Digital Commons Network^™

The Future (Or Lack Of Future) Of Personalized Prescription In Psychiatry, Jose De Leon

Psychiatry Faculty Publications

Rapid technological advances in genetics have created conceptual chaos regarding the genetics of drug response. Terms for differing concepts are used interchangeably: pharmacogenetics with pharmacogenomics, personalized medicine with personalized prescription. Biomarker has many definitions. The author prefers the concept of personalized prescription and uses it with implications beyond pharmacogenetics by considering all scientific information valid for prescribing medication. Genetics may not be crucial for all drugs. In this comprehensive view, clinicians must consider genetic, environmental and personal variables when prescribing medication and incorporate some basic pharmacological principles: (1) safety and efficacy, (2) pharmacokinetics and pharmacodynamics, (3) therapeutic window and prescriber's …

Experimental Painting Of The I-64 Riverside Parkway In Louisville, Ky, Rick Younce, Theodore Hopwood Ii, Sudhir Palle

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet conducted a large-scale zone maintenance painting operation on 13 elevated steel bridges along the I-64 Riverside Parkway in Louisville, KY in 2007. That work included abrasive blast-cleaning and painting of steel underlying open deck joints on 3.2 miles of steel structures. The painting was performed by spray application of one coat of a calcium sulfonate alkyd coating. The painting covered an area of 237,060 ft2 of steel cleaned and painted at a unit cost of $15.82/ft2.

The project incorporated a high level of containment as the existing coating possessed lead-based paints and the project was located …

The Role Of Nf-Κb In Pparα-Mediated Hepatocarcinogenesis, Howard P. Glauert, Karen Calfee-Mason, Yixin Li, Vani Nilakantan, Michelle L. Twaroski, Job Tharappel, Brett T. Spear

Graduate Center for Nutritional Sciences Faculty Publications

In this review, the role of NF-kappaB in the induction of hepatocarcinogenesis by peroxisome proliferators is examined. The administration of peroxisome proliferators for more than a three-day period leads to the activation of NF-kappaB in the livers of rats and mice. On the other hand, peroxisome proliferator activated receptor-alpha (PPARalpha) activation in non-hepatic tissues can lead to the inhibition of NF-kappaB activation. Several lines of evidence support the hypothesis that the activation of NF-kappaB by peroxisome proliferators in the liver is mediated by oxidative stress. The role of NF-kappaB in peroxisome proliferator-induced hepatocarcinogenesis has been examined using NF-kappaB knockout models. …

Early Activities For Public Health Pbrns, Glen P. Mays

UKCPHSSR Research Briefs and Reports

Launching a successful public health practice-based research network requires a planned approach to developing the necessary infrastructure, relationships, and scientific direction.

Exploring The Impact And Implications Of Residential Mobility: From The Neighborhood To The School, Robin L. Ersing, Richard D. Sutphen, Diane N. Loeffler

Social Work Faculty Publications

This cross-sectional study examines residential relocation among a cohort of 495 fifth graders in one urban community in the Southeastern U.S. The impact of residential mobility is discussed in relation to student/family outcomes as well as the stressors placed upon schools. Results support previous findings which suggest residential relocation is correlated with academic problems. In addition, highly mobile students are twice as likely to be referred by teachers for disciplinary intervention and families are five times more likely than their residentially stable counterparts to be involved with child protective services. Implications from this study address the need for school systems, …

The Relationship Between Language Teaching And Mayan Language Conservation In Guatemala., Rusty Barrett

Linguistics Presentations

Although the Kaqchikel program was the model and inspiration for the K’iche’ program, the two programs differ in a number of ways because of differences in the sociolinguistic contexts in which they operate:

• Approaches to pedagogy and dialectal variation
• Integration with local communities
• Relationship to language documentation

The Organization Of Discipline: From Performance Management To Perversity And Punishment, Joe Soss, Richard Fording, Sanford F. Schram

University of Kentucky Center for Poverty Research Discussion Paper Series

Over the past few decades, poverty governance in the United States has been transformed by the convergence of two powerful reform movements. The first, often referred to as “paternalist,” has shifted poverty governance from an emphasis on rights and opportunities to a stance that is more directive and supervisory in promoting preferred behaviors among the poor. The second, often described as “neoliberal,” has shifted governance away from federal government control toward a system that emphasizes policy devolution, privatization, and performance competition. During this period, public officials have proved remarkably willing to hand policy control over to lower jurisdictions and private …

Breast Cancer Screening In Women Exposed In Utero To Diethylstilbestrol, Elizabeth A. Camp, Ann L. Coker, Stanley J. Robboy, Kenneth L. Noller, Karen J. Goodman, Linda T. Titus-Ernstoff, Elizabeth E. Hatch, Arthur L. Herbst, Rebecca Troisi, Raymond H. Kaufman, Ervin Adam

CRVAW Faculty Journal Articles

Purpose: To determine if women exposed in utero to diethylstilbestrol (DES) are more likely than unexposed women to receive recommended or additional breast cancer screening examinations.

Methods: 1994 Diethylstilbestrol-Adenosis (DESAD) cohort data are used to assess the degree of recommended compliance of breast cancer screenings found in 3140 DES-exposed and 826 unexposed women. Participants were enrolled at four sites: Houston, Boston, Rochester, and Los Angeles. Logistic regression modeling was used to analyze mailed questionnaire data that included reported frequency over the preceding 5 years (1990–1994) of breast-self examinations (BSEs), clinical breast examinations (CBEs), and mammograms.

Results: DES-exposed women exceeded annual …

Ethnic Disparities In Cervical Cancer Survival Among Medicare Eligible Women In A Multiethnic Population, Ann L. Coker, Katherine S. Eggleston, Xianglin L. Du, Lois Ramondetta

CRVAW Faculty Journal Articles

To determine predictors of cervical cancer survival by socioeconomic status (SES), urbanization, race/ethnicity, comorbid conditions, and treatment among elderly Medicare-eligible women whose conditions were diagnosed with cervical cancer in a multiethnic population.

Methods: A total of 538 women with cervical cancer aged 65 years or older were identified from 1999 to 2001 from the Texas Cancer Registry and were linked with the state Medicare data and Texas Vital Records to determine survival times. All women had similar access to care through Medicare fee-for-services insurance. A composite measure of SES was created using census tract-level data as was urbanization. Treatment and …

Global Ky (Winter 2009), University Of Kentucky International Center

Global Kentucky

No abstract provided.

Optical Properties Of Coal Combustion Byproducts For Particle-Size Analysis By Laser Diffraction, Robert B. Jewell, Robert F. Rathbone

Coal Combustion and Gasification Products Journal Archive

Laser diffraction analysis is commonly used for determining the particle-size distribution (PSD) of fly ash. However, there is currently no standard method for preparing samples and analyzing them. The Mie and Fraunhofer optical models are used to calculate the PSD of fly ash from laser diffraction data. The Mie theory is most applicable for particles smaller than 50 mm, and is therefore the most accurate model for the analysis of fly ash. However, the refractive index (RI) of fly ash is complex and not well known. This study presents the analysis of several supplementary cementitious materials (SCMs) such as coal …

Young Geniuses And Old Masters: The Life Cycles Of Great Artists From Masaccio To Jasper Johns, David W. Galenson, Robert Jensen

Art and Visual Studies Faculty Publications

No abstract provided.

Buying Or Selling A Horse In France: An Introduction To The Legal Context Proposed To The Attention Of U.S. Equine Lawyers, Philippe E. Corruble

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Procedural Due Process Implications Of Kentucky's Thoroughbred Medication Regulations, W. Chapman Hopkins

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

The Mississippian Section At Paddys Bluff, Crittenden County, Kentucky, Ron Counts, F. Brett Denny, James C. Hower, Zakaria Lasemi, Rodney D. Norby, Paul E. Potter, Scott Waninger, David A. Williams

Map and Chart--KGS

Paddys Bluff (Figs. 1-3) is located on the south side of the Illinois Basin on the Cumberland River, 1.7 miles downstream from Dycusburg in Crittenden County, Ky., in Carter coordinate section 23-I-16 and ecoregion 71f of the Western Highland Rim of Kentucky (Woods and others, 2002). This bluff is on a right-descending bend 18 liver miles above its junction with the Ohio River at Smithland, Livingston County. The bluff (Figs. 4A, B) is locally famous as the location for a scene from the classic 1962 film, "How the West Was Won,' a winner of three Academy Awards, starling James Stewart, …

Southeastern Law Librarian Winter 2009, Seaall

Newsletters

No abstract provided.

How Driver Risk Perception Affects Operating Speeds, Nikiforos Stamatiadis, Ted H. Grossardt, Keiron Bailey

Kentucky Transportation Center Faculty and Researcher Publications

Excessive speed is one of the primary safety hazards facing highway users. However, in many cases operating speeds exceed design speeds, and drivers generally ignore posted speed limits. The main objective of this research was to identify roadway elements and roadside features that could influence driver operating speeds in rural two-lane roads without compromising safety.

Virtual Reality video simulations were employed and drivers recorded the influence of these elements on their judgments about the appropriate driving speed. The driver/participants viewed 22 models projected on a large screen in a darkened room, simulating the windshield of a vehicle.

The viewing sessions …

Practical Metadata, Kathryn Lybarger

Library Presentations

No abstract provided.

Angiotensin Ii Induction Of Regional Effects In Murine Vasculature, Albert Phillip Owens Iii

University of Kentucky Doctoral Dissertations

The renin angiotensin system (RAS) exerts many diverse physiological functions throughout the body, mediated by its effector peptide, angiotensin II (AngII). AngII has been linked with a variety of different functions ranging from the initiation of severe vascular pathologies, such as atherosclerosis and abdominal aortic aneurysm (AAA), to mundane physiological processes of fluid homeostasis, vascular contraction, and regulation of blood pressure. To provide a potential link between these functions, an in-depth analysis of regional effects of AngII on aortic vasculature was performed.

The studies presented in this dissertation tested the overall hypothesis of whether regional changes exist in the vasculature …

Low Density Lipoprotein Receptor And Alzheimers Disease, Rangaraj K. Gopalraj

University of Kentucky Doctoral Dissertations

Since apoE allele status is the predominant Alzheimers disease (AD) genetic risk factor, functional single nucleotide polymorphisms (SNPs) in brain apoE receptors represent excellent candidates for association with AD. Therefore, three low density lipoprotein receptor (LDLR) SNPs were evaluated by TaqMan allelic discrimination assays for association with AD and I found that certain haplotypes alter the odds of AD. A SNP within LDLR exon 12, rs688, was identified in silico as neutralizing a putative exon splicing enhancer (ESE). Since LDLR is a major apoE receptor in the brain, I hypothesized that rs688 modulates LDLR splicing in neural tissues and associates …

A Protocol Suite For Wireless Personal Area Networks, Karl E. Persson

University of Kentucky Doctoral Dissertations

A Wireless Personal Area Network (WPAN) is an ad hoc network that consists of devices that surround an individual or an object. Bluetooth^® technology is especially suitable for formation of WPANs due to the pervasiveness of devices with Bluetooth^® chipsets, its operation in the unlicensed Industrial, Scientific, Medical (ISM) frequency band, and its interference resilience. Bluetooth^® technology has great potential to become the de facto standard for communication between heterogeneous devices in WPANs.

The piconet, which is the basic Bluetooth^® networking unit, utilizes a Master/Slave (MS) configuration that permits only a single master and up to …

Analysis Of Esl Teacher Endorsement Effects On English Language Learners' Student Achievement And English Language Acquisition, Anna Marie Tracy

University of Kentucky Doctoral Dissertations

Over the past twenty years, classrooms throughout the United States have becomes more ethnically and linguistically diverse with the influx of immigrant residents. The impact of this demographic change has directly affected the makeup of the mainstream classroom. One response to this rapid growth in diversity demographics has been the requirement of additional teacher preparation for instruction of English language learners.

The study focuses on the impact of English as a Second Language endorsement (ESL) on the English language acquisition and academic achievement of elementary English language learners (ELL) over a two year period in a large mountain west urbansuburban …

Investigations Of S-Glutathionylation Of Brain Proteins In The Progression Of Alzheimer's Disease And Of A Potential Glutatione Mimetic As A Treatment Of Alzheimer's Disease, Shelley Faye Newman

University of Kentucky Doctoral Dissertations

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by neurofibrillary tangles, senile plaques and loss of synapses. Many studies support the notion that oxidative stress plays an important role in AD pathogenesis. Previous studies from our laboratory employed redox proteomics to identify oxidatively modified proteins in the AD inferior parietal lobule (IPL). The proteins were consistent with AD pathology and have been central to further investigations of the disease. The present study was focused on the identification of specific targets of protein S-glutathionylation in AD, early AD (EAD), and mild cognative impairment (MCI) using a redox proteomics approach. In AD …

Political Piety: Evangelicals And The American Revolution In South Carolina And Georgia, David E. Hollingsworth

University of Kentucky Doctoral Dissertations

The study of southern evangelicals during the late colonial and revolutionary eras of American history has focused primarily on the social antagonisms that separated evangelicals from southern elites and has concluded that the rapid growth of post-war evangelicalism came as a result of evangelical acquiescence to southern gentry mores. Most study of southern evangelicals has concentrated on the upper South missing important developments in the Deep South which contradict historical assumptions of Separate triumph and the subsequent subversion of radical evangelicalism by evangelical leaders eager for societal acceptance. Evangelicals were not a monolithic movement. Key doctrines, primarily the need for …

Lipid-Based Paclitaxel And Doxorubicin Nanoparticles To Overcome P-Gp-Mediated Drug Resistance In Solid Tumors, Xiaowei Dong

University of Kentucky Doctoral Dissertations

Multidrug resistance (MDR) is a major obstacle limiting chemotherapeutic efficacy. The purpose of these studies was to investigate the potential application of injectable paclitaxel (PX) and doxorubicin (Dox)-loaded nanoparticles (NPs) engineered from oil-in-water microemulsion precursors for overcoming P-glycoprotein (P-gp)- mediated drug resistance in solid tumors.

An in-vitro study was performed to test whether the oil (stearyl alcohol and cetyl alcohol) used to make lipid nanoparticles could be metabolized. The results showed that the concentrations of the fatty alcohols within nanoparticles, which were quantitatively determined over time by gas chromatography, decreased to only 10-20% of the initial concentration after 15-24 h …

Early Heidegger's Transition From Life To Being, Gilbert Vasile Lepadatu

University of Kentucky Doctoral Dissertations

Heidegger was not always preoccupied, as he himself would later come to believe, with the question regarding the sense of being. Eight years before he published his magnum opus, Sein und Zeit, in 1927 he was totally devoted to finding a systematic way to bringing “life” as the ultimate source of meaning to explicate itself. In the years between 1919-1923, “life”, and not “being”, is the matter of philosophy par excellence, only to be disregarded, even refuted as a “proper” matter of philosophy in the subsequent years. In this paper I examine the philosophical motives that led Heidegger …

Analysis Of Security Measures For Sequences, Ramakanth Kavuluru

University of Kentucky Doctoral Dissertations

Stream ciphers are private key cryptosystems used for security in communication and data transmission systems. Because they are used to encrypt streams of data, it is necessary for stream ciphers to use primitives that are easy to implement and fast to operate. LFSRs and the recently invented FCSRs are two such primitives, which give rise to certain security measures for the cryptographic strength of sequences, which we refer to as complexity measures henceforth following the convention. The linear (resp. N-adic) complexity of a sequence is the length of the shortest LFSR (resp. FCSR) that can generate the sequence. Due …

Pattern Recognition Integrated Sensing Methodologies (Prisms) In Pharmaceutical Process Validation, Remote Sensing And Astrobiology, Thaddaeus S. Hannel

University of Kentucky Doctoral Dissertations

Modern analytical instrumentation is capable of creating enormous and complex volumes of data. Analysis of large data volumes are complicated by lengthy analysis time and high computational demand. Incorporating real-time analysis methods that are computationally efficient are desirable for modern analytical methods to be fully utilized. The use of modern instrumentation in on-line pharmaceutical process validation, remote sensing, and astrobiology applications requires real-time analysis methods that are computationally efficient.

Integrated sensing and processing (ISP) is a method for minimizing the data burden and sensing time of a system. ISP is accomplished through implementation of chemometric calculations in the physics of …

Long-Period Ground Motions In The Upper Mississippi Embayment From Finite-Fault, Finite-Difference Simulations, Kenneth A. Macpherson

University of Kentucky Doctoral Dissertations

A 3D velocity model and 3D wave propagation code have been employed to simulate long-period ground motions in the upper Mississippi embayment. This region is exposed to seismic hazard in the form of large earthquakes in the New Madrid seismic zone and observational data are sparse, making simulation a valuable tool for predicting the effects of large events. These simulations were undertaken in order to estimate ground-motion characteristics and to investigate the influence of the 3D embayment structure and finite-fault mechanics. There are three primary fault zones in the New Madrid seismic zone, each of which was likely associated with …

The Role Of Pragmatic Language Use In Mediating The Relation Between Adhd Symptomatology And Social Skills, Melinda Apel Leonard

University of Kentucky Doctoral Dissertations

The goal of the current study was to investigate the social skills of a community sample of children that would vary in their level of ADHD symptomatology (e.g., inattention and hyperactivity), with a specific focus on their communication patterns and pragmatic language use (PLU). The study explored whether PLU was associated with, and perhaps accounted for, the social skills problems children with different degrees of ADHD symptomatology experience. Pragmatic language use, ADHD symptomatology, and social skills were examined with traditional standardized measures as well as a detailed investigation of communication patterns and PLU obtained from sampling behaviors from a semi-structured …