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Movilidades Posapocalípticas: Un Nuevo Acercamiento A La Película De La Migración Irregular, Arturo Vargas

Nomenclatura: aproximaciones a los estudios hispánicos

No abstract provided.

Genetically Engineered Equine Influenza Virus And Uses Thereof, Peter Palese, Adolfo Garcia-Sastre, Thomas Chambers

Veterinary Science Faculty Patents

The present invention relates, in general, to attenuated equine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated equine influenza viruses having modifications to an equine NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. These viruses replicate in vivo, but demonstrate decreased replication, virulence and increased attenuation, and therefore are well suited for use in live virus vaccines, and pharmaceutical formulations.

Poster Session, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Western Kentucky Deep Saline Reservoir CO₂ Storage Test: Shallow Groundwater Monitoring Results, E. Glynn Beck and others, Kentucky Geological Survey
• Baseline Soil Properties of a Central Kentucky Riparian Buffer, Amanda Gumbert and others, Dept of Plant and Soil Science, UK
• The Kentucky Water Well Driller’s Certification Program, Scotty E. Robertson and David A. Jackson, Kentucky Division of Water, Frankfort, KY
• Influences of Cladophora Bloom on the Diets of Amblema plicata and Elliptio dilatata in the Upper Green River, Kentucky, Jennifer M. Yates and others, Dept of Biology, Western Kentucky University
• Using Electrical Resistivity to Locate …

Session 1a, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• A Regionally-Calibrated Critical Flow for Stream Channel Protection, Bob Hawley and others, Sustainable Streams LLC, Louisville, KY
• Monitoring Wetland Restoration Success at North Fork of Irish Creek, Brian C. Reeder, Center for Environmental Education and Institute for Regional Analysis and Public Policy, Morehead State University
• NC2D Open Channel Flow Model: Development and Applications for Stream Restoration Design in Kentucky, Brian J. Belcher, Beaver Creek Hydrology LLC, Lexington, KY
• Using Remote Sensing Tools to Target Stream Protection and Wastewater Treatment BMPs in Rural Kentucky, Catherine Carter and others, Tetra Tech, Research Triangle Park, NC
• Improving Water Quality …

Proceedings Of 2012 Kentucky Water Resources Annual Symposium, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

This symposium was planned and conducted as a part of the state water resources research institute annual program that is supported by Grant/Cooperative Agreement Number G11AP20081 from the United States Geological Survey. The contents of this proceedings document and the views and conclusions presented at the symposium are solely the responsibility of the individual authors and presenters and do not necessarily represent the official views of the USGS or of the symposium organizers and sponsors. This publication is produced with the understanding that the United States Government is authorized to reproduce and distribute reprints for government purposes.

Inhibition Of Fatty Acid Synthase Attenuates Cd44-Associated Signaling And Reduces Metastasis In Colorectal Cancer, Yekaterina Y. Zaytseva, Piotr G. Rychahou, Pat Gulhati, Victoria Allison Elliott, William Conan Mustain, Kathleen O'Connor, Andrew J. Morris, Manjula Sunkara, Heidi L. Weiss, Eun Young Lee, B. Mark Evers

Markey Cancer Center Faculty Publications

Fatty acid synthase (FASN) and ATP-citrate lyase, key enzymes of de novo lipogenesis, are significantly upregulated and activated in many cancers and portend poor prognosis. Even though the role of lipogenesis in providing proliferative and survival advantages to cancer cells has been described, the impact of aberrant activation of lipogenic enzymes on cancer progression remains unknown. In this study, we found that elevated expression of FASN is associated with advanced stages of colorectal cancer (CRC) and liver metastasis, suggesting that it may play a role in progression of CRC to metastatic disease. Targeted inhibition of lipogenic enzymes abolished expression of …

Drug Dosage Individualization Based On A Random-Effects Linear Model, Francisco J. Diaz, Myladis R. Cogollo, Edoardo Spina, Vincenza Santoro, Diego M. Rendon, Jose De Leon

Psychiatry Faculty Publications

This article investigates drug dosage individualization when the patient population can be described with a random-effects linear model of a continuous pharmacokinetic or pharmacodynamic response. Specifically, we show through both decision-theoretic arguments and simulations that a published clinical algorithm may produce better individualized dosages than some traditional methods of therapeutic drug monitoring. Since empirical evidence suggests that the linear model may adequately describe drugs and patient populations, and linear models are easier to handle than the nonlinear models traditionally used in population pharmacokinetics, our results highlight the potential applicability of linear mixed models to dosage computations and personalized medicine.

Fibrinogen, Chronic Obstructive Pulmonary Disease (Copd) And Outcomes In Two United States Cohorts, Deepa Valvi, David M. Mannino, Hana Müllerova, Ruth Tal-Singer

Preventive Medicine and Environmental Health Faculty Publications

BACKGROUND: Fibrinogen is a marker of systemic inflammation and may be important in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD).

METHODS: We used baseline data from Atherosclerosis Risk in Communities and Cardiovascular Health Studies to determine the relation between fibrinogen levels and COPD and to examine how fibrinogen levels at baseline affected outcomes of death, development of COPD, lung function decline, and COPD-hospitalizations.

RESULTS: Our study sample included 20,192 subjects, of whom 2995 died during the follow-up period. The mean fibrinogen level was 307.6 mg/dL and 10% of the sample had levels >393.0 mg/dL. Subjects with Stage …

Inverse Relationship Between Psa And Il-8 In Prostate Cancer: An Insight Into A Nf-Κb-Mediated Mechanism, Yong Xu, Daret K. St. Clair, Fang Fang, William H. St. Clair

Toxicology and Cancer Biology Faculty Publications

Background: Prostate specific antigen (PSA) is traditionally used as an indicator for the presence of prostate cancer (PCa) and radiotherapy is generally used to treat inoperable and locally advanced PCa. However, how cellular PSA level is associated with sensitivity of PCa to radiotherapy is unknown. The previous finding that the RelB-based NF-κB alternative pathway differentially regulates PSA and interleukin-8 (IL-8) in aggressive PCa has directed our attention to the role of RelB in the response of PCa to radiotherapy.

Methodology/Principal Findings: RelB and its targets PSA and IL-8 in PCa cells were manipulated by ectopic expression in PCa …

Smoking On The Margins? Assessing The Effects Of A Smoke-Free Law In Parks And On Beaches, Ann Pederson, Chizimuzo T.C. Okoli, Wendy Rice, Steve Chasey, Arezu Moshrefzadeh, Joan L. Bottorff, Natalie Hemsing, Lorraine Greaves, Nancy Poole

Nursing Presentations

This study uses a health equity lens to examine the development, adoption and implementation of an outdoor smoke-free bylaw in Vancouver, BC, Canada. The study aims to:

• Understand the health and health equity effects of a new outdoor smoke-free policy in parks and on beaches;

• Assess the differential impacts of the policy for diverse groups of women and men, in particular those with a high prevalence and susceptibility to smoking and those who are exposed to secondhand smoke (SHS);

• Develop recommendations to enhance the effectiveness of future smoke-free policies to reduce any unintended contributions to health inequities arising from their …

Effects Of A Smoke-Free Law In Parks And Beaches On Smoking Behaviour: Methods To Determine Effectiveness, Chizimuzo T.C. Okoli, Ann Pederson, Steve Chasey, Anna Liwander, Andrew Johnson

Nursing Presentations

OVERVIEW

As part of a comprehensive approach to tobacco control, smoke free laws have resulted in reductions of indoor air pollution, improvements in respiratory and cardiovascular health, reduction of smoking uptake by youth, and increasing tobacco use cessations in various jurisdictions.

Although many studies have demonstrated the beneficial effects of smoke-free policies in indoor spaces (e.g. restaurants, bars, workplaces, hospital settings, etc.), little is known about the effectiveness of such policies in outdoor public spaces.

On September 1^st, 2010, Vancouver’s smoke-free by-law for the city’s parks, beaches, and facilities came into effect.

The aims of this study are …

Forage News [2012-03], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Alfalfa Conference
• Kentucky Alfalfa Awards
• Alfalfa Hay Awards
• Kentucky Grazing School
• Cool Season Grass Workshop May 16th
• Attend the AFGC Summer Tour - May 17-18
• Saturated Fat and Cholesterol: Health Hazards or Vital Nutrients?
• Hay Contest Rules and Information
• The Relationship of Yield and Digestibility in Commonly Used Summer Annual Grasses
• Determining the Effect of Mowing Height and Fertility on Orchardgrass Yield and Persistence
• Extension's Response to the Fescue Endophyte Problem

Lower Gastrointestinal Bleeding And Paroxetine Use: Two Case Reports, Hilario Blasco-Fontecilla, Jose De Leon

Psychiatry Faculty Publications

Paroxetine is a selective serotonin reuptake inhibitor (SSRI), and an effective long-term treatment for social anxiety and major depression. SSRIs in general, and paroxetine in particular, were described as associated with depletion of serotonin in platelets. Serotonin is involved in platelet aggregation, and the association of bleeding and SSRI use was suggested two decades ago. In the last few years, some reviews have confirmed that initial fear. In contrast with aspirin, SSRIs seem to be related to non-ulcer, non-variceal gastrointestinal bleeds. SSRIs are usually associated with upper gastrointestinal bleeding but there is surprisingly little literature on lower gastrointestinal bleeding (LGIB) …

Equity, Evidence & Ethics: Assessing The Implications Of Outdoor Smoke-Free Policies For Vulnerable Populations, Natasha Jategaonkar, Ann Pederson, Chizimuzo T.C. Okoli, Wendy Rice, Phoebe M. Long, Joan L. Bottorff, Natalie Hemsing, Lorraine Greaves

Nursing Presentations

Smoke-free policies in outdoor settings are becoming increasingly common. Economic and social conditions tend to influence tobacco use patterns as well as exposure to secondhand smoke. Thus, active and passive smoking are both health equity and social justice concerns.

Smoking on the Margins is a multi-component,mixed-methods project that applies an ethical framework to outdoor smoke-free policies in order to identify both concerns and opportunities to promote health and health equity.

Justification for smoke-free policies

Smoke-free spaces are primarily justified on the basis of three goals:

1) Reducing exposure to secondhand smoke;

2) Encouraging people to quit smoking; and

3) Preventing …

Outcomes Of A Tailored Smoking Cessation Program For Individuals With A Substance Use And/Or Psychiatric Disorder, Chizimuzo T.C. Okoli, Milan Khara

Nursing Presentations

BACKGROUND: Tobacco use remains a significant cause of morbidity and mortality globally. Although there has been a steady decline in the overall smoking prevalence in North America during the last decade some subsets of the population continue to smoke at high rates, particularly individuals with a history of substance use disorders (SUD) and/or psychiatric disorders (PD). Studies suggest that individuals with SUD’s and PD’s often have disproportionately higher smoking-related mortality. Studies further suggest that in clinical samples an estimated 75% of individuals with PD and up to 90% of individuals with PD concurrently smoke. This high prevalence of smoking among …

The Economic, Institutional, And Political Determinants Of Public Health Delivery System Structures, Richard C. Ingram, F. Douglas Scutchfield, Glen P. Mays, Michelyn W. Bhandari

Preventive Medicine and Environmental Health Faculty Publications

OBJECTIVES: A typology of local public health systems was recently introduced, and a large degree of structural transformation over time was discovered in the systems analyzed. We present a qualitative exploration of the factors that determine variation and change in the seven structural configurations that comprise the local public health delivery system typology.

METHODS: We applied a 10-item semistructured telephone interview protocol to representatives from the local health agency in two randomly selected systems from each configuration--one that had maintained configuration over time and one that had changed configuration over time. We assessed the interviews for patterns of variation between …

Developing And Implementing Strategies To Address “Freddie Freeroader”, David Q. Hunsucker, Mark S. Spellman, Mark Bell

Kentucky Transportation Center Research Report

Although the majority Kentucky’s citizens pay their fair share of motor vehicle registration taxes, there are indications that a number of citizens evade motor vehicle property and usage tax through a variety of means. Some individuals license their cars in states that have no, or very low, property taxes on motor vehicles; others abuse the use of temporary tags, or simply fail to renew the registration on their vehicles. As a result, Kentucky is losing income that would be used to repair the state’s roadways and fund local services such as schools, libraries, health departments, and police and fire services. …

Interactions Between Antiepileptics And Second-Generation Antipsychotics, Jose De Leon, Vincenza Santoro, Concetta D'Arrigo, Edoardo Spina

Psychiatry Faculty Publications

INTRODUCTION: Pharmacokinetic and pharmacodynamic drug interactions (DIs) can occur between antiepileptics (AEDs) and second-generation antipsychotics (SGAPs). Some AED and SGAP pharmacodynamic mechanisms are poorly understood. AED-SGAP combinations are used for treating comorbid illnesses or increasing efficacy, particularly in bipolar disorder.

AREAS COVERED: This article provides a comprehensive review of the interactions between antiepileptics and second-generation antipsychotics. The authors cover pharmacokinetic AED-SGAP DI studies, the newest drug pharmacokinetics in addition to the limited pharmacodynamic DI studies.

EXPERT OPINION: Dosing correction factors and measuring SGAP levels can help to compensate for the inductive properties of carbamazepine, phenytoin, phenobarbital and primidone. Further studies …

Americans' Unwillingness To Pay Taxes Before The American Revolution: An Uncomfortable Legacy, Richard A. Westin

Law Faculty Scholarly Articles

When one reflects on the sorry condition of America’s finances one has to wonder why there is such resistance to fiscal discipline. Is it merely because there is an obstreperous group in the US Congress who cannot abide any tax? Has the public been subtly lobbied into believing that American taxes are high, pointless and intolerable or is there some gene in the America’s body politic that has always been there that expresses itself from time to time in a pernicious cheapness? Perhaps all those things are true, or perhaps none. Nevertheless, a glance backward at Colonial days can stimulate …

Gender Identity, Ethnic Identity, And Smoking Among First Nations Adolescents, Lorraine Greaves, Joy Johnson, Annie Qu, Chizimuzo T.C. Okoli, Natalie Hemsing, Lucy Barney

Nursing Faculty Publications

Smoking rates among Aboriginal adolescents are the highest of any population group in British Columbia, Canada. Recent studies suggest that substance use is affected by gender and ethnic identity among youth. The purpose of our study was to explore the association of gender and ethnic identity with smoking behaviour among First Nations adolescents. This study is based on a convenience sample (i.e., an on-hand, readily available sample) of 124 youth (123 First Nations and 1 Métis) recruited at youth drop-in centres, health fairs, and cultural activities. We obtained information on demographics, smoking history, Bem Sex Role Inventory (BSRI), composite measure …

Estimating Medical Cost Offsets Attributable To Public Health Spending, Glen P. Mays

Health Management and Policy Presentations

Uncertainty about the magnitude and timing of economic returns associated with spending on public health services has contributed to policy debates about the optimal role of the federal government in financing these services.

A Perspective On The Design And Development Of The Spacex Dragon Spacecraft Heatshield, Daniel J. Rasky

Ablation Workshop

In December, 2010, Space Exploration Technologies (SpaceX) successfully orbited, re-entered and recovered their Dragon spacecraft, on an almost “picture perfect” first full mission. Earlier in 2009, SpaceX, announced the passing of a significant technical milestone with the successful arc jet testing of a their new high performance heat shield material, called PICA-X, which provided the primary (forebody) thermal protection for Dragon.

In 2008 and 2009, Dr. Rasky worked closely with SpaceX on the Dragon heatshield design and also developing the ability to manufacture PICA-X. The “X” stands for the SpaceX-developed variants that have several improved properties and greater ease of …

Preparing Nasa For The 21st Century: Oct Perspective On Edl, Harry Partridge

Ablation Workshop

NASA’s Chief Technologist, within the Office of the Chief Technologist (OCT), is the principal advisor to the NASA Administrator in matters related to Agency-wide technology policy and programs and is responsible for the planning, advocacy and coordination of technology development activities within NASA to meet future mission needs. OCT works with the Mission Directorates and mission planners to infuse new technologies into future missions and with other Governmental Agencies to coordinate technology development efforts of mutual interest. In addition, OCT manages NASA’s Space Technology Program (STP), which also includes the SBIR and STTR programs. In this presentation OCT’s role within …

Alteration Of Tobacco Alkaloid Content Through Modification Of Specific Cytochrome P450 Genes, Ralph E. Dewey, Balaz Siminszky, Steven W. Bowen, Lily Gavilano

Plant and Soil Sciences Faculty Patents

Compositions and methods for reducing the level of nornicotine and N′-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in …

Use Of Parthenolide Derivatives As Antileukemic And Cytotoxic Agents, Peter A. Crooks, Craig T. Jordan, Xiaochen Wei

Pharmaceutical Sciences Faculty Patents

To view this abstract, please download this patent.

Glycoinositolphospholipids From Leishmania Braziliensis And L. Infantum: Modulation Of Innate Immune System And Variations In Carbohydrate Structure, Rafael Ramiro Assis, Izabela Coimbra Ibraim, Fátima Soares Noronha, Salvatore J. Turco, Rodrigo Pedro Soares

Molecular and Cellular Biochemistry Faculty Publications

The essential role of the lipophosphoglycan (LPG) of Leishmania in innate immune response has been extensively reported. However, information about the role of the LPG-related glycoinositolphospholipids (GIPLs) is limited, especially with respect to the New World species of Leishmania. GIPLs are low molecular weight molecules covering the parasite surface and are similar to LPG in sharing a common lipid backbone and a glycan motif containing up to 7 sugars. Critical aspects of their structure and functions are still obscure in the interaction with the vertebrate host. In this study, we evaluated the role of those molecules in two medically important …

A Special Issue On Dna Damage Response And Genome Stability, Guo-Min Li

Markey Cancer Center Faculty Publications

No abstract provided.

Krüppel-Like Factor 4 Regulates Intestinal Epithelial Cell Morphology And Polarity, Tianxin Yu, Xi Chen, Wen Zhang, Juan Li, Ren Xu, Timothy C Wang, Walden Ai, Chunming Liu

Markey Cancer Center Faculty Publications

Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine. In normal intestine, KLF4 is predominantly expressed in the differentiated epithelial cells. It has been identified as a tumor suppressor in colorectal cancer. KLF4 knockout mice demonstrated a decrease in number of goblet cells in the colon, and conditional ablation of KLF4 from the intestinal epithelium led to altered epithelial homeostasis. However, the role of KLF4 in differentiated intestinal cells and colon cancer cells, as well as the mechanism by which …

Marketing Quality Hay, Tom Keene

Kentucky Alfalfa and Stored Forage Conference

When marketing quality alfalfa hay, you basically have two markets that you are going to try to target. First, you are going to be in the cash hay market, that’s where you will sell alfalfa hay to several different entities…..locally, statewide, nationally, or potentially internationally. Secondly, and more commonly, you will be marketing your hay to your own livestock enterprise on your farm. Several times every month, I have people call me and ask me what their hay is worth. I tell them very honestly I have no idea what their hay is worth; only by keeping track of their …

Active Site Mutations Change The Cleavage Specificity Of Neprilysin., Travis Sexton, Lisa J. Hitchcook, David W. Rodgers, Luke H. Bradley, Louis B. Hersh

Molecular and Cellular Biochemistry Faculty Publications

Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides. We have generated a series of neprilysin variants containing mutations at either one of two active site residues, Phe⁵⁶³ and Ser⁵⁴⁶. Among the mutants studied in detail we observed changes in their activity towards leucine⁵-enkephalin, insulin B chain, and amyloid β_1-40. For example, NEP^F563I displayed an increase in preference towards cleaving leucine⁵-enkephalin relative to insulin B chain, while mutant NEP^S546E was less discriminating …