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Prediction Of Herbage Accumulation Of Cynodon Grasses By An Empirical Model Based On Temperature And Daylength, H. R. De Medeiros, Carlos G. S. Pedreira, N. A. Villa Nova, L. G. Barioni, A. C. C. Mello

IGC Proceedings (1977-2023)

The objective of this work was to estimate dry matter production of Cynodon grasses as a function of photothermal units (PU). Total PU values were calculated for the period from February 1 to April 24, 1996, from a location in southeastern Brazil. Regression analysis was run between PU and herbage production from a published data set on five Cynodon cultivars, with an r² of 0.9983. Differences between measured and estimated values were under 5%. Model testing using an independent data set on herbage dry matter production from grazed Cynodon pastures showed an overestimation, probably due to water deficit during …

Application Of Near Infrared Reflectance Spectroscopy (Nirs) For Macronutrients Analysis In Alfalfa (Medicago Sativa L.), A. Morón, D. Cozzolino

IGC Proceedings (1977-2023)

Near infrared reflectance spectroscopy was used to assess the mineral composition of alfalfa (Medicago sativa L.) as a tool for nutritional diagnosis. One hundred and ninety four (n = 194) samples of alfalfa from different locations representing a wide range of soils were used. Samples were reflectance scanned in a NIRS 6500 (NIRSystems, USA) instrument. The coefficients of determination (R²) of the regression estimate of the concentration of nitrogen, calcium, phosphorus, potassium, magnesium and sulphur and the errors in cross validation (SECV) were 0.93 (SECV: 1.6), 0.95 (SECV: 1.3), 0.93 (SECV: 1.9), 0.88 (SECV: 2.8), 0.82 (SECV: …

Phosphorus, Sulphur And Micronutrients On Grassland Improvement With White Clover (Trifolium Repens L.) On Basaltic Soils In Uruguay, A. Morón, D. F. Risso

IGC Proceedings (1977-2023)

Grasslands improvement with legumes is a promising technology for increasing forage quality and productivity on basaltic soils, but requires the correction of nutrient deficiencies. Phosphorus is a key element, but usual techniques of soil analysis are not good predictors. An experimental work was conducted in the northern region of the country. Evaluating the response of an improvement with white clover to P. Citric Acid showed a good association between soil P status and legume behavior. In addition there was a positive trend in forage production, in relation to S application, even though this effect was only significant in legume yield …

Smartphone Use And Psychological Well-Being Among College Students In China: A Qualitative Assessment, Cheng Dai, Zixue Tai, Shan Ni

Journalism and Media Faculty Publications

Background: Problematic smartphone use is widespread, and college-age youth faces an especially high risk of its associated consequences. While a promising body of research has emerged in recent years in this area, the domination of quantitative inquiries can be fruitfully and conceptually complemented by perspectives informed through qualitative research. Toward that end, this study aimed to interrogate the myriad behavioral, attitudinal, and psychological tendencies as a side effect of college students’ engagement with the smartphone in their everyday lived experience through in-depth interviews.

Methods: We recruited 70 participants from seven college campuses hailing from different geographic regions in China, and …

Improving The Methodology For Identifying Mild Cognitive Impairment In Intellectually High-Functioning Adults Using The Nih Toolbox Cognition Battery, Grant L. Iverson, Justin E. Karr

Psychology Faculty Publications

Objective: Low scores on neuropsychological tests are considered objective evidence of mild cognitive impairment. In clinical practice and research, it can be challenging to identify a cognitive deficit or mild cognitive impairment in high-functioning people because they are much less likely to obtain low test scores. This study was designed to improve the methodology for identifying mild cognitive impairment in adults who have above average or superior intellectual abilities.

Method: Participants completed the National Institutes of Health Toolbox for the Assessment of Neurological and Behavioral Function Cognition Battery (NIHTB-CB). The sample included 384 adults between the ages of 20 and …

Predicting The Effect Of Indirect Cell Kill In The Treatment Of Multiple Brain Metastases Via Single-Isocenter/Multitarget Volumetric Modulated Arc Therapy Stereotactic Radiosurgery, Allison N. Palmiero, Denise Fabian, Marcus E. Randall, William St. Clair, Damodar Pokhrel

Radiation Medicine Faculty Publications

PURPOSE: Due to spatial uncertainty, patient setup errors are of major concern for radiosurgery of multiple brain metastases (m-bm) when using single-isocenter/multitarget (SIMT) volumetric modulated arc therapy (VMAT) techniques. However, recent clinical outcome studies show high rates of tumor local control for SIMT-VMAT. In addition to direct cell kill (DCK), another possible explanation includes the effects of indirect cell kill (ICK) via devascularization for a single dose of 15 Gy or more and by inducing a radiation immune intratumor response. This study quantifies the role of indirect cell death in dosimetric errors as a function of spatial patient setup uncertainty …

The Regulation Landscape Of Mapk Signaling Cascade For Thwarting Bacillus Thuringiensis Infection In An Insect Host, Zhaojiang Guo, Shi Kang, Qingjun Wu, Shaoli Wang, Neil Crickmore, Xuguo Zhou, Alejandra Bravo, Mario Soberón, Youjun Zhang

Entomology Faculty Publications

Host-pathogen interactions are central components of ecological networks where the MAPK signaling pathways act as central hubs of these complex interactions. We have previously shown that an insect hormone modulated MAPK signaling cascade participates as a general switch to trans-regulate differential expression of diverse midgut genes in the diamondback moth, Plutella xylostella (L.) to cope with the insecticidal action of Cry1Ac toxin, produced by the entomopathogenic bacterium Bacillus thuringiensis (Bt). The relationship between topology and functions of this four-tiered phosphorylation signaling cascade, however, is an uncharted territory. Here, we carried out a genome-wide characterization of all the MAPK orthologs …

Nitrogen Or Water Limitation To Grassland Growth During A Moderate Dry Season In The Humid Tropics, P. Cruz, M. Boval

IGC Proceedings (1977-2023)

The aim of this work was to compare the effects of nitrogen and water shortage on grassland production during a moderate dry season in a tropical humid environment. The results of two experiments carried out in Guadeloupe (FWI) have shown that during dry spells, the reduction in growth of natural grasslands based on Angleton grass (Dichantium aristatum) is more easily corrected by nitrogen fertiliser application than by irrigation. This shows that it is not the availability of water, but that of nitrogen, which is limiting the primary production of Angleton grass, stands. This result is less clear for …

A Call To Action Toward Optimizing The Electrical Dose Received By Neural Targets In Spinal Cord Stimulation Therapy For Neuropathic Pain, Krishnan Chakravarthy, Rajiv Reddy, Adnan Al-Kaisy, Thomas Yearwood, Jay S. Grider

Anesthesiology Faculty Publications

Spinal cord stimulation has seen unprecedented growth in new technology in the 50 years since the first subdural implant. As we continue to grow our understanding of spinal cord stimulation and relevant mechanisms of action, novel questions arise as to electrical dosing optimization. Programming adjustment — dose titration — is often a process of trial and error that can be time-consuming and frustrating for both patient and clinician. In this report, we review the current preclinical and clinical knowledge base in order to provide insights that may be helpful in developing more rational approaches to spinal cord stimulation dosing. We …

Apoε4 Lowers Energy Expenditure In Females And Impairs Glucose Oxidation By Increasing Flux Through Aerobic Glycolysis, Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron, Grant K. Nation, David J. Carter, Adeline E. Walsh, Rebika Khanal, Lyndsay E. A. Young, Jude C. Kluemper, Gabriela Hernandez, Elizabeth J. Allenger, Rachel Mooney, Lesley R. Golden, Cathryn T. Smith, J. Anthony Brandon, Vedant A. Gupta, Philip A. Kern, Matthew S. Gentry, Josh M. Morganti, Ramon C. Sun, Lance A. Johnson

Physiology Faculty Publications

BACKGROUND: Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer's disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of Apolipoprotein E (APOE), the strongest genetic predictor of late-onset AD. While this clinical feature has been described for over two decades, the mechanism underlying these changes in cerebral glucose metabolism remains a critical knowledge gap in the field.

METHODS: Here, we undertook a multi-omic approach by combining single-cell RNA sequencing (scRNAseq) and stable isotope resolved metabolomics (SIRM) to define a metabolic rewiring across astrocytes, brain tissue, mice, and human subjects expressing APOE4.

RESULTS: Single-cell …

Bone Quality And Fractures In Women With Osteoporosis Treated With Bisphosphonates For 1 To 14 Years, Hartmut H. Malluche, Jin Chen, Florence Lima, Lucas J. Liu, Marie-Claude Monier-Faugere, David A. Pienkowski

Internal Medicine Faculty Publications

Oral bisphosphonates are the primary medication for osteoporosis, but concerns exist regarding potential bone-quality changes or low-energy fractures. This cross-sectional study used artificial intelligence methods to analyze relationships among bisphosphonate treatment duration, a wide variety of bone-quality parameters, and low-energy fractures. Fourier transform infrared spectroscopy and histomorphometry quantified bone-quality parameters in 67 osteoporotic women treated with oral bisphosphonates for 1 to 14 years. Artificial intelligence methods established two models relating bisphosphonate treatment duration to bone-quality changes and to low-energy clinical fractures. The model relating bisphosphonate treatment duration to bone quality demonstrated optimal performance when treatment durations of 1 to 8 …

Competitive Rationales: Beneath The Surface Of Competitive Behavior, Goce Andrevski, Danny Miller, Isabelle Le Breton-Miller, Walter Ferrier

Management Faculty Publications

Competitive dynamics research has focused on studying whether rivals are able and likely to carry out competitive actions, typically by examining indirect reasons such as characteristics of the actions themselves, the firms involved, or the competitive context. We explore why rivals initiate a specific competitive action at a particular time and situation. Drawing from the philosophy of action literature, we introduce the concept of competitive rationales to examine the primary reasons that cause tactical actions. Given the rapid exchanges characterizing tactical competitive dynamics, we conducted an inductive, multicase study to explore the reasons behind over 800 discrete tactical decisions carried …

Influence Of Speed, Ground Surface And Shoeing Condition On Hoof Breakover Duration In Galloping Thoroughbred Racehorses, Kate Horan, James Coburn, Kieran Kourdache, Peter Day, Dan Harborne, Liam Brinkley, Henry Carnall, Lucy Hammond, Michael L. Peterson, Sean Millard, Thilo Pfau

Biosystems and Agricultural Engineering Faculty Publications

Understanding the effect of horseshoe–surface combinations on hoof kinematics at gallop is relevant for optimising performance and minimising injury in racehorse–jockey dyads. This intervention study assessed hoof breakover duration in Thoroughbred ex-racehorses from the British Racing School galloping on turf and artificial tracks in four shoeing conditions: aluminium, barefoot, aluminium–rubber composite (GluShu) and steel. Shoe–surface combinations were tested in a randomized order and horse–jockey pairings (n = 14) remained constant. High-speed video cameras (Sony DSC-RX100M5) filmed the hoof-ground interactions at 1000 frames per second. The time taken for a hoof marker wand fixed to the lateral hoof wall to …

Knowledge And Beliefs Associated With Environmental Health Literacy: A Case Study Focused On Toxic Metals Contamination Of Well Water, Kathleen M. Gray, Victoria Triana, Marti Lindsey, Benjamin Richmond, Anna G. Hoover, Chris Wiesen

Preventive Medicine and Environmental Health Faculty Publications

Environmental health literacy (EHL) is developing as a framework that can inform educational interventions designed to facilitate individual and collective action to protect health, yet EHL measurement poses several challenges. While some studies have measured environmental health knowledge resulting from interventions, few have incorporated skills and self-efficacy. In this study, a process-focused EHL instrument was developed, using the Newest Vital Sign (NVS) health literacy instrument as a model and tailoring it for the context of private well contamination with toxic metals. Forty-seven (47) participants, including undergraduate students and residents of communities with contaminated well water, piloted a prototype EHL instrument …

Engineering Properties Of Sweet Potato Starch For Industrial Applications By Biotechnological Techniques Including Genome Editing, Ruiqing Lyu, Sulaiman Ahmed, Weijuan Fan, Jun Yang, Xiaoyun Wu, Wenzhi Zhou, Peng Zhang, Ling Yuan, Hongxia Wang

Plant and Soil Sciences Faculty Publications

Sweet potato (Ipomoea batatas) is one of the largest food crops in the world. Due to its abundance of starch, sweet potato is a valuable ingredient in food derivatives, dietary supplements, and industrial raw materials. In addition, due to its ability to adapt to a wide range of harsh climate and soil conditions, sweet potato is a crop that copes well with the environmental stresses caused by climate change. However, due to the complexity of the sweet potato genome and the long breeding cycle, our ability to modify sweet potato starch is limited. In this review, we cover …

In Situ Imaging Of Bacterial Outer Membrane Projections And Associated Protein Complexes Using Electron Cryo-Tomography, Mohammed Kaplan, Georges Chreifi, Lauren Ann Metskas, Janine Liedtke, Cecily R. Wood, Catherine M. Oikonomou, William J. Nicolas, Poorna Subramanian, Lori A. Zacharoff, Yuhang Wang, Yi-Wei Chang, Morgan Beeby, Megan J. Dobro, Yongtao Zhu, Mark J. Mcbride, Ariane Briegel, Carrie L. Shaffer, Grant J. Jensen

Veterinary Science Faculty Publications

The ability to produce outer membrane projections in the form of tubular membrane extensions (MEs) and membrane vesicles (MVs) is a widespread phenomenon among diderm bacteria. Despite this, our knowledge of the ultrastructure of these extensions and their associated protein complexes remains limited. Here, we surveyed the ultrastructure and formation of MEs and MVs, and their associated protein complexes, in tens of thousands of electron cryo-tomograms of ~90 bacterial species that we have collected for various projects over the past 15 years (Jensen lab database), in addition to data generated in the Briegel lab. We identified outer MEs and MVs …

Power Factor And Reactive Power In Us Residences – Survey And Energyplus Modeling, Hope C. Anderson, Abdullah Al Hadi, Evan S. Jones, Dan M. Ionel

Power and Energy Institute of Kentucky Faculty Publications

Electric power systems are experiencing a growing number of electronic loads in the residential sector as modern appliance technology progresses, and it has become increasingly more important to consider the total power factor (PF) of residential communities. This paper provides a survey based on literature and publicly available information of typical appliance PF values and effects at the residential level as well as a discussion on appliance energy use and corresponding operation schedules. A procedure for the calculation of equivalent PF is proposed and exemplified with minutely experimental data at 15-minute and hourly time intervals, which correspond to smart metering …

Improving Overweight And Over-Dimensional Logistics And Truck Routing, Jerry Kissick, Jerry Pigman, Jennifer Walton

Kentucky Transportation Center Research Report

In 2012, the Kentucky Transportation Cabinet’s (KYTC) Division of Motor Carriers (DMC) issued 98,196 overweight or over-dimensional (OW/OD) permits. To determine whether a route can accommodate an OW/OD vehicle, analysts must have current and accurate data on construction schedules, road conditions, and detour routes, among other factors. This study documents processes used by DMC for permitting and routing OW/OD vehicles. It includes detailed flowcharts that capture each aspect analysts follow during the decision-making process. As part of this project, state transportation agency representatives from states bordering Kentucky (Illinois, Indiana, Ohio, West Virginia, Virginia, Tennessee, and Missouri) were interviewed to identify …

Crash Data Analysis Tool 2.0 Research Report And User Guide, Eric Green, Paul Ross

Kentucky Transportation Center Research Report

No abstract provided.

In-Cab Alert System For Commercial Motor Vehicle Drivers, Brian Howell, Jennifer Walton, Jeeyen Koo

Kentucky Transportation Center Research Report

In-cab telematic devices use an increasingly robust data platform and can be used to share safety alerts with other commercial vehicle drivers (CMV) drivers. Real-time alert data can come from state transportation agencies as well as from private companies. To address common quality and coordination issues among differing data sources, the Kentucky Transportation Center (KTC) partnered with the Kentucky Transportation Cabinet (KYTC) and a private vendor, PrePass, to share its App used to send information to CMV drivers. The project demonstrated a proof of concept for the delivery of timely in-cab alerts to warn CMV drivers of approaching roadway hazards. …

Application Of Artificial Neural Networks To Power System State Estimation, James P. Carmichael, Yuan Liao

Electrical and Computer Engineering Presentations

State estimation function is essential for effective and timely execution of power system automation and control systems, especially in modern active distribution systems where more intermittent renewable energy systems are integrated into the grid. Distribution system state estimation faces a lot of challenges including lack of monitoring devices and possible incorrect topology information. Developing efficient state estimation for distribution systems is thus of great interest. This paper presents results on utilizing artificial neural networks for this purpose.

Artificial neural networks have been used in power distribution system state estimation. However, there is a lack of systematic analysis and study of …

Role Of Protective Relaying In The Smart Grid, J. Anderson, Alex Apostolov, R. Fowler, J. Gers, R. Kazimier, S. Klecker, Yuan Liao, M. Majidi, P. Myrda, T. Raffield

Electrical and Computer Engineering Presentations

This paper discusses the role of protective relaying in a Smart Grid. It outlines the definition, attributes, and benefits of a Smart Grid. The role that protective relays can play in implementing Smart Grid functionality and the impact that a Smart Grid design may have on modern protective relays is discussed. Specific examples of Smart Grid applications that may be implemented using modern protective relays and other intelligent electronic devices are provided.

Geomagnetic Disturbances (Gmd) Impacts On Protection Systems, Qun Qiu, V. Madani, Tapan Manna, T. Raffield, S. Klecker, Yuan Liao, S. Meliopoulos, D. Fontana

Electrical and Computer Engineering Presentations

This paper provides background and historical events of Geomagnetic Disturbances (GMD), and reviews GMD impacts on power systems equipment, and associated protection and control systems, mitigating measures, and Geomagnetic Induced Current (GIC) monitoring methods. This paper is a summary of the IEEE PES-TR72 report, titled, GMD Impacts on Protection Systems, prepared by the K17 Working Group of the IEEE Power System Relaying and Control committee.

Aqueous Photochemistry Of 2-Oxocarboxylic Acids: Evidence, Mechanisms, And Atmospheric Impact, Marcelo I. Guzman, Alexis J. Eugene

Chemistry Faculty Publications

Atmospheric organic aerosols play a major role in climate, demanding a better understanding of their formation mechanisms by contributing multiphase chemical reactions with the participation of water. The sunlight driven aqueous photochemistry of small 2-oxocarboxylic acids is a potential major source of organic aerosol, which prompted the investigations into the mechanisms of glyoxylic acid and pyruvic acid photochemistry reviewed here. While 2-oxocarboxylic acids can be contained or directly created in the particles, the majorities of these abundant and available molecules are in the gas phase and must first undergo the surface uptake process to react in, and on the surface, …

Micrornas As Biomarkers For Predicting Complications Following Aneurysmal Subarachnoid Hemorrhage, Wang-Xia Wang, Joe E. Springer, Kevin W. Hatton

Sanders-Brown Center on Aging Faculty Publications

Aneurysmal subarachnoid hemorrhage (aSAH) is a high mortality hemorrhagic stroke that affects nearly 30,000 patients annually in the United States. Approximately 30% of aSAH patients die during initial hospitalization and those who survive often carry poor prognosis with one in five having permanent physical and/or cognitive disabilities. The poor outcome of aSAH can be the result of the initial catastrophic event or due to the many acute or delayed neurological complications, such as cerebral ischemia, hydrocephalus, and re-bleeding. Unfortunately, no effective biomarker exists to predict or diagnose these complications at a clinically relevant time point when neurologic injury can be …

Management Of Large Cell Neuroendocrine Carcinoma, Virginia Corbett, Susanne M. Arnold, Lowell B. Anthony, Aman Chauhan

Internal Medicine Faculty Publications

Background: Large cell neuroendocrine carcinoma (LCNEC) is a rare, aggressive cancer with a dismal prognosis. The majority of cases occur in the lung and the gastrointestinal tract; however, it can occur throughout the body. Recently advances in the understanding of the molecular underpinnings of this disease have paved the way for additional novel promising therapies. This review will discuss the current best evidence for management of LCNEC and new directions in the classification and treatment of this rare disease.

Methods: We performed a PubMed search for “Large cell neuroendocrine carcinoma” and “High grade neuroendocrine carcinoma.” All titles were screened for …

Analysis Of Rock Varnish From The Mojave Desert By Handheld Laser-Induced Breakdown Spectroscopy, Russell S. Harmon, Daria Khashchevskaya, Michelle Morency, Lewis A. Owen, Morgan Jennings, Jeffrey R. Knott, Jason M. Dortch

Faculty, Staff, and Affiliated Publications--KGS

Laser-induced breakdown spectroscopy (LIBS) is a form of optical emission spectroscopy that can be used for the rapid analysis of geological materials in the field under ambient environmental conditions. We describe here the innovative use of handheld LIBS for the in situ analysis of rock varnish. This thinly laminated and compositionally complex veneer forms slowly over time on rock surfaces in dryland regions and is particularly abundant across the Mojave Desert climatic region of east-central California (USA). Following the depth profiling examination of a varnished clast from colluvial gravel in Death Valley in the laboratory, our in situ analysis of …

Dietary And Pharmacologic Manipulations Of Host Lipids And Their Interaction With The Gut Microbiome In Non-Human Primates, Jennifer M. Lang, Leslie R. Sedgeman, Lei Cai, Joseph D. Layne, Zhen Wang, Calvin Pan, Richard Lee, Ryan E. Temel, Aldons J. Lusis

Physiology Faculty Publications

The gut microbiome influences nutrient processing as well as host physiology. Plasma lipid levels have been associated with the microbiome, although the underlying mechanisms are largely unknown, and the effects of dietary lipids on the gut microbiome in humans are not well-studied. We used a compilation of four studies utilizing non-human primates (Chlorocebus aethiops and Macaca fascicularis) with treatments that manipulated plasma lipid levels using dietary and pharmacological techniques, and characterized the microbiome using 16S rDNA. High-fat diets significantly reduced alpha diversity (Shannon) and the Firmicutes/Bacteroidetes ratio compared to chow diets, even when the diets had different compositions …

Cognitive And Behavioral Domains That Reliably Differentiate Normal Aging And Dementia In Down Syndrome, Jordan P. Harp, Lisa M. Koehl, Kathryn L. Van Pelt, Christy L. Hom, Eric Doran, Elizabeth Head, Ira T. Lott, Frederick A. Schmitt

Neurology Faculty Publications

Primary care integration of Down syndrome (DS)-specific dementia screening is strongly advised. The current study employed principal components analysis (PCA) and classification and regression tree (CART) analyses to identify an abbreviated battery for dementia classification. Scale- and subscale-level scores from 141 participants (no dementia n = 68; probable Alzheimer’s disease n = 73), for the Severe Impairment Battery (SIB), Dementia Scale for People with Learning Disabilities (DLD), and Vineland Adaptive Behavior Scales—Second Edition (Vineland-II) were analyzed. Two principle components (PC1, PC2) were identified with the odds of a probable dementia diagnosis increasing 2.54 times per PC1 unit increase and by …

The Effect Of Severe Intraventricular Hemorrhage On The Biorhythms Of Feeding In Premature Infants, Ira H. Gewolb, Babatunde T. Sobowale, Frank L. Vice, Abhijit R. Patwardhan, Nino Solomonia, Eric W. Reynolds

Biomedical Engineering Faculty Publications

Background: Suck-swallow rhythmicity and the integration of breathing into infant feeding are developmentally regulated. Neurological injury and breathing abnormalities can both impact feeding in preterm infants.

Objective: To determine the effects of neurologic injury independent of effects of disordered breathing on feeding biorhythms in premature infants.

Methods: Low-risk preterm infants (LRP), infants with Grade 3–4 Intraventricular Hemorrhage (IVH), those with bronchopulmonary dysplasia (BPD), and those with both BPD and IVH (BPD+IVH) were identified. Forty-seven infants, 32–42 weeks Postmenstrual Age (PMA) were evaluated on one or more occasions (131 studies). Of these, 39 infants (81 studies) were performed at >35 weeks …