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The Design And Synthesis Of Novel Chelates For The Precipitation Of Mercury, Aaron Robert Hutchison Jan 2007

The Design And Synthesis Of Novel Chelates For The Precipitation Of Mercury, Aaron Robert Hutchison

University of Kentucky Doctoral Dissertations

Mercury has been an element of great industrial importance since early times.This wide utilization of the element has led to pervasive mercury contamination in theglobal environment. Due to mercury's high toxicity, this is a matter of great concern. Anumber of methods, includ ing phytoremediation, filtration, and precipitation/chelation,have been investigated to remove mercury from the environment. Unfortunately, thesemethods are not entirely satisfactory for the in-situ remediation of mercury from aqueousenvironments.The hypothesis of this dissertation is that this can best be accomplished by theaddition of a large and flexible sulfur-based chelate, that will bind mercury in atetracoordinate and presumably tetrahedral environment, to …

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Carbon Nanotube Augmentation Of A Bone Cement Polymer, Brock Holston Marrs Jan 2007

Carbon Nanotube Augmentation Of A Bone Cement Polymer, Brock Holston Marrs

University of Kentucky Doctoral Dissertations

Acrylic bone cement is widely used as a structural material in orthopaedics, dentistry, and orofacial surgery. Although bone cement celebrates four decades of success, it remains susceptible to fatigue fracture. This type of failure can directly lead to implant loosening, revision surgery, and increased healthcare expenditures. The mechanism of fatigue failure is divided into three stages: 1) fatigue crack initiation, 2) fatigue crack propagation, and 3) fast, brittle fracture. Adding reinforcing fibers and particles to bone cement is a proposed solution for improving fatigue performance. The mechanical performance of these reinforced bone cements is limited by fiber ductility, fibermatrix de-bonding, …

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Virtual' Brides In The Post-Soviet Context, Michael Paul Begin Jan 2007

Virtual' Brides In The Post-Soviet Context, Michael Paul Begin

University of Kentucky Doctoral Dissertations

This project offers a multifaceted, interdisciplinary approach to understanding the contemporary post-Soviet Internet bride phenomenon and the rationales, motives, and aspirations of the industry's participants. As international marriage services have incorporated information and communications technologies (ICTs) to assist in the marketing of women of post-communist nations for correspondence courtship with Western men, the industry has furthered the globalization of marriage markets and the opportunities for communicative exchange among disparate nations and cultures. By way of case study, the project takes a special focus on the Belarusian/American segment of the industry, turning to personal interviews with participants and employing qualitative techniques …

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A Comparison Of Select Trunk Muscle Thickness Change Between Subjects With Low Back Pain Classified In The Treatment-Based Classification System And Asymptomatic Controls, Kyle Benjamin Kiesel Jan 2007

A Comparison Of Select Trunk Muscle Thickness Change Between Subjects With Low Back Pain Classified In The Treatment-Based Classification System And Asymptomatic Controls, Kyle Benjamin Kiesel

University of Kentucky Doctoral Dissertations

The purposes of this dissertation were to determine: 1) the relationship betweenmuscle thickness change (MTC) as measured by rehabilitative ultrasound imaging(RUSI) and EMG activity in the lumbar multifidus (LM), 2) if motor control changesproduced by experimentally induced pain are measurable with RUSI, 3) if a differenceexists in MTC between subjects with low back pain (LBP) classified in the treatmentbasedclassification system (TBC) system and controls, 4) if MTC improves followingintervention.Current literature suggests sub-groups of patients with LBP exist and responddifferently to treatment, challenging whether the majority of LBP is "nonspecific". TheTBC system categorizes subjects into one of four categories (stabilization, mobilization,direction …

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Prevention Of Hormonal Mammary Carcinogenesis In Rats By Dietary Berries And Ellagic Acid, Harini Sankaran Aiyer Jan 2007

Prevention Of Hormonal Mammary Carcinogenesis In Rats By Dietary Berries And Ellagic Acid, Harini Sankaran Aiyer

University of Kentucky Doctoral Dissertations

Breast cancer is the most frequently diagnosed cancer among women around the world. The hormone 17-estradiol (E2) is strongly implicated as a causative agent in this cancer. Since estrogen acts as a complete carcinogen, agents that interfere with the carcinogenic actions of E2 are required. Most agents effective against experimental mammary carcinogenesis have been employed as pure compounds disregarding the synergy that exists between several phytonutrients in a whole food. In these studies we have taken a unified approach, by employing a pure phytonutrient ellagic acid and whole foods that contain the phytonutrient at various levels berries, in the prevention …

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Environmental Regulatory Policy: Political Economy, Industrial Geography, And Intergovernmental Fiscal Effects, Douglas Alan Carr Jan 2007

Environmental Regulatory Policy: Political Economy, Industrial Geography, And Intergovernmental Fiscal Effects, Douglas Alan Carr

University of Kentucky Doctoral Dissertations

Environmental regulatory policy in the U.S. is a mixture of federal, state, and local activity and impacts. This is true of air quality regulations, which are governed at the federal level by the Clean Air Act. This dissertation analyzes both the political economy of federal environmental regulations and the empirical effects of ozone regulations under the Clean Air Act.A political economy model is developed that offers a motivation for political support of national environmental policy that regulates strictly local pollution. Altering local environmental policies in other jurisdictions will cause capital migration, which may increase local welfare. Thus, individuals have an …

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Characterization Of Polyphenol Oxidase And Antioxidants From Pawpaw (Asimina Tribola) Fruit, Caodi Fang Jan 2007

Characterization Of Polyphenol Oxidase And Antioxidants From Pawpaw (Asimina Tribola) Fruit, Caodi Fang

University of Kentucky Master's Theses

The latest generation of fighter aircraft utilizes a 270Vdc power system [1]. Such high voltage DC power systems are difficult to protect with conventional circuit breakers because the current does not automatically go to zero twice per cycle during a fault like it does in an AC power system and thus arcing of the contacts is a problem. Solid state power controllers (SSPCs) are the solid state equivalent of a circuit breaker that do not arc and which can respond more rapidly to a fault than a mechanical breaker [2]. Present SSPCs are limited to lower voltages and currents by …

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Influence Of Surface Roughness Of Copper Substrate On Wetting Behavior Of Molten Solder Alloys, Dinesh Reddy Nalagatla Jan 2007

Influence Of Surface Roughness Of Copper Substrate On Wetting Behavior Of Molten Solder Alloys, Dinesh Reddy Nalagatla

University of Kentucky Master's Theses

The objective of this study is to understand the effect of surface roughness of the Cu substrate on the wetting of molten solder alloys. Eutectic Sn-Pb, pure Sn and eutectic Sn-Cu solder alloys and Cu substrates with different surface finish viz., highly polished surface, polished surface and unpolished surface were used in this work. Highly polished surface was prepared in Metallography lab, University of Kentucky while other two substrates were obtained from a vendor. Surface roughness properties of each substrate were measured using an optical profilometer. Highly polished surface was found to be of least surface roughness, while unpolished surface …

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Validity Of The Pendulum Test To Measure Quadriceps Spasticity In Children Diagnosed With Cerebral Palsy, Henry Dulin White Ii Jan 2007

Validity Of The Pendulum Test To Measure Quadriceps Spasticity In Children Diagnosed With Cerebral Palsy, Henry Dulin White Ii

University of Kentucky Doctoral Dissertations

The stiff-knee gait pattern of children diagnosed with cerebral palsy (CP) is assumed to be caused by spasticity of the quadriceps which interferes with knee flexion normally occurring during the swing phase of walking. In current clinical practice, the ability to assess quadriceps spasticity is limited by the lack of an objective and reliable test that discriminates the role spasticity plays in functional limitations. The primary purpose of this series of studies was to assess the pendulum test as an objective measure of quadriceps spasticity. The first study assessed the reliability of the pendulum test. Moderate to very high between …

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Cyclooxygenase-2-Dependent Remodeling Of The Ductus Arteriosus, Darshini Trivedi Jan 2007

Cyclooxygenase-2-Dependent Remodeling Of The Ductus Arteriosus, Darshini Trivedi

University of Kentucky Doctoral Dissertations

Transition of the cardiopulmonary circulation at birth requires functional closure of the ductus arteriosus (DA). The DA is an arterial shunt that is vital in the fetus for diverting the pulmonary circulation away from the uninflated lungs. Failure of the vessel to functionally close after birth is known as patent DA, which is the second most common congenital heart disease. Patent DA may seriously compromise neonatal health and current pharmacological treatments are often limited by serious complications or a significant failure rate, thereby increasing the necessity for surgical intervention. Recently, we were the first to show that genetic or pharmacological …

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Drug Milk To Serum Ratio Prediction And Ontogeny Of Cyp3a Clearance Pathway As A Model Of Drug Exposure In The Developing Rat, Maggie Magdi Abbassi Jan 2007

Drug Milk To Serum Ratio Prediction And Ontogeny Of Cyp3a Clearance Pathway As A Model Of Drug Exposure In The Developing Rat, Maggie Magdi Abbassi

University of Kentucky Doctoral Dissertations

Transfer of drugs into milk and the clearance of drugs in neonates are critical determinants of the exposure of infants to drugs in breast milk. Models predicting both parameters have been proposed. The objective of this dissertation is to test two models predicting milk to serum ratio and an ontogeny clearance model predicting clearance in the neonate. Predicted milk to serum ratio (M/S) values were generated according to the Atkinson and Begg model. The model did not adequately predict M/S when comparing the predicted values to observed values in the literature. The Fleishaker model was also tested. The model was …

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The Willingness To Pay For The Detection And Treatment Of Vulnerable Plaque Related To Heart Attacks, Patricia L. Ryan Jan 2007

The Willingness To Pay For The Detection And Treatment Of Vulnerable Plaque Related To Heart Attacks, Patricia L. Ryan

University of Kentucky Doctoral Dissertations

Recent medical studies have led cardiologists to revise theories regarding the cause of heart attacks. Rather than a gradual clogging of the arteries, eruption of a vulnerable plaque is thought to be the cause of approximately 75% of all heart attacks. As a result, traditional risk factors are no longer sufficient indicators of who is at risk for a heart attack. Therefore, this research investigates the willingness to pay (WTP) for a new, hypothetical detection (screening) and treatment method for vulnerable plaque. For this study, two survey instruments were developed that take advantage of the visual and interactive aspects of …

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The Role Of Shearing In The Transmission Of Diplodia Pinea In Scots Pine Christmas Trees In Kentucky, Amy Bateman Jan 2007

The Role Of Shearing In The Transmission Of Diplodia Pinea In Scots Pine Christmas Trees In Kentucky, Amy Bateman

University of Kentucky Master's Theses

Diplodia tip blight is an important disease of pines, especially Scots pine Christmas trees in Kentucky. The hypothesis for my thesis work was that D. pinea could be acquired and transmitted on the tools during annual shearing of the Christmas trees. Samples taken from tools after shearing on two different Christmas tree farms in Kentucky in 2005 and 2006 yielded D. pinea colony forming units, but in very low quantities; typically less than 10 CFUs per collection. Diplodia-associated dieback from the sheared tips was never found in the field, suggesting that transmission and subsequent infections were not occurring via these …

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Processes Leading Self-Identified Heterosexuals To Develop Into Sexual Minority Social Justice Allies: A Qualitative Exploration, Julie Marie Duhigg Jan 2007

Processes Leading Self-Identified Heterosexuals To Develop Into Sexual Minority Social Justice Allies: A Qualitative Exploration, Julie Marie Duhigg

University of Kentucky Doctoral Dissertations

The impact of homonegativity on both sexual minorities and heterosexuals is profoundly debilitating. Due to the implicit power of their privileged status, heterosexually-identified individuals can serve a crucial role as allies in eliminating sexual minority oppression. Because minimal research exists around heterosexual identity issues, broadly, and sexual minority ally development, specifically, it is difficult to promote such ally work without a clear understanding of the developmental processes and motivational issues that lead heterosexuals to sexual minority social justice action. The current study sought to explore the developmental experiences of heterosexuallyidentified exemplars who work in their communities for sexual minority social …

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Essays In Health Economics, Rachel Pauline Lange Jan 2007

Essays In Health Economics, Rachel Pauline Lange

University of Kentucky Doctoral Dissertations

Health and health care are dominant economic and political issues in the United States and many other countries. This dissertation contains two essays addressing different subjects within the field of health economics. The first essay is labor market oriented: An Economic Analysis of the Effects of Obesity on Wages. It examines the effects of overweight and obesity on the wages of men and women. The second essay, An Economic Analysis of the Impact on Health Care of Certain Medicare Provisions of the Balanced Budget Act of 1997 examines changes in the treatment of Medicare patients in light of reimbursement changes …

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Use Of In-Situ Fish Populations For Biomonitoring Polychlorinated Biphenyl And Metal Pollution In Moderately Impacted Freshwater Streams, David John Price Jan 2007

Use Of In-Situ Fish Populations For Biomonitoring Polychlorinated Biphenyl And Metal Pollution In Moderately Impacted Freshwater Streams, David John Price

University of Kentucky Doctoral Dissertations

Water, sediments, floodplain soils, and fish from Big and Little Bayou creeks were assessed for polychlorinated biphenyls (PCBs) and metals in 1987-2005. The streams were impacted by effluents from the Paducah Gaseous Diffusion Plant (PGDP). PCBs were rarely detected in water samples. Aroclor 1248 detections in sediments and floodplains were sporadic, but 1254 and 1260 were consistent. Seasonal variations were only observed for Aroclor 1248. Detection of PCBs in floodplains indicated recent influx of contaminated sediments. Species-specific PCB residues patterns were studied for Lepomis cyanellus, L. megalotis, L. macrochirus, and Campostoma anomalum. Highest PCB concentrations were found in stoneroller minnows. …

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Three-Dimensional Quantitative Analysis Of The Trajectory Of The Foot While Running, Thomas J. Cunningham Jan 2007

Three-Dimensional Quantitative Analysis Of The Trajectory Of The Foot While Running, Thomas J. Cunningham

University of Kentucky Master's Theses

Exercising the leg in a manner similar to running is theorized to have the potential effect of increasing performance and reducing occurrence of injuries in running athletes. Development of an exercise device that can help facilitate this method of specificity training could be beneficial to the sports community and should be investigated. Understanding the trajectory of the foot during the running gait is primary to further pursue this concept. 26 running athletes of varying characteristics participated in this study. Each subjects sex, age, weight, height, leg length, activity level and participation amount in their respective sport was recorded. Retro-reflective cameras …

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Tracing The Origin Of The Recent Rise In Neuropathogenic Ehv-1, Kathryn Laura Smith Jan 2007

Tracing The Origin Of The Recent Rise In Neuropathogenic Ehv-1, Kathryn Laura Smith

University of Kentucky Master's Theses

Equine herpesvirus type-1(EHV-1) is a complex virus known for inducing various forms of disease in horses. In recent years, the number of cases of neurological disease caused by this virus has increased. While there are a number of possible sources for this recent surge, this project set out to determine if a genotypic shift in the latent population of the virus in favor of the neuropathogenic form of EHV-1 is the basis for the recent increase in frequency of EHV-1 neurologic disease. To ascertain if such a shift has in fact occurred, 450 EHV-1 isolates were obtained from fetal tissues …

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Identification And Characterization Of Proteins That Interact With Agamous-Like 15 (Agl15), A Mads-Domain Transcription Factor That Preferentially Accumulates In The Plant Embryo, Kristine Hill Jan 2007

Identification And Characterization Of Proteins That Interact With Agamous-Like 15 (Agl15), A Mads-Domain Transcription Factor That Preferentially Accumulates In The Plant Embryo, Kristine Hill

University of Kentucky Doctoral Dissertations

AGAMOUS-Like 15 (AGL15) encodes a MADS-domain transcription factor that is preferentially expressed in the plant embryo, and may function as a regulator in embryonic developmental programs. A number of direct downstream targets of AGL15 have been identified, and while some of these target genes are induced in response to AGL15, others are repressed. Additionally, direct target genes have been analyzed that exhibit strong association with AGL15 in vivo, yet in vitro, AGL15 binds only weakly. Taken together these data suggest that AGL15 may form heterodimers, or ternary complexes with other proteins, thus modulating the specificity and function of AGL15 in …

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Molecular Transport Properties Through Carbon Nanotube Membranes, Mainak Majumder Jan 2007

Molecular Transport Properties Through Carbon Nanotube Membranes, Mainak Majumder

University of Kentucky Doctoral Dissertations

Molecular transport through hollow cores of crystalline carbon nanotubes (CNTs) are of considerable interest from the fundamental and application point of view. This dissertation focuses on understanding molecular transport through a membrane platform consisting of open ended CNTs with ~ 7 nm core diameter and ~ 1010 CNTs/cm2 encapsulated in an inert polymer matrix. While ionic diffusion through the membrane is close to bulk diffusion expectations, gases and liquids were respectively observed to be transported ~ 10 times faster than Knudsen diffusion and ~ 10000-100000 times faster than hydrodynamic flow predictions. This phenomenon has been attributed to the non-interactive and …

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Modulation Of Endothelial Cell Activation By Omega-6 And Omega-3 Fatty Acids, Lei Wang Jan 2007

Modulation Of Endothelial Cell Activation By Omega-6 And Omega-3 Fatty Acids, Lei Wang

University of Kentucky Doctoral Dissertations

Endothelial activation is considered to be an early and critical event in the pathology of atherogenesis which can be modified by environmental factors such as diet, pollutants, and lifestyle habits. Dietary andamp;ugrave;-6 and andamp;ugrave;-3 fatty acids have been reported to either amplify or diminish inflammatory responses related to atherosclerosis development. However, the interactions of andamp;ugrave;-6 and andamp;ugrave;-3 fatty acids with inflammatory cytokines or organic pollutants on endothelial cell activation are not well understood. The studies presented in this dissertation tested the hypothesis that andamp;ugrave;-6 and andamp;ugrave;-3 fatty acids alone, or in varying ratios can differently modulate pro-atherogenic mediators and inflammatory …

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Aging And The Dynorphinergic System: Evaluation Of Memory And Motor Systems In Prodynorphin Knockout Mice, Xuan V. Nguyen Jan 2007

Aging And The Dynorphinergic System: Evaluation Of Memory And Motor Systems In Prodynorphin Knockout Mice, Xuan V. Nguyen

University of Kentucky Doctoral Dissertations

Dynorphins, endogenous peptide neurotransmitters expressed in the central nervous system, have been implicated in diverse pathophysiological processes, including excitotoxicity, chronic inflammation, traumatic injury, cognitive impairment, and motor dysfunction, with significant changes with aging or age-related disease processes. This has led to the hypothesis that the suppression of dynorphin expression would produce beneficial effects on learning and memory and motor function. To assess the phenotypic manifestations of chronic suppression of endogenous dynorphin, knockout (KO) mice lacking the coding exons of the gene encoding the prodynorphin (Pdyn) precursor protein, were tested in a series of behavioral, biochemical, and molecular biological studies. Moderately …

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Molecular Mechanisms Of Olfactory Neurodegeneration, Radhika Anand Vaishnav Jan 2007

Molecular Mechanisms Of Olfactory Neurodegeneration, Radhika Anand Vaishnav

University of Kentucky Doctoral Dissertations

Olfactory sensory decline has been associated with normal aging as well as neurodegenerative disorders, yet the underlying mechanisms are unclear. The overall aim of this dissertation was to investigate the fundamental molecular and cellular mechanisms associated with olfactory neurodegeneration. This investigation uses an integrative approach, combining proteomics and gene expression analyses with cellular and tissuelevel characterization. Using these approaches, two model systems were investigated: 1) normally aging C57BL/6 mice of ages 1.5-, 6- and 20-months; and 2) a mouse model of elevated endogenous oxidative stress-associated neurodegeneration, namely, the Harlequin mutant mouse. The first specific aim was to test the hypothesis …

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Determining Factors That Contribute To Nonpoint Source Pollution In The Lower Kentucky Watershed, James A. Wermuth Jan 2007

Determining Factors That Contribute To Nonpoint Source Pollution In The Lower Kentucky Watershed, James A. Wermuth

University of Kentucky Master's Theses

The water quality in the United States has greatly improved since the implementation of the Clean Water Act (CWA) in the early 1970s. Unfortunately, the Clean Water Act only addresses one kind of water pollution, point source pollution. The major problem that is present in the degradation of todays water quality has to deal with nonpoint source pollution. Agriculture is commonly regarded as the leading contributor to nonpoint source pollution in the United States. This study uses two analytical tools to try to determine the significant factors in the transport of pollutants in the Lower Kentucky Watershed, located in central …

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Recent Advances In Basic Neurosciences And Brain Disease: From Synapses To Behavior, Guo-Qiang Bi, Vadim Bolshakov, Guojun Bu, Catherine M. Cahill, Zhou-Feng Chen, Graham L. Collingridge, Robin L. Cooper, Jens R. Coorssen, Alaa El-Husseini, Vasco Galhardo, Wen-Biao Gan, Jianguo Gu, Kazuhide Inoue, John Isaac, Koichi Iwata, Zhengping Jia, Bong-Kiun Kaang, Mikito Kawamata, Satoshi Kida, Eric Klann, Tatsuro Kohno, Min Li, Xiao-Jiang Li, John F. Macdonald, Karim Nader, Peter V. Nguyen, Uhtaek Oh, Ke Ren, John C. Roder, Michael W. Salter, Weihong Song, Shuzo Sugita, Shao-Jun Tang, Yuanxiang Tao, Yu Tian Wang, Newton Woo, Melanie A. Woodin, Zhen Yan, Megumu Yoshimura, Ming Xu, Zao C. Xu, Xia Zhang, Mei Zhen, Min Zhuo Dec 2006

Recent Advances In Basic Neurosciences And Brain Disease: From Synapses To Behavior, Guo-Qiang Bi, Vadim Bolshakov, Guojun Bu, Catherine M. Cahill, Zhou-Feng Chen, Graham L. Collingridge, Robin L. Cooper, Jens R. Coorssen, Alaa El-Husseini, Vasco Galhardo, Wen-Biao Gan, Jianguo Gu, Kazuhide Inoue, John Isaac, Koichi Iwata, Zhengping Jia, Bong-Kiun Kaang, Mikito Kawamata, Satoshi Kida, Eric Klann, Tatsuro Kohno, Min Li, Xiao-Jiang Li, John F. Macdonald, Karim Nader, Peter V. Nguyen, Uhtaek Oh, Ke Ren, John C. Roder, Michael W. Salter, Weihong Song, Shuzo Sugita, Shao-Jun Tang, Yuanxiang Tao, Yu Tian Wang, Newton Woo, Melanie A. Woodin, Zhen Yan, Megumu Yoshimura, Ming Xu, Zao C. Xu, Xia Zhang, Mei Zhen, Min Zhuo

Biology Faculty Publications

Understanding basic neuronal mechanisms hold the hope for future treatment of brain disease. The 1st international conference on synapse, memory, drug addiction and pain was held in beautiful downtown Toronto, Canada on August 21-23, 2006. Unlike other traditional conferences, this new meeting focused on three major aims: (1) to promote new and cutting edge research in neuroscience; (2) to encourage international information exchange and scientific collaborations; and (3) to provide a platform for active scientists to discuss new findings. Up to 64 investigators presented their recent discoveries, from basic synaptic mechanisms to genes related to human brain disease. This meeting …

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Microemulsions As Precursors To Solid Nanoparticles, Russell John Mumper, Michael Jay Dec 2006

Microemulsions As Precursors To Solid Nanoparticles, Russell John Mumper, Michael Jay

Pharmaceutical Sciences Faculty Patents

The preparation of novel microemulsions to be used as precursors for solid nanoparticles is described. The microemulsion precursors consist of either alcohol-in-fluorocarbon microemulsions, liquid hydrocarbon-in-fluorocarbon microemulsions, or liquid hydrocarbon-in-water microemulsions. The formed solid nanoparticles have diameters below 200 nanometers and can be made to entrap various materials including drugs, magnets, and sensors. The solid nanoparticles can be made to target different cells in the body by the inclusion of a cell-specific targeting ligand. Methods of preparing the novel microemulsion precursors and methods to cure solid nanoparticles are provided.

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Modified Soy Products And Methods For Reducing Odor And Improving Flavor Of Soy Products, William L. Boatright Dec 2006

Modified Soy Products And Methods For Reducing Odor And Improving Flavor Of Soy Products, William L. Boatright

Animal and Food Sciences Faculty Patents

A method for reducing odor in soy products and compositions containing soy products by adding or admixing a compound having one or more disulfide bonds to the soy product or composition. The disulfide compound includes a peptide containing at least cystine residue, a peptide or polypeptide containing at least one disulfide bond, L-cystine, D-cystine, DL-cystine and any combination thereof.

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Evidence That Talin Alternative Splice Variants From Ciona Intestinalis Have Different Roles In Cell Adhesion, Richard H. Singiser, Richard O. Mccann Dec 2006

Evidence That Talin Alternative Splice Variants From Ciona Intestinalis Have Different Roles In Cell Adhesion, Richard H. Singiser, Richard O. Mccann

Molecular and Cellular Biochemistry Faculty Publications

BACKGROUND: Talins are large, modular cytoskeletal proteins found in animals and amoebozoans such as Dictyostelium discoideum. Since the identification of a second talin gene in vertebrates, it has become increasingly clear that vertebrate Talin1 and Talin2 have non-redundant roles as essential links between integrins and the actin cytoskeleton in distinct plasma membrane-associated adhesion complexes. The conserved C-terminal I/LWEQ module is important for talin function. This structural element mediates the interaction of talins with F-actin. The I/LWEQ module also targets mammalian Talin1 to focal adhesion complexes, which are dynamic multicomponent assemblies required for cell adhesion and cell motility. Although Talin1 is …

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Oxpat/Pat-1 Is A Ppar-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization, Nathan E. Wolins, Benjamin K. Quaynor, James R. Skinner, Anatoly Tzekov, Michelle A. Croce, Matthew C. Gropler, Vijayalakshmi Varma, Aiwei Yao-Borengasser, Neda Rasouli, Philip A. Kern, Brian N. Finck, Perry E. Bickel Dec 2006

Oxpat/Pat-1 Is A Ppar-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization, Nathan E. Wolins, Benjamin K. Quaynor, James R. Skinner, Anatoly Tzekov, Michelle A. Croce, Matthew C. Gropler, Vijayalakshmi Varma, Aiwei Yao-Borengasser, Neda Rasouli, Philip A. Kern, Brian N. Finck, Perry E. Bickel

Clinical and Translational Science Faculty Publications

Lipid droplet proteins of the PAT (perilipin, adipophilin, and TIP47) family regulate cellular neutral lipid stores. We have studied a new member of this family, PAT-1, and found that it is expressed in highly oxidative tissues. We refer to this protein as "OXPAT." Physiologic lipid loading of mouse liver by fasting enriches OXPAT in the lipid droplet tissue fraction. OXPAT resides on lipid droplets with the PAT protein adipophilin in primary cardiomyocytes. Ectopic expression of OXPAT promotes fatty acid-induced triacylglycerol accumulation, long-chain fatty acid oxidation, and mRNAs associated with oxidative metabolism. Consistent with these observations, OXPAT is induced in mouse …

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Southeastern Law Librarian December 2006, Seaall Dec 2006

Southeastern Law Librarian December 2006, Seaall

Newsletters

No abstract provided.

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