Digital Commons Network^™

Water Exchange Rate Across The Blood-Brain Barrier Is Associated With Csf Amyloid-Β 42 In Healthy Older Adults, Brian T. Gold, Xingfeng Shao, Tiffany L. Sudduth, Gregory A. Jicha, Donna M. Wilcock, Elayna R. Seago, Danny J. J. Wang

Sanders-Brown Center on Aging Faculty Publications

INTRODUCTION: We tested if water exchange across the blood-brain barrier (BBB), estimated with a noninvasive magnetic resonance imaging (MRI) technique, is associated with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and neuropsychological function.

METHODS: Forty cognitively normal older adults (67–86 years old) were scanned with diffusion‐prepared, arterial spin labeling (DP‐ASL), which estimates water exchange rate across the BBB (k_w). Participants also underwent CSF draw and neuropsychological testing. Multiple linear regression models were run with kw as a predictor of CSF concentrations and neuropsychological scores.

RESULTS: In multiple brain regions, BBB kw was positively associated with CSF amyloid …

Perceived Ability To Treat Opioid Use Disorder In West Virginia, A. Brianna Sheppard, Jonathan C. Young, Steve M. Davis, Garrett E. Moran

Journal of Appalachian Health

Introduction: Medication-assisted treatment (MAT) is an evidence-based therapy for opioid use disorder (OUD) that has not been fully implemented in rural areas due to patient, provider, and logistical barriers. Limited information is available on provider perceptions of barriers to MAT in rural Central Appalachia which has very high rates of OUD compared to the rest the United States.

Purpose: Determine perceived barriers for potential prescribers to using MAT, including buprenorphine, as part of treatment for OUD in West Virginia.

Methods: A 30-question, anonymous survey was sent to physicians, physician assistants and advanced practice registered nurses using an online link. Link …

Analysis Of Covid-19 Concerns Raised By The Construction Workforce And Development Of Mitigation Practices, Makram Bou Hatoum, Ali Faisal, Hala Nassereddine, Hadi Sarvari

Civil Engineering Faculty Publications

The coronavirus outbreak has created a global health crisis that has disrupted all industries, including the construction industry. Following the onset of the pandemic, construction workers faced and continue to face unprecedented safety and health challenges. Therefore, construction employers established new safety precautions to protect the health and safety of the workforce and minimize the spread of the virus. The new precautions followed the advice and guidelines offered by different health and safety agencies like the Occupational Safety and Health Administration (OSHA), Centers of Disease Control and Prevention (CDC), and the Associated General Contractors of America (AGC). With construction projects …

Effects Of Seed Size And Temperature On Seed Dormancy In An Alpine Meadow On The Eastern Tsinghai‐Tibet Plateau, Wenlong Li, Jing Xu, Guozhen Du, Zizhen Li

IGC Proceedings (1977-2023)

No abstract provided.

Forage News [2021-05], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

School Reopenings, Mobility, And Covid-19 Spread: Evidence From Texas, Charles J. Courtemanche, Anh Le, Aaron Yelowitz, Ron Zimmer

Institute for the Study of Free Enterprise Working Papers

This paper examines the effect of fall 2020 school reopenings in Texas on county-level COVID19 cases and fatalities. Previous evidence suggests that schools can be reopened safely if community spread is low and public health guidelines are followed. However, in Texas, reopenings often occurred alongside high community spread and at near capacity, likely making it difficult to meet social distancing recommendations. Using event-study models and hand-collected instruction modality and start dates for all school districts, we find robust evidence that reopening Texas schools gradually but substantially accelerated the community spread of COVID-19. Results from our preferred specification imply that school …

Epigenome-Wide Association Study Of Kidney Function Identifies Trans-Ethnic And Ethnic-Specific Loci, Charles E. Breeze, Anna Batorsky, Mi Kyeong Lee, Mindy D. Szeto, Xiaoguang Xu, Daniel L. Mccartney, Rong Jiang, Amit Patki, Holly J. Kramer, James M. Eales, Laura Raffield, Leslie Lange, Ethan Lange, Peter Durda, Yongmei Liu, Russ P. Tracy, David Van Den Berg, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium, Topmed Mesa Multi-Omics Working Group, Kathryn L. Evans, William E. Kraus, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poorly understood. We aimed to identify trans-ethnic and ethnic-specific differentially methylated positions (DMPs) associated with eGFR using an agnostic, genome-wide approach.

METHODS: The study included up to 5428 participants from multi-ethnic studies for discovery and 8109 participants for replication. We tested the associations between whole blood DNAm and eGFR using beta values from Illumina 450K or EPIC arrays. Ethnicity-stratified analyses were performed using linear …

Hemodynamic Management Of Patients With Ejection Fraction < 50% Undergoing Pulmonary Vein Ablation, Aaron B. Hesselson, Heather Hesselson

Internal Medicine Faculty Publications

There is no consensus regarding optimal methodology forblood pressure monitoring inpatients with a depressed ejection fraction undergoingcatheter ablationfor atrial fibrillation. Our goalswere to determine ifhemodynamicmanagementdifferences exist during radiofrequency ablation for atrial fibrillation in patients with and without an ejection fraction< 50%, and whether management was influenced by the utilization of invasive arterial blood pressure monitoring. This single-center trial retrospectively compared blood pressure management during catheterablation of atrial fibrillationin all patients with an ejection fraction< 50% over a 2-year span (n=44), and compared to an age-matched cohort with preserved ejection fraction ablated over the same span in time (n=44). Blood pressure was not significantly managed differently between the groups, and did not appear to be influenced by the use of invasive arterial blood pressure monitoring. Hemodynamic management is similar across the spectrum of ejection fraction, regardless of invasive arterial blood pressure monitoring, which challenges the need for invasive arterial blood pressure monitoringduringcatheter ablation ofatrial fibrillationin left ventricular systolic dysfunction.

Application Of Eh-Ph Diagrams On Acid Leaching Systems For The Recovery Of Rees From Bastnaesite, Monazite And Xenotime, Peijia Lin, Xinbo Yang, Joshua M. Werner, Rick Q. Honaker

Mining Engineering Faculty Publications

Bastnaesite, monazite and xenotime are rare earth minerals (REMs) that are typical sources for rare earth elements (REEs). To advance the understanding of their leaching and precipitation behavior in different hydrometallurgical processes, Eh-pH diagrams were constructed and modified using the HSC 9.9 software. The aqueous stability of rare earth elements in H₂O and acid leaching systems, i.e., the REE-Ligands-H₂O systems, were depicted and studied based on the Eh-pH diagrams. This study considers the most relevant lixiviants, their resulting equilibrium states and the importance in the hydrometallurgical recovery of rare earth elements (REMs). A literature review was …

Cross-Sectional Exploration Of Plasma Biomarkers Of Alzheimer's Disease In Down Syndrome: Early Data From The Longitudinal Investigation For Enhancing Down Syndrome Research (Life-Dsr) Study, James A. Hendrix, David C. Airey, Angela Britton, Anna D. Burke, George T. Capone, Ronelyn Chavez, Jacqueline Chen, Brian Chicoine, Alberto C. S. Costa, Jeffrey L. Dage, Eric Doran, Anna Esbensen, Casey L. Evans, Kelley M. Faber, Tatiana M. Foroud, Sarah Hart, Kelsey Haugen, Elizabeth Head, Suzanne Hendrix, Hampus Hillerstrom, Frederick A. Schmitt

Sanders-Brown Center on Aging Faculty Publications

With improved healthcare, the Down syndrome (DS) population is both growing and aging rapidly. However, with longevity comes a very high risk of Alzheimer’s disease (AD). The LIFE-DSR study (NCT04149197) is a longitudinal natural history study recruiting 270 adults with DS over the age of 25. The study is designed to characterize trajectories of change in DS-associated AD (DS-AD). The current study reports its cross-sectional analysis of the first 90 subjects enrolled. Plasma biomarkers phosphorylated tau protein (p-tau), neurofilament light chain (NfL), amyloid β peptides (Aβ_1-40, Aβ_1-42), and glial fibrillary acidic protein (GFAP) were undertaken with …

Disability-Free Life Expectancy Among People Over 60 Years Old By Sex, Urban And Rural Areas In Jiangxi Province, China, Shengwei Wang, Songbo Hu, Pei Wang, Yuhang Wu, Zhitao Liu, Huilie Zheng

Statistics Graduate Research

Objective: To estimate and compare age trends and the disability-free life expectancy (DFLE) of the population over 60 years old in 2018 in Jiangxi Province, China, by sex and urban–rural areas. Methods: The model life table was employed to estimate the age-specific mortality rate by sex and urban–rural areas, based on the Summary of Health Statistics of Jiangxi Province in 2018 and the Sixth National Health Service survey of Jiangxi Province. DFLE and its ratio to life expectancy (LE) were obtained by the Sullivan method. Results: In 2018, the DFLE among people over 60 is 17.157 years for men and …

Cleaning Up Cercla: Uniroyal Chemical Company V. Deltech Corporation Helps Define The Disposal Requirement And The Consumer Product Exception, M. Trent Spurlock

Journal of Natural Resources & Environmental Law

No abstract provided.

Corporate Parent Liability Under Cercla In United States V. Bestfoods: Taking Us Back To The Basics, Emily Melvin Mooring, Ruth Lerner

Journal of Natural Resources & Environmental Law

No abstract provided.

Repeal Of The Tulloch Rule: Is The Tide Of Wetland Regulation Receding?, J. Richard Cheeks

Journal of Natural Resources & Environmental Law

No abstract provided.

The Economics And Ethics Of Land Reform: A Critique Of The Pontifical Council For Justice And Peace's "Toward A Better Distribution Of Land: The Challenge Of Agrarian Reform", Walter Block, Guillermo Yeatts

Journal of Natural Resources & Environmental Law

No abstract provided.

Marking The Path Post-Cotton: The Supreme Court Reaffirms Dual Taxation In Montana V. Crow Tribe Of Indians, Heather G. Pennington

Journal of Natural Resources & Environmental Law

No abstract provided.

Forage Conservation In Tropical Zones: Potential And Limitations Of Grass Silages In South America, Luiz Gustavo Nussio, José Leonardo Ribeiro

IGC Proceedings (1977-2023)

No abstract provided.

A Scientific Approach To Protecting Biodiversity, Judith I. Mcgeary

Journal of Natural Resources & Environmental Law

No abstract provided.

Cercla's Retroactivity: Has The Door Been Opened For A Reevaluation Of Whether Cercla Applies To Preenactment Activities?, Theodore Waugh

Journal of Natural Resources & Environmental Law

No abstract provided.

Common Law Remedies Available For Petroleum Contamination Of Soil And Groundwater In Kentucky, Henry L. Stephens Jr.

Journal of Natural Resources & Environmental Law

No abstract provided.

Bone Quality In Ckd Patients: Current Concepts And Future Directions – Part I, Kamyar Asadipooya, Mohamed Abdalbary, Yahya Ahmad, Elijah Kakani, Marie-Claude Monier-Faugere, Amr El-Husseini

Internal Medicine Faculty Publications

Background: There is ample evidence that patients with CKD have an increased risk of osteoporotic fractures. Bone fragility is not only influenced by low bone volume and mass but also by poor microarchitecture and tissue quality. More emphasis has been given to the quantitative rather than qualitative assessment of bone health, both in general population and CKD patients. Although bone mineral density (BMD) is a very useful clinical tool in assessing bone strength, it may underestimate the fracture risk in CKD patients. Serum and urinary bone biomarkers have been found to be reflective of bone activities and predictive of fractures …

Gauge Invariant Target Space Entanglement In D-Brane Holography, Sumit R. Das, Anurag Kaushal, Sinong Liu, Gautam Mandal, Sandip P. Trivedi

Physics and Astronomy Faculty Publications

It has been suggested in arXiv:2004.00613 that in Dp-brane holography, entanglement in the target space of the D-brane Yang-Mills theory provides a precise notion of bulk entanglement in the gravity dual. We expand on this discussion by providing a gauge invariant characterization of operator sub-algebras corresponding to such entanglement. This is achieved by finding a projection operator which imposes a constraint characterizing the target space region of interest. By considering probe branes in the Coloumb branch we provide motivation for why the operator sub-algebras we consider are appropriate for describing a class of measurements carried out with low-energy probes in …

The Context-Dependent Impact Of Integrin-Associated Cd151 And Other Tetraspanins On Cancer Development And Progression: A Class Of Versatile Mediators Of Cellular Function And Signaling, Tumorigenesis And Metastasis, Sonia F. Erfani, Hui Hua, Yueyin Pan, Binhua P. Zhou, Xiuwei H. Yang

Molecular and Cellular Biochemistry Faculty Publications

As a family of integral membrane proteins, tetraspanins have been functionally linked to a wide spectrum of human cancers, ranging from breast, colon, lung, ovarian, prostate, and skin carcinomas to glioblastoma. CD151 is one such prominent member of the tetraspanin family recently suggested to mediate tumor development, growth, and progression in oncogenic context- and cell lineage-dependent manners. In the current review, we summarize recent advances in mechanistic understanding of the function and signaling of integrin-associated CD151 and other tetraspanins in multiple cancer types. We also highlight emerging genetic and epigenetic evidence on the intrinsic links between tetraspanins, the epithelial-mesenchymal transition …

Suppressing Bias Stress Degradation In High Performance Solution Processed Organic Transistors Operating In Air, Hamna F. Iqbal, Qianxiang Ai, Karl J. Thorley, Hu Chen, Iain Mcculloch, Chad Risko, John E. Anthony, Oana D. Jurchescu

Chemistry Faculty Publications

Solution processed organic field effect transistors can become ubiquitous in flexible optoelectronics. While progress in material and device design has been astonishing, low environmental and operational stabilities remain longstanding problems obstructing their immediate deployment in real world applications. Here, we introduce a strategy to identify the most probable and severe degradation pathways in organic transistors and then implement a method to eliminate the main sources of instabilities. Real time monitoring of the energetic distribution and transformation of electronic trap states during device operation, in conjunction with simulations, revealed the nature of traps responsible for performance degradation. With this information, we …

Experimental And Numerical Investigation Of The Effect Of Integration Of A Flooded-Bed Scrubber Into A Longwall Shearer On Airflow Along A Coal Mine Longwall Face, Sampurna Arya, Thomas Novak, Joseph Sottile

Mining Engineering Faculty Publications

Dust control is one of the most difficult challenges for underground coal mine operators, especially longwall mine operators. The most widely used dust control technologies at a longwall section are ventilation air and water sprays, whereas a continuous miner section has the added advantage of having a dust scrubber built into the continuous miner. To test the potential benefits of integrating a flooded-bed scrubber into a longwall shearer, the authors designed and built a dust scrubber system for a full-scale mock-up of a longwall shearer. The mock-up was installed in the longwall test gallery at the Pittsburgh Research Laboratory (PRL) …

Vitamin D Promotes Skeletal Muscle Regeneration And Mitochondrial Health, Christine M. Latham, Camille R. Brightwell, Alexander R. Keeble, Brooke D. Munson, Nicholas T. Thomas, Alyaa M. Zagzoog, Christopher S. Fry, Jean L. Fry

Athletic Training and Clinical Nutrition Faculty Publications

Vitamin D is an essential nutrient for the maintenance of skeletal muscle and bone health. The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. Furthermore, mounting evidence suggests that vitamin D may play an important role during muscle damage and regeneration. Muscle damage is characterized by compromised muscle fiber architecture, disruption of contractile protein integrity, and mitochondrial dysfunction. Muscle regeneration is a complex process that involves restoration of mitochondrial function and activation of satellite cells (SC), the resident skeletal muscle stem cells. VDR expression is strongly upregulated …

A Demand-Supply Matching-Based Approach For Mapping Renewable Resources Towards 100% Renewable Grids In 2050, Loiy Al-Ghussain, Adnan Darwish Ahmad, Ahmad M. Abubaker, Mohammad Abujubbeh, Abdulaziz Almalaq, Mohamed A. Mohamed

Mechanical Engineering Graduate Research

Recently, many renewable energy (RE) initiatives around the world are based on general frameworks that accommodate the regional assessment taking into account the mismatch of supply and demand with pre-set goals to reduce energy costs and harmful emissions. Hence, relying entirely on individual assessment and RE deployment scenarios may not be effective. Instead, developing a multi-faceted RE assessment framework is vital to achieving these goals. In this study, a regional RE assessment approach is presented taking into account the mismatch of supply and demand with an emphasis on Photovoltaic (PV) and wind turbine systems. The study incorporates mapping of renewable …

Fertilizer Management For Seed Production Of Perennial Forage Crops In The Canadian Great Plains, S. S. Malhi, C. L. Vera

IGC Proceedings (1977-2023)

No abstract provided.

Tax Consequences Of Environmental Cleanup Costs: The Uncertainty Continues, Lisa Stephenson

Journal of Natural Resources & Environmental Law

No abstract provided.

How A City's Pilot Project Can Influence A State's Brownfields Program, Bonnie Biemer

Journal of Natural Resources & Environmental Law

No abstract provided.