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Baseline Modeling Of The Maysville Cable-Stayed Bridge Over The Ohio River, Issam E. Harik, Jindong Hu, Suzanne Weaver Smith, Wei-Xin Ren, Tong Zhao, Jennie E. Campbell, Clark Graves

Kentucky Transportation Center Research Report

This report presents the baseline modeling of the Maysville cable-stayed bridge which connects Maysville, Kentucky and Aberdeen, Ohio over the Ohio River. The objective of this study is to establish the bridge baseline model via the dynamics-based technique and finite element method. The scope of research includes finite element modeling and modal analysis, field free vibration testing, finite element model calibration using field test results, and cable dynamic testing and modeling. It is demonstrated that a cable-stayed bridge is a highly pre-stressed structure. The stress stiffening of cable elements plays an important role in both static and dynamic analysis. The …

Innovative Rapid Construction/Reconstruction Methods, Paul M. Goodrum, Yinggang Wang, Chris N. Jones, Philippe C. Fenouil, Donn E. Hancher

Kentucky Transportation Center Research Report

Innovative construction and reconstruction methods provide the opportunity to significantly reduce the time of roadway projects while maintaining the necessary quality of workmanship. The need for these “rapid” methods stems from the increase in traffic on Kentucky roadways coupled with the rise in conventional road and bridge construction methods. Conventional construction methods cannot maintain the demand for progress necessitated by the future needs of the Kentucky Transportation Cabinet, especially the current philosophy of “Get In, Get Out, and Stay Out.” This research documents a series of case studies that examined past projects which used innovative rapid construction methods. This document …

Avoiding Versus Seeking: The Relationship Of Information Seeking To Avoidance, Blunting, Coping, Dissonance, And Related Concepts, Donald O. Case, James E. Andrews, J. David Johnson, Suzanne L. Allard

Information Science Faculty Publications

QUESTION: How have theorists and empirical researchers treated the human tendency to avoid discomforting information?

DATA SOURCES: A historical review (1890-2004) of theory literature in communication and information studies, coupled with searches of recent studies on uptake of genetic testing and on coping strategies of cancer patients, was performed.

STUDY SELECTION: The authors' review of the recent literature included searches of the MEDLINE, PsychInfo, and CINAHL databases between 1992 and summer of 2004 and selective, manual searches of earlier literature. Search strategies included the following subject headings and key words: MeSH headings: Genetic Screening/psychology, Decision Making, Neoplasms/diagnosis/genetics/psychology; CINAHL headings: Genetic …

A Model Program For Youth Suicide Prevention, Hatim A. Omar

Pediatrics Faculty Publications

Youth suicide continues to be one of the leading causes of death in the United States. Nation wide it is the third leading cause of death in the 10-24 year old age group. The rate of suicide varies somewhat from state to state. In the state of Kentucky, youth suicide is the second leading cause of death. This article describes a grass root, community-based program for youth suicide prevention and its impact on the community. The Stop Youth Suicide Campaign was launched in October 2000 and included more than 30 local agencies. This program worked. through public education, education of …

Intention To Seek Information On Cancer Genetics, James E. Andrews, J. David Johnson, Donald O. Case, Suzanne L. Allard, Kimberly Kelly

Communication Faculty Publications

Objective. The public has a high interest in seeking personal genetic information, which holds implications for health information seeking research and health care policy. Rapid advances in cancer genetics research promise early detection, prevention and treatment, yet consumers may have greater difficulty finding and using the information they may need to make informed decisions regarding their personal health and the future of their families.

Design. A statewide telephone survey was conducted of non-institutionalized Kentucky residents 18 years of age or older to investigate factors associated with the intention to seek cancer genetics information, including the need for such information seeking …

Genes Encoding Several Poly (Adp-Ribose) Glycohydrolase (Parg) Enzymes, The Proteins And Fragments Thereof, And Antibodies Immnoreactive Therewith, Myron Jacobson, Elaine L. Jacobson, Jean-Christoph Amé, Winston Lin

Graduate Center for Nutritional Sciences Faculty Patents

The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 kDa. Methods …

Gonadal Steroids Differentially Modulate Neurotoxicity Of Hiv And Cocaine: Testosterone And Ici 182,780 Sensitive Mechanism, Sherie L. Kendall, Caroline F. Anderson, Avindra Nath, Jadwiga Turchan-Cholewo, Cantey L. Land, Charles F. Mactutus, Rosemarie M. Booze

Behavioral Science Faculty Publications

BACKGROUND: HIV Associated Dementia (HAD) is a common complication of human immunodeficiency virus (HIV) infection that erodes the quality of life for patients and burdens health care providers. Intravenous drug use is a major route of HIV transmission, and drug use is associated with increased HAD. Specific proteins released as a consequence of HIV infection (e.g., gp120, the HIV envelope protein and Tat, the nuclear transactivating protein) have been implicated in the pathogenesis of HAD. In primary cultures of human fetal brain tissue, subtoxic doses of gp120 and Tat are capable of interacting with a physiologically relevant dose of cocaine, …

Horse Farm Owner Dies When Pinned Under Golf Cart, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On January 31, 2004, a 45-year old female horse farm owner (decedent) died when she was pinned under a golf cart. The woman had driven a gas-powered golf cart from her house on the farm to the horse barn to muck stalls and put horses in the barn. After driving the golf cart into the barn, the farm owner placed two square bales of hay on the golf cart; one on the back and one on the passenger side of the front seat. Leaving the ignition key of the golf cart in the “on” position, she left the golf cart …

Manganese Distribution Across The Blood-Brain Barrier. Iv. Evidence For Brain Influx Through Store-Operated Calcium Channels, Janelle S. Crossgrove, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

Manganese (Mn) is a required co-factor for many ubiquitous enzymes; however, chronic Mn overexposure can cause manganism, a parkinsonian-like syndrome. Previous studies showed Mn influx into brain is carrier-mediated, though the putative carrier(s) were not established. Studies conducted with cultured bovine brain microvascular endothelial cells (bBMECs), which comprise the blood–brain barrier, revealed ⁵⁴Mn (II) uptake positively correlated with pH, was temperature-dependent, and was sodium- and energy-independent. Brain ⁵⁴Mn uptake correlated inversely with calcium (Ca) concentration, but ⁴⁵Ca uptake was unaltered by high Mn concentration. Lanthanum (La), a non-selective inhibitor of several Ca channel types, as well as …

Protection Against Ischemia And Reperfusion Injury, Peter R. Oeltgen, Paul D. Bishop, Mark S. Kindy, Juan A. Sanchez

Molecular and Cellular Biochemistry Faculty Patents

A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound, either Deltorphin A and/or Dermorphin H, may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.

Oligonucleotide Delivery Systems For Camptothecins, Thomas Burke, Ayhan S. Demir, Ashok J. Chavan, Danzhou Yang

Pharmaceutical Sciences Faculty Patents

Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy.

Traffic Technician Dies From Fall While Changing Traffic Signal Bulb, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On Monday, March 31, 2003, a 39-year-old male (decedent) highway traffic technician, working alone, received fatal head injuries after falling out of the bucket of an aerial boom truck. Injuries sustained in the fall resulted in his death four days later. He was changing a burned-out green traffic bulb in a traffic signal suspended over 2 lanes of traffic. As he worked from the aerial lift suspended over traffic to change the burned out bulb, a cargo truck drove underneath the bucket, striking it, and causing the decedent to fall to the asphalt below. As the worker fell approximately 10 …

Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase. with or without a substrate bound in the active site.

Exposure To Secondhand Smoke And Nicotine Dependence, Chizimuzo T.C. Okoli, Ellen J. Hahn, Steven R. Browning, Mary Kay Rayens

Nursing Presentations

Background

• Nicotine dependence (ND) : “the smoking behavior accompanied by a reluctance to quit (Khurana, Batra, Patkar, & Leone, 2003).

• The US Public Health Service Clinical Practice Guideline ‘Treating Tobacco Use and Dependence’: A chronic condition that often requires repeated interventions (Office of the Surgeon General, 2000).

• Secondhand Smoke (SHS) is a potential source of exposure to high levels of nicotine. (Dimich-Ward, Gee, Brauer, Leung,1997)

• No current studies addressing the contribution of SHS to Nicotine Dependence (ND) or smoking behaviors

Osler And The Infected Letter, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The spread of infectious agents through the mail has concerned public health officials for 5 centuries. The dissemination of anthrax spores in the US mail in 2001 was a recent example. In 1901, two medical journals reported outbreaks of smallpox presumably introduced by letters contaminated with variola viruses. The stability and infectivity of the smallpox virus are reviewed from both a historical (anecdotal) perspective and modern virologic studies. Bubonic plague was the contagious disease that led to quarantines as early as the 14th century in port cities in southern Europe. Later, smallpox, cholera, typhus, and yellow fever were recognized as …

Landscaping Laborer Dies When Struck By Bouncing Log, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

On March 5, 2004, a 57-year-old male laborer died when a 19 inch wide x 31 inch long log rolled down a mountain hitting him in his head and chest. The laborer had been employed for three days by a landscaping company contracted to clear the tree canopy over a gas line right-of-way. At approximately 2:20 pm, the company owner and five laborers were felling trees and bucking downed trees with chain saws and pole saws to remove the trees and limbs hanging over and growing in the gas line right-of-way. Two of the laborers were working topside at the …

Review Of State Regulations, Standards, And Practices, Related To The Use Of Coal Combustion Products: Texas Review Case Study, Tera D. Buckley, Debra F. Pflughoeft-Hassett, John Sager, John Ward

World of Coal Ash Proceedings

No abstract provided.

Haitian Vodou Possession And Zombification: Desire And Return Of The Repressed, Niame

disClosure: A Journal of Social Theory

No abstract provided.

Development Of A Co-Disposal Protocol For The Neutralization And Amelioration Of Acid Mine Drainage With Fly Ash, Damini Surender, Leslie Petrik

World of Coal Ash Proceedings

No abstract provided.

Trace Element Chemistry Of Fly Ashes From Co-Combusted Petroleum Coke And Coal, Kevin R. Henke

World of Coal Ash Proceedings

No abstract provided.

The State Of Indiana’S Experience In Regulating The Disposal Of Coal Ash At Surface Coal Mines, Paul J. Ehret

World of Coal Ash Proceedings

No abstract provided.

The Use Of Coal Ash And Dredged Materials In Large Scale Abandoned Mine Reclamation, Andrew S. Voros

World of Coal Ash Proceedings

No abstract provided.

State Regulation Of Ccps & Ccbs In Texas, Michael J. Nasi, Rebecca L. Fink

World of Coal Ash Proceedings

No abstract provided.

Coal Ash Beneficial Use At Mine Sites In Pennsylvania, Roger J. Hornberger, Alfred D. Dalberto, Michael J. Menghini, Timothy C. Kania

World of Coal Ash Proceedings

No abstract provided.

Improving Freezing And Thawing Properties Of Fly Ash Bricks, Henry Liu, Williams Burkett, Kirk Haynes

World of Coal Ash Proceedings

No abstract provided.

State Perspective On Regulation Of Mine Placement Of Coal Combustion Wastes, Greg Conrad

World of Coal Ash Proceedings

No abstract provided.

The Environmental Bonafides For Ccp Use In Australian Agricultural And Horticultural Systems, Craig Heidrich

World of Coal Ash Proceedings

No abstract provided.

Prospects For Coal Ash In The Management Of Australian Soils, I. A.M. Yunusa, D. Eamus, D. L. De Silva, B. R. Murray

World of Coal Ash Proceedings

No abstract provided.

Release Of Ammonia From Scr / Sncr Fly Ashes, Carol Cardone, Ann Kim, Karl Schroeder

World of Coal Ash Proceedings

No abstract provided.

Treatment Of Acid Mine Drainage With Fly Ash: Removal Of Major, Minor Elements, So4 And Utilization Of The Solid Residues For Wastewater Treatment, W.M. Gitari, V.S Somerset, L.F Petrik, D. Key

World of Coal Ash Proceedings

No abstract provided.