Digital Commons Network^™

Formation Of A Prism-Focused Working Group To Address Mcrs Issues And Expanded Prism Requirements, Brian Howell, Robin Baskette, Jennifer Walton

Kentucky Transportation Center Research Report

This study, sponsored by the International Registration Plan (IRP), Inc. in partnership with the Kentucky Transportation Center (KTC), examined systemic challenges and opportunities to strengthen two critical safety oversight mechanisms in U.S. commercial vehicle operations—the Motor Carrier Responsible for Safety (MCRS) and the Expanded Performance and Registration Information Systems Management (PRISM) program. The research traced the evolution of federal and state data systems used to identify and monitor carriers, emphasizing the modernization role of the IRP Data Repository (IDR). The IDR now provides a secure, centralized platform for daily vehicle registration data and financial transactions, facilitating the exchange of carrier …

Kentucky Model Minimum Uniform Crash Criteria (Mmucc) Sixth Edition Report Card, William Staats, Nikiforos Stamatiadis, Eric Green, Nathaniel Swallom

Kentucky Transportation Center Research Report

The National Highway Traffic Safety Administration published the Model Minimum Uniform Crash Criteria (6th Edition) (MMUCC) in 2024. This updated version of the MMUCC contains recommendations for improving and standardizing electronic crash data. Its guidelines address the collection and presentation of 105 data elements and 1,056 data attributes. To facilitate a possible redesign of Kentucky’s crash reporting process, Kentucky Transportation Center (KTC) researchers reviewed the updated criteria and evaluated the degree to which the state complies with its recommended methods of gathering, storing, and presenting crash data. At the level of data elements, Kentucky is 25 percent compliant; for data …

Multidimensional Biocircuitry Of Exercise Adaptation, Jeremy S. Mcadam, Zachary A. Graham, S. Craig Tuggle, Kaleen M. Lavin, Marcas M. Bamman, Jeremy S. Mcadam, Zachary A. Graham, Brandon Peoples, Regina S. Seay, Kaleen M. Lavin, Amber B. Gargus, Sufen Yang, Samia M. O’Bryan, Devin J. Drummer, Christian J. Kelley, Margaret B. Bell, Inmaculada Aban, Gary R. Cutter, Marcas M. Bamman, Michael P. Craig, Jin Zhang, Akshay Hira, Timothy J. Broderick, Madhavi P. Kadakia, Zachary A. Graham, Kalyani Peri, Margaret B. Bell, Inmaculada Aban

Physiology Faculty Publications

In a randomized, dose-response trial, we used molecular and phenomic profiling to compare responses with traditional moder ate-intensity endurance and resistance training (TRAD) versus high-intensity tactical training (HITT) that encompassed explosive whole-body interval training and high-intensity resistance training. Ninety-four participants (18–27 yr) completed 12 wk of TRAD or HITT followed by 4 wk of detraining. Although similar performance and body composition improvements were observed in response to HITT and TRAD, some dose-dependent differences were observed for: 1) ex vivo muscle tissue changes in myofiber size, capillarization, satellite cell frequency, and mitochondrial function and 2) differential gene expression (DGE) of muscle …

Satellite Cells Choreograph An Immune Cell-Fibrogenic Cell Circuit During Mechanical Loading In Geriatric Skeletal Muscle, Nicholas T. Thomas, Camille R. Brightwell, Allison M. Owen, Alexander R. Keeble, Sabin Khadgi, Yuan Wen, Christopher S. Fry, Kevin A. Murach

Physiology Faculty Publications

Muscle stem cells, or satellite cells (SCs), decline in number throughout the lifespan and may become senescent in very old age. Whether and how remaining SCs contribute to muscle adaptation in the oldest-old is unclear. Using acute mechanical overload in geriatric SC replete and depleted mice (28-month-old) combined with single-cell RNA-sequencing, we show: (i) subsets of geriatric SCs display signs of senescence as well as normal fate progression during overload, (ii) SCs express markers that may contribute to the regulation of innervation, (iii) the presence of SCs during overload enhances global intercellular communication and increases mRNA levels of the cell …

Noncontact Diffuse Optical Imaging Of Blood Flow And Oxygenation Distributions In Reconstructive Rat Skin Flaps, Samaneh Rabienia Haratbar, Fatemeh Hamedi, Mehrana Mohtasebi, Faraneh Fathi, Faezeh Akbari, Dara Singh, L. I.U. Xuhui, Li Chen, Lesley Wong, Lei Chen, Guoqiang Yu

Surgery Faculty Publications

Perioperative identification of ischemic-hypoxic tissue is essential for reducing the risk of mastectomy skin flap necrosis (MSFN), a major complication following mastectomy. Implant-based breast reconstruction is jeopardized in the presence of MSFN. However, existing technologies are limited by depth insensitivity, dye-related risks, the need for contact sensors, and an inability to simultaneously assess both blood flow and oxygenation. A multi-wavelength speckle contrast diffuse correlation tomography (MW-scDCT) system was developed for noncontact, dye-free, and depth-sensitive imaging of tissue hemodynamics in a rat model incorporating four distinct flap scenarios: sham (SH), implant (IM), half necrosis (HN), and full necrosis (FN), representing varying …

Intersystem Crossing Outcompetes Triplet-Pair Separation From1(Tt) Below 270 K In Anthradithiophene Films, Eman M. Bu Ali, Arnau Bertran, Gabriel Moise, Shuangqing Wang, Rachel C. Kilbride, John E. Anthony, Claudia E. Tait, Jenny Clark

Chemistry Faculty Publications

Singlet fission (SF) and triplet–triplet annihilation (TTA) are processes which may be exploited to boost the efficiency of solar energy technology. Despite being studied since the late 1960s, the mechanism of singlet fission is still not fully understood. This is partly because the main technique used to study singlet fission, optical or visible/near-IR transient absorption spectroscopy, cannot distinguish between the strongly coupled triplet-pair state¹(TT), weakly interacting triplet pairs (T..T), and independent triplet states T₁+ T₁. To solve this problem, we combine transient optical spectroscopy performed as a function of magnetic field and transient electron …

Report On The First Year Of Operation Of Kentucky’S First Utility Wind Turbine, Lawrence E. Holloway, Sophia A. Hahn, Aron Patrick

Electrical and Computer Engineering Faculty Publications

This report examines the first year’s operational data from Kentucky’s first utility wind turbine, the 37 m hub-height 90-kilowatt NPS100C-27, operated by the PPL Corporation Research and Development at their Renewable Integration Research Facility in Mercer County, Kentucky. During that year, the turbine was available 95% of the time, spinning 85% of the time, and generating power 78% of the time, and had a net capacity factor of 11%. This report analyzes the turbine performance and uses the collected wind data to project the performance of an example turbine more typical of larger commercial turbines recently installed elsewhere in the …

Data For Services For Children Of All Abilities In Libraries (Scale) Project, Maria Cahill, Denice Adkins, Bobbie Sartin Long, Derek Thomas Myles Daskalakes, Caroline Gooden, Melissa Stormont, Alicia K. Long, Carol Russell

Information Science Faculty Data

The University of Kentucky, in collaboration with the University of Missouri and Emporia State University, and in partnership with the Kentucky Department of Libraries and Archives, the State Library of Kansas, the State Library of Missouri, the Kansas State Department of Education, the Kentucky Department of Education, and the Kentucky Governor’s Office of Early Childhood, engaged in a four-year exploratory stage, multi-state, Research in Service to Practice project investigating the effectiveness of library services, practices, and behaviors effective for serving children with disabilities and/or developmental delays who span ages birth to 5-years. Aligned with the IMLS agency-level Promote Lifelong Learning …

Proto-Oncogene Hras Transcript Level And Overall Survival In Stages Ii And Iii Colorectal Cancer, Donghyun Kim, Saima Sharif, Juan Antonio Raygoza Garay, Avanish S. Bhakta, Patrick M. Boland, Michael J. Cavnar, Michelle L. Churchman, Hassan Hatoum, Lyen C. Huang, Joseph Kim, Richard Kim, Robert W. Lentz, Sarbajit Mukherjee, Mary T. O'Donnell, Benjamin Quartey, Matthew J. Reilley, Robert J. Rounbehler, Bodour Salhia, Bryan P. Schneider, Carlos H. Chan

Surgery Faculty Publications

Background: Mutational landscape is prognostic in colorectal cancer (CRC). Rat sarcoma (RAS) oncogenes, such as KRAS and NRAS, with driver mutations, portend poor survival outcomes, whereas pathologic mutations in HRAS are extremely rare, and their prognostic value remains uncertain. Methods: This retrospective study analyzed the Oncology Research Information Exchange Network (ORIEN) alliance tumor RNA-Seq data in Stages II and III CRC to investigate the association between RAS gene expression and survival outcomes. Results: High transcript levels of HRAS were associated with superior overall survival (OS). The high HRAS-associated OS benefit was most pronounced in patients with right-sided primary expressing low …

Influence Of The Age Of Chicken On The Metabolizable Energy Value Of Alfalfa Leaf Protein Concentrate, S Terapuntuwat, I Tasaki

IGC Proceedings (1977-2023)

Influence of the age of chicken on the nitrogen corrected metabolizable energy (MEn) value of alfalfa leaf protein concentrate (LPC) was investigated. Chickens of various ages were fed diets containing certain amounts of the LPC, and droppings were collected quantitatively. The MEn of the diets was determined as the difference between consumed energy and excreted energy which was corrected with retained energy as body protein. Then the MEn value of the LPC was calculated using the values of the LPC containing diets and that of cornstarch which was obtained from data for a LPC-free diet. As a result, the MEn …

A Technique To Study The Relative Merits Of Different Silage Additves, A D. Drysdale, D A. Parker

IGC Proceedings (1977-2023)

Expansion in the use of silage additives in the more difficult silage-making areas of Europe has created the need for a simple laboratory method to assess the relative values of the wide range of products now offered. A technique is described which can be used to study potential new additives and to monitor existing products. Using direct-cut lucerne(Medicago sativa) ensiled quickly it is possible to produce a high pH, poorly fermented, untreated silage and against this the relative effects of different additive treatments can be assessed. In an example discussed, lucerne of 14% dry matter (DM) and buffering capacity 44m-equiv …

An Application Of Fuzzy Cluster Analysis In The Classification Of Grazing Retrogressive Succession Stages Of The Stipa Steppe, Chen Qing Cheng

IGC Proceedings (1977-2023)

In this paper, two methods of Fuzzy Cluster Analysis-the A cut-set classification and the Interative Self-organization Data Analysis technique (ISODATA method)-are introduced to the classification of plant communities. The results show that using these methods, one may classify a number of sample quadrats obtained from vegetation mosaic which fails to possess definite lines among communities by means of random sampling rapidly and correctly. Moreover, it seems that the combination of the principal components analysis (PCA) and the ISODATA method in the classification is successful in reducing the subjective influence of the research worker and their results can be compared and …

Regulating Grass And Clover Growth With Mefludide, R J. Haggar, S P. Isaac

IGC Proceedings (1977-2023)

A three-year study on the use of mefluidide, a plant growth regulator, for suppressing seed-head production in a range of grass is reported. The first stage, involving the evaluation of a range of does and timings on up to nine grass species, indicated the potential of mefluidide applied at 150 g ha-1 in early spring to prevent the normal decline in herbage quality associated with flowering and to transfer growth from spring to mid-summer, albeit at a loss of some 30% in total dry-matter production. A supplementary investigation showed that white clover was reasonably tolerant to mefluidide treatment although a …

Using Grinding Energy Measurements For Predicting Crude Fibre Content In First Growths Of Permanent Grassland, Chr Paul, U V. Borstel, E Zimmer

IGC Proceedings (1977-2023)

The performance of a grinding energy test for the simple and rapid prediction of crude fibre content in spring growth of grassland was investigated during three successive years and its potential for deriving recommendations on appropriate cutting dates demonstrated. The grinding energy test appeared to achieve a precision comparable to that for near infrared based predictions of crude fibre reported from the literature. Prediction bias consisting in a mean 2% crude fibre underestimation was found to occur in one year presumably due to an anomalous _constellation of environmental conditions. This appeared to have affected the pattern of plant development and …

The Timing And Significance Of Mid-Crustal Shearing And Exhumation Of Amphibolite-Facies Rocks Along The Great Glen Fault Zone, Scotland, Richard D. Law, J. Ryan Thigpen, Calvin A. Mako, Andrew Kylander-Clark, Mark J. Caddick, Lowell R. Moore, Cassandra Becker, Robert E. Holdsworth, Robin A. Strachan, A. Graham Leslie

Earth and Environmental Sciences Faculty Publications

The Rosemarkie Inlier lies on the NW side of the Great Glen Fault Zone (GGFZ) and is composed of foliated and lineated Archean orthogneisses and Moine metasedimentary rocks. The mylonitic foliation strikes NE–SW (parallel to the GGFZ), dips steeply SE and contains a gently to moderately plunging mineral lineation. Microstructural and quartz c-axis fabric analyses indicate that oblique sinistral shearing occurred under amphibolite-facies conditions. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) analyses on monazite rims in the gneisses yielded ²⁰⁶Pb/²³⁸U ages of 401.8 ± 4.8 Ma (including 2 (Formula presented.) uncertainty and a propagated additional 1% …

Genetically Proxied Blood Pressure, Vascular Brain Injury, And Alzheimer's Disease Pathology, Iyas Daghlas, Michelle R. Caunca, Lincoln M.P. Shade, Malik Nassan, Kristine Yaffe, David W. Fardo, Dipender Gill

Biostatistics Faculty Publications

INTRODUCTION: Lower blood pressure (BP) is linked to reduced dementia risk, though it is uncertain whether this benefit stems solely from mitigating vascular brain injury (VBI) or also extends to directly influencing Alzheimer's disease (AD) pathology. We leveraged Mendelian randomization (MR) to assess whether lifelong lower BP is causally associated with neuropathological correlates of VBI and AD. METHODS: We identified genetic proxies for systolic and diastolic BP (n = 1,028,980) and applied them in MR analyses of post mortem neuropathological measures of VBI and AD (n = 6363–7786). RESULTS: Genetically proxied lower systolic BP associated with reduced risk of all …

At The Nexus Between Epigenetics And Senescence, Toby L. Chambers, Jaden Wells, Pieter Jan Koopmans, Francielly Morena, Zain B. Malik, Nicholas P. Greene, Antonio Filareto, Michael Franti, Patrizia Sini, Harald Weinstabl, Robert T. Brooke, Milda Milčiūtė, Juozas Gordevičius, Steve Horvath, Yuan Wen, Cory M. Dungan, Kevin A. Murach

Physiology Faculty Publications

Senescent cells emerge with aging and injury. The contribution of senescent cells to DNA methylation age (DNAmAGE) in vivo is uncertain. Furthermore, stem cell therapy can mediate “rejuvenation”, but how tissue regeneration controlled by resident stem cells affects whole tissue DNAmAGE is unclear. We assessed DNAmAGE with or without senolytics (BI01) in aged male mice (24–25 months) 35 days following muscle healing (BaCl₂-induced regeneration versus non-injured). Young injured mice (5–6 months) without senolytics were comparators. DNAmAGE was decelerated by up to 68% after injury in aged muscle. DNAmAGE was modestly but further significantly decelerated by injury recovery with …

Multiple Of The Intermountain Region, Forest Service, United States Department Of Agriculture, J S. Tixier, A H. Winward

IGC Proceedings (1977-2023)

Initial custodians of the National Forests of the United States were primarily concerned about protecting what were perceived as deteriorating timber stands and watersheds. Con­siderable progress was made in correcting these problems in the first half of this Century. As the population of the United States grew, more people became interested in management of all resources on these public lands. Forest Officers gradually became stewards managing a broad array of lands and resources for which there were often conflicting interests and uses. A primary use of National Forests in the Western United States has been livestock grazing. Here, animals are …

Agronomic Methods To Increase Pastureland Production In Mediterranean Marginal Areas, P Bullitta, Simonetta Bullitta, P P. Roggero

IGC Proceedings (1977-2023)

Sardinian pasturelands covering 1.200.000 ha represent nearly the 50 % of the island surface and are the most import­ant resource for animal feeding. Pastureland productivity is scarce, annual dry matter ranging from 6 to 12 q ha-1. Low pro­duction is mainly due to climate, scarce deepness and type of soils and by competition of mediterranean shrubs, mainly Cistus spp. that infests nearly 500.000 ha with a percentage of covering ranging from 20 to 100 % . The control of Cistus is normally done by means of fire and by ploughing but results are poor because a correct management of the …

Diagnostics Des Conduites De Paturage Tournant Et Continu Chargement, Hauter D'Herbe Et Jours D'Avance, J L. Fiorelli, J Husson, B Lavalette, E Vaubernier

IGC Proceedings (1977-2023)

L'efficacite d'une conduite de paturage reside dans son apti­tude a favoriser la production animale au moyen, notamment, de la mise a la disposition du troupeau d'une ressource herbacee la moins limitante possible (en quantite et en qualite) par rapport au potentiel de production des animaux et ce, le plus longtemps et le plus regulierement possible durant la periode de vegetation. Si le resultat zootechnique est generalement assez aisement evaluable, par contre les modalites de conduite du paturage ne sont que fort peu considerees. En consequence, aucun diagnos­tic ne peut etre correctement etabli et les recommendations d'amelioration eventuelle restent le plus …

Efficiency Measurement Of Pasture Use On Dairy Farms, G J. Piggot, D G. Clayton

IGC Proceedings (1977-2023)

Dairy farmers in northern regions of New Zealand look to Ruakura Research Station to provide them with technical information on farm production. Ruakura farms are outstand­ing examples of fully pasturefed dairy technology. In regions distant from the research station, such as Northland, parochial attitudes inhibit the complete extension of research station results. The project described here aimed to examine the current management practices on typical dairy farms in North­land. By identifying differences between Northland farms and Ruakura research farms, corrective management strategies could be recommended in order to increase dairy farm efficiency in the region.

Corn Stover In Comparison With Pasture Hay For Beef Production In Temperate Areas Of Argentina, J A. Josifovich, J Carrete

IGC Proceedings (1977-2023)

The amount of corn stover left in the fields after the harvest in the humid Pampa of Argentina can be estimated in 18 mil­lions tons. Even large part of these residues are grazed by bovines, in general this is done in fall, after harvest, during short periods (Josifovich, 1975), (Maddaloni, 1981), (Fattet, 1981). Part of this large amount of forage can be transferred to winter as large round bales. The efficiency of these reserves can be more useful in winter, during the dry season. Due to low quality these residues can't be used alone, with confined anim­als (Jackson, 1978; Maddaloni …

Production De Viande Bovine Et Ovine Sur Prairie Dans Les Monts Sudetes, Janina Fatyga

IGC Proceedings (1977-2023)

Par suite du depeuplement des villages et de !'abandon de la culture dans des zones situees en altitude dans !es Sudetes, on y observe l'accroissement de la superficie des paturages perma­nents. Des 1968, on y cree des zones de pature OU en ete de jeu­nes bovins et des ovins provenant des fermes situees plus bas sont conduits en permanence. L'importance du phenomene est illustre par le fait qu'a present, sur le terrain d'une seule region de Walbrzych, il y a 103 bases de pature d'une superficie de 7.000 ha, appartenant a 54 fermes d'etat ou paissent environ 25.000 ovins et …

Glacial Erosion And History Of Inglefield Land, Northwestern Greenland, Caleb K. Walcott-George, Allie Balter-Kennedy, Jason P. Briner, Joerg M. Schaefer, Nicolás E. Young

Earth and Environmental Sciences Faculty Publications

We used mapping of bedrock lithology, bedrock fractures, and lake density in Inglefield Land, northwestern Greenland, combined with cosmogenic nuclide (¹⁰Be and ²⁶Al) measurements in bedrock surfaces, to investigate glacial erosion and the ice sheet history of the northwestern Greenland Ice Sheet. The pattern of eroded versus weathered bedrock surfaces and other glacial erosion indicators reveal temporally and spatially varying erosion under cold- and warm-based ice. All of the bedrock surfaces that we measured in Inglefield Land contain cosmogenic nuclide inheritance with apparent ¹⁰Be ages ranging from 24.9 ± 0.5 to 215.8 ± 7.4 ka. The …

Measurement Of Moisture Levels In Oils And Lubricants Using A Novel Moisture Sensor, Aaron Swartz, Ronak Ali

Electrical and Computer Engineering Graduate Research

It is very challenging to measure moisture levels in oils. There is not a good method to measure it. Using the novel moisture sensor invented by Dr. Zhi David Chen, we tried various methods to measure the moisture levels in oils. The initial trials are to immerse the sensor chip into the oils to see any sensor reading changes with the change of moisture levels in oils. It was observed that the sensor reading was unstable even after immersion into the oil for two weeks. The idea for immersion of the sensor chip into the oils failed due to the …

The Rhetoric Of Responsibilization: A Rhetorical Analysis Of Pre-Exposure Prophylaxis Campaigns For Hiv Prevention, Catherine M. Pabalate

Kentucky Undergraduate Journal for the Health Humanities

Responsibilization refers to the process by which patients are made accountable for their health and wellbeing, which is determined by their habits and behaviors. Though responsibilization affords greater agency to patients, it can also result in anxiety and guilt when the patient appears "deviant" or "noncompliant." Because sexual behavior is attributed to the causality of HIV/AIDS, patients’ sexual patterns and choices are included within their medical decision-making. This rhetorical analysis focuses on pharmaceutical campaigns and commercials for pre-exposure prophylaxis (PrEP), which were released between 2012 and 2024 and are targeted towards patients at-risk for HIV/AIDS. Findings suggest that specific rhetorical …

How To Gender Include, Stephen Krueger

Library Faculty and Staff Publications

Gender inclusion is not an optional part of library work—at least, it isn’t if we want all those “Libraries Are For Everyone” signs to be true. And yet, the reality is that many libraries fail the most basic aspects of gender inclusion for patrons, employees, or both. Even in libraries where Trans 101 trainings do occur and are well received, or where the baseline of knowledge among employees is relatively high, the question remains: What now?

This article intends to answer that question. Very broadly speaking, gender inclusion work in libraries means sustained action to ensure that some patrons and …

Thriving In The Tropics, Hansika K. Herath, D. Nicholas Mcletchie

Biology Faculty Publications

Increasing frequency and intensity of global warming pose a profound threat to plant species persistence. Most investigations on plants' resilience to heat events focus on few genotypes of model species. Novel insights into resilience mechanisms will be gained by focusing on natural variation in thermotolerance and its relationship to local-abiotic factors. Additionally, studying species that survived 'ancient periods' of high temperatures provides insight into resilience mechanisms. Within a species, we assessed spatial thermotolerance variation, its association with temperature and light, while testing for thermotolerance sex differences and its relationship with population sex ratios. We used Marchantia inflexa, a species with …

Hybrid Fea And Meta-Modeling For De Optimization Of A Pm Stator-Excited Motor With A Reluctance Rotor, Oluwaseun A. Badewa, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper presents an innovative method for designing high-performance electric motors by integrating machine learning (ML) based meta-modeling with a differential evolution (DE) optimization algorithm. The approach utilizes finite element analysis (FEA) data to train the ML meta-model, allowing for efficient optimization of high-power-density machines, such as the reluctance rotor and permanent magnet (PM) stator combined excitation motor, which is characterized by nonlinearities. The meta-modeling process employs an Artificial Neural Network (ANN) with 3 hidden layers and uses the motor’s geometrical variables as inputs. The accuracy of the meta-model in capturing the nonlinear relationships between design parameters, core losses, and …

Late-Nc Stage 3, Ryan K. Shahidehpour, Yuriko Katsumata, Dennis W. Dickson, Nikhil B. Ghayal, Khine Zin Aung, Xian Wu, Panhavuth Phe, Gregory A. Jicha, Allison M. Neltner, Jessalin R.C. Archer, Maria M. Corrada, Claudia H. Kawas, S. Ahmad Sajjadi, Davis C. Woodworth, Syed A. Bukhari, Thomas J. Montine, David W. Fardo, Peter T. Nelson

Biostatistics Faculty Publications

A diagnostic rubric is required to distinguish between limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). In LATE-NC Stage 3, TDP-43 proteinopathy is present in the middle frontal gyrus (MFG), thus posing a potential diagnostic challenge in differentiating these severe LATE-NC cases from FTLD-TDP. LATE-NC Stage 3 cases and other TDP-43 proteinopathies were analyzed from the University of Kentucky (total n = 514 with TDP-43 pathology assessed), The 90+ Study at the University of California Irvine (n = 458), and the Mayo Clinic (n = 5067) brain banks. Digital pathology was used to …