized both chronic continuous and interval exercise training would prevent coronary artery stiffness associated with inhibition of PVAT secreted AGE. Yucatan mininature swine were divided into four groups: control-sedentary (CON), aortic-banded sedentary heart failure (HF), aortic-banded HF continuous exercise trained (HF+CONT), and aortic-banded HF interval exercise trained …

Heart Rate Dynamics During And After Simulated Fire Ground Tasks: Effects Of Physical Fitness And Training, Anssi Ilmari Saari

Theses and Dissertations--Kinesiology and Health Promotion

Firefighting is a strenuous occupation that increases the risk of cardiovascular events. Greater levels of physical fitness and training improve firefighters’ occupational performance, but little is known whether they are related to lower physiological stress and recovery from fire ground tasks. Heart rate, heart rate recovery and heart rate variability have been used to evaluate physical stress in association with exercise and fire ground tasks. However, there is a paucity of research evaluating the effects of physical fitness and training on heart rate dynamics during a simulated fire ground test (SFGT). Therefore, the primary purposes of this study were to …

Analysis Of Push-Up And Pull-Up Variants To Develop An Upper Extremity Model, Ashley Carlene Wimsett

Theses and Dissertations--Kinesiology and Health Promotion

Musculoskeletal Injuries are the most common cause of severe long-term pain and physical disability. Push-Ups and Pull-Ups are effective dynamic exercises that mimic high level function activities, such as those used in the military. The model developed allows for researchers to analyze the forces and moments associated with the shoulder, elbow and wrist, to further assess function in military personnel, athletes and the active population. The model also follows the guidelines set forth by the International Society of Biomechanics (ISB).

Circadian Rhythm Phase Shifts Caused By Timed Exercise Vary With Chronotype In Young Adults, J. Matthew Thomas

Theses and Dissertations--Kinesiology and Health Promotion

The circadian system controls 24-hour cycles of behavior and physiology, such as rest-activity and feeding rhythms. The human circadian system synchronizes with, or entrains to, the light/dark cycle (sunrise/sunset) to promote activity and food consumption during the day and rest at night. However, strict work schedules and nighttime light exposure impair proper entrainment of the circadian system, resulting in chronic circadian misalignment. Numerous studies have shown that chronic circadian misalignment results in poor health. Therefore, therapeutic interventions that could shift circadian rhythms and alleviate circadian misalignment could broadly impact public health. Although light is the most salient time cue for …

Examining Attitudes, Perceptions, And Observations Of Tobacco Use And Compliance At A Small Private Liberal Arts College In Kentucky With A Designated Area Tobacco Policy, Michael Dalessio

Theses and Dissertations--Kinesiology and Health Promotion

A multitude of higher education institutions have adopted comprehensive smoke- and tobacco-free policies to minimize tobacco use, increase quit attempts, and reduce exposure to secondhand smoke on campus. However, the majority of campuses across the U.S. still have non-comprehensive policies and/or designated tobacco use areas. Given the limited research in this area, the purpose of this dissertation was to assess the attitudes, perceptions, tobacco use behaviors, and actual observational compliance of students, faculty, and staff on a college campus that possesses a designated area tobacco policy.

This two-phased cross-sectional study included both direct observations and online survey data collection. For …

Longitudinal Descriptive Profile Of Collegiate Pitchers Participating In A Summer Baseball League, Isabelle Leslie Gillis

Theses and Dissertations--Kinesiology and Health Promotion

The purpose of this study was to provide a longitudinal profile of pitching performance in a cohort of pitchers over two collegiate seasons and a summer league. Thus, this study utilized a longitudinal design to evaluate the impact of summer league participation on subsequent collegiate regular season pitching performance. Specifically, the performance of a cohort of Division 1 collegiate baseball pitchers during the 2018 Spring collegiate season, 2018 Summer League season, and the 2019 Spring collegiate season was evaluated and stratified by pitcher designation, arm dominance, and academic status. Analyses of variance were used to identify main and interaction effects …

Susceptibility To Ankle Sprain Injury Between Dominant And Non-Dominant Leg During Jump Landings, Riley Pashak

Theses and Dissertations--Kinesiology and Health Promotion

Ankle sprains are one of the most common injuries within athletics in the United States with approximately one-million student athletes experiencing ankle sprains each year. Studies argue excessive or rapid ankle inversion occurring from jump landings may cause ankle sprains. Also, the effect of limb dominance on risk of ankle sprain is not well documented.

The aim of this study was to determine if there is an affect of leg dominance on landing mechanism of the ankle joint that predisposes either ankle joint to greater risk of ankle sprain.

Twelve recreationally active subjects were recruited and completed four maximal vertical …

The Effects Of Curcumin And Fenugreek Soluble Fiber On The Physical Working Capacity At The Fatigue Threshold, Peak Oxygen Consumption, And Time To Exhaustion, Lauren Herrick

Theses and Dissertations--Kinesiology and Health Promotion

Curcumin, a polyphenol, has been suggested to improve metabolic byproduct clearance and increase nitric oxide production in working muscle. These purported effects may delay neuromuscular fatigue. Therefore, the purpose of this study was to examine the effects of curcumin in combination with fenugreek (CUR) or fenugreek soluble fiber alone (FEN) on the neuromuscular fatigue threshold (PWC_FT), time to exhaustion (T_lim) on a graded exercise test (GXT), and O₂peak in untrained subjects.Forty-seven,college-aged, aerobically untrained individuals were randomly assigned to one of three supplementation groups; placebo (PLA, n=15),curcumin + fenugreek, CurQfen® (CUR, n=18), or fenugreek soluble …

Effects Of Curcumin And Fenugreek Soluble Fiber Supplements On Submaximal And Maximal Aerobic Performance Indices In Untrained College-Aged Subjects, Jensen Goh Zhong Sheng

Theses and Dissertations--Kinesiology and Health Promotion

Submaximal exercise performance is, in part, limited by the accumulation of metabolic byproducts and energy system capacities. Curcumin and the combination of curcumin and fenugreek soluble fiber (CurQfen^®) have been shown to increase endogenous antioxidants and metabolic byproduct clearance as well as reduce inflammation and lipid peroxidation, and therefore, may enhance submaximal aerobic thresholds. In addition, there is evidence that the galactomannan component of fenugreek, used to enhance bioavailability of curcumin, may also have potential physiological effects related to the up regulation of free fatty acid oxidation Therefore, the purpose of this study was to examine the effects …

An Examination Of The Effects Of Bilateral And Unilateral Very Short-Term Dcer Training On Strength And Neuromuscular Responses Within The Lower Limb Bilateral Deficit, Mark Travis Byrd

Theses and Dissertations--Kinesiology and Health Promotion

The very short-term resistance training (VST) model, utilizing only 2-3 training sessions, has been used to examine early phase skeletal muscle, neural, and performance adaptations. The VST model has previously been used to examine these early phase adaptations in bilateral and unilateral, isometric, isokinetic, and dynamic muscle actions in the limbs of the upper- and lower-body. The bilateral deficit (BLD) is a phenomenon in which the sum of the forces produced unilaterally is greater than the force produced bilaterally during maximal contraction of the limbs. The appearance of a bilateral deficit has been be related to various factors; including training …

Numerical Simulations Of Premixed Flames Of Multi Component Fuels/Air Mixtures And Their Applications, Essa Kh I J Salem

Theses and Dissertations--Mechanical and Aerospace Engineering

Combustion has been used for a long time as a means of energy extraction. However, in the recent years there has been further increase in air pollution, through pollutants such as nitrogen oxides, acid rain etc. To solve this problem, there is a need to reduce carbon and nitrogen oxides through lean burning, fuel dilution and usage of bi-product fuel gases. A numerical analysis has been carried out to investigate the effectiveness of several reduced mechanisms, in terms of computational time and accuracy. The cases were tested for the combustion of hydrocarbons diluted with hydrogen, syngas, and bi-product fuel in …

Patients' Perceptions And Patient-Reported Outcomes In Progressive-Fibrosing Interstitial Lung Diseases, Jeffrey J. Swigris, Kevin K. Brown, Rayid Abdulqawi, Ketan Buch, Daniel F. Dilling, Dirk Koschel, Krishna Thavarajah, Rade Tomic, Yoshikazu Inoue

Internal Medicine Faculty Publications

The effects of interstitial lung disease (ILD) create a significant burden on patients, unsettling almost every domain of their lives, disrupting their physical and emotional well-being and impairing their quality of life (QoL). Because many ILDs are incurable, and there are limited reliably-effective, life-prolonging treatment options available, the focus of many therapeutic interventions has been on improving or maintaining how patients with ILD feel and function, and by extension, their QoL. Such patient-centred outcomes are best assessed by patients themselves through tools that capture their perceptions, which inherently incorporate their values and judgements. These patient-reported outcome measures (PROs) can be …

Patients' Perceptions And Patient-Reported Outcomes In Progressive-Fibrosing Interstitial Lung Diseases, Jeffrey J. Swigris, Kevin K. Brown, Rayid Abdulqawi, Ketan Buch, Daniel F. Dilling, Dirk Koschel, Krishna Thavarajah, Rade Tomic, Yoshikazu Inoue

Internal Medicine Faculty Publications

The effects of interstitial lung disease (ILD) create a significant burden on patients, unsettling almost every domain of their lives, disrupting their physical and emotional well-being and impairing their quality of life (QoL). Because many ILDs are incurable, and there are limited reliably-effective, life-prolonging treatment options available, the focus of many therapeutic interventions has been on improving or maintaining how patients with ILD feel and function, and by extension, their QoL. Such patient-centred outcomes are best assessed by patients themselves through tools that capture their perceptions, which inherently incorporate their values and judgements. These patient-reported outcome measures (PROs) can be …

Performance Of C2H4 Reductant In Activated-Carbon-Supported Mnox-Based Scr Catalyst At Low Temperatures, Guangli Liu, Dongtai Han, Jie Cheng, Yongshi Feng, Wenbin Quan, Li Yang, Kozo Saito

Mechanical Engineering Faculty Publications

Hydrocarbons as reductants show promising results for replacing NH₃ in SCR technology. Therefore, considerable interest exists for developing low-temperature (< 200 °C) and environmentally friendly HC-SCR catalysts. Hence, C₂H₄ was examined as a reductant using activated-carbon-supported MnOx-based catalyst in low-temperature SCR operation. Its sensitivity to Mn concentration and operating temperature was parametrically studied, the results of which showed that the catalyst activity followed the order of 130 °C > 150 °C > 180 °C with an optimized Mn concentration near 3.0 wt.%. However, rapid deactivation of catalytic activity also occurred when using C₂H₄ as the reductant. The mechanism of deactivation was explored and is …

The Relative Financial Cost And Benefit Of An Ophthalmology Resident Compared To An Advanced Practice Provider, Optometrist, Or Faculty Ophthalmologist, Daniel B. Moore, William Barr

Ophthalmology and Visual Science Faculty Publications

Objective The main objective of the article is to determine the relative direct financial cost and benefit of an advanced practice provider (APP), optometrist, and faculty ophthalmologist compared with an ophthalmology resident.

Design Single center cost–benefit financial analysis.

Methods The direct total expenses, including mean salary and benefits; the cost/week, based upon calculated hours worked; and net revenue, based upon technical collections subtracted from total expenses were collected for all APPs, optometrists, faculty ophthalmologists, and ophthalmology residents at the University of Kentucky for the 2016 to 2017 academic year. Optometry and ophthalmology faculty collections were adjusted for clinical full-time equivalents. …

Discerning Novel Splice Junctions Derived From Rna-Seq Alignment: A Deep Learning Approach, Yi Zhang, Xinan Liu, James N. Macleod, Jinze Liu

Computer Science Faculty Publications

Background: Exon splicing is a regulated cellular process in the transcription of protein-coding genes. Technological advancements and cost reductions in RNA sequencing have made quantitative and qualitative assessments of the transcriptome both possible and widely available. RNA-seq provides unprecedented resolution to identify gene structures and resolve the diversity of splicing variants. However, currently available ab initio aligners are vulnerable to spurious alignments due to random sequence matches and sample-reference genome discordance. As a consequence, a significant set of false positive exon junction predictions would be introduced, which will further confuse downstream analyses of splice variant discovery and abundance estimation.

Results: …

Mutants Of Cocaine Esterase, Donald Landry, Chang-Guo Zhan

Pharmaceutical Sciences Faculty Patents

Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.

Bovine Mammary Gland Biopsy Techniques, Veridiana L. Daley, Charles Dye, Sophie H. Bogers, R. Michael Akers, Francisco C. Rodriguez, John P. Cant, John Doelman, Peter Yoder, Karan Kumar, Dane Webster, Mark D. Hanigan

Animal and Food Sciences Faculty Publications

Bovine mammary gland biopsies allow researchers to collect tissue samples to study cell biology including gene expression, histological analysis, signaling pathways, and protein translation. This article describes two techniques for biopsy of the bovine mammary gland (MG). Three healthy Holstein dairy cows were the subjects. Before biopsies, cows were milked and subsequently restrained in a cattle chute. An analgesic (flunixin meglumine, 1.1 to 2.2 mg/kg of body weight) was administered via jugular intravenous [IV] injection 15-20 min prior to biopsy. For standing sedation, xylazine hydrochloride (0.01-0.05 mg/kg of body weight) was injected via the coccygeal vessels 5-10 min before the …

Self-Compassion And Cultural Values: A Cross-Cultural Study Of Self-Compassion Using A Multitrait-Multimethod (Mtmm) Analytical Procedure, Jesus Montero-Marin, Willem Kuyken, Catherine Crane, Jenny Gu, Ruth A. Baer, Aida A. Al-Awamleh, Satoshi Akutsu, Claudio Araya-Véliz, Nima Ghorbani, Zhuo Job Chen, Min-Sun Kim, Michail Mantzios, Danilo N. Rolim Dos Santos, Luiz C. Serramo López, Ahmed A. Teleb, P. J. Watson, Ayano Yamaguchi, Eunjoo Yang, Javier García-Campayo

Psychology Faculty Publications

Self-compassion is natural, trainable and multi-faceted human capacity. To date there has been little research into the role of culture in influencing the conceptual structure of the underlying construct, the relative importance of different facets of self-compassion, nor its relationships to cultural values. This study employed a cross-cultural design, with 4,124 participants from 11 purposively sampled datasets drawn from different countries. We aimed to assess the relevance of positive and negative items when building the self-compassion construct, the convergence among the self-compassion components, and the possible influence of cultural values. Each dataset comprised undergraduate students who completed the “Self-Compassion Scale” …