Digital Commons Network^™

Cognitive And Somatic Item Response Pattern Of Orofacial Pain Patients Compared To Fibromyalgia Patients And A Non-Pain Control Group, Morten Hadsel

University of Kentucky Master's Theses

Previous work has suggested that chronic pain patients report psychological distress through higher endorsement of somatic rather than cognitive signs of anxiety and depression. The present study compared female Non-Pain (11=52), Orofacial Pain (n=3 17) and Fibromyalgia (n=50) groups. on SCL-90-R Somatization, Anxiety and Depression raw scores and cognitive-somatic symptom patterning of the Anxiety and Depression scales. Comparisons were also made amongst orofacial pain diagnostic subgroups and subgroups based on Multidimensional Pain Inventory (MPI) classification groups. The Somatization. Anxiety and Depression scores were higher in the OroFacial Pain and Fibromyalgia than Non-Pain group and higher in the Dysfunctional than Adaptive …

The Place Of Dietary Practices In The Lives Of Older Women, Lisa Marie Curch

University of Kentucky Doctoral Dissertations

Studies have supported the benefits of positive dietary behaviors in preventing or reducing morbidity and extending longevity, as well as the psychosocial function of dietary practices for quality of life. Research is needed though on the dietary behaviors of elders in general and older women in particular, for whom gender affects lifelong dietary patterns. Health behavior theory has typically focused on psychological factors, to the neglect of sociocultural processes. This investigation utilized a life course perspective, enhanced by social interactionist elements, to address aspects of development and change in behavior neglected by health behavior theories, such as temporal dimensions and …

Spatio-Temporal Variation In Activation Intervals During Ventricular Fibrillation, Sachin Anil Moghe

University of Kentucky Doctoral Dissertations

Spatio-temporal variation in activation rates during ventricular fibrillation (VF)provides insight into mechanisms of sustained re-entry during VF. This study had three objectives related to spatio-temporal dynamics in activation rates during VF.

The first objective was to quantify spatio-temporal variability in activation rates,that is, in dominant frequencies, computed from epicardial electrograms recorded during VF in swine. Results showed that temporally and spatially, dominant frequencies variedas much as 20% of the mean dominant frequency, and the mean dominant frequencies increased during first 30 sec of VF. These results suggest that activation rates are nonstationary during VF.

The second objective of the study …

Multigenerations And Multidisciplines: Inheriting Fifty Years Of Gwembe Tonga Research, Lisa Cliggett

Anthropology Faculty Publications

No abstract provided.

The Role Of Social And Dispositional Variables Associated With Emotional Processing In Adjustment To Breast Cancer, John E. Schmidt

University of Kentucky Master's Theses

Recent theories suggest that cognitive and emotional processing is critical to successful adjustment to traumatic experiences, such as breast cancer. Cognitive and emotional processing of trauma can be facilitated by both dispositional (e.g., emotional intelligence) and situational (e.g., social supports, social constraints) factors. The present study investigated the relationship between emotional intelligence and current social support and constraints in a sample of 190 breast cancer survivors (mean age=48.3 years; SD=8.9). Women were recruited via postings to on-line breast cancer support groups. Postings to support groups described the study, and provided a link to the study web site. The study consisted …

The Relationship Between Religiosity And Psychological Distress: A Scale Development Strategy With The Scl-90-R, John M. Salsman

University of Kentucky Master's Theses

There are substantial data exploring the link between religiosity and health, yet there is no consensus regarding the appropriate measurement tool for assessing religiosity in health psychology settings. The purpose of this study was to identify a set of items that could serve as a reliable and valid proxy measure of religiosity. Participants included 251 (M=19.02; range = 17-25) young adults who completed self-report measures of religiosity (Intrinsic-Extrinsic/Revised, Quest Scale, Faith Maturity Scale), psychological distress (SCL-90-R), and personality (NEOPI-R). Individual item pools for religiosity were developed by identifying significant correlations between each of the religiosity measures and the SCL-90-R items. …

Creation Of A Bacterial Mutagenicity Assay Highly Sensitive To Dialkylnitrosamines, Matthew Troy Cooper

University of Kentucky Doctoral Dissertations

Although dialkylnitrosamines are environmentally significant carcinogens, the use of short-term bioassays to assess the mutagenic potential of these compounds remains problematic. The Ames test, a mutagenicity assay based on the reversion of Salmonella typhimurium histidine auxotrophs, is the most widely used bioassay in genetic toxicology, but the traditional Ames tester strains are largely insensitive to dialkylnitrosamine mutagenicity. I have constructed several mutagenicity tester strains that co-express combinations of full-length human cytochrome P450 2E1, rat cytochrome P450 reductase, and human cytochrome b5 in S. typhimurium lacking ogt and ada methyltransferases (YG7104ER, ogt-; and YG7108ER, ogt-, ada-). These new strains are susceptible …

The Impact Of Natural Disasters On Economic Growth: A Study Of Mexico And Central America, Sharon Louise Garcia

University of Kentucky Master's Theses

Natural disasters have potentially large economic impacts on developing nations. Thereis a small, but growing literature analyzing these impacts on variables such as gross domesticproduct. In this study Belize, Costa Rica, El Salvador, Guatemala, Honduras, Mexico, andNicaragua are studied to measure the impact that disasters have had on economic growth overthe past twenty-nine years (1970-1998). The development indicator, gross domestic product(GDP) growth rate, will be measured over the twenty-nine year study period and analyzed withrespect to correlation with natural disasters. Regression analysis is used to investigate therelationship between natural disasters and economic growth.It is hypothesized that the number of natural …

Identification And Characterization Of Contact Sites Between Human Chorionic Gonadotropin And The Amino Terminal Region Of The Luteinizing Hormone/Choriogonadotropin Receptor, Rebecca Mccaffrey

University of Kentucky Master's Theses

The luteinizing hormone / choriogonadotropin receptor (LH/CG-R) is a member of theG protein-coupled receptor family. The LH/CG-R has seven transmembrane helices, threeexoloops, three cytoloops, a C-terminal tail, and an extensive N-terminal exodomain. Theexodomain is capable of binding hormone with high affinity without hormone action. Previousstudies have shown that the amino-terminal region of the LH/CG receptor contacts both subunitsof human chorionic gonadotropin (hCG). In particular, three residues (Leu20, Cys22, and Gly24)were found to be crucial for hormone binding. In this thesis work, benzoylphenylalanine (Bpa),a photoactivatable reagent, was used to continue investigating the interactions of the N-terminalregion of the LH/CG-R with hCG. …

Pigs In Space: Ghosts, Gender And Sexuality In A Debate About Regulating Industrial Hog Farms In Kentucky, Mary E. Curran

University of Kentucky Doctoral Dissertations

In 1997, Governor Paul Patton of Kentucky asked the state Cabinet of Natural Resources and Environmental Protection to develop administrative regulations for industrial hog farms in the state. The regulatory process has been contentious. From 1997 through 1998, the Cabinet held five public hearings to elicit comments on the proposed regulations. This study is designed to answer two questions. First, how, within parameters of participation established by the Kentucky Cabinet of Natural Resources and Environmental Protection, have participants in the debate deployed notions of risk to privilege certain gendered and sexualized farming identities, farming practices, and notions of rurality? Second, …

Genes Encoding Several Poly (Adp-Ribose) Glycohydrolase (Parg) Enzymes, The Proteins And Fragments Thereof, And Antibodies Immnoreactive Therewith, Myron Jacobson, Elaine L. Jacobson, Jean-Christoph Amé, Winston Lin

Graduate Center for Nutritional Sciences Faculty Patents

The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 kDa. Methods …

Improving Incident Management Response And Coordination Of Resources, Jennifer R. Walton, Monica L. Barrett, Jerry G. Pigman

Kentucky Transportation Center Research Report

Highway crashes cause a major impact to the transportation network by critically limiting the operational efficiency of the roadway. Traveler delay is the problem most often associated with highway crashes, but by far the most serious problem is the resulting secondary crashes that occur. Another related issue is the danger posed to response personnel serving the public at the scene. The magnitude of these problems is severe. A coordinated plan for managing the scene is needed to reduce the impact of highway crashes and improve the safety for everyone.

A Checklist and interagency workshop has been developed to address ways …

Fiscal Year 2001 Fhwa-536 Report For The Kentucky Transportation Cabinet, Steven Douglas Kreis

Kentucky Transportation Center Research Report

The Federal Highway Administration (FHWA) requires state transportation agencies to submit a biennial report on local highway finances. The purpose of these reports is to provide FHWA with the data it needs to capture the financing of highway activities at the local level. Based on this information, it can identify trends in revenue, expenditures, investments, and program development, and in turn make decisions about future investments. The report, FHWA-536, asks agencies to report on four areas of local highway finance: 1) disposition of highway-user revenues; 2) revenues used for roads and streets identified by source and funding type; 3) road …

Accommodating Pedestrian And Bicycle Access On Parkers Mill Road From New Circle Road To Man O War Boulevard In Lexington, Lisa Aultman-Hall, Eric Jackson

Kentucky Transportation Center Research Report

In the fall of 2000 the Kentucky Transportation Center (KTC) began a planning study on behalf of the Kentucky Transporta tion Cabinet (KYTC) to investigate the bicycle and pedestrian access on KY 1968 (Parkers Mill Road) from Man O War Boulevard to New Circle Road in Lexington. The 1-mile section has a rural design with two 9-foot lanes, limited 3-foot earth shoulders and adjacent objects in the clear zone making travel on this road uncomfortable for pedestrians and cyclists. Yet this section of Parkers Mill Road represents a line of desired non-motorized travel due to parks, neighborhoods, a local high …

Protection Against Ischemia And Reperfusion Injury, Peter R. Oeltgen, Paul D. Bishop, Mark S. Kindy, Juan A. Sanchez

Molecular and Cellular Biochemistry Faculty Patents

A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.

Forage News [2001-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Grazing Conference November 29^th
• Alfalfa Yield vs. Stand Age
• Feed & Forage Composition
• Upcoming Events

Return To Fertility After Extended Chemical Castration With A Gnrh Antagonist, Janusz W. Kostanski, Ge Jiang, Bhas A. Dani, Santos B. Murty, Wei Qiu, Bruce Schrier, B. C. Thanoo, Patrick P. Deluca

Pharmaceutical Sciences Faculty Publications

BACKGROUND: Antagonistic analogues of GnRH for the treatment of prostate cancer may be used clinically in persons for whom return to fertility after such treatment is important or desirable. The purpose of this study was, therefore, to evaluate the effects of a long term treatment with orntide, a GnRH antagonist, on testosterone levels and fertility in male rats.

METHODS: Two groups of male rats received either 120-day orntide microspheres (8.8 mg orntide/kg/120 days) or vehicle alone (control group). Serum orntide and testosterone levels in both groups were monitored at certain intervals for 9 months from the initiation of treatment. After …

Drug Delivery System Involving Interaction Between Protein Or Polypeptide And Hydrophobic Biodegradable Polymer, Patrick P. Deluca

Pharmaceutical Sciences Faculty Patents

A drug delivery system for controlled release of a protein or polypeptide comprising a hydrophobic biodegradable polymer and a protein or polypeptide. A physical interaction is present between the polymer and the protein or polypeptide, thus, allowing protection and controlled release of the protein or polypeptide in-vivo. The drug delivery system may be prepared by a polymer precipitation technique or a microsphere technique.

Evidence And Trial Practice, Office Of Continuing Legal Education At The University Of Kentucky College Of Law

Continuing Legal Education Materials

Materials from the conference on Evidence and Trial Practice held by UK/CLE in October 2001.

Psychosocial Stress And Prostate Cancer: A Theoretical Model, Gary L. Ellison, Ann L. Coker, James R. Hebert, Maureen Sanderson, Charmaine D. Royal, Sally P. Weinrich

CRVAW Faculty Journal Articles

African-American men are more likely to develop and die from prostate cancer than are European-American men; yet, factors responsible for the racial disparity in incidence and mortality have not been elucidated. Socioeconomic disadvantage can lead to psychosocial stress and may be linked to negative lifestyle behaviors. Regardless of socioeconomic position, African-American men routinely experience racism-induced stress. We propose a theoretical framework for an association between psychosocial stress and prostate cancer. With the context of history and culture, we further propose that psychosocial stress may partially explain the variable incidence of prostate cancer between these diverse groups. Psychosocial stress may negatively …

Forage News [2001-10], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Grazing Conference
• Beware of Prussic Acid as Frost Approaches
• Forage Conference Set for Farm Bureau Convention
• Hay Testing is Best Bargain
• Crop Residue: Questions & Answers
• KFGC Award Nominations Deadline October 15
• Upcoming Events

Trade Secrets, Non-Competes, And Unfair Competition, Office Of Continuing Legal Education At The University Of Kentucky College Of Law

Continuing Legal Education Materials

Materials from the conference on Trade Secrets, Non-Competes, and Unfair Competition held by UK/CLE in October 2001.

Mysterious Rectal Bleeding In A Female Adolescent, Hatim A. Omar

Pediatrics Faculty Publications

A 15-year-old female referred to our adolescent clinic for further evaluation of rectal bleeding was seen a week earlier in the acute care clinic with a two-day history of bright red rectal bleeding. The physical examination at that time was reportedly normal, including the rectal exam. The blood count with differential, liver function tests, ESR, and barium enema were all within normal limits. The patient, however, continued to complain of rectal bleeding and this led to the referral. She was known in the adolescent clinic as having a history of learning disability and mild mental retardation. She was started on …

Labial Adhesion As A Complication Of Primary Genital Herpes In Young Women, Hatim A. Omar

Pediatrics Faculty Publications

Genital herpes is a common sexually transmitted disease in adolescents. It may be associated with significant morbidity if not diagnosed on time or not properly treated. The objective of this study was to determine the incidence of labial adhesion secondary to primary herpes in young women and the possible predisposing factors for this complication. The method was analysis of clinical data regarding primary genital herpes in young women seen in an adolescent outpatient clinic at a university hospital. Cases of primary genital herpes seen between December 1^st 1998 and November 30^th 1999 were included. A total of 34 …

Method For Treating Ischemia, Peter R. Oeltgen, Mark S. Kindy, Paul D. Bishop

Molecular and Cellular Biochemistry Faculty Patents

A method for treating ischemia by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, delntorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration of about 0.5-20 mg/kg body weight, or alternatively a lower concentration of about 1-1000 μg/kg body weight of the mammal in a physiologically acceptable formulation is administered up to four hours after an ischemic episode. Deltorphins may also be administered prior to or concurrently with onset of ischemia. Cerebral or spinal cord ischemia or ischemic heart disease may be treated …

Water Soluble Derivatives Of Camptothecin/Homocamptothecin, Thomas Burke, Ayhan Demir, Cihangir Tanyeli, Ashok J. Chavan, Tie-Lin Wang, Yves Pommier

Pharmaceutical Sciences Faculty Patents

Camptothecin and homocamptothecin analogs and derivatives are provided incorporating alkylamine and polyalkylamine moieties.

Farnesyl Pyrophosphate Analogs, Hans Peter Spielmann, Douglas A. Andres, Kareem A.H. Chehade

Molecular and Cellular Biochemistry Faculty Patents

The post-translational addition of a farnesyl moiety to the Ras oncoprotein is essential for its membrane localization and is required for both its biological activity and ability to induce malignant transformation. The present invention describes design and synthesis of a farnesylpyrophosphate (FPP) analog, 8-anilinogeranyl pyrophosphate (AGPP) that is transferred to Ras by farnesyltransferase (FTase), in which the ω-terminal isoprene unit of the farnesyl group has been replaced with an aniline functionality. AGPP potently inhibited FTase activity in vitro (IC₅₀=0.6 μM) and is highly selective showing little inhibitory activity against either geranylgeranyl-protein transferase type I (GGTase I) (IC_{50 …}

Iodo-Nonoxynol-9-Derivatives And Methods For Their Use, George Digenis, Philip Fowler, Kazuya Matsumoto, Gustavo Doncel

Pharmaceutical Sciences Faculty Patents

Mono- and di-iodinated nonoxynol-9-derivatives and methods for their use are disclosed.

Analysis Of Traffic Growth Rates, Monica L. Barrett, R. Clark Graves, David L. Allen, Jerry G. Pigman, Ghassan Abu-Lebdeh, Lisa Aultman-Hall, Sarah T. Bowling

Kentucky Transportation Center Research Report

The primary objectives of this study were to determine patterns of traffic flow and develop traffic growth rates by traffic composition and highway type for Kentucky’s system of highways. Additional subtasks included the following: 1) a literature search to determine if there were new procedures being used to more accurately represent traffic growth rates, 2) development of a random sampling procedure for collecting traffic count data on local roads and streets, 3) prediction of vehicle miles traveled based on socioeconomic data, 4) development of a procedure for explaining the relationship and magnitude of traffic volumes on routes functionally classified as …

Tractor Driving Among Kentucky Farm Youth: Results From The Farm Family Health And Hazard Surveillance Project, Steven R. Browning, Susan C. Westneat, Raeanne Szeluga

Epidemiology and Environmental Health Faculty Publications

This article documents the extent of children's involvement in tractor operations among a representative sample of Kentucky children living and working on family farms. Specifically, we describe children's exposures to tractor-related work activities, profile their use of the tractor (number of days worked), and assess compliance with generally recommended safety measures, such as using tractors equipped with ROPS (rollover protective structures), avoiding riding as passengers on tractors, and operating tractors on public roadways. Data for this study were collected in 1994 and 1995 as part of the NIOSH-sponsored Farm Family Health and Hazard Surveillance Project (FFHHSP). Despite recognition in the …