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Degradation And Vulnerability To Climate Change In High Andean Rangelands, Samuel Pizarro, Javier Ñaupari Nov 2023

Degradation And Vulnerability To Climate Change In High Andean Rangelands, Samuel Pizarro, Javier Ñaupari

IGC Proceedings (1977-2023)

Rangeland degradation is a process associated with loss of ecosystem equilibrium. Therefore, this work seeks to identify the most important factors that cause the degradation process of rangelands, assess the degree of degradation and vulnerability to current climate change of these ecosystems; and determine if there is a relationship between the degree of rangeland degradation and vulnerability to climate change in high Andean rangelands. The study was located in the central highlands of Peru (Ancash, Junín, Pasco, Huancavelica and Lima) and involved the design of a framework to assess rangeland degradation based on field information and Landsat satellite products that …

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Crop Yield Estimation And Carrying Capacity In Sar Ali-Abad Summer Rangelands Of Golestan Province, Iran, Mansour Mesdaghi, Nafiseh Fakhar Izadi Nov 2023

Crop Yield Estimation And Carrying Capacity In Sar Ali-Abad Summer Rangelands Of Golestan Province, Iran, Mansour Mesdaghi, Nafiseh Fakhar Izadi

IGC Proceedings (1977-2023)

High mountain grassland ecosystems are the best pastures of Golestan province in Iran. These grasslands are an effective means of soil conservation and offer standing green fodder for livestock. Sar Ali-abad summer rangeland with an area of 780 ha is a representative of mountain ecosystems of Golestan province. Estimating forage production to avoid overgrazing is a necessity to ensure the long-term sustainability of these natural ecosystems. To estimate rangeland productivity and carrying capacity was the major objective while, comparing three methods of clipping and weighing (CW), double sampling (DS), and comparative yield (CY) by using 1-m2 plots was the …

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Soil C Change Over 14 Years In Grasslands Sown Into A Highly Disturbed Soil, R. D. Jackson, J. Stier Nov 2023

Soil C Change Over 14 Years In Grasslands Sown Into A Highly Disturbed Soil, R. D. Jackson, J. Stier

IGC Proceedings (1977-2023)

Perennial grasslands are thought to sequester C, so restoring them is touted as part of the solution for mitigating climate change. Moreover, there is growing interest among managed grassland stakeholders in selling C credits on nascent C markets. Former agricultural and municipal sites are often considered viable areas for conversion to grasslands, with types ranging from unmanaged prairies with diverse plant communities to monocultures in highly managed urban environments. We sowed five perennial plant communities into an area that had undergone massive soil disturbance five years previous during conversion from row crop agriculture to C3 turf. We found that soils …

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Evaluation Of Herbicides For Saltcedar Control In Southwest Kansas, W. H. Fick Nov 2023

Evaluation Of Herbicides For Saltcedar Control In Southwest Kansas, W. H. Fick

IGC Proceedings (1977-2023)

Saltcedar is an invasive species along some of the major rivers and tributaries in Kansas. The objective of this study is to determine control of saltcedar in southwestern Kansas using herbicides applied to individual trees as cut-stump, basal, and foliar treatments. Cut-stump treatments were applied in 2004-2010 during the months of April or May. Basal applications with 10% triclopyr in diesel were applied between 2007-2021 during the months of August through early October. Foliar treatments were applied during 2008-2021 using 467 L/ha spray volumes during August through early October. Chi square analysis at P < 0.05 was used to compare treatments. In initial studies, imazapyr (Arsenal) at 10% v/v in water, triclopyr (Remedy) at 10% v/v in diesel, and undiluted triclopyr (Pathfinder II) provided 80- 100% control of saltcedar, and were more effective than triclopyr + 2,4-D (Crossbow) applied as a 4% v/v solution in diesel (60% control). During 2008-2010, 10% imazapyr, 50% glyphosate, glyphosate + imazapyr (0.5% + 0.5%), triclopyr at 10 or 25%, and a mixture of triclopyr + fluroxypyr (PastureGard) at 25% all provided greater than 91% control of saltcedar. Basal bark control using 10% v/v triclopyr in diesel averaged 72% control. Foliar applications with 0.5 or 1% imazapyr and 0.5% + 1% imazapyr + glyphosate all provided greater than 84% control of saltcedar treated in 2008-2011. Imazapic (Plateau) at 1% was first compared with 1% imazapyr during 2014-2016 with both treatments providing about 80% control. During 2017-2021, 1% imazapyr (82% control), 1% imazapic (79% control), and 0.5% + 0.5% imazapyr + glyphosate (92% control) were all more effective than a combination of aminopyralid (Milestone) + triclopyr applied at 239 g/L + 359 g/L (42% control). Herbicides can be applied as cutstump, basal bark, or foliar treatments for the control of saltcedar.

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Association Of Elevated Serum Aldosterone Concentrations In Pregnancy With Hypertension, Robin C. Shoemaker, Marko Poglitsch, Dolph Lewis Davis Iii, Hong Huang, Aric Schadler, Neil Patel, Katherine Vignes, Aarthi Srinivasan, Cynthia Cockerham-Morris, John Anthony Bauer, John M. O’Brien Nov 2023

Association Of Elevated Serum Aldosterone Concentrations In Pregnancy With Hypertension, Robin C. Shoemaker, Marko Poglitsch, Dolph Lewis Davis Iii, Hong Huang, Aric Schadler, Neil Patel, Katherine Vignes, Aarthi Srinivasan, Cynthia Cockerham-Morris, John Anthony Bauer, John M. O’Brien

UK CARES Faculty Publications

Emerging evidence indicates a previously unrecognized, clinically relevant spectrum of abnormal aldosterone secretion associated with hypertension severity. It is not known whether excess aldosterone secretion contributes to hypertension during pregnancy. We quantified aldosterone concentrations and angiotensin peptides in serum (using liquid chromatography with tandem mass spectrometry) in a cohort of 128 pregnant women recruited from a high-risk obstetrics clinic and followed prospectively for the development of gestational hypertension, pre-eclampsia, superimposed pre-eclampsia, chronic hypertension, or remaining normotensive. The cohort was grouped by quartile of aldosterone concentration in serum measured in the first trimester, and blood pressure, angiotensin peptides, and hypertension outcomes …

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Chain Conformation And Exciton Delocalization In A Push-Pull Conjugated Polymer, Yulong Zheng, Rahul Venkatesh, Connor P. Callaway, Campbell Viersen, Kehinde H. Fagbohungbe, Aaron L. Liu, Chad Risko, Elsa Reichmanis, Carlos Silva-AcuñA Nov 2023

Chain Conformation And Exciton Delocalization In A Push-Pull Conjugated Polymer, Yulong Zheng, Rahul Venkatesh, Connor P. Callaway, Campbell Viersen, Kehinde H. Fagbohungbe, Aaron L. Liu, Chad Risko, Elsa Reichmanis, Carlos Silva-AcuñA

UK CARES Faculty Publications

Linear and nonlinear optical line shapes reveal details of excitonic structure in polymer semiconductors. We implement absorption, photoluminescence, and transient absorption spectroscopies in DPP-DTT, an electron push−pull copolymer, to explore the relationship between their spectral line shapes and chain conformation, deduced from resonance Raman spectroscopy and from ab initio calculations. The viscosity of precursor polymer solutions before film casting displays a transition that suggests gel formation above a critical concentration. Upon crossing this viscosity deflection concentration, the line shape analysis of the absorption spectra within a photophysical aggregate model reveals a gradual increase in interchain excitonic coupling. We also observe …

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Benchmark Dataset For Training Machine Learning Models To Predict The Pathway Involvement Of Metabolites, Erik D. Huckvale, Christian D. Powell, Huan Jin, Hunter N. B. Moseley Nov 2023

Benchmark Dataset For Training Machine Learning Models To Predict The Pathway Involvement Of Metabolites, Erik D. Huckvale, Christian D. Powell, Huan Jin, Hunter N. B. Moseley

Markey Cancer Center Faculty Publications

Metabolic pathways are a human-defined grouping of life sustaining biochemical reactions, metabolites being both the reactants and products of these reactions. But many public datasets include identified metabolites whose pathway involvement is unknown, hindering metabolic interpretation. To address these shortcomings, various machine learning models, including those trained on data from the Kyoto Encyclopedia of Genes and Genomes (KEGG), have been developed to predict the pathway involvement of metabolites based on their chemical descriptions; however, these prior models are based on old metabolite KEGG-based datasets, including one benchmark dataset that is invalid due to the presence of over 1500 duplicate entries. …

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Α-Synuclein Is The Major Platelet Isoform But Is Dispensable For Activation, Secretion, And Thrombosis, Alexis N. Smith, Smita Joshi, Harry Chanzu, Hammodah Rawhi Hammodah Alfar, Kanakanagavalli Shravani Prakhya, Sidney W. Whiteheart Nov 2023

Α-Synuclein Is The Major Platelet Isoform But Is Dispensable For Activation, Secretion, And Thrombosis, Alexis N. Smith, Smita Joshi, Harry Chanzu, Hammodah Rawhi Hammodah Alfar, Kanakanagavalli Shravani Prakhya, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Platelets play many roles in the vasculature ensuring proper hemostasis and maintaining integrity. These roles are facilitated, in part, by cargo molecules released from platelet granules via Soluble NSF Attachment Protein Receptor (SNARE) mediated membrane fusion, which is controlled by several protein-protein interactions. Chaperones have been characterized for t-SNAREs (i.e. Munc18b for Syntaxin-11), but none have been clearly identified for v-SNAREs. α- Synuclein has been proposed as a v-SNARE chaperone which may affect SNARE-complex assembly, fusion pore opening, and thus secretion. Despite its abundance and that it is the only isoform present, α-synuclein’s role in platelet secretion is uncharacterized. In …

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Human Schwann Cells In Vitro I. Nerve Tissue Processing, Pre-Degeneration, Isolation, And Culturing Of Primary Cells, Gabriela I. Aparicio, Paula V. Monje Nov 2023

Human Schwann Cells In Vitro I. Nerve Tissue Processing, Pre-Degeneration, Isolation, And Culturing Of Primary Cells, Gabriela I. Aparicio, Paula V. Monje

Markey Cancer Center Faculty Publications

This paper presents versatile protocols to prepare primary human Schwann cell (hSC) cultures from mature peripheral nervous system tissues, including fascicles from long spinal nerves, nerve roots, and ganglia. This protocol starts with a description of nerve tissue procurement, handling, and dissection to obtain tissue sections suitable for hSC isolation and culturing. A description follows on how to disintegrate the nerve tissue by delayed enzymatic dissociation, plate the initial cell suspensions on a two-dimensional substrate, and culture the primary hSCs. Each section contains detailed procedures, technical notes, and background information to aid investigators in understanding and managing all steps. Some …

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2023 Final Report For Databases In The 2022 Traffic Records Improvement Plan: Facilitating The Development Of Projects To Attain The Goals In The Implementation Plan For The 2022-26 Traffic Records Strategic Plan, Lenahan O'Connell, Samantha Wright, Reginald Souleyrette Oct 2023

2023 Final Report For Databases In The 2022 Traffic Records Improvement Plan: Facilitating The Development Of Projects To Attain The Goals In The Implementation Plan For The 2022-26 Traffic Records Strategic Plan, Lenahan O'Connell, Samantha Wright, Reginald Souleyrette

Kentucky Transportation Center Research Report

During fiscal year 2023, with financial support (Grant #M3Da-2022-04) from the Kentucky Office of Highway Safety, the Kentucky Transportation Center (KTC)-continued its work with traffic database officials to facilitate successful attainment of the remaining goals from the 2017-21 Traffic Records Strategic Plan (TRSP), which goals are in the 2022-26 TRSP Transportation Records Improvement Plan (TRIP). For most databases, some new goals were developed; this required further refinement of some projects or strategies to improve database performance. Projects to complete the goals in the TRIP were continued and some completed for the following databases: CRASH, Citation/Adjudication, Injury Surveillance (KIPRC and EMS), …

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Novel Strategies In Antithrombotic Therapy: Targeting Thrombosis While Preserving Hemostasis, Martha M. S. Sim, Semekidus Shiferawe, Jeremy P. Wood Oct 2023

Novel Strategies In Antithrombotic Therapy: Targeting Thrombosis While Preserving Hemostasis, Martha M. S. Sim, Semekidus Shiferawe, Jeremy P. Wood

Saha Cardiovascular Research Center Faculty Publications

Antithrombotic therapy is a delicate balance between the benefits of preventing a thrombotic event and the risks of inducing a major bleed. Traditional approaches have included antiplatelet and anticoagulant medications, require careful dosing and monitoring, and all carry some risk of bleeding. In recent years, several new targets have been identified, both in the platelet and coagulation systems, which may mitigate this bleeding risk. In this review, we briefly describe the current state of antithrombotic therapy, and then present a detailed discussion of the new generation of drugs that are being developed to target more safely existing or newly identified …

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A Blunted Th17 Cytokine Signature In Women With Mild Cognitive Impairment: Insights From Inflammatory Profiling Of A Community-Based Cohort Of Older Adults, Adam D. Bachstetter, Jenny Lutshumba, Edric D. Winford, Erin L. Abner, Barbra J. Martin, Jordan P. Harp, Linda J. Van Eldik, Frederick A. Schmitt, Donna M. Wilcock, Ann M. Stowe, Gregory A. Jicha, Barbara S. Nikolajczyk Oct 2023

A Blunted Th17 Cytokine Signature In Women With Mild Cognitive Impairment: Insights From Inflammatory Profiling Of A Community-Based Cohort Of Older Adults, Adam D. Bachstetter, Jenny Lutshumba, Edric D. Winford, Erin L. Abner, Barbra J. Martin, Jordan P. Harp, Linda J. Van Eldik, Frederick A. Schmitt, Donna M. Wilcock, Ann M. Stowe, Gregory A. Jicha, Barbara S. Nikolajczyk

Markey Cancer Center Faculty Publications

People with dementia have an increase in brain inflammation, caused in part by innate and adaptive immune cells. However, it remains unknown whether dementia-associated diseases alter neuro-immune reflex arcs to impact the systemic immune system. We examined peripheral immune cells from a community-based cohort of older adults to test if systemic inflammatory cytokine signatures associated with early stages of cognitive impairment. Human peripheral blood mononuclear cells were cultured with monocyte or T-cell-targeted stimuli, and multiplex assays quantitated cytokines in the conditioned media. Following T-cell-targeted stimulation, cells from women with cognitive impairment produced lower amounts of TH17 cytokines compared with cells …

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Copy Number Variation That Influences The Ionizing Radiation Sensitivity Of Oral Squamous Cell Carcinoma, Tadahide Izumi, Piotr G. Rychahou, Li Chen, Molly H. Smith, Joseph Valentino Oct 2023

Copy Number Variation That Influences The Ionizing Radiation Sensitivity Of Oral Squamous Cell Carcinoma, Tadahide Izumi, Piotr G. Rychahou, Li Chen, Molly H. Smith, Joseph Valentino

Markey Cancer Center Faculty Publications

Genome instability in cancer cells causes not only point mutations but also structural variations of the genome, including copy number variations (CNVs). It has recently been proposed that CNVs arise in cancer to adapt to a given microenvironment to survive. However, how CNV influences cellular resistance against ionizing radiation remains unknown. PRMT5 (protein arginine methyltransferase 5) and APE1 (apurinic/apyrimidinic endonuclease 1), which enhance repair of DNA double-strand breaks and oxidative DNA damage, are closely localized in the chromosome 14 of the human genome. In this study, the genomics data for the PRMT5 and APE1 genes, including their expression, CNVs, and …

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Elongation Of Very Long Chain Fatty Acids-3 (Elovl3) Is Activated By Zhx2 And Is A Regulator Of Cell Cycle Progression, Kate Townsend Creasy, Hui Ren, Jieyun Jiang, Martha L. Peterson, Brett T. Spear Oct 2023

Elongation Of Very Long Chain Fatty Acids-3 (Elovl3) Is Activated By Zhx2 And Is A Regulator Of Cell Cycle Progression, Kate Townsend Creasy, Hui Ren, Jieyun Jiang, Martha L. Peterson, Brett T. Spear

Markey Cancer Center Faculty Publications

Zinc fingers and homeoboxes 2 (Zhx2) are transcriptional regulators of liver gene expression with key functions in embryonic development as well as tissue regeneration in response to damage and disease, presumably through its control of target genes. Previous microarray data suggested that elongation of very long chain fatty acids-3 (Elovl3), a member of the ELOVL family of enzymes that synthesize very long chain fatty acids (VLCFAs), is a putative Zhx2 target gene. VLCFAs are core component of ceramides and other bioactive sphingolipids that are often dysregulated in diseases and regulate key cellular processes including proliferation. Since several previously identified Zhx2 …

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Phosphatidic Acid Binding To Patched Contributes To The Inhibition Of Smoothened And Hedgehog Signaling In Drosophila Wing Development, Jie Zhang, Yajuan Liu, Chi Wang, Craig W. Vander Kooi, Jianhang Jia Oct 2023

Phosphatidic Acid Binding To Patched Contributes To The Inhibition Of Smoothened And Hedgehog Signaling In Drosophila Wing Development, Jie Zhang, Yajuan Liu, Chi Wang, Craig W. Vander Kooi, Jianhang Jia

Markey Cancer Center Faculty Publications

Hedgehog (Hh) signaling controls growth and patterning during embryonic development and homeostasis in adult tissues. Hh binding to the receptor Patched (Ptc) elicits intracellular signaling by relieving Ptc-mediated inhibition of the transmembrane protein Smoothened (Smo). We uncovered a role for the lipid phosphatidic acid (PA) in the regulation of the Hh pathway in Drosophila melanogaster. Deleting the Ptc C-terminal tail or mutating the predicted PA-binding sites within it prevented Ptc from inhibiting Smo in wing discs and in cultured cells. The C-terminal tail of Ptc directly interacted with PA in vitro, an association that was reduced by Hh, and increased …

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Stat3 Modulates Cd4+ T Mitochondrial Dynamics And Function In Aging, Emelia Zukowski, Marco Sannella, Jack Donato Rockhold, Gabriella Kalantar, Jingting Yu, Sara Santacruz-Calvo, Madison K. Kuhn, Nasun Hah, Ling Ouyang, Tzu-Wen Wang, Lyanne Murphy, Heather Marszalkowski, Kaleigh Gibney, Micah J. Drummond, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath Oct 2023

Stat3 Modulates Cd4+ T Mitochondrial Dynamics And Function In Aging, Emelia Zukowski, Marco Sannella, Jack Donato Rockhold, Gabriella Kalantar, Jingting Yu, Sara Santacruz-Calvo, Madison K. Kuhn, Nasun Hah, Ling Ouyang, Tzu-Wen Wang, Lyanne Murphy, Heather Marszalkowski, Kaleigh Gibney, Micah J. Drummond, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath

Markey Cancer Center Faculty Publications

Aging promotes numerous intracellular changes in T cells that impact their effector function. Our data show that aging promotes an increase in the localization of STAT3 to the mitochondria (mitoSTAT3), which promotes changes in mitochondrial dynamics and function and T-cell cytokine production. Mechanistically, mitoSTAT3 increased the activity of aging T-cell mitochondria by increasing complex II. Limiting mitoSTAT3 using a mitochondria-targeted STAT3 inhibitor, Mtcur-1 lowered complex II activity, prevented age-induced changes in mitochondrial dynamics and function, and reduced Th17 inflammation. Exogenous expression of a constitutively phosphorylated form of STAT3 in T cells from young adults mimicked changes in mitochondrial dynamics and …

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Characterizing Louisville Wetlands From Above And Below To Better Predict Wetland Carbon Sink-Source Status, Andrea E. Gaughan, Andrew S. Mehring, Mark Tierney, David Brown, Kassidy Haynes, Madison Cicha Sep 2023

Characterizing Louisville Wetlands From Above And Below To Better Predict Wetland Carbon Sink-Source Status, Andrea E. Gaughan, Andrew S. Mehring, Mark Tierney, David Brown, Kassidy Haynes, Madison Cicha

Kentucky Water Resources Annual Symposium

No abstract provided.

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Full Program Proceedings For 2023 Kentucky Water Resources Symposium, Kentucky Water Research Institute Sep 2023

Full Program Proceedings For 2023 Kentucky Water Resources Symposium, Kentucky Water Research Institute

Kentucky Water Resources Annual Symposium

No abstract provided.

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Evaluation Of Durable Pavement Striping, William Staats, Erin Lammers-Staats Sep 2023

Evaluation Of Durable Pavement Striping, William Staats, Erin Lammers-Staats

Kentucky Transportation Center Research Report

Roadway pavement markings, colloquially referred to as “striping”, can be made of various combinations of paint and reflective beads. In the interest of aligning Kentucky with the state-of-the-art durable pavement marking practices of other states, the Kentucky Transportation Cabinet (KYTC) developed a research study aimed at improving pavement marking specifications and practices. This study reviewed current practices, identified potential improvements, and performed a systematic evaluation in a controlled environment on both asphalt and concrete roads. The state evaluated high-build waterborne paint, extruded and spray thermoplastic, polyurea, and preformed plastic tape, as well as several bead packages including M247, Missouri blend, …

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Inspection Training Course On Bridge Preventive Maintenance Activities, Danny Wells, Sudhir Palle Sep 2023

Inspection Training Course On Bridge Preventive Maintenance Activities, Danny Wells, Sudhir Palle

Kentucky Transportation Center Research Report

Despite over 30 percent of bridges in the United States having exceeded their 50-year design lives, most state departments of transportation (DOTs) lack the funding needed to replace bridges on a large scale. In response, agencies have increasingly turned to bridge preventive maintenance activities to prolong bridge service lives. These activities provide a safe and cost-effective way to slow the rate at which structures deteriorate, mitigate the effects of aging, and improve bridge functional condition. The Kentucky Transportation Cabinet (KYTC) has become increasingly reliant on preventive maintenance to preserve and extend the service lives of its steel and concrete bridges. …

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Cell-Free, High-Density Lipoprotein-Specific Phospholipid Efflux Assay Predicts Incident Cardiovascular Disease, Masaki Sato, Edward B. Neufeld, Martin P. Playford, Yu Lei, Alexander V. Sorokin, Angel M. Aponte, Lita A. Freeman, Scott M. Gordon, Amit K. Dey, Kianoush Jeiran, Masato Hamasaki, Maureen L. Sampson, Robert D. Shamburek, Jingrong Tang, Marcus Y. Chen, Kazuhiko Kotani, Josephine L. C. Anderson, Robin P. F. Dullaart, Nehal N. Mehta, Uwe T. F. Tietge, Alan Thomas Remaley Sep 2023

Cell-Free, High-Density Lipoprotein-Specific Phospholipid Efflux Assay Predicts Incident Cardiovascular Disease, Masaki Sato, Edward B. Neufeld, Martin P. Playford, Yu Lei, Alexander V. Sorokin, Angel M. Aponte, Lita A. Freeman, Scott M. Gordon, Amit K. Dey, Kianoush Jeiran, Masato Hamasaki, Maureen L. Sampson, Robert D. Shamburek, Jingrong Tang, Marcus Y. Chen, Kazuhiko Kotani, Josephine L. C. Anderson, Robin P. F. Dullaart, Nehal N. Mehta, Uwe T. F. Tietge, Alan Thomas Remaley

Saha Cardiovascular Research Center Faculty Publications

BACKGROUND. Cellular cholesterol efflux capacity (CEC) is a better predictor of cardiovascular disease (CVD) events than HDL- cholesterol (HDL-C) but is not suitable as a routine clinical METHODS. We developed an HDL-specific phospholipid efflux (HDL-SPE) assay to assess HDL functionality based on whole plasma HDL apolipoprotein–mediated solubilization of fluorescent phosphatidylethanolamine from artificial lipid donor particles. We first assessed the association of HDL-SPE with prevalent coronary artery disease (CAD): study I included NIH severe-CAD (n = 50) and non-CAD (n = 50) participants, who were frequency matched for sex, BMI, type 2 diabetes mellitus, and smoking; study II included Japanese CAD …

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A Lamprey Neural Cell Type Atlas Illuminates The Origins Of The Vertebrate Brain, Francesco Lamanna, Francisca Hervas-Sotomayor, A. Phillip Oel, David Jandzik, Daniel Sobrido-Cameán, Gabriel N. Santos-Durán, Megan L. Martik, Jan Stundl, Stephen A. Green, Thoomke Brüning, Katharina Mößinger, Julia Schmidt, Celine Schneider, Mari Sepp, Florent Murat, Jeramiah J. Smith, Marianne E. Bronner, María Celina Rodicio, Antón Barreiro-Iglesias, Daniel M. Medeiros, Detlev Arendt, Henrik Kaessmann Sep 2023

A Lamprey Neural Cell Type Atlas Illuminates The Origins Of The Vertebrate Brain, Francesco Lamanna, Francisca Hervas-Sotomayor, A. Phillip Oel, David Jandzik, Daniel Sobrido-Cameán, Gabriel N. Santos-Durán, Megan L. Martik, Jan Stundl, Stephen A. Green, Thoomke Brüning, Katharina Mößinger, Julia Schmidt, Celine Schneider, Mari Sepp, Florent Murat, Jeramiah J. Smith, Marianne E. Bronner, María Celina Rodicio, Antón Barreiro-Iglesias, Daniel M. Medeiros, Detlev Arendt, Henrik Kaessmann

Markey Cancer Center Faculty Publications

The vertebrate brain emerged more than ~500 million years ago in common evolutionary ancestors. To systematically trace its cellular and molecular origins, we established a spatially resolved cell type atlas of the entire brain of the sea lamprey—a jawless species whose phylogenetic position affords the reconstruction of ancestral vertebrate traits—based on extensive single-cell RNA-seq and in situ sequencing data. Comparisons of this atlas to neural data from the mouse and other jawed vertebrates unveiled various shared features that enabled the reconstruction of cell types, tissue structures and gene expression programs of the ancestral vertebrate brain. However, our analyses also revealed …

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Bacteroides Fragilis In The Gut Microbiomes Of Alzheimer’S Disease Activates Microglia And Triggers Pathogenesis In Neuronal C/Ebpβ Transgenic Mice, Yiyuan Xia, Yifan Xiao, Zi-Hao Wang, Ashfaqul M. Alam, John P. Haran, Beth A. Mccormick, Xiji Shu, Xiaochuan Wang, Keqiang Ye Sep 2023

Bacteroides Fragilis In The Gut Microbiomes Of Alzheimer’S Disease Activates Microglia And Triggers Pathogenesis In Neuronal C/Ebpβ Transgenic Mice, Yiyuan Xia, Yifan Xiao, Zi-Hao Wang, Ashfaqul M. Alam, John P. Haran, Beth A. Mccormick, Xiji Shu, Xiaochuan Wang, Keqiang Ye

Markey Cancer Center Faculty Publications

Gut dysbiosis contributes to Alzheimer’s disease (AD) pathogenesis, and Bacteroides strains are selectively elevated in AD gut microbiota. However, it remains unknown which Bacteroides species and how their metabolites trigger AD pathologies. Here we show that Bacteroides fragilis and their metabolites 12-hydroxy-heptadecatrienoic acid (12-HHTrE) and Prostaglandin E2 (PGE2) activate microglia and induce AD pathogenesis in neuronal C/EBPβ transgenic mice. Recolonization of antibiotics cocktail-pretreated Thy1-C/EBPβ transgenic mice with AD patient fecal samples elicits AD pathologies, associated with C/EBPβ/Asparaginyl endopeptidase (AEP) pathway upregulation, microglia activation, and cognitive disorders compared to mice receiving healthy donors’ fecal microbiota transplantation (FMT). Microbial 16S rRNA sequencing …

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Syne1 Mutation Is Associated With Increased Tumor Mutation Burden And Immune Cell Infiltration In Ovarian Cancer, Laura M. Harbin, Nan Lin, Frederick R. Ueland, Jill M. Kolesar Sep 2023

Syne1 Mutation Is Associated With Increased Tumor Mutation Burden And Immune Cell Infiltration In Ovarian Cancer, Laura M. Harbin, Nan Lin, Frederick R. Ueland, Jill M. Kolesar

Markey Cancer Center Faculty Publications

SYNE1, a nuclear envelope protein critical for cellular structure and signaling, is downregulated in numerous malignancies. SYNE1 alterations are found in 10% of gynecologic malignancies and 5% of epithelial ovarian cancers. Previous studies demonstrated an association between SYNE1 mutation, increased tumor mutation burden (TMB), and immunotherapy response. This study evaluates the SYNE1 mutation frequency, association with TMB, and downstream effects of SYNE1 mutation in ovarian cancer. Genetic information, including whole-exome sequencing, RNA analysis, and somatic tumor testing, was obtained for consenting ovarian cancer patients at an academic medical center. Mutation frequencies were compared between the institutional cohort and The Cancer …

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Evaluation Of Sweet Grain Sorghum Silage For Dairy Cows As An Alternative To Irrigated Maize Silage, W. G. Do Nascimento, Y. Barrière, X. Charrier, Christian Huyghe, J. C. Emile Aug 2023

Evaluation Of Sweet Grain Sorghum Silage For Dairy Cows As An Alternative To Irrigated Maize Silage, W. G. Do Nascimento, Y. Barrière, X. Charrier, Christian Huyghe, J. C. Emile

IGC Proceedings (1977-2023)

Under European dairy cattle rearing conditions, whole plant maize silage is the main part of the dairy cow's diet especially during the winter season. Nevertheless maize production can be limited in some areas because summer rainfall is insufficient and so irrigation is necessary. Grain sorghum hybrids, and especially sweet sorghum types, are potentially of great interest to avoid this water consumption (Lemaire et al., 1996, Legarto, 2000). For this reason we evaluated in 2003 the benefits and limits of a sweet grain sorghum silage for dairy milk production, compared to an irrigated maize silage. We paid particularl attention to …

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Nitrate Leaching In The Meadows Of Western Lithuania With Different Liming And Fertilisation Levels, Ruta Butkute, N. Daugeliene Aug 2023

Nitrate Leaching In The Meadows Of Western Lithuania With Different Liming And Fertilisation Levels, Ruta Butkute, N. Daugeliene

IGC Proceedings (1977-2023)

Investigations of recent decades in the Baltic region including Lithuania showed that intensive liming and mineral fertilisation are the main factors achieving maximum crop yield. However, this farming method had a negative effect on soil quality and nutrient leaching became more intensive. Grassland fertilisation with nitrogen (N) helps plants to assimilate P, K, Ca, Na, but it may increase leaching of nutrients (Niczyporuk & Jankowska, 1995). Nitrate leaching is usually low from grasslands, primarily due to their long growing season compared to arable crops (Korsaeth et.al., 2003). The objective of this research was to determine the effect of liming …

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A Situation Analysis Of Ley Pasture Utilisation In The Western Downs And Maranoa Regions Of S Queensland, Australia, K. J. Sibson, L. Bahnisch, R. Routley, K. Taylor Aug 2023

A Situation Analysis Of Ley Pasture Utilisation In The Western Downs And Maranoa Regions Of S Queensland, Australia, K. J. Sibson, L. Bahnisch, R. Routley, K. Taylor

IGC Proceedings (1977-2023)

Previous studies have shown that the uptake of ley pasture systems in S Queensland's grain growing region has been slow when compared with mixed farming systems in S Australia. This is despite their demonstrated benefits to subsequent crops, livestock production and the environment. A survey was conducted that aimed to determine the level of utilisation of ley pastures in the Western Downs and Maranoa regions of S Queensland, and the possible constraints to their adoption, and benefits arising from their use. The survey also aimed to determine the commonly used pasture species, the reasons for their use and their contribution …

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A Situation Analysis Of Ley Pasture Utilisation In The Western Downs And Maranoa Regions Of S Queensland, Australia, K. J. Sibson, L. Bahnisch, R. Routley, K. Taylor Aug 2023

A Situation Analysis Of Ley Pasture Utilisation In The Western Downs And Maranoa Regions Of S Queensland, Australia, K. J. Sibson, L. Bahnisch, R. Routley, K. Taylor

IGC Proceedings (1977-2023)

Previous studies have shown that the uptake of ley pasture systems in S Queensland's grain growing region has been slow when compared with mixed farming systems in S Australia. This is despite their demonstrated benefits to subsequent crops, livestock production and the environment. A survey was conducted that aimed to determine the level of utilisation of ley pastures in the Western Downs and Maranoa regions of S Queensland, and the possible constraints to their adoption, and benefits arising from their use. The survey also aimed to determine the commonly used pasture species, the reasons for their use and their contribution …

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Sustaining Grass-Legume Pastures For Cow-Calf Herds: A Case Study, John L. Caddel, D. D. Redfearn, R. L. Woods Aug 2023

Sustaining Grass-Legume Pastures For Cow-Calf Herds: A Case Study, John L. Caddel, D. D. Redfearn, R. L. Woods

IGC Proceedings (1977-2023)

An on-going pasture demonstration study has been used since 1988 to demonstrate methods to improve pasture production for small beef cow-calf herds. Many cattle enterprises are not economically viable because poor management decisions lead to excessive stocking rate, ineffective fertilisation programmes etc., leading to a dependence on hay purchases. The initial objective, continued until 2001, was to maintain one cow- calf pair per ha without purchasing forage or grain produced off farm. More recently, reducing the dependence on harvested forage has been added as an objective.

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Potentialities Of Near Infrared Spectroscopy To Assess Nitrogen, Phosphorus And Potassium Nutrient Status Of Grasslands In The Reunion Island, Philippe Lecomte, Vincent Blanfort, Michael Duru, P. Thomas, P. Grimaud Aug 2023

Potentialities Of Near Infrared Spectroscopy To Assess Nitrogen, Phosphorus And Potassium Nutrient Status Of Grasslands In The Reunion Island, Philippe Lecomte, Vincent Blanfort, Michael Duru, P. Thomas, P. Grimaud

IGC Proceedings (1977-2023)

Controlled mineral fertilisation practices are an important component for sustainable management of grasslands. The assessment of available nutrients for plants and the general recommendations on the level of phosphorus and potassium to apply to grasslands are classically based on classical soil analysis and average regional levels. For nitrogen, mid or long term recommendations cannot easily be derived solely from soil composition, because it may be rapidly leached from the soil. Recent approaches tended to show that herbage plant N (Lemaire & Gastal, 1997), P, K (Duru & Huché, 1997) mineral analyses associated with actual biomass measurement could be useful for …

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