Digital Commons Network^™

Encephalopathy And Complex Hyperkinesia In A Patient With Severe Acute Respiratory Syndrome Coronavirus-2 Infection, Wenyang Li, Elif Pinar Coskun, Rolando Berger, John T. Slevin, L. Creed Pettigrew

Neurology Faculty Publications

No abstract provided.

Challenges When Identifying Migration From Geo-Located Twitter Data, Caitrin Armstrong, Ate Poorthuis, Matthew Zook, Derek Ruths, Thomas Soehl

Geography Faculty Publications

Given the challenges in collecting up-to-date, comparable data on migrant populations the potential of digital trace data to study migration and migrants has sparked considerable interest among researchers and policy makers. In this paper we assess the reliability of one such data source that is heavily used within the research community: geolocated tweets. We assess strategies used in previous work to identify migrants based on their geolocation histories. We apply these approaches to infer the travel history of a set of Twitter users who regularly posted geolocated tweets between July 2012 and June 2015. In a second step we hand-code …

Improving Evidence-Based Grouping Of Transitional Care Strategies In Hospital Implementation Using Statistical Tools And Expert Review, Jing Li, Gaixin Du, Jessica Miller Clouser, Arnold J. Stromberg, Glen Mays, Joann Sorra, Jane Brock, Terry Davis, Suzanne Mitchell, Huong Q. Nguyen, Mark V. Williams

Center for Health Services Research Faculty Publications

BACKGROUND: As health systems transition to value-based care, improving transitional care (TC) remains a priority. Hospitals implementing evidence-based TC models often adapt them to local contexts. However, limited research has evaluated which groups of TC strategies, or transitional care activities, commonly implemented by hospitals correspond with improved patient outcomes. In order to identify TC strategy groups for evaluation, we applied a data-driven approach informed by literature review and expert opinion.

METHODS: Based on a review of evidence-based TC models and the literature, focus groups with patients and family caregivers identifying what matters most to them during care transitions, and expert …

Intragenic Dna Methylation Regulates Insect Gene Expression And Reproduction Through The Mbd/Tip60 Complex, Guanfeng Xu, Hao Lyu, Yangqin Yi, Yuling Peng, Qili Feng, Qisheng Song, Chengcheng Gong, Xuezhen Peng, Subba Reddy Palli, Sichun Zheng

Entomology Faculty Publications

DNA methylation is an important epigenetic modification. However, the regulations and functions of insect intragenic DNA methylation remain unknown. Here, we demonstrate that a regulatory mechanism involving intragenic DNA methylation controls ovarian and embryonic developmental processes in Bombyx mori. In B. mori, DNA methylation is found near the transcription start site (TSS) of ovarian genes. By promoter activity analysis, we observed that 5′ UTR methylation enhances gene expression. Moreover, methyl-DNA-binding domain protein 2/3 (MBD2/3) binds to the intragenic methyl-CpG fragment and recruits acetyltransferase Tip60 to promote histone H3K27 acetylation and gene expression. Additionally, genome-wide analyses showed that the peak …

Wine Terroir And The Soil Bacteria: An Amplicon Sequencing-Based Assessment Of The Barossa Valley And Its Sub-Regions, Jia Zhou, Timothy R. Cavagnaro, Roberta De Bei, Tiffanie M. Nelson, John R. Stephen, Andrew Metcalfe, Matthew Gilliham, James Breen, Cassandra Collins, Carlos M. Rodríguez López

Horticulture Faculty Publications

A wines’ terroir, represented as wine traits with regional distinctiveness, is a reflection of both the biophysical and human-driven conditions in which the grapes were grown and wine made. Soil is an important factor contributing to the uniqueness of a wine produced by vines grown in specific conditions. Here, we evaluated the impact of environmental variables on the soil bacteria of 22 Barossa Valley vineyard sites based on the 16S rRNA gene hypervariable region 4. In this study, we report that both dispersal isolation by geographic distance and environmental heterogeneity (soil plant-available P content, elevation, rainfall, temperature, spacing between row …

Discussion The Signification Of Chinese Grassland Reclamation Reasons In The Historical Period, Miao Yang

IGC Proceedings (1977-2023)

No abstract provided.

Mutyh As An Emerging Predictive Biomarker In Ovarian Cancer, Megan L. Hutchcraft, Holly H. Gallion, Jill M. Kolesar

Obstetrics and Gynecology Faculty Publications

Approximately 18% of ovarian cancers have an underlying genetic predisposition and many of the genetic alterations have become intervention and therapy targets. Although mutations in MutY homolog (MUTYH) are best known for MUTYH associated polyposis and colorectal cancer, it plays a role in the development of ovarian cancer. In this review, we discuss the function of the MUTYH gene, mutation epidemiology, and its mechanism for carcinogenesis. We additionally examine its emerging role in the development of ovarian cancer and how it may be used as a predictive and targetable biomarker. MUTYH mutations may confer the risk of ovarian …

Electrical Double Layer In Nanopores For Detection And Identification Of Molecules And Submolecular Units, Guigen Zhang, Samuel Bearden

Biomedical Engineering Faculty Patents

Systems for detecting analytes in electrical double layer nanopore devices and methods of use are provided.

In Vivo Optical Metabolic Imaging Of Long-Chain Fatty Acid Uptake In Orthotopic Models Of Triple-Negative Breast Cancer, Megan C. Madonna, Joy E. Duer, Joyce V. Lee, Jeremy Williams, Baris Avsaroglu, Caigang Zhu, Riley Deutsch, Roujia Wang, Brian T. Crouch, Matthew D. Hirschey, Andrei Goga, Nirmala Ramanujam

Biomedical Engineering Faculty Publications

Targeting a tumor’s metabolic dependencies is a clinically actionable therapeutic approach; however, identifying subtypes of tumors likely to respond remains difficult. The use of lipids as a nutrient source is of particular importance, especially in breast cancer. Imaging techniques offer the opportunity to quantify nutrient use in preclinical tumor models to guide development of new drugs that restrict uptake or utilization of these nutrients. We describe a fast and dynamic approach to image fatty acid uptake in vivo and demonstrate its relevance to study both tumor metabolic reprogramming directly, as well as the effectiveness of drugs targeting lipid metabolism. Specifically, …

Protein Roughages For Growing Goats, J. B. Moura Neto, Tadeu V. Voltolini, J. N. Moreira, D. M. Nogueira, R. D. Dos Santos, Luiz G. R. Pereira

IGC Proceedings (1977-2023)

No abstract provided.

Numerical Reconstruction Of Spalled Particle Trajectories In An Arc-Jet Environment, Raghava S. C. Davuluri, Sean C. C. Bailey, Kaveh A. Tagavi, Alexandre Martin

Mechanical Engineering Faculty Publications

To evaluate the effects of spallation on ablative material, it is necessary to evaluate the mass loss. To do so, a Lagrangian particle trajectory code is used to reconstruct trajectories that match the experimental data for all kinematic parameters. The results from spallation experiments conducted at the NASA HYMETS facility over a wedge sample were used. A data-driven adaptive methodology was used to adapts the ejection parameters until the numerical trajectory matches the experimental data. The preliminary reconstruction results show that the size of the particles seemed to be correlated with the location of the ejection event. The size of …

Excess Extracellular K+ Causes Inner Hair Cell Ribbon Synapse Degeneration, Hong-Bo Zhao, Yan Zhu, Li-Man Liu

Otolaryngology--Head & Neck Surgery Faculty Publications

Inner hair cell (IHC) ribbon synapses are the first synapse in the auditory system and can be degenerated by noise and aging, thereby leading to hidden hearing loss (HHL) and other hearing disorders. However, the mechanism underlying this cochlear synaptopathy remains unclear. Here, we report that elevation of extracellular K⁺, which is a consequence of noise exposure, could cause IHC ribbon synapse degeneration and swelling. Like intensity dependence in noise-induced cochlear synaptopathy, the K⁺-induced degeneration was dose-dependent, and could be attenuated by BK channel blockers. However, application of glutamate receptor (GluR) agonists caused ribbon swelling but …

N-Type Charge Transport In Heavily P-Doped Polymers, Zhiming Liang, Hyun Ho Choi, Xuyi Luo, Tuo Liu, Ashkan Abtahi, Uma Shantini Ramasamy, J. Andrew Hitron, Kyle N. Baustert, Jacob L. Hempel, Alex M. Boehm, Armin Ansary, Douglas R. Strachan, Jianguo Mei, Chad Risko, Vitaly Podzorov, Kenneth R. Graham

Chemistry Faculty Publications

It is commonly assumed that charge-carrier transport in doped π-conjugated polymers is dominated by one type of charge carrier, either holes or electrons, as determined by the chemistry of the dopant. Here, through Seebeck coefficient and Hall effect measurements, we show that mobile electrons contribute substantially to charge-carrier transport in π-conjugated polymers that are heavily p-doped with strong electron acceptors. Specifically, the Seebeck coefficient of several p-doped polymers changes sign from positive to negative as the concentration of the oxidizing agents FeCl3 or NOBF4 increase, and Hall effect measurements for the same p-doped polymers reveal that …

Vehicle-Life Interaction In Fog-Enabled Smart Connected And Autonomous Vehicles, Bushra Feroz, Amjad Mehmood, Hafsa Maryam, Sherali Zeadally, Carsten Maple, Munam Ali Shah

Information Science Faculty Publications

Traffic accidents have become a major issue for researchers, academia, government and vehicle manufacturers over the last few years. Many accidents and emergency situations frequently occur on the road. Unfortunately, accidents lead to health injuries, destruction of some infrastructure, bad traffic flow, and more importantly these events cause deaths of hundreds of thousands of people due to not getting treatment in time. Thus, we need to develop an efficient and smart emergency system to ensure the timely arrival of an ambulance service to the place of the accident in order to provide timely medical help to those injured. In addition, …

Management Of The Sensitized Cardiac Transplantation Recipient, Michael Mazzei, Suresh Keshavamurthy, Olga Timofeeva, Yoshiya Toyoda

Surgery Faculty Publications

Preoperative sensitization of the cardiac transplant recipient, defined as the presence of anti-Human Leukocyte Antigen (HLA) antibodies before transplant, represents a significant management challenge for physicians. Sensitization prolongs the pre-transplant wait time and is associated with postoperative transplant complications and death. It is critical that sensitized heart transplant candidates be identified and optimized before surgery. In this review, we describe the risk for sensitization, discuss the means through which sensitization may be diagnosed, and highlight some of the new therapeutic options for managing the sensitized cardiac transplant patients.

2020 Kentucky Nursing Workforce Report, Sydney P. Thompson

Center of Excellence in Rural Health Infographics

No abstract provided.

Why Won’T Grandma Cross The Road? Neighborhood Perceptions And Walking Behavior Among Older Adults In Lexington, Kentucky, Sadie Middleton

Theses and Dissertations--Urban and Environmental Design

Many urban places contain subtle details that can unintentionally deter pedestrian activity. These details can be assessed through six themes: safety, comfort, pedestrian infrastructure, aesthetics, proximity, and ease of navigation. Adults over age 65 may have more concerns about walking in urban settings than people in other age groups. This study identifies urban design elements that encourage and discourage walking among older adults and makes recommendations for design improvements. Study participants (n= 67) completed an online survey about walking behaviors, perceptions of health and community, and perceptions of seven unidentified scenes of pedestrian environments in Lexington, Kentucky. Findings suggest that …

Invoking Criminal Equity's Roots, Cortney Lollar

Law Faculty Scholarly Articles

Equitable remedies have begun to play a critical role in addressing

some of the systemic issues in criminal cases. Invoked when other

solutions are inadequate to the fair and just resolution of the case,

equitable remedies, such as injunctions and specific performance,

operate as an unappreciated and underutilized safety valve that

protects against the procedural strictures and dehumanization that are

hallmarks of our criminal legal system. Less familiar equitable-like

legal remedies, such as writs of mandamus, writs of coram nobis, and

writs of audita querela, likewise serve to alleviate fundamental errors

in the criminal process. Several barriers contribute to the …

Using Landslide-Inventory Mapping For A Combined Bagged-Trees And Logistic-Regression Approach To Determining Landslide Susceptibility In Eastern Kentucky, Usa, Matthew M. Crawford, Jason M. Dortch, Hudson J. Koch, Ashton A. Killen, Junfeng Zhu, Yichuan Zhu, Lindsey Sebastian Bryson, William C. Haneburg

Faculty, Staff, and Affiliated Publications--KGS

High-resolution LiDAR-derived datasets from a 1.5 m digital elevation model and a detailed landslide inventory (n ≥ 1000) for Magoffin County, Kentucky, USA were used to develop a combined machine-learning and statistical approach to improve geomorphic-based landslide-susceptibility mapping.

An initial dataset of 36 variables was compiled to investigate the connection between slope morphology and landslide occurrence. Bagged trees, a machine-learning random-forest classifier, was used to evaluate the geomorphic variables, and 12 were identified as important: standard deviation of plan curvature, standard deviation of elevation, sum of plan curvature, minimum slope, mean plan curvature, range of elevation, sum of roughness, …

The Oil Curse Validated: Evidence From Eurasia And Latin America, Barrak Algharabali, J. S. Butler, Stacy Closson

Public Policy and Administration Faculty Publications

Many studies have found a negative relationship between oil abundance and democracy. However, recent studies have tried to upend this correlation by employing time-series techniques or finding a conditionality on other factors. This study contributes to the literature by employing an Arellano Bond model that corrects for fixed effects and adopts new variables from recent empirical studies. Comparing Eurasia and Latin America from the 1960s to 2010, we find that the theory of a negative relationship between an abundance of natural resources and democracy remains valid.

Metaphor And The Struggle Between Populism And Liberal Democracy, Daniel Cole

Theses and Dissertations--Philosophy

Populist movements have emerged the world over, appearing even in countries in which it had long been assumed that liberal democracy was unassailable. Scholars have been grappling with the concept of populism for decades, but as populists have won victories close to home, the research has taken on a heightened sense of urgency. Two of the common theses that have appeared in the recent literature are, (a) populism is opposed to liberal democracy, and (b) populism is linked to a democratic tradition of thought that originates with Rousseau. While I am willing to grant (a), I argue in this dissertation …

Three Essays On Tax Compliance In Indonesia, Himawan Saputro

Theses and Dissertations--Public Policy and Administration

This dissertation studies the impacts of major tax reforms designed to improve tax compliance, particularly in the context of developing countries with limited enforcement capacity due to informality and lack of third-party data using the Indonesian tax administrative data as well as relevant empirical research methods. In order to describe this dissertation, I discuss each essay as the following.

The first essay is titled "How Do Small Taxpayers Respond to Tax Simplification? Evidence from the Indonesian Turnover Tax Reform." This essay studies the firms' behavioral responses to tax simplification in Indonesia by exploiting the implementation of turnover tax in 2013 …

Analysis Of Graded Sensorimotor Rhythms For Brain-Computer Interface Applications, Chase Allen Haddix

Theses and Dissertations--Biomedical Engineering

The emerging field of neural engineering is tasked with applying engineering principles towards understanding neuroscience. A by-product of such a venture has been the development of a class of assistive devices known as brain-computer interfaces (BCIs) which link brain activity to actions performed by external devices. One application of this technology is in the rehabilitative sector for individuals with neuromuscular diseases and disorders. Despite tremendous efforts in the last few decades, a reliable signal that reflects fine motor control has yet to be adequately investigated. This gap in knowledge has limited the potential of BCIs to restore movement and communication. …

Maternal Proximity To Mountaintop Removal Mining And Birth Defects In Appalachian Kentucky, 1997-2003, Daniel B. Cooper

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background: Extraction of coal through mountaintop removal mining (MTR) alters many dimensions of the landscape, and explosive blasts, exposed rock, and coal washing have the potential to pollute air and water with substances known to increase risk of developmental and birth anomalies. Previous research suggests that infants born to mothers living in MTR coal mining counties have higher prevalence of most types of birth defects.

Objectives: This study seeks to examine further the relationship between MTR activity and birth defects by employing individual level exposure estimation through precise satellite data of MTR activity in the Appalachian region and maternal residence …

Patient Engagement In Patient Portals In Appalachia Versus Surrounding Us Census Regions: An Analysis Of Hints (Health Information National Trends Survey) Data, 2017 - 2020, Heather Lea Tudor

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

OBJECTIVE: Those living in the Appalachian regions face more significant healthcare disparities than those in the US. Patient portals can decrease disparities and increase health outcomes and health literacy. The purpose of this study was to determine if those living in the Appalachian region were offered access to and used their patient portals differently than the surrounding US Census region. Additionally, we aimed to determine if there was a difference in reported reasons for non-use of patient portals.

METHODS: This was a descriptive study using data from the National Cancer Institute’s Health Information National Trends Survey (HINTS) data (2017-2020) to …

“I Knew I Wanted More For Myself”: Sexual Minority Men’S Narratives About Getting Help For Intimate Partner Violence, Jonathan Ryser-Oatman

Theses and Dissertations--Educational, School, and Counseling Psychology

Sexual minority men experience intimate partner violence (IPV) at rates similar to, if not higher, than heterosexual individuals (Finneran & Stephenson, 2013). IPV is associated with a range of negative health outcomes in this population, such as increased risk for depression and anxiety (Miller & Irvin, 2017) and increased sexual risk-taking and subsequent HIV acquisition (Craft & Serovich, 2005; Houston & McKirnan, 2007). Many barriers prevent sexual minority men from getting help for IPV including stigma-related stressors, socioeconomic status, HIV status, perceived lack of helping resources, and a lack of knowledge about IPV (Duke & Davidson, 2009; Edwards, Sylaska, & …

Framing Early Adolescents’ Self-Efficacy Development: Precursors To The Sources Of Math Self-Efficacy, Calah J. Ford

Theses and Dissertations--Educational, School, and Counseling Psychology

Self-efficacy, the beliefs learners hold about what they can do, develops largely from how learners perceive and interpret four main sources of information: mastery experiences, vicarious experiences, social persuasions, and physiological states. Although researchers have shown a relationship between these sources and math self-efficacy, less is known about the factors that may influence how early adolescent learners perceive and interpret information from these sources. The purpose of this dissertation was to investigate two possible factors (i.e., perfectionism, performance-related factors) that might predict how learners perceive efficacy-relevant information in the domain of math. Study 1 used a correlational design to investigate …

The Transnational Diffusion Of Human Trafficking Policy, Glenn M. Harden

Theses and Dissertations--Political Science

Globalization has promoted the transnational diffusion of public policies. Recognizing that policies of one country are shaped by policies of others, scholars have developed several theories to explain policy diffusion. Because empirical evidence for these theories is contested, this study evaluates the relative explanatory power of the major theories of policy diffusion for human trafficking policies. To test competing theoretical claims, this study uses quantitative methods on an original, cross-national data set to analyze how human trafficking policies diffused. The results reveal that for the diffusion of human trafficking policies coercion and constructivist theories have robust support, while support is …

Epigenetic States Regulate Tumor Aggressiveness And Response To Targeted Therapies In Lung Adenocarcinoma, Fan Chen

Theses and Dissertations--Toxicology and Cancer Biology

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, 85% of which are lung adenocarcinomas (LUAD). Although molecular studies of NSCLC identified targetable mutations of some oncogenes including BRAF, EGFR and ALK, no targeted therapies exist for most cases. Cancer epigenetics is the study of epigenetic modifications, including histone modifications, that control gene expression in cancer. Recent advances have revealed numerous epigenetic abnormalities in human cancers, and targeting epigenetic regulators could be effective at reversing dysregulated epigenetic programs or driving sensitivity to other targeted therapies.

Inhibitors of the histone methyltransferase EZH2 have recently been approved as …

Science-Based Regulation Of Pharmacological Substances In Competition Horses, Jacob Machin

Theses and Dissertations--Toxicology and Cancer Biology

Current testing methodologies within equine forensic toxicology focus on arbitrary thresholds and zero-tolerance policy. Modern analytical chemistry’s limits of detection are low enough that oftentimes femtogram-per-milliliter amounts of a substance can readily be identified in both blood and urine of a horse. For most pharmacologically relevant compounds, these concentrations have no relevance to pharmacological effect. It is therefore crucial that testing methodologies to determine appropriate thresholds and cut-offs be developed that are driven by biological activity rather than arbitrary limits of detection. This dissertation looks to address this by suggesting a system of calculated Effective Plasma Concentrations by which a …