Digital Commons Network^™

Targeting Dnmts To Overcome Enzalutamide Resistance In Prostate Cancer, Elia Farah, Zhuangzhuang Zhang, Sagar M. Utturkar, Jinpeng Liu, Timothy L. Ratliff, Xiaoqi Liu

Toxicology and Cancer Biology Faculty Publications

Prostate cancer is the second leading cause of cancer death among men in the United States. The androgen receptor (AR) antagonist enzalutamide is an FDA-approved drug for treatment of patients with late-stage prostate cancer and is currently under clinical study for early-stage prostate cancer treatment. After a short positive response period to enzalutamide, tumors will develop drug resistance. In this study, we uncovered that DNA methylation was deregulated in enzalutamide-resistant cells. DNMT activity and DNMT3B expression were upregulated in resistant cell lines. Enzalutamide induced the expression of DNMT3A and DNMT3B in prostate cancer cells with a potential role of p53 …

Esfuerzos Realizados En Puerto Rico Hacia La Consolidación De Políticas Públicas Para La Prevención De Cánceres Asociados Al Vph, Diana T. Medina-Laabes, Vivian Colón-López, Vilnery Rivera-Figueroa, Coralia Vázquez-Otero, Glizette O. Arroyo-Morales, Lara Arce-Cintrón, Paola Fernández-Rivera, Idamaris Vega, Roxana Soto-Abreu, Olga L. Díaz-Miranda, Ángel Rivera, Iris Cardona, Ana P. Ortiz, Lilliam Rodríguez Capó, Pamela C. Hull

Behavioral Science Faculty Publications

El propósito de este informe especial es describir cronológicamente los eventos que contribuyeron al desarrollo y aprobación de la legislación e implementación del requisito escolar de vacunación en Puerto Rico (PR), con el fin de prevenir el VPH y los cánceres asociados a este. A partir del 2010, PR inició las aprobaciones de políticas públicas con el objetivo de mejorar el registro de casos de los cánceres y la cobertura de la vacuna contra el VPH a través de los planes médicos en adolescentes de 11 a 18 años. En el 2014, los esfuerzos científicos y comunitarios lograron documentar la …

Significance Of Pelvic Fluid Observed During Ovarian Cancer Screening With Transvaginal Sonogram, Justin W. Gorski, Charles S. Dietrich Iii, Caeli Davis, Lindsay Erol, Hayley Dietrich, Nicholas J. Per, Emily Lenk Ferrell, Anthony B. Mcdowell, Mckayla J. Riggs, Megan L. Hutchcraft, Lauren A. Baldwin-Branch, Rachel W. Miller, Christopher P. Desimone, Holly H. Gallion, Frederick R. Ueland, John R. Van Nagell Jr., Edward J. Pavlik

Markey Cancer Center Faculty Publications

The primary objective was to examine the role of pelvic fluid observed during transvaginal ultrasonography (TVS) in identifying ovarian malignancy. A single-institution, observational study was conducted within the University of Kentucky Ovarian Cancer Screening trial from January 1987 to September 2019. We analyzed true-positive (TP), false-positive (FP), true-negative (TN), and false-negative (FN) groups for the presence of pelvic fluid during screening encounters. Measured outcomes were the presence and duration of fluid over successive screening encounters. Of the 48,925 women surveyed, 2001 (4.1%) had pelvic fluid present during a TVS exam. The odds ratio (OR) of detecting fluid in the comparison …

Ultrasonographic Visualization Of The Ovaries To Detect Ovarian Cancer According To Age, Menopausal Status And Body Type, Edward J. Pavlik, Emily Brekke, Justin Gorski, Lauren Baldwin-Branch, Rachel Miller, Christopher P. Desimone, Charles S. Dietrich, Holly S. Gallion, Frederick Rand Ueland, John R. Van Nagell, Jr.

Obstetrics and Gynecology Faculty Publications

Because the effects of age, menopausal status, weight and body mass index (BMI) on ovarian detectability by transvaginal ultrasound (TVS) have not been established, we determined their contributions to TVS visualization of the ovaries. A total of 29,877 women that had both ovaries visualized on their first exam were followed over 202,639 prospective TVS exams. All images were reviewed by a physician. While visualization of both ovaries decreased with age, one or both ovaries could be visualized in two of every three women over 80 years of age. Around 93% of pre-menopausal women and ~69% of post-menopausal women had both …

Developing A National Alfalfa Information System, David B. Hannaway, K. J. Hannaway, P. Sohn, S. Griffith, B. E. Avery, E. Nowick, W. F. Wedin, L. R. Vough, S. C. Bosworth, Garry D. Lacefield, Gary E. Bates, D. Undersander, N. P. Martin, J. Caddel, G. L. Kilgore, S. B. Orloff, A. M. Gray, R. Ditterline, T. Griggs, D. H. Putnam, M. J. Ottman

IGC Proceedings (1977-2023)

Using state-of-the-art telecommunication technologies, this project is developing a comprehensive knowledge resource for alfalfa (Medicago sativa L.); the National Alfalfa Information System (NAIS). This project will serve as an improved model for Extension educational programs. Alfalfa is the most important forage crop in the USA and grown worldwide for feeding millions of livestock and in many cropping systems. As a legume, it is important in sustaining the environment and the productivity of agriculture. Information needs are present in every state and internationally. The NAIS is being developed through national and international cooperation, putting the best science-based alfalfa information and …

Tracking Sentiments Toward Fat Acceptance Over A Decade On Twitter, Sadie Bograd, Benjamin Chen, Ramakanth Kavuluru

Internal Medicine Faculty Publications

The fat acceptance (FA) movement aims to counteract weight stigma and discrimination against individuals who are overweight/obese. We developed a supervised neural network model to classify sentiment toward the FA movement in tweets and identify links between FA sentiment and various Twitter user characteristics. We collected any tweet containing either “fat acceptance” or “#fatacceptance” from 2010–2019 and obtained 48,974 unique tweets. We independently labeled 2000 of them and implemented/trained an Average stochastic gradient descent Weight-Dropped Long Short-Term Memory (AWD-LSTM) neural network that incorporates transfer learning from language modeling to automatically identify each tweet’s stance toward the FA movement. Our model …

Sensory Processing Abnormalities In Community-Dwelling Older Adults With Cognitive Impairment: A Mixed Methods Study, Elizabeth K. Rhodus, Elizabeth G. Hunter, Graham D. Rowles, Shoshana H. Bardach, Kelly Parsons, Justin M. Barber, Maryellen Thompson, Gregory A. Jicha

Sanders-Brown Center on Aging Faculty Publications

Mild cognitive impairment (MCI) or dementia often leads to behavioral and psychiatric symptoms of dementia (BPSD). Sensory processing abnormalities may be associated with BPSD. The purpose of this study was to explore relationships among sensory processing, behavior, and environmental features within the homes of people with MCI or dementia. This project used mixed methods to assess participants’ sensory processing, care partner perspectives on behaviors, and in situ observations of the home environment. Nine participants with cognitive impairment (MCI n = 8, early dementia = 1) and their care partners were included. Seven participants with cognitive impairment were reported to have …

Upregulation Of Cd36, A Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis By Increasing Mmp28 And Decreasing E-Cadherin Expression, James Drury, Piotr G. Rychahou, Courtney O. Kelson, Mariah E. Geisen, Yuanyuan Wu, Daheng He, Chi Wang, Eun Y. Lee, B. Mark Evers, Yekaterina Y. Zaytseva

Surgery Faculty Publications

Altered fatty acid metabolism continues to be an attractive target for therapeutic intervention in cancer. We previously found that colorectal cancer (CRC) cells with a higher metastatic potential express a higher level of fatty acid translocase (CD36). However, the role of CD36 in CRC metastasis has not been studied. Here, we demonstrate that high expression of CD36 promotes invasion of CRC cells. Consistently, CD36 promoted lung metastasis in the tail vein model and GI metastasis in the cecum injection model. RNA-Seq analysis of CRC cells with altered expression of CD36 revealed an association between high expression of CD36 and upregulation …

Remote Sensing Application To Grassland Monitoring, Z. B. Nan

IGC Proceedings (1977-2023)

Application of remote sensing to the management of grassland resources, the role this plays in developing sustainable grassland farming systems and opportunities for further development are outlined. Use of remote sensing technologies in grassland monitoring has a history of more than 30 years. Both fine- and coarse-grained remote sensing techniques are used to monitor and study grasslands. Fine-grained techniques are used to study landscape scale processes through the use of sensors providing spatial resolution of a few meters, whereas coarse-grained techniques are used to study catchment scale areas, and even entire biomes, using satellite-based sensors with a spatial resolution of …

Lack Of Knowledge Is The Leading Key For The Growing Cervical Cancer Incidents In Bangladesh: A Population Based, Cross-Sectional Study, Nur E. Alam, Md. Shariful Islam, Fabia Rayyan, Humaira Nur Ifa, Md. Imam Ul Khabir, Kamal Chowdhury, A. K. M. Mohiuddin

Biology Graduate Research

Introduction

Cervical cancer is the second most common gynecological cancer in Bangladesh. Lack of awareness of screening methods, risk factors, and symptoms may lead to presenting most cervical cancers at an advanced stage. We investigated knowledge and awareness of cervical cancer (CCa) among females at the Sheikh Hasina Medical College (SHMC) of Tangail district in Bangladesh.

Methods

A cross sectional survey was conducted to collect data via a structured questionnaire from SHMC during the period of February 2019 to January 2020. Data on socio-demographic characteristics and knowledge of cervical cancer were collected. Multivariable logistic regression models were used to identify …

Grassland Management And Animal Product Quality, G. W. Sheath, J. B. Coulon, Q. A. Young

IGC Proceedings (1977-2023)

The expectations of consumers ultimately determine the specification of product quality; and grassland systems produce a wide range of animal-based products. Therefore, to provide focus, this paper deals only with food products that are destined for markets that exhibit strong discretionary choice. Quality expectations of consumers have traditionally been based on product attributes such as taste, freshness, nutritional value and appearance, but customer expectations are expanding to encompass food safety, environmental care, animal welfare and biotechnologies.

Grassland forages and their management influence the intrinsic sensory properties of food. A dairy products case study is presented, indicating that pasture species and …

Priority Setting And Funding Of Agricultural Research, M. Petit

IGC Proceedings (1977-2023)

Agricultural research funding amounts and modalities have been profoundly transformed in recent years in many countries. For instance, competitive funding has become the norm rather than the exception in most countries and funding sources have been greatly diversified. In addition, in some major countries, the private sector has become a major actor In agricultural research, both as a funder of research and as a provider research results. This poses a major challenge to public research institutions, which remain the major agricultural research actors and employers of researchers in most countries. With these changes in funding, formal procedures for research priority-setting …

Contextual Factors In The Management Of Common Grazing Lands: Lessons From Mongolia And Northwestern China, R. Mearns

IGC Proceedings (1977-2023)

Seen in a global perspective, pastoral development is now increasingly motivated by social and environmental objectives rather than by production- or output-orientated objectives. Attention is shifting towards a broader concern with sustainability, both of grasslands, and of the livelihoods of those who rely on them (de Haan et al, 1997, Fratkin and Mearns forthcoming). Quite how these twin sustainability objectives may be achieved in particular contexts, however, is an empirical question. Drawing on examples from a diverse range of natural grassland-based livestock production systems under economic transition in Mongolia and northwestern China, this summary paper aims to show how an …

De-Intensification Of Grasslands: Understanding The Processes To Find The Balance, K. C. Hodgkinson

IGC Proceedings (1977-2023)

There is a growing trend in Australia and other developed countries for deintensification of animal production from grasslands and for grasslands to be used for purposes other than livestock grazing. These shifts are occurring for a variety of reasons including unsustainable land management practices, environmental pollution, loss of conservation value, poor commodity prices and declining rural infra-structure and communities. In Australia, the shifts are under way in agricultural grasslands, where sown pastures occur in a matrix of semi-natural woodlands, but less so in the other three major natural grasslands that forms the arid and semi-arid rangelands.

The conversion of natural …

Southeastern Law Librarian Winter 2022, Seaall

Newsletters

No abstract provided.

Gadolinium Enrichment In Association With The Magnetic Fraction Of 1 Fly Ash: Real Or An Illusion?, James C. Hower, John G. Groppo, Dali Qian, Nicolas J. Briot, Tonya D. Morgan, Shelley D. Hopps, Elizabeth Cantando

Coal Combustion and Gasification Products Journal Archive

Gadolinium, and possibly praseodymium, are relatively enriched in the magnetic 24 fractions of Class F fly ashes from Central Appalachian coal sources. Although the enrichment is 25 evident in the inductively coupled plasma–atomic emission spectroscopy (ICP-AES) 26 determinations of the rare earth content, transmission electron microscopy–energy dispersive x-27 ray spectroscopy (TEM-EDS) examination of the fly ash fails to show the sites of the Gd or Pr. 28 This apparent lack of correlation could be due to the inability of the EDS to detect low 29 concentrations of the rare earth elements definitively; interferences in the analytics, leading to 30 false …

The Federally Regulated Decline, Rebirth, And Decline Of The United States Hemp Industry, Henry Webb, Patrick R. Baker, Paula H. Moore, Karen Scanlon

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Juror Perceptions Of Heterosexual And Same-Sex Spousal Rape In The Courtroom, Haley D. Hintz

Lewis Honors College Thesis Collection

Approximately 10-15% of American women will be raped by a spouse in their lifetime (Bureau of Justice Statistics, 2002). Research suggests that the American public regards spousal rape as wrong but not rape (Lynch et al., 2017). Research on spousal rape has centered on heterosexual couples despite a higher likelihood that LGBTQ+ individuals will experience severe intimate partner violence (IPV) (Rollé et al., 2019). Therefore, the present study investigated mock juror perceptions of spousal rape of heterosexual and same-sex couples in the courtroom. We employed a 2 (victim gender) x 2 (defendant gender) x 2 (participant gender) between-participants design. Participants …

Demand Analysis Of Vietnamese Coffee In The U.S., Leo Kyaw Zin

Theses and Dissertations--Agricultural Economics

Coffee production in Vietnam has increased almost 100-fold within the past three decades, positioning it to become the second-largest coffee exporter in the world after Brazil. The U.S. is a top market for Vietnamese coffee. In this study, we estimate a conditional demand system of expenditure share equations for coffee from Vietnam, Brazil, Colombia, and an aggregate of seven other countries in the U.S. coffee market using the Linear Approximation Almost Ideal Demand System (LA/AIDS) and based on monthly time-series data from 2000 to 2020 with a total of 252 observations. Compensated and uncompensated own-price, cross-price, and expenditure elasticities were …

Spent Hemp As An Animal Feed And Vertical Price Transmission In Us Hemp Value-Added Supply Chain, Solomon E. Odiase

Theses and Dissertations--Agricultural Economics

This thesis comprises of two articles covering spent hemp's prospects as an animal feed and the price interaction across the hemp commodity value-added supply chain. The first article uses a comparative analysis tool to analyze the potential of spent hemp as an animal feed or feed ingredient based on its yield, nutritional composition and market price. This comparative advantage analysis revealed that spent hemp is competitive based on its rich essential nutritional content, comparatively high yield per acre, and low market price. Furthermore, with the increasing drought conditions, production cost and market price of alfalfa hay, spent hemp may fill …

Quantitative Sustainable Design (Qsd) For The Prioritization Of Research, Development, And Deployment Of Technologies: A Tutorial And Review, Yalin Li, John T. Trimmer, Steven Hand, Xinyi Zhang, Katherine G. Chambers, Hannah A. C. Lohman, Rui Shi, Diana M. Byrne, Sherri M. Cook, Jeremy S. Guest

UK CARES Faculty Publications

The pursuit of sustainability has catalyzed broad investment in the research, development, and deployment (RD&D) of innovative water, sanitation, and resource recovery technologies, yet the lack of transparent and agile methodologies to navigate the expansive landscape of technology development pathways remains a critical challenge. This challenge is further complicated by the higher levels of uncertainty that are intrinsic to early-stage technologies. In this work, we review and synthesize published literature on the sustainability analyses of water and related technologies to present quantitative sustainable design (QSD) – a methodology to expedite and support technology RD&D. With a shared lexicon and a …

Longitudinal Dynamics Between Parenting And Adolescent Deviance: Direct Links And Underlying Mechanisms, Dan Liu

Theses and Dissertations--Family Sciences

The current dissertation, based on three separate and yet closely related studies, tested the longitudinal dynamic relationships of maternal and paternal parenting factors with adolescent deviance, the direct links as well as underlying mechanisms. Study 1, based on longitudinal data collected from 570 early adolescents, part of the Brno Longitudinal Study of Youth (BLSY), used latent growth modeling and tested the development of three parenting measures, including parental solicitation, knowledge, and peer approval, and deviance during early adolescence, as well as the developmental (i.e., growth to growth) links of these three parenting measures with adolescent deviance over time. Results indicated …

Contextualizing Artificial Intelligence: The History, Values, And Epistemology Of Technology In The Philosophy Of Science, Christopher Grimsley

Theses and Dissertations--Philosophy

Artificial intelligence (AI) and other advanced technologies pose new questions for philosophers of science regarding epistemology, science and values, and the history of science. I will address these issues across three essays in this dissertation. The first essay concerns epistemic problems that emerge with existing accounts of scientific explanation when they are applied to deep neural networks (DNNs). Causal explanations in particular, which appear at first to be well suited to the task of explaining DNNs, fail to provide any such explanation. The second essay will explore bias in systems of automated decision-making, and the role of various conceptions of …

Learner Outcomes From An Echo In Augmentative And Alternative Communication, Lillie Reinhart

Theses and Dissertations--Communication Sciences and Disorders

Background: Students with complex communication needs (CCN) rely on the use of augmentative and alternative communication (AAC) to support their communication; however, many students are leaving high school without an effective form of communication. To build capacity and increase school professionals’ knowledge and self-efficacy in AAC, this thesis used an adaptation of Project ECHO (Extension for Community Healthcare Outcomes) for use with AAC.

Methods: Using a post then pre-retrospective survey, participants self-reported changes in knowledge, confidence, and overall satisfaction with ECHO sessions. Paired sample t-tests assessed participant-reported change in knowledge. Frequency counts were used to analyze responses about confidence and …

Voluntary Control Of Breathing According To The Breathing Pattern During Listening To Music And Non-Contact Measurement Of Heart Rate And Respiration, Dibyajyoti Biswal

Theses and Dissertations--Biomedical Engineering

We investigated if listening to songs changes breathing pattern which changes autonomic responses such as heart rate (HR) and heart rate variability (HRV) or change in breathing pattern is a byproduct of listening to songs or change in breathing pattern as well as listening to songs causes changes in autonomic responses. Seven subjects (4 males and 3 females) participated in a pilot study where they listened to two types of songs and used a custom developed biofeedback program to control their breathing pattern to match the one recorded during listening to the songs.

Coherencies between EEG, breathing pattern and RR …

Increasing Hpv Vaccination In Elliott And Lawrence Counties, Keeghan Francis

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Appalachian counties within Kentucky have higher rates of HPV-related cancers, including cervical cancer. HPV vaccines are effective at reducing the risk of cervical cancer, but vaccination coverage in Appalachia remains low. The proposed program relies on recommended strategies to improve vaccine uptake by increasing access and demand for HPV vaccines. This will be done through school vaccine clinics and parent education on HPV, cervical cancer, and HPV vaccines.

Key Factors Associated With Late-Stage Diagnosis Of Endometrial Cancer In Kentucky, Lexee Long

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objectives: Cancer of the endometrium is the most common female reproductive cancer in the United States, but is understudied in relation to stage at diagnosis, which is a potential predictor of survival. The primary objective of this study is to analyze potential associations of independent variables such as age at diagnosis, race, marital status, smoking status, Appalachian status, and insurance type with late-stage diagnosis of endometrial cancer.

Methods: This population-based study used Kentucky Cancer Registry data to study endometrial cancer cases diagnosed between January 1^st,2015 and December 31^st, 2019. Chi-square statistics were used to examine bivariate …

Patterns Of Continuous Glucose Monitoring Utilization Among Adults With Type 1 Diabetes, 2016-2018, Katherine Elizabeth Lee

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

BACKGROUND: Continuous glucose monitoring (CGM) improves diabetes control by reducing HbA1c and decreasing rates of hypoglycemia. Despite clinical benefits and clear guidelines from the American Diabetes Association, <20% of patients with type 1 diabetes mellitus (T1DM) use CGM. Studies report disparities in CGM among youth with T1DM by race/ethnicity, socioeconomic status, and region, but, insight into patterns of CGM utilization in adults with T1D is limited. METHODS: This project retrospectively analyzed CGM utilization among individuals with T1DM age 18-64 using the Truven MarketScan® Commercial Claims and Encounters (CCAE) database from 1/1/2016-12/31/2018. CGM utilization was determined using National Drug Code (NDC), Current Procedural Terminology (CPT), or Healthcare Common Procedure Coding system II (HCPCS II) claim identifiers. Individuals with >365 days of continuous medical and pharmacy insurance eligibility were followed from their first Type 1 diabetes-related diagnosis code until the end of the study period or >120 day gap in coverage. Using descriptive statistical analysis, CGM utilization was examined in the overall population and was stratified by patient demographics (age, sex, region), and clinical characteristics (insulin pump, diabetes complications). As a secondary analysis, CGM utilization was further stratified by both calendar year …

Community-Oriented Policing: Building Trust And Collaborative Relationships With The Black Community, Tunice M. Cole

DSW Capstone Projects

Black people die at the hands of police at a disproportionate rate. In the United States, Black citizens are three times more likely to be killed by police than White citizens. This, along with other factors, has caused a lack of trust, legitimacy, and relationships between police and the Black community. Examining this problem from a socio-ecological and social constructivist perspective suggests that the solution encompasses the use of community feedback and experiences to build and develop a model of community-oriented policing that addresses the issues of the community being served.

Product one of this capstone was a systematic literature …

Black Men Need Love Too, Addressing Unaddressed Mental Health In African American Men, D'Quayvion Cloud

DSW Capstone Projects

The objective of this capstone is to analyze and demonstrate the importance of studies on unaddressed mental health among African American males. The major aim is to demonstrate why research, policy, and funding are vital to knowing how to work with this specific clinical group, allowing us to build effective and inclusive programs for these African American males and eliminate the stigma associated with members of this community. Due to unaddressed mental health and a lack of treatment options for our people, research has shown that African American men aged 20 to 24 had the highest suicide rate of any …