Digital Commons Network^™

16th Annual Environmental Law Institute, Office Of Continuing Legal Education At The University Of Kentucky College Of Law, Christopher R. Fitzpatrick, Carl W. Breeding, Timothy J. Hagerty, Marc S. Murphy, Wanda Ballard Repasky, Clinton J. Elliott, Thomas W. Fitzgerald, Dennis J. Conniff, Laura D. Keller, W. Blaine Early, Eric A. Braun, Michael P. Healy, Glenna Jo Curry, James L. Dickinson, W. Patrick Stallard, Richard H. Underwood

Continuing Legal Education Materials

Materials from the 16th Annual Environmental Law Institute held by UK/CLE in May 2000.

Regulation Of Acetylated Low Density Lipoprotein Uptake In Macrophages By Pertussis Toxin-Sensitive G Proteins, Stewart C. Whitman, Alan Daugherty, Steven R. Post

Gill Heart & Vascular Institute Faculty Publications

Class A scavenger receptors (SR-A) mediate the uptake of modified low density lipoprotein (LDL) by macrophages. Although not typically associated with the activation of intracellular signaling cascades, results with peritoneal macrophages indicate that the SR-A ligand acetylated LDL (AcLDL) promotes activation of cytosolic kinases and phospholipases. These signaling responses were blocked by the treatment of cells with pertussis toxin (PTX) indicating that SR-A activates G_i/o-linked signaling pathways. The functional significance of SR-A-mediated G_i/o activation is not clear. In this study, we investigated the potential role of G_i/o activation in regulating SR-A-mediated lipoprotein uptake. Treatment of mouse …

Richmond Public Transportation Study Report, Lenahan O'Connell, Bruce Siria

Kentucky Transportation Center Research Report

This study looked at the possible costs and benefits associated with the creation of a small deviated fixed route bus service in Richmond. It concluded that the circumstances in Richmond favor the creation of such a system. It also concluded that only one route–operating one bus, twelve hours per day, Monday through Saturday–is needed at this time.

Solute Transport As Related To Soil Structure In Unsaturated Intact Soil Blocks, L. Bejat, E. Perfect, V. L. Quisenberry, Mark S. Coyne, G. R. Haszler

Plant and Soil Sciences Faculty Publications

Concern about soil and groundwater pollution has resulted in numerous studies focused on solute transport. The objectives of our study were to investigate the effect of soil type and land-use management on solute movement. Transport of water and Cl⁻ were measured through intact blocks of Maury (fine, mixed, semiactive, mesic Typic Paleudalf) and Cecil (fine, kaolinitic, thermic Typic Kanhapludult) soils, under steady-state, unsaturated flow conditions. Three replicate blocks for the Maury soil and two replicate blocks for the Cecil soil were studied per land-use treatment. The land-use treatments were conventional-till corn (Zea mays L.) production and long-term grass …

Means To Achieve Sustained Release Of Synergistic Drugs By Conjugation, Paul Ashton, Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hone Guo

Ophthalmology and Visual Science Faculty Patents

A codrug composition of at least two drug compounds covalently linked to one another via a labile bond to form a single codrug composition, or ionically linked to one another to form a single workings composition, and methods of use of the codrug for the treatment of various medical conditions. The codrug may be administered by itself or in the form of a bioerodible or nonbioerodible substance.

(Un)Settling Accounts: Disclosure Interviews Peter Jackson, Paul Kingsbury, Jennifer Kopf, Matt Mccourt, Theresa Zawacki

disClosure: A Journal of Social Theory

No abstract provided.

20th Annual Conference On Legal Issues For Financial Institutions, Office Of Continuing Legal Education At The University Of Kentucky College Of Law

Continuing Legal Education Materials

Program and materials from the 20th Annual Legal Issues for Financial Institutions Conference held by UK/CLE in April of 2000.

Population-Based Survey Of Complementary And Alternative Medicine Usage, Patient Satisfaction, And Physician Involvement, Robert Oldendick, Ann L. Coker, Darryl Wieland, James I. Raymond, Janice C. Probst, Bruce J. Schell, Carleen H. Stopskopf

CRVAW Faculty Journal Articles

Background. With an increasing proportion of Americans using complementary or alternative medicine (CAM), physicians need to know which patients are using CAM to effectively manage care.

Methods. In this cross-sectional study, telephone interviews were conducted with 1,584 South Carolina adults (ages 18 and older); 66% responded to the survey of demographics, general health, frequency of CAM use, perceived CAM effectiveness, and physician knowledge of CAM use.

Results. A total of 44% had used a CAM during the past year. Increasing age and higher education were significantly associated with CAM use. More than 60% perceived CAM therapy as very effective, and …

Southeastern Law Librarian Spring 2000, Seaall

Newsletters

No abstract provided.

“Waive” Goodbye To Tort Liability: A Proposal To Remove Paternalism From Product Sales Transactions, Richard C. Ausness

Law Faculty Scholarly Articles

This Article argues that waivers of tort liability should be permitted in connection with product sales. Currently, sellers cannot limit their liability under tort law for personal injuries caused by defective products even though such waivers are allowed, albeit reluctantly, under principles of negligence and warranty law. Existing principles of products liability law should be modified, either by legislation or by court action, to allow at least limited use of these waivers.

Novel Function Of Phosphoinositide 3-Kinase In T Cell Ca2+ Signaling, Ao-Lin Hsu, Tsui-Ting Ching, Goutam Sen, Da-Sheng Wan, Subbarao Bondada, Kalwant S. Authi, Ching-Shih Chen

Pharmaceutical Sciences Faculty Publications

This study presents evidence that phosphoinositide (PI) 3-kinase is involved in T cell Ca²⁺ signaling via a phosphatidylinositol 3,4,5-trisphosphate PI(3,4,5)P₃-sensitive Ca²⁺entry pathway. First, exogenous PI(3,4,5)P₃ at concentrations close to its physiological levels induces Ca²⁺ influx in T cells, whereas PI(3,4)P₂, PI(4,5)P₂, and PI(3)P have no effect on [Ca²⁺]_i. This Ca²⁺ entry mechanism is cell type-specific as B cells and a number of cell lines examined do not respond to PI(3,4,5)P₃ stimulation. Second, inhibition of PI 3-kinase by wortmannin and by overexpression of the …

2nd Annual Computer & Technology Law Institute, Office Of Continuing Legal Education At The University Of Kentucky College Of Law, Carlyle C. Ring, Holly K. Towle, Timothy E. Nielander, John G. Hundley, J. Mark Grundy, Matthew M. Clark, David E. Fleenor, William L. Montague Jr., Jack E. Toliver, Joel T. Beres, Cynthia L. Stewart, Kenneth J. Tuggle, Kenneth R. Sagan, Stephen E. Gillen

Continuing Legal Education Materials

Materials from the 2nd Annual Computer & Technology Law Institute held by UK/CLE in March 2000.

Seaall Chapter Handbook And Procedures Manual, March 2000, Seaall

Administrative Materials

This handbook is a revised version of the March 2000 SEAALL Chapter Handbook and Procedures Manual.

Cervical Pathology In West Virginia Adolescents, Hatim A. Omar, Patricia Callahan, Sanu Aggarwal, Kathaleen Perkins, Kathy Young

Pediatrics Faculty Publications

Cytologic screening is an important diagnostic tool used to detect precancerous and cancerous lesions of the cervix. We studied the prevalence of cervical abnormalities, based on Pap smear results, in patients at the Outpatient Adolescent Clinic at West Virginia University. We found a high incidence of overall intraepithelial cell pathology (24%) in this group with 2.4% high grade and 9.9% low-grade lesions. These findings show that major cervical pathology is present in this age group. Furthermore, repeat smears at intervals of < one year were performed on 317 patients. Of these repeat smears, 7% changed from normal to abnormal in this period. Sexually active adolescent females should have Pap smears at least annually to detect abnormalities that may otherwise not be detected until they are more advanced and difficult to manage. Higher risk adolescents may need semiannual screening.

Reducing Alfalfa Harvesting Losses, Michael Collins

Kentucky Alfalfa and Stored Forage Conference

In some areas of the country, producers store a substantial portion of their forage for winter feeding as silage or haylage. However, hay remains the most popular storage method for forage. Hay stores well for long periods and is better suited to cash sale and transportation than silage. Mechanical conditioning, which gained acceptance during the 1950's is probably still the greatest single change in hay harvesting and storage technology during this century. However, a number of other noteworthy changes and innovations have occurred in recent years which have helped to reduce the extent of losses during hay harvesting and storage.

Fungal Ipc Synthase Assay, Jeffery Radding, Robert C. Dickson, Robert L. Lester

Molecular and Cellular Biochemistry Faculty Patents

The presently-disclosed IPC synthase-inhibitor assays comprise the steps of: (1) expression of the IPC1 gene in a cell; (2) introducing labeled starting substrates for ceramide conversion as well as potential inhibitor(s) of such conversion to the expressed gene product in an environment which allows time and conditions for conversion, and (3) identifying those potential inhibitors which actually inhibit conversion. The present invention also provides methods to determine the ability of a test compound to inhibit fungal growth, comprising the steps of (1) presenting active inositolphosophotidylceramide synthase in a manner such that synthesis of inositolphosphotidylceramide can occur; (2) introducing ceramide and …

Escherichia Coli Pathogen O157:H7 Does Not Survive Longer In Soil Than A Nonpathogenic Fecal Coliform, D. N. Mubiru, Mark S. Coyne, John H. Grove

Agronomy Notes

Survival rates for individual types of fecal organisms are quite different. Although some pathogens may persist as long as 5 years in soil, most fecal pathogens from human and animal waste usually die very quickly. Two to three months is sufficient in most cases to reduce pathogens to negligible numbers once they have been excreted or land-applied in animal wastes.

It is expensive and time- consuming to test for individual pathogens. Consequently, nonpathogenic fecal indicator bacteria, which are easily and inexpensively detected, are often used to study pathogen survival in soil and water. Current methods for rapidly detecting fecal indicator …

Intimate Partner Violence Among Men And Women In South Carolina, 1998, Ann L. Coker, Christina Derrick, Julia L. Lumpkin, Robert Oldendick, R H. Potter

CRVAW Faculty Journal Articles

Few studies provide population-based estimates of intimate partner violence (IPV) for men and women, especially at the state level. IPV may result in adverse health effects for victims and perpetrators (1-3). To estimate the lifetime incidence of IPV by type of violence (e.g., physical, sexual, and perceived emotional abuse) and to explore demographic correlates of reporting IPV among men and women, the South Carolina Department of Health and Environmental Control and the University of South Carolina conducted a population-based random-digit-dialed telephone survey of adults in the state. This report summarizes the results of the survey, which indicated that approximately 25% …

Intimate Partner Violence And Cervical Neoplasia, Ann L. Coker, Maureen Sanderson, Mary Kay Fadden, Lucia Pirisi

CRVAW Faculty Journal Articles

Intimate partner violence (IPV) is associated with a range of adverse physical health outcomes, including chronic and infectious diseases. An emerging literature suggests that partner violence and specifically sexual violence may be associated with an increased risk of cervical neoplasia. To assess the risk of preinvasive and invasive cervical cancer in a cross-sectional study of women screened for IPV by type, frequency and duration, 1152 women ages 18–65 were recruited from family practice clinics in 1997–1998. They were screened for IPV during a brief in-clinic interview, and health history and current status were assessed in a follow-up interview. Of 1152 …

Limited Liability Companies In Kentucky, Second Edition, Office Of Continuing Legal Education At The University Of Kentucky College Of Law, Scott W. Dolson, John S. Egan, Charles Fassler, Glenn D. Gunnels, C. Bradford Harris, Charles R. Keeton, Charles J. (Chaz) Lavelle, Alan K. Macdonald, Debbie R. Reiss, Thomas E. Rutledge, James C. Seiffert, William G. Strench

Continuing Legal Education Materials

The Kentucky Limited Liability Company Act, KRS Chapter 275, went into effect July 15, 1994, allowing Kentuckians to conduct business under the LLC form. With over 10,000 LLCs formed in the Commonwealth since the Act's inception, this flexible business entity has become the most popular way to conduct business in Kentucky.

The LLC has become so pervasive that business law practitioners, accountants, tax advisors and estate planners must all be well-versed in the myriad of issues and creative applications that accompany this business entity. With flexible tax-treatment and the liability protection of a traditional corporation this entity is utilized not …

Redistribution Under The Current Social Security System, Kathryn L. Moore

Law Faculty Scholarly Articles

Arguably the most successful program of the modern welfare state, Social Security has been enormously successful in lifting the elderly out of poverty. Thirty years ago, almost 30% of the elderly were in poverty, a poverty rate that was more than twice as high as the rate for the population as a whole. Today, in contrast, only about 12% of the elderly are subject to poverty, a rate that is about the same as the rest of the adult population.

This Article describes how the current system redistributes income. The Article does not attempt to develop a mathematical model to …

Kentucky Annual Economic Report 2000, Mark C. Berger, Glenn C. Blomquist, Richard W. Furst, Steven N. Allen

Kentucky Annual Economic Report

No abstract provided.

Exposure To 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (Tcdd) Is Associated With Hyperinsulinemia And Insulin Resistance, Morris Cranmer, Shirley Louie, Richard H. Kennedy, Philip A. Kern, Vivian A. Fonseca

Clinical and Translational Science Faculty Publications

High exposures of Vietnam veterans to 2,3,7,8-Tetrachlorodibenzo-p- dioxin, a dioxin contained in the herbicide mixture Agent Orange, have previously been demonstrated to be associated with an increased prevalence of diabetes and hyperinsulinemia in non-diabetic subjects. Sixty-nine persons were identified who were in good health and had normal glucose levels during glucose tolerance testing. These subjects lived within 25 miles of the Vertac/Hercules Superfund site located in Jacksonville, Arkansas. The blood sera lipid concentrations of TCDD for the 69 subjects ranged between 2 and 94 ppt. When subjects with blood sera lipid TCDD levels in the top 10% (TCDD > 15 ppt, …

Remifentanil In The Horse: Identification And Detection Of Its Major Urinary Metabolite, A. F. Lehner, P. Almeida, J. Jacobs, J Daniel Harkins, W. Karpiesiuk, W. E. Woods, L. Dirikolu, Jeffrey M Bosken, W. G. Carter, J. Boyles, C. Holtz, T. Heller, C. Nattrass, M. Fisher, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Remifentanil (4-methoxycarbonyl-4-[(1-oxopropyl)phyenylamino]-1- piperidinepropionic acid methyl ester) is a μ-opioid receptor agonist with considerable abuse potential in racing horses. The identification of its major equine urinary metabolite, 4-methoxycarbonyl-4-[(1- oxopropyl)phenylamino]-1-piperidinepropionic acid, an ester hydrolysis product of remifentanil is reported. Administration of remifentanil HCl (5 mg, intravenous) produced clear-cut locomotor responses, establishing the clinical efficacy of this dose. ELISA analysis of postadministration urine samples readily detected fentanyl equivalents in these samples. Mass spectrometric analysis, using solid-phase extraction and trimethylsilyl (TMS) derivatization, showed the urine samples contained parent remifentanil in low concentrations, peaking at 1 h. More significantly, a major peak was identified as …

Seaall Membership Directory, 2000, Seaall

Administrative Materials

No abstract provided.

A Custody System Free Of Gender Preferences And Consistent With The Best Interests Of The Child: Suggestions For A More Protective And Equitable Custody System, Shannon Dean Sexton

Kentucky Law Journal

No abstract provided.

1998-1999 Monitoring Strategy, Kentucky River Basin Management Unit, L. Ormsbee, G. Epp, E. Caudill, Lee Colten

KWRRI Research Reports

During the fall of 1997 and spring of 1998 about 40 individuals and more than 30 organizations and agencies provided input into the development of a monitoring strategy for the Kentucky River basin under the Kentucky Watershed Management Framework. In addition to the agencies that were able to commit resources to the monitoring effort, citizen input was sought in the design of the strategy. Citizen monitoring efforts are also providing valuable information in many portions of the state. The intent of the coordinated planning process was to carefully consider agency resources and capabilities, taking into account where and when each …

Kentucky Water Resources Research Institute Annual Technical Report Fy 1999, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Annual Technical Reports (USGS’s 104b Grant Program)

The FY 1999 Annual Technical Report for Kentucky consolidates the reporting requirements of the Section 104(b) base grant and regional competitive grant awards in a single technical report which includes: 1) a synopsis of each ongoing research project and each research project completed during the period, 2) a list of related reports published, 3) a brief description of information transfer activities, 4) a summary of student support during the reporting period, and 5) notable achievements and awards during the year. The activities supported by Section 104 (b) and the required matching funds are interwoven into the Kentucky Water Resources ResearchInsitute's …

Effect Of Amitraz And Xylazine On Some Physiological Variables Of Horses, A. Queiroz-Neto, A. B. Carregaro, G. Zamur, J Daniel Harkins, Thomas Tobin, M. I. Mataqueiro, S. C. Gonçalves

Maxwell H. Gluck Equine Research Center Faculty Publications

The effect of the intravenous injection of amitraz (0.1 mg/kg) to horses on cardiac activity, respiratory rate, intestinal motor activity, rectal temperature, sweating and masticating was evaluated and compared to the effect of intravenous administration of xylazine (1mg/kg, iv) on heart rate, respiratory rate and intestinal activity. Amitraz caused a significant decrease in heart activity, respiratory rate and intestinal movements, but these effects were not as pronounced as those caused by xylazine. Amitraz also caused a significant relaxation of the rectal smooth muscle, and an apparent increase in sweating and in the frequency of horses found masticating hay. Rectal temperature …

Capital Punishment As Human Sacrifice: A Societal Ritual As Depicted In George Eliot's Adam Bede, Roberta M. Harding

Law Faculty Scholarly Articles

The purpose of this article is to identify, describe, and analyze the historic and contemporary connection between the practices of capital punishment and human sacrifice. After describing how human sacrifice constitutes an integral component of capital punishment, it will be argued that the institutionalization of this antiquated barbaric ritual, vis-a-vis the use of capital punishment, renders the present use of the death penalty in the United States incompatible with "the evolving standards of decency that mark the progress of a maturing society"; and that consequently, this facet of capital punishment renders the penalty at odds with the Eighth Amendment's prohibition …