Digital Commons Network^™

Hpr6 Mutants And Uses Thereof, Rolf Joseph Craven

Pharmacology and Nutritional Sciences Faculty Patents

Methods and agents that interfere with Hpr6 function in non-sarcoma tumor cells are disclosed. Anti-Hpr6 agents are used to enhance the killing effect of anti-cancer agents in non-sarcoma tumor cells and to teat non-sarcoma tumors.

Social Factors Affecting Treatment Of Cervical Cancer: Ethical Issues And Policy Implications, Shannon N. Westin, Dan Bustillos, Jacalyn B. Gano, Margaret M. Fields, Ann L. Coker, Charlotte C. Sun, Lois M. Ramondetta

CRVAW Faculty Journal Articles

Health care in the United States has become a privilege rather than a right. Patients who have the greatest need are the ones most likely to be denied this privilege. Despite recent advances in disease detection and treatment, many patients do not receive even the bare minimum of care. The high complexity of the health care system in the setting of patients with low levels of health literacy significantly affects the ability to seek and receive treatment in a timely fashion. In addition, lack of insurance, transportation, and social support further complicate access to care. To truly provide a standard …

Evaluation Of Noise Impact Mitigation Protocols To Support Css, Ted Grossardt, Lou Cohn, Al Harris, Keiron Bailey, John Ripy

Kentucky Transportation Center Research Report

This research project developed and evaluated practical ways of involving the public in context sensitive sound mitigation strategies. The integrated use of photo montage, PowerPoint presentation, linked traffic sound files, and audience response systems demonstrated that significant visual and aural differences could be clearly portrayed and clear preferences could be expressed by citizens and professionals alike, even where the choice menu was quite complex.

Investigation Of Voids/Cracking On The I-275 Twin Bridges Over The Ohio River In Kenton County - Phase I, Brad Rister, Theodore Hopwood Ii

Kentucky Transportation Center Research Report

An evaluation of the northbound bridge approach and the abutment wall of (Combs-Hehl) bridge on I-275 in Kenton County was conducted in September 2007. The inspection consisted of using ground penetrating radar to look for potential voids beneath the concrete approach slab and a video camera inspection to inspect the void space beneath the pier cap/concrete beam in front of the abutment wall.

Results of field testing and recommendations:

A possible void approximately 1-2 inches in depth resides under the approach slab approximately 105 feet before the bridge abutment in the fast lane. It is recommended that this section be …

Enkephalin-Encoding Herpes Simplex Virus-1 Decreases Inflammation And Hotplate Sensitivity In A Chronic Pancreatitis Model, Hong Yang, Terry A. Mcnearney, Rong Chu, Ying Lu, Yong Ren, David C. Yeomans, Steven P. Wilson, Karin N. Westlund

Physiology Faculty Publications

Background: A chronic pancreatitis model was developed in young male Lewis rats fed a high-fat and alcohol liquid diet beginning at three weeks. The model was used to assess time course and efficacy of a replication defective herpes simplex virus type 1 vector construct delivering human cDNA encoding preproenkephalin (HSV-ENK).

Results: Most surprising was the relative lack of inflammation and tissue disruption after HSV-ENK treatment compared to the histopathology consistent with pancreatitis (inflammatory cell infiltration, edema, acinar cell hypertrophy, fibrosis) present as a result of the high-fat and alcohol diet in controls. The HSV-ENK vector delivered to the pancreatic surface …

Alfalfa: Forage Crop Of The Future, Neal P. Martin, David Mertens, Ronald Hatfield, Hans Jung

Kentucky Alfalfa and Stored Forage Conference

In 2007, U.S. farmers harvested 23.6 million acres of alfalfa. Alfalfa harvested as hay and haylage produced 82.8 million tons valued at approximately $9.4 billion, ranking behind only corn and soybeans. Alfalfa hay supports dairy, beef, sheep, and horse production in the U.S. as well as a growing export market.

National Hay Association President's Perspective: What A Year To Be President, Ron Tombaugh

Kentucky Alfalfa and Stored Forage Conference

Over the years, I have had the opportunity to attend the Kentucky Alfalfa Conference in Cave City. Usually it was combined with a trip to deliver hay into Kentucky to either a dairy, beef, or horse customer. This is an excellent event.

The following is my “acceptance” speech given in September 2007 in Columbus, Ohio, when I was installed as President of the National Hay Association.

Coal Truck Driver Fatally Injured In Collision With Another Coal Tractor-Trailer, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

During the winter of 2008, a 39 –year-old tractor-trailer driver died after striking the right rear of a coal tractor-trailer with his vehicle, then veering into an embankment, rolling over and catching fire. The driver of a coal tractor-trailer (Truck 1) and the decedent driver of a second coal tractor-trailer (Truck 2) had descended a hill in the lane next to one another on a four-lane undivided highway. Truck 1 stopped at a traffic light at an intersection at the bottom of a hill while Truck 2 approached the intersection from behind in the left lane. The light turned green …

Thrombospondin-1 Is An Adipokine Associated With Obesity, Adipose Inflammation, And Insulin Resistance, Vijayalakshmi Varma, Aiwei Yao-Borengasser, Angela M. Bodles, Neda Rasouli, Bounleut Phanavanh, Greg T. Nolen, Emily M. Kern, Radhakrishnan Nagarajan, Horace J. Spencer, Mi-Jeong Lee, Susan K. Fried, Charlotte A. Peterson, Philip A. Kern

Clinical and Translational Science Faculty Publications

OBJECTIVE-We examined the relationship between the expression of thrombospondin (TSP)1, an antiangiogenic factor and regulator of transforming growth factor-β activity, obesity, adipose inflammation, and insulin resistance.

RESEARCH DESIGN AND METHODS-TSP1 gene expression was quantified in subcutaneous adipose tissue (SAT) of 86 nondiabetic subjects covering a wide range of BMI and insulin sensitivity, from visceral adipose (VAT) and SAT from 14 surgical patients and from 38 subjects with impaired glucose tolerance randomized to receive either pioglitazone or metformin for 10 weeks. An adipocyte culture system was also used to assess the effects of pioglitazone and coculture with macrophages on …

Hispanic Carpenter Dies After Falling From Homemade Platform, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Falls

In the Spring of 2007, a 32-year-old Hispanic male carpenter (decedent) died when he fell from a homemade platform (extended approximately seven feet in the air) after it detached from a telehandler (forklift). The decedent and two other carpenters were framing a new construction, single-family residence located on a hillside which was rough and steep. The three carpenters were framing the wall at the rear corner of the house which was high because of the sloping terrain. To reach the area, the crew decided to use a homemade platform as a makeshift scaffold. A fourth worker operated a rough-terrain forklift …

System And Process For Providing Auxiliary Information For A Packet-Switched Network Of Shared Nodes Using Dedicated Associative Store, Kenneth L. Calver, James N. Griffieon

Computer Science Faculty Patents

A system and process for providing auxiliary information about a distributed network of shared nodes, at least a plurality of the nodes being adapted for receiving at least one type of ESP-(associative ephemeral store processing) packet. Available for access at each of the plurality of ESP-adapted nodes is a dedicated associative store wherein a value, if bound to a tag, is only accessible as a bound (tag, value) pair for a short time period, τ. Different types of packets are contemplated for routing through the ESP-capable plurality of nodes such as those arbitrarily identified herein as a ‘first’ and ‘second’ …

Genome-Wide Analysis Of The Interaction Between The Endosymbiotic Bacterium Wolbachia And Its Drosophila Host, Zhiyong Xi, Laurent Gavotte, Yan Xie, Stephen L. Dobson

Entomology Faculty Publications

BACKGROUND: Intracellular Wolbachia bacteria are obligate, maternally-inherited, endosymbionts found frequently in insects and other invertebrates. The success of Wolbachia can be attributed in part to an ability to alter host reproduction via mechanisms including cytoplasmic incompatibility (CI), parthenogenesis, feminization and male killing. Despite substantial scientific effort, the molecular mechanisms underlying the Wolbachia/host interaction are unknown.

RESULTS: Here, an in vitro Wolbachia infection was generated in the Drosophila S2 cell line, and transcription profiles of infected and uninfected cells were compared by microarray. Differentially-expressed patterns related to reproduction, immune response and heat stress response are observed, including multiple genes that have …

Blending Innovation With Tradition: Trends In Academic And Public Libraries In The Usa, Antoinette Paris Greider

Library Presentations

No abstract provided.

The Denial Of Emergency Protection: Factors Associated With Court Decision Making, Carol E. Jordan, Adam J. Pritchard, Pamela Wilcox, Danielle Duckett-Pritchard

Office for Policy Studies on Violence Against Women Publications

Despite the importance of civil orders of protection as a legal resource for victims of intimate partner violence, research is limited in this area, and most studies focus on the process following a court’s initial issuance of an emergency order. The purpose of this study is to address a major gap in the literature by examining cases where victims of intimate partner violence are denied access to temporary orders of protection. The study sample included a review of 2,205 petitions that had been denied by a Kentucky court during the 2003 fiscal year. The study offers important insights into the …

Assessing The Felt Reports Of The 1811-12 New Madrid Earthquakes In The Central United States, Ron Street, John D. Kiefer, Jerry L. Raisor

Report of Investigations--KGS

The damage and felt reports describing the New Madrid, Mo., earthquakes of 1811-12 need to be assessed in the historical context in which the events occurred. Log cabins in the frontier settlements along the lower Ohio River Valley, for example, were built with a rudimentary form of base isolation, and their response to the earthquakes should not be evaluated in the same way that a modern wood-frame or brick building would be.

Also, inaccuracies have crept into the databases used for estimating the epicenters and magnitudes of the earthquakes. For example, the magnitude of the December 16, 1811, earthquake has …

Kentucky Water Resources Research Institute Annual Technical Report Fy 2007, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Annual Technical Reports (USGS’s 104b Grant Program)

The 2007 Annual Technical Report for Kentucky consolidates reporting requirements of the Section 104(b) base grant award into a single document that includes: 1) a synopsis of each student research enhancement project conducted during the period, 2) citations for related publications, reports, and presentations, 3) a description of information transfer activities, 4) a summary of student support during the reporting period, and 5) notable awards and achievements during the year.

Digital Archiving, Kathryn Lybarger

Library Presentations

No abstract provided.

State Regulation Of Complementary And Alternative Veterinary Therapies: Defining The Practice Of Veterinary Medicine In The 21st Century, Milton C. Toby

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Opening The Door: Recognizing The Many Hats Of Jockeys For Workers' Compensation Coverage, Erin N. Malony

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

The Role Of Administrative Law In Regulating "Mad Cow Disease" As Explained In Creekstone Farms Premium Beef, Llc V. Department Of Agriculture, Courtney E. Ross

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Southeastern Law Librarian Winter 2008, Seaall

Newsletters

No abstract provided.

Assessment Of Water Quality Trends In The North Fork Of Kentucky River Basin: Focus On Pathogen Impairment, Kentucky Water Resources Research Institute

KWRRI Research Reports

This project consisted of analyzing existing water quality data for streams in the Upper Forks of Kentucky River Basin, with a particular focus on pathogen trends. According to the most recent 303(d) list of Kentucky waters, the majority of streams assessed in the Upper Forks of Kentucky River Basin are impaired for primary recreational contact as a result of pathogens. The state pathogen standard for primary contact recreation is expressed in a dual form which specifies that the 30-day geometric mean of fecal coliform counts not exceed 200 colonies per 100 mL (on a minimum of five samples) and not …

Uk Law Notes, 2008, University Of Kentucky College Of Law

Annual Magazines

No abstract provided.

“There's Danger Here, Cherie!”: Liability For The Promotion And Marketing Of Drugs And Medical Devices For Off-Label Uses, Richard C. Ausness

Law Faculty Scholarly Articles

Physicians often prescribe prescription drugs and other medications for uses that are not approved by the Food and Drug Administration ("FDA"), and such "off label" prescription is widely accepted within the medical community as a legitimate form of treatment. However, the federal government discourages off-label prescription and use in various ways. For example, the FDA restricts the dissemination of information by drug companies about potential off-label therapies. In addition, federally funded health insurance programs such as Medicaid do not reimburse health care providers for off-label uses. Because drug companies make large profits from off-label prescriptions, they are often tempted to …

Foundation Problems And Pyrite Oxidation In The Chattanooga Shale, Estill County, Kentucky, Warren H. Anderson

Report of Investigations--KGS

Pyrite oxidation in the Chattanooga Shale has caused serious foundation problems in numerous buildings and structures in Estill County, Ky. Pyrite oxidizes and various secondary sulfates form when excavated shale or shale fill are used in foundations. These secondary sulfates are water- and humidity-sensitive and can form when only minor amounts of water are present in foundation materials. These sulfates form by crystal growth and expand by volume change, which causes subsequent soil expansion and heaving of any foundation materials when the materials are confined. Several structures have undergone expensive remediation to repair damaged sidewalks, floors, walls, and foundations. Zones …

"Insuring" Quality: Restrictions On Legislative Control Of Partner Benefits At Kentucky's Public Universities, Jacinta Feldman Manning

Kentucky Law Journal

No abstract provided.

Using Dlxs For Oral Histories, Kathryn Lybarger

Library Presentations

No abstract provided.

Routing In Mobile Ad-Hoc Networks: Scalability And Efficiency, Rendong Bai

University of Kentucky Doctoral Dissertations

Mobile Ad-hoc Networks (MANETs) have received considerable research interest in recent years. Because of dynamic topology and limited resources, it is challenging to design routing protocols for MANETs. In this dissertation, we focus on the scalability and efficiency problems in designing routing protocols for MANETs. We design the Way Point Routing (WPR) model for medium to large networks. WPR selects a number of nodes on a route as waypoints and divides the route into segments at the waypoints. Waypoint nodes run a high-level inter-segment routing protocol, and nodes on each segment run a low-level intra-segment routing protocol. We use DSR …

Design And Evaluation Of Inflatable Wings For Uavs, Andrew D. Simpson

University of Kentucky Doctoral Dissertations

Performance of inflatable wings was investigated through laboratory, wind tunnel and flight-testing. Three airfoils were investigated, an inflatable-rigidazable wing, an inflatable polyurethane wing and a fabric wing restraint with a polyurethane bladder. The inflatable wings developed and used within this research had a unique outer airfoil profile. The airfoil surface consisted of a series of chord-wise \bumps.andamp;quot; The effect of the bumps or \surface perturbationsandamp;quot; on the performance of the wings was of concern and was investigated through smoke-wire flow visualization. Aerodynamic measurements and predictions were made to determine the performance of the wings at varying chord based Reynolds Numbers …

Loline Alkaloid Biosynthesis Gene Expression In Epichloe Endophytes Of Grasses, Dong-Xiu Zhang

University of Kentucky Doctoral Dissertations

Loline alkaloids (LA) are secondary metabolites produced by Epichloandamp;euml; (anamorph, Neotyphodium) grass endophytes. They are toxic and deterrent to a broad range of herbivorous insects but not to livestock. This protective bioactivity has spurred considerable research into the LA biosynthetic pathway. LOL, the gene cluster containing nine genes, is required for LA biosynthesis. The regulation of LOL genes during LA production in culture and in symbio is of interest. In this study, coordinate regulation between LOL gene expression and LA production level was investigated in both MM culture and symbiota. Results showed that expression of LOL genes in N. uncinatum …