Digital Commons Network^™

Current Therapeutic Approaches To Equine Protozoal Myeloencephalitis, L. Dirikolu, Jonathan H. Foreman, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Equine protozoal myeloencephalitis is the most important infectious neurologic disease of horses in the Western Hemisphere. Equine protozoal myeloencephalitis can interfere with a horse's ability to race, work, and perform; untreated, EPM can be lethal. Antemortem diagnosis of EPM is challenging, requiring careful evaluation of the animal's history, clinical signs, and laboratory data, with rigorous exclusion of other causes.

Therapeutic approaches to EPM are evolving. First-generation therapeutic approaches for EPM were based on the classic anti–Toxoplasma gondii pyrimethamine–sulfonamide combinations; treatment is prolonged and can be associated with a considerable relapse rate, which may be associated with the difficulty in …

Venlafaxine-Induced Orthostatic Hypotension In A Geriatric Patient, Vidyashree Chikkaramanjegowda, Jose De Leon

Psychiatry Faculty Publications

Venlafaxine is not usually associated with risk of orthostatic hypotension. A 65-year-old US Caucasian female taking 225 mg/day of venlafaxine extended-release developed symptomatic orthostatic hypotension. The systolic and diastolic blood pressure dropped by 25 and 18 mm Hg, respectively, from supine position to standing position within 3 minutes. The patient was otherwise healthy and the orthostatic hypotension resolved with venlafaxine discontinuation. This was a probable venlafaxine adverse drug reaction according to the Naranjo scale. This case contributes to the scarce literature that indicates that clinicians need to be aware that occasionally venlafaxine can induce clinically significant orthostatic hypotension, particularly in …

Supplier Sustainability Evaluation Utilizing Multi Attribute Utility Modeling, Scott E. Ladd

Theses and Dissertations--Manufacturing Systems Engineering

Conventionally, the focus during supplier evaluation has been to assess cost, quality and delivery effectiveness due to their impact on profitability. In recent years, there has been increased emphasis on promoting more sustainable business practices that focus on reducing environmental impact and improve societal well-being, in addition to economic benefits. However, most of the existing supplier evaluation methods in literature as well as those used by leading companies fall short of comprehensively assessing suppliers from a Triple Bottom Line (TBL) perspective. TBL defined as holistically looking at the economic, environmental, and societal aspects of an entity. This paper presents a …

An Observational Study Of The Methods And Progress In Enterprise Lean Transformation At A Learning Health Care Organization, Christopher Michael Rosenbaum

Theses and Dissertations--Manufacturing Systems Engineering

The health care industry in the United States is increasingly pressured to improve safety and quality performance and increase revenue. In response, many health care institutions are moving to redesign their processes and practices in an effort to decrease costs and provide safer, higher quality, and more efficient care. The purpose of this paper is to document the Lean implementation strategy and progress in implementation at a large teaching health care organization undergoing Lean transformation in order to understand enterprise transformation strategies and the impact of leadership involvement on culture development and Lean implementation. Through direct observations and involvement and …

Multifactorial Modulation Of The Blood-Brain Barrier: Relationship To Stroke, Bei Zhang

Theses and Dissertations--Nutritional Sciences

The blood-brain barrier (BBB) is a dynamic interface, mainly consisting of highly specialized brain microvascular endothelial cells (BMECs) that segregate the central nervous system (CNS) from the peripheral circulation. Impairment of the BBB, due to disruption of tight junction (TJ) proteins and inflammatory responses, may initiate and/or contribute to the progress of CNS disorders, including stroke. Stroke is the second leading cause of death worldwide. It has been shown that aging and environmental pollutants can induce brain endothelium dysfunction, and are considered as risk factors for stroke.

Deficiency of telomerase is highly linked with aging-associated vascular diseases. Evidence indicates that …

Polychlorinated Biphenyl Ligands Of The Aryl Hydrocarbon Receptor Promote Adipocyte-Mediated Diabetes, Nicki A. Baker

Theses and Dissertations--Nutritional Sciences

Numerous epidemiology studies suggest a correlation between exposures to polychlorinated biphenyls (PCBs) and the development and severity of type 2 diabetes (T2D); however, mechanisms remain largely unknown. Previous studies demonstrated that PCBs that are ligands of the aryl hydrocarbon receptor (AhR) promote the expression of proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), that are linked to insulin resistance in adipocytes. To explore potential mechanisms linking PCB exposures to diabetes, we developed a mouse model of glucose and insulin intolerance induced by acute and chronic exposures to PCB-77. We hypothesized that PCB ligands of AhR result in adipocyte-specific elevations in TNF-α …

Coplanar Pcb-Induced Inflammation And Dietary Interventions, Katryn Elizabeth Eske

Theses and Dissertations--Nutritional Sciences

Diseases, such as cardiovascular disease (CVD), are linked to chronic low levels of inflammation. This inflamed state is the product of risk factors including exposure to environmental pollutants, such as polychlorinated biphenyls (PCBs), which are correlated with increased risk for CVD and diabetes. In response to this health risk, our research addresses the mechanisms by which coplanar PCBs elicit an inflammatory response and the mitigation of PCB-induced inflammation through dietary intervention using docosahexaenoic acid (DHA), an omega-3 lipid. Investigators from the University of Kentucky Engineering Department are developing remediation technologies that detoxify PCBs through dechlorination. We studied the cellular toxicity …

Novel Insights Into The Function And Regulation Of Group X Secretory Phospholipase A2, Joseph D. Layne Jr

Theses and Dissertations--Nutritional Sciences

Group X secretory phospholipase A₂ (GX sPLA₂) hydrolyzes membrane phospholipids producing free fatty acids and lysophospholipids. Previous studies from our lab suggest that mice with targeted deletion of GX sPLA₂ (GX KO) have increased age-related weight gain due to an increase in overall adiposity. Paradoxically, this increased adiposity is associated with improved age-related glucose intolerance. GX KO mice also demonstrate a reduced inflammatory response to lipopolysaccharide injection. In vitro studies indicate this phenotype may be attributable to blunted macrophage mediated inflammatory responses. Given the role of macrophages in promoting adipose tissue (AT) inflammation and metabolic dysfunction …

Kentucky Water Resources Research Institute Annual Technical Report Fy 2012, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Annual Technical Reports (USGS’s 104b Grant Program)

The 2012 Annual Technical Report for Kentucky consolidates reporting requirements for the Section 104(b) base grant award into a single document that includes; 1) a synopsis of each research project that was conducted during the period, 2) citations for related publications, reports, and presentations, 3) a description of information transfer activities, 4) a summary of student support during the reporting period, and 5) notable awards and achievements during the year.

A Summary Of The Kentucky River Watershed Watch 2013 Water Sampling Results, Kentucky Water Resources Research Institute

Kentucky River Watershed Watch

No abstract provided.

White Screen/White Noise: Racism And The Internet, Rebecca Martin, Heather Mccann, Myrna E. Morales, Stacie M. Williams

Library Faculty and Staff Publications

The Internet is critical for disseminating information, but it does not discriminate against information it carries. Hate speech and racist representations proliferate in social media, online news comment sections and community forums. What can information workers do to counteract those messages? How can critical race consciousness enhance on- and off-line library services? This article attempts to explore how information in the age of rapid technology innovation contributes to structural racism and what librarians and other information professionals can do about it.

An Exploratory Study Of User-Centered Indexing Of Published Biomedical Images, Sujin Kim

Pathology and Laboratory Medicine Faculty Publications

User-centered image indexing—often reported in research on collaborative tagging, social classification, folksonomy, or personal tagging—has received a considerable amount of attention [1-7]. The general themes in more recent studies on this topic include user-centered tagging behavior by types of images, pros and cons of user-created tags as compared to controlled index terms; assessment of the value added by user-generated tags, and comparison of automatic indexing versus human indexing in the context of web digital image collections such as Flickr. For instance, Golbeck's finding restates the importance of indexer experience, order, and type of images [8]. Rorissa has found a significant …

Peripheral T-Cell Lymphoma With Aberrant Expression Of Cd19, Cd20, And Cd79a: Case Report And Literature Review, Rahul G. Matnani, Rachel L. Stewart, Joseph Pulliam, Chester D. Jennings, Melissa Kesler

Pathology and Laboratory Medicine Faculty Publications

A case of lymphoma of T-cell derivation with aberrant expression of three B-cell lineage markers (CD19, CD20, and CD79a), which was diagnosed on a left axillary excision, is described. Immunohistochemical studies and flow cytometry analysis demonstrated neoplastic cells expressing CD3, CD19, CD20, and CD79a with absence of CD4, CD8, CD10, CD30, CD34, CD56, CD68, TDT, MPO, PAX-5, and surface immunoglobulin. Gene rearrangement studies performed on paraffin blocks demonstrated monoclonal T-cell receptor gamma chain rearrangement with no evidence of clonal heavy chain rearrangement. The neoplastic cells were negative for Epstein-Barr virus (EBV) or Human Herpes Virus 8 (HHV-8). At the time …

Reviving The Federal Crime Of Gratuities, Sarah N. Welling

Law Faculty Scholarly Articles

The federal crime of gratuities prohibits people from giving gifts to federal public officials if the gift is tied to an official act. Both the donor and the donee are liable. The gratuities crime is dysfunctional in two main ways. It is overinclusive in that it covers conduct indistinguishable from bribery. It is underinclusive in that it does not cover conduct that is clearly dangerous: gifts to public officials because of their positions that are not tied to a particular official act.

This Article argues that Congress should extend the crime of gratuities to cover gifts because of an official’s …

A New Millennium: A New Age Of Behavioral Disorders?, Artemis Tsitsika, Mari Janikian, Donald E. Greydanus, Hatim A. Omar, Joav Merrick

Pediatrics Faculty Publications

The internet has become one of the most widely accessible media and is a significant part of everyday life in adolescence, offering opportunities for social networking and communication, education and entertainment. However, over the past decade a specific behavioral pattern has been researched in respect to Internet use, leading to isolation and neglect of everyday activities, social life –even personal health in general. The phenomenon has received increasing attention from the scientific community, describing it in various terms such as “excessive”, “problematic”, “pathological”, “addictive” use among others.

European research on Internet addictive behavior have been conducted in the past years …

Bioavailability Of Manufactured Nanomaterials In Terrestrial Ecosystems, Jonathan D. Judy

Theses and Dissertations--Plant and Soil Sciences

Manufactured nanomaterials (MNMs) from the rapidly increasing number of consumer products that contain MNMs are being discharged into waste streams. Increasing evidence suggests that several classes of MNMs may accumulate in sludge derived from wastewater treatment and ultimately in soil following land application as biosolids. Little research has been conducted to evaluate the impact of MNMs on terrestrial ecosystems, despite the fact that land application of biosolids from wastewater treatment will be a major pathway for the introduction of MNMs to the environment. To begin addressing this knowledge gap, we have conducted a series of experiments designed to test how …

Evaluating The Sustainability Of Four Organic Vegetable Production Systems, Delia W. Scott

Theses and Dissertations--Plant and Soil Sciences

A field study evaluating the sustainability of four organic vegetable production systems was conducted in Lexington, Kentucky in 2006 and 2007. The four systems included no-till, raised beds covered with biodegradable black mulch, bare ground with shallow cultivation, and bare ground with shallow cultivation and wood chip mulch. The two-year study compared yield, weed control, labor, and costs associated with each system, as well as physical, chemical, and microbiological soil characteristics. In 2006, tomatoes (Lycopersicon esculentum Mill.) were grown in the four systems, with no significant difference in yield. Summer squash (Cucurbita pepo L.) was grown in the …

Trapped In Transition: Examining First-Semester College Students’ Discursive Struggles About Home And School, Molly A. Reynolds

Theses and Dissertations--Communication

The study examines how messages to, from, and concerning home may impact first-semester college student retention. The current study extends previous retention research in several ways. Rather than collect data regarding retention after students drop out, this study analyzed free write responses of 135 participants while they were enrolled in 15 sections of CIS 110 (Composition and Communication I) throughout the course of the Fall 2010 semester. Using relational dialectics theory (RDT) (Baxter & Montgomery, 1996) as a sensitizing framework, this study identified three discursive struggles and associated radiants of meaning present in the free write responses of these 135 …

An Exploratory Study Of Social Support For Health-Related Purposes On Weibo In China, Chen Chen

Theses and Dissertations--Communication

This study explores how people with medical concerns seek and perceive social support via Weibo—a social network site in China. The study conducts both a content analysis and an in-depth interview for a comprehensive understanding of the nature of social support on Weibo. Altogether 2548 postings and replies from four Weibo support groups—the Breast Cancer Group, the Arthritis Group, Baby Eczema Group and Children’s Health Group—were categorized into 9 types with a deductive thematic analysis; twenty participants from these four Weibo groups were recruited in the in-depth interview to explore how people seek and perceive social support from Weibo. Weibo …

“Advise Me!” Understanding Undergraduate Student Perceptions Of Learning In Academic Advising, Schyler Simpson

Theses and Dissertations--Communication

This dissertation is a theoretically driven empirical analysis of instructional communication in academic advising. It explores the effects of perceived advisor accommodation on advisee learning. Specifically, it examines whether academic advisors employ accommodation communication that influence affect, cognitive learning, and behavioral learning outcomes in advisees. Four hundred and seventeen students were asked to report on their perceptions of learning through an online cross-sectional survey that addressed communication accommodation strategies employed in the advisor/advisee experience. Results show that behavioral learning (measured by intentions) was significantly predicted by advisor inquiry of school-related content (β = .391, p < .01); advisor attentiveness (β = -.169, p < .01); affect toward advising content (β = .154, p < .01); and cognitive knowledge (β = .244, p < .01)].

The Role Of Acculturation On Bosnian Refugee Adult Child Mate Selection, Emina Herovic

Theses and Dissertations--Communication

Forced by the atrocities of war from their native country, Bosnian families came to United States seeking refuge and a new life. Immigrating to a new country, however, involves the process of acculturation which can dilute many native practices. Like many refugees that immigrated, Bosnians sought to adapt to the American way of life, while keeping their traditional ethnic customs, practices, and religion (Val & Iain-Walker, 2003). Many Bosnian refugee parents worked to keep the Bosnian practices prevalent in their first and second generation Bosnian American children. By doing so, Bosnian parents imbedded into their children the original customs, practices, …

A Message-Centered Approach To Understanding Young Women’S Decision-Making About Hpv Vaccination, Katharine J. Head

Theses and Dissertations--Communication

The HPV vaccine represents an important step in the primary prevention of cervical cancer, yet uptake rates for the vaccine remain below what is needed to establish "herd immunity" from the virus. While many studies have examined both psychosocial and communication factors affecting HPV vaccination decisions, this study adopts a unique approach to understand the communication environment within which this health decision happens, such as the many and sometimes conflicting messages about vaccine efficacy and safety guiding young women's decisions. Using the message convergence framework, this project identifies how further study of converging and diverging messages in the communication environment …

Communication At Superfund Sites And The Reification Of Division: Toward A Convergence-Building Model Of Risk Communication, Anna G. Hoover

Theses and Dissertations--Communication

This case study evaluates government communication practices at Superfund sites. I describe agency communication practices in Superfund communities, paying particular attention to the U.S. Environmental Protection Agency's

Seven Cardinal Rules of Risk Communication and its role as a model for federal agencies engaged at these sites. Situating the study within a theoretical milieu that includes sensemaking and symbolic interactionism, I examine whether current practices deepen divisions among stakeholders, reducing the possibility for communicative convergence.

I implement textual analysis and narrative inquiry to examine written and spoken communication about the Paducah Gaseous Diffusion Plant National Priorities List Superfund site. Through …

Both Sides Of Our Mouths: Contemporary Legends As A Means Of Dissent In A Time Of Global Modernism, Gerald D. Abbott Jr.

Theses and Dissertations--Communication

The legend is a permanent fixture of human societies. Though the legends themselves are permanent, their functions and meanings can fluctuate as the context in which they are told and retold shifts. As societies move through history, certain authoritative institutions create narratives that direct those societies and frame debates within them. Issues neglected by these institutions yet experienced by members of the population can be said to be unconstructed. Social problems that have achieved some level of construction inevitably provoke those who dissent from those constructions.

In these situations, members of a society look for alternative means for talking about …

Organizational Response To Perceptual Risk: Managing Substantial Response To Unsubstantiated Events, Elizabeth L. Petrun

Theses and Dissertations--Communication

Analysis and perceived severity of risk influences organizational decisions to anticipated threats. As economic development and technology improve our standards of living, they also create new challenges to conceptualizing concrete and abstract threats. Organizations that face new threats, along with agencies that oversee these organizations, produce tightly coupled systems that increase risks for direct, indirect, and future stakeholders (Perrow, 1999). Natural disasters, political misbehavior, organizational corruption, financial collapse, food and water contaminations, chemical or nuclear accidents, international tension, to name a few, all present risks and challenges. Unfortunately, many of these situations endanger the lives and well-being of persons. The …

Expressions Of Concern And Social Support About Reproductive Care For Young Women On An Online Message Board, Sarah E. Riley

Theses and Dissertations--Communication

The experience of a pelvic exam or Pap smear is something that, while necessary to maintain reproductive health, can be fraught with difficulty for women. Ouj, Igberase, Exe, and Ejikeme (2011) note that “[m]ost women feel a level of discomfort or pain and for some it is embarrassing, dehumanizing, degrading and associated with fear, anxiety and apprehension” (p. 637). However, little recent research has focused on the specific communication surrounding reproductive care for young women. The Internet is a common place for young people to seek health information, understand their own health risks, and seek social support from others. The …

The Role Of The Message Convergence Framework In Obstetricians’ Clinical And Communicative Practices, Kathryn E. Anthony

Theses and Dissertations--Communication

Over the past few years, the rate of elective interventions in pregnancy in the United States, including elective inductions of labor and elective cesarean deliveries, has increased dramatically. While scholars attribute some of the increase in elective interventions to the female patients who request elective procedures from obstetricians, some literature contradicts that notion and suggests physicians are actually the primary perpetuators of the growth in elective procedures. Although pregnant women may seek elective interventions because of desired convenience, physicians can also claim the benefit of convenience in scheduling deliveries. In addition, elective procedures provide physicians greater monetary compensation than labor …

Marijuana Behaviors In The Arabian Gulf (Gcc): Applying Theory Of Planned Behavior, Nola Almageni

Theses and Dissertations--Communication

The theory of planned behavior is a great tool for understanding predictors of drug use, specifically marijuana. Although the theory has been applied in the U.S. and European context, research on the predictors of behavioral intention for marijuana use within the Arabian Gulf context is limited. This thesis provides an overview of the theory of planned behavior as used in the U.S. and European context. An argument for the need to better understand predictors of behavioral intentions to use drugs, in the Arabian Gulf Region, prior to developing interventions and preventions is presented. Data was collected from 95 participants between …

Development Of 15 Psi Safe Haven Polycarbonate Walls For Use In Underground Coal Mines, Rex Allen Meyr Jr.

Theses and Dissertations--Mining Engineering

Following three major mining accidents in 2006, the MINER Act of 2006 was enacted by MSHA and required every underground coal mine to install refuge alternatives to help prevent future fatalities of trapped miners in the event of a disaster. The following research was performed in response to NIOSH’s call for the investigation into new refuge alternatives. A 15 psi safe haven polycarbonate wall for use in underground coal mines was designed and modeled using finite element modeling in ANSYS Explicit Dynamics. The successful design was tested multiple times in both half-scale and small scale using a high explosive shock …

Economic Optimization And Precision Agriculture: A Carbon Footprint Story, Rachael M. Brown

Theses and Dissertations--Agricultural Economics

This thesis examines the economic and environmental impacts that precision agriculture technologies (PATs) can have on the carbon footprint of a grain farm. An analysis is offered using two manuscripts. The first examines the impacts of three PATs and compares the findings to a conventional farming method. It was found that all three PATs investigated showed a potential Pareto improvement over conventional farming. The second manuscript expanded the model used previously to in order to develop a process to construct a carbon efficient frontier (CEF). The model employed examined uniform and variable rate technologies. In addition to the CEF, a …