Digital Commons Network^™

Novel Approaches To Analyze Consumer Behavior And Policies To Promote Sustainable Consumption, Bhagyashree Katare, Xuejian Wang, Shuoli Zhao, Jacqueline Yenerall

Agricultural Economics Faculty Publications

Technological advancements, such as online grocery shopping, have significantly transformed consumer retail environments and experiences. Effectively studying consumer behavior in these new environments requires the use of novel methodological approaches, which will also aid in developing interventions to encourage sustainable consumption. This paper begins by providing an overview of the current literature on novel approaches to analyzing consumer behavior, then provides an empirical application by examining consumer decision-making pathways within an online grocery shopping platform. Specifically, the paper focuses on exploring the consumers’ digital footprints, such as page visits, product additions and removals, and interactions with information labels to identify …

Candidates Be Posting, Josephine Lukito, Maggie Macdonald, Bin Chen, Megan A. Brown, Stephen Prochaska, Yunkang Yang, Jason Greenfield, Jiyoun Suk, Wei Zhong, Ross Dahlke, Porismita Borah

Political Science Faculty Publications

In this multi-platform, comparative study, we analyze social media messages from political candidates (N = 1,517) running for Congress during the 2022 U.S. Midterm election. We collect data from seven social media platforms: Facebook, Twitter, Truth Social, Gettr, Instagram, YouTube, and Rumble over the 4 weeks before and after election day. With this unique dataset of posts, we apply computational methods to identify messages that sought to mobilize individuals (online and offline) to donate money, vote, attend events, engage with the campaign online, and visit the campaign’s content on other platforms. We find that Democrats were not on alt-tech platforms …

The Role Of Race/Ethnicity On The Association Between Neighborhood Deprivation And Breast Cancer Outcomes Among Kentucky Patients With Breast Cancer (2010–2022), Breyanna Walker, Elinita Pollard, Sydney P. Howard, V. Morgan Jones, Kathleen L. O’Connor, Eric B. Durbin, Pamela C. Hull, Samantha R. Jones, Adebola Adegboyega, Xiaoqin Wang, Wendi A.B. Owen, Margaret M. Szabunio, Lovoria B. Williams, Justin X. Moore

Surgery Faculty Publications

Background: Kentucky is within the top five leading states for breast cancer mortality nationwide. This study investigates the association between neighborhood socioeconomic disadvantage and breast cancer outcomes, including surgical treatment, radiotherapy, chemotherapy, and survival, and how associations vary by race and ethnicity in Kentucky. Methods: We conducted a retrospective cohort analysis using data from the Kentucky Cancer Registry for patients with breast cancer diagnosed between 2010 and 2017, with follow-up through December 31, 2022. We linked Kentucky Cancer Registry data with census tract data to examine the relationship between area deprivation index (ADI) and breast cancer outcomes. Logistic regression and …

A Satellite Cell-Dependent Epigenetic Fingerprint In Skeletal Muscle Identity Genes After Lifelong Physical Activity, Kevin A. Murach, Davis A. Englund, Toby L. Chambers, Cory M. Dungan, Hunter L. Porter, Jonathan D. Wren, Willard M. Freeman, Esther E. Dupont-Versteegden, Yuan Wen

Physiology Faculty Publications

Satellite cells comprise a small proportion of mononuclear cells in adult skeletal muscle. Despite their relative rarity, satellite cells have critical functions in muscle adaptation, particularly during prolonged exercise training. The mechanisms by which satellite cells mediate skeletal muscle responsiveness to physical activity throughout the lifespan are still being defined, but epigenetic regulation may play a role. To explore this possibility, we analyzed global DNA methylation patterns in muscle tissue from female mice that engaged in lifelong voluntary unweighted wheel running with or without satellite cells. Satellite cells were ablated in adulthood using the tamoxifen-inducible Pax7-DTA model. Compared to sedentary …

Closing Ceremony Speech, S. Ray Smith

IGC Proceedings (1977-2023)

No abstract provided.

Quantifying Temporal Dynamics Of E. Coli Concentration And Quantitative Microbial Risk Assessment Of Pathogen In A Karst Basin, Shishir K. Sarker, Ryan T. Dapkus, Diana M. Byrne, Alan E. Fryar, Justin M. Hutchison

Earth and Environmental Sciences Faculty Publications

Karst aquifers can be highly productive water sources but are vulnerable to contamination by pathogens because of integrated surface and subsurface drainage. Our study focuses on the karstic Royal Spring basin in Kentucky, encompassing urban and agricultural land uses. The city of Georgetown distributes treated water from Royal Spring to over 33,000 customers. We examined E. coli dynamics at Royal Spring from June 2021 through June 2022, assessing variability under wet versus dry weather conditions. We also used quantitative microbial risk assessment (QMRA) to estimate potential health risks from the pathogenic bacterium E. coli O157:H7. E. coli concentrations in weekly …

Utility Of The Social Skills Improvement System–Rating Scales For Capturing Dynamic Social Constructs, Katherine E. Frye, Christopher J. Anthony, Pui Wa Lei, Kyle D. Husmann, James C. Diperna

Educational, School, and Counseling Psychology Faculty Publications

Social skills are dynamic developmental constructs typically measured using assessments developed via cross-sectional methods. The measurement model of derivatives (MMOD), a factor analytic approach targeting individual growth trajectories, was used to evaluate the longitudinal factor structure of the Social Skills Improvement System—Rating Scales (SSIS-RS) teacher form with a sample of 1320 first and second grade students (51.6% female, 54.8% white, 20.6% Black, 14.4% Hispanic). Although results provided support for three of the original SSIS-RS factors (Assertion, Empathy, Self-Control), there was some evidence that the other four original domains (Cooperation, Responsibility, Engagement, Communication) could be explained by two factors in this …

Exploring Oxylipins In Host–Microbe Interactions And Their Impact On Infection And Immunity, Robert J. Neff, Christopher D. Radka

Markey Cancer Center Faculty Publications

Plasma lipids are essential components of biological systems, transported through interactions with proteins to maintain cellular functions. These lipids exist in various forms, such as fatty acids, glycerolipids, glycerophospholipids, sphingolipids, sterols, and prenol lipids, derived from dietary intake, adipose tissue, and biosynthesis. While the association between certain fatty acids and cardiovascular diseases has been widely recognized, polyunsaturated fatty acids (PUFAs) exhibit cardioprotective effects, reducing risks of arrhythmias and heart-related mortality. This is due to their role in the production of eicosanoids, which modulate inflammation. Chronic inflammation, particularly in obesity, is significantly influenced by fatty acids, with saturated fatty acids promoting …

Crystal Structure And Hirshfeld-Surface Analysis Of The Pesticide Etoxazole, Chaluvarangaiah Sowbhagya, Thaluru M.Mohan Kumar, Hemmige S. Yathirajan, Sean Parkin

Chemistry Faculty Publications

Etoxazole (C21H23F2NO2), systematic name 4-(4-tert-butyl-2-ethoxyphenyl)-2- (2,6-difluorophenyl)-4,5-dihydro-1,3-oxazole, is a fluorinated insecticide and acaricide that inhibits chitin biosynthesis, disrupting insect development by preventing proper exoskeleton formation. Widely used in agriculture since 1998, it is readily absorbed by plant tissues and translocates within leaves. Metabolic studies have identified several oxidative degradation products, while toxicological assessments have examined potential effects, including oxidative stress. This study presents a detailed crystallographic and Hirshfeld surface analysis of etoxazole. The molecule consists of a central dihydro-oxazole ring flanked by 2,6-difluorophenyl and 4-tert-butyl-2-ethoxyphenyl groups, each twisted relative to the oxazole core. The dihydro-oxazole ring is nearly planar, with the …

Panchromatic Absorption Of Unsymmetrical Donor-Acceptor Dyes Based On A Meta-Conjugated 1,3,5-Heteroaryltriazine Core, Jacob G. Rothera, Hi Taing, Menandro Cruz, Anton Dmitrienko, V. Nicholas Vukotic, Sean M. Ryno, Chad Risko, A. Mohan Raj, William G. Skene, S. Holger Eichhorn

Chemistry Faculty Publications

Attachment of three different heterocycles with electron donor or acceptor character to a central 1,3,5-triazine core generates readily soluble side-chain free dyes with two displaying soft crystalline mesomorphism and one displaying a nematic liquid crystal phase as confirmed by polarized optical microscopy, calorimetry, gravimetric analysis, and powder X-ray diffraction. Equally intriguing is the dyes’ relatively strong electronic communication between donor and acceptor subchromophores that are meta-conjugated to one another, which is experimentally observed as a broad intramolecular charge-transfer absorption that can extend over 100 nm past the most intense absorption event and is computationally confirmed through density functional theory (DFT) …

Sowing The Seeds Of Confusion To Reap Content Mastery, Rebecca Mcgrail

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Engaged Pedagogy And The Three C'S: Incorporating Student Emotions Within Institutions Of Higher Education, Kathryn Mattingly Flynn

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Overcoming Students' Resistance To The Flipped Classroom, Koji Tanno

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Pathways To Discover: Exploring Transdisciplinary Learning With Primary Sources, Matthew Strandmark

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Varied Uses Of Class Time: A Case Study Of Epe 301, Zitsi Mirakhur, Spencer Crawford, Wyatt Driskell

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

What In The World Can I Do With This Degree? Showcase Profile Assignment, Sarah Kercsmar

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Groupme In The Classroom, Christopher Huggins

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Meeting Community Need In The Classroom: Creative Collaborations Between Students And Cooperative Extension, Liz Combs, Heather Norman-Burgdolf

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Zines: Radical Tools For Empathy And Introspection, Aanya Chugh

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Conversations By Design: Student Research Using Oral Histories, Jennifer Bartlett, Patrick Lee Lucas

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Current Practices In Rock Scaling, Daryl J. Greer, Kean H. Ashurst Jr

Kentucky Transportation Center Research Report

Rockfalls, which result from the chemical and physical weathering of aging exposed rock cuts, occur frequently along many Kentucky roadways and can endanger travelers. Mitigating rockfalls often requires substantial excavation, procuring additional right of way, and/or hiring specialty contractors. An alternative to these expensive processes is rock scaling, which can be a cost-effective tool for mitigating rockfalls. Rock scaling entails removing loose and unstable rocks from rock cut slopes within the right of way to reduce rockfall risk and is being used with increased frequency by state transportation agencies around the country. The Kentucky Transportation Cabinet (KYTC) has completed several …

Amidst The Frenzy Over Deepseek Ai, Us Federal Science And Tech Policy Is A Mess Of Internal Contradictions, Yujia He

Patterson School of Diplomacy and International Commerce Faculty Publications

The release of the R1 model by the Chinese artificial intelligence (AI) company, DeepSeek, shocked the US tech industry. Yujia He writes that while DeepSeek’s model may not be quite as superior compared to its competitors as originally thought, the Trump administration has responded to its innovations by further pushing for US leadership in AI. Taking a close look at US research and development policy under the second Trump administration, however, shows the significant disconnect between rhetoric and policy. Federal funding freezes and reduced funding for the National Science Foundation could have dire long-term consequences for research and international cooperation …

Gdp-Mannose 4,6-Dehydratase Is A Key Driver Of Mycn- Amplified Neuroblastoma Core Fucosylation And Tumorigenesis, Beibei Zhu, Michelle G. Pitts, Michael D. Buoncristiani, Lindsay T. Bryant, Oscar Lopez-Nunez, Juan P. Gurria, Cameron Shedlock, Roberto Ribas, Shannon Keohane, Jinpeng Liu, Chi Wang, Matthew S. Gentry, Nathan R. Shelman, Derek B. Allison, B. Mark Evers, Ramon C. Sun, Eric J. Rellinger

Markey Cancer Center Faculty Publications

MYCN-amplification is a genetic hallmark of ~40% of high-risk neuroblastomas (NBs). Altered glycosylation is a common feature of adult cancer progression, but little is known about how genetic signatures such as MYCN-amplification alter glycosylation profiles. Herein, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) revealed increased core fucosylated glycan abundance within neuroblast-rich regions of human MYCN-amplified NB tumors. GDP-mannose 4,6-dehydratase (GMDS) is responsible for the first-committed and rate-limiting step of de novo GDP-fucose synthesis. High GMDS expression was found to be associated with poor patient survival, advanced stage disease, and MYCN-amplification in human NB tumors. Chromatin immunoprecipitation and promoter reporter assays …

Comparative Outcomes Following Randomization To A Pilot Facebook-Based Hiv Prevention Intervention Among Appalachian Women Involved In The Criminal Legal System, Megan F. Dickson, Erika Pike, Michele Staton

Journal of Appalachian Health

Introduction: Rural Appalachian women who use drugs and are involved in the criminal legal system are at increased risk for health consequences (such as HIV/Hepatitis C). Service barriers throughout rural communities have prompted a need to examine the effectiveness of novel intervention delivery methods (e.g., social media).

Purpose: This study aims to determine if enhancing an existing HIV prevention intervention with additional modules delivered via Facebook improves service access by examining short-term outcomes among Appalachian women returning to the community following jail release.

Methods: Between 2019 and 2022, consenting women from two rural Appalachian jails were randomly selected, screened, interviewed, …

Clinician Attitudes And Experiences In Screening Patients For Social Determinants Of Health Using Prapare, Pranav Rane, Mathew B. Weimer M.D., Adam Baus

Journal of Appalachian Health

Introduction: Social Determinants of Health (SDOH) are the conditions in which people are born, grow, live, work, and age. SDOH significantly influence health outcomes; as such, healthcare systems should screen for patients’ social needs. PRAPARE is standardized screening tool designed to assess and address patients’ social needs.

Purpose: This study examines SDOH screening at Valley Health Systems, a federally qualified health center based in Huntington, West Virginia. The aim of this research is to assess clinician attitudes and experiences in using the PRAPARE tool to screen for SDOH.

Methods: A self-administered online survey was conducted from April to May 2022 …

Rural Reflections Of Appalachia: A Qualitative Study Of Health Professional Students’ Experiences From A Rural Immersion Experience In West Virginia, Treah Haggerty Md Ms, Jessica Stidham Ma, Stephan Brooks Mph, Abigail Cowher Ba, Sandra Pope Msw, Patricia Dekeseredy Mscn Rn, Cara L. Sedney Md,Ma

Journal of Appalachian Health

Introduction: Conventional academic rotations lack in-depth exposure to rural community members, systems, and resources surrounding specific rural-focused health issues.

Purpose: This study aims to explore health professional students’ experiences within a community-based multidisciplinary rural immersion through their personal reflections.

Methods: Written reflective entries were extracted from the online classroom system from 2019–2021. Data analysis was guided by thematic analysis. An iterative process of qualitatively coding the interviews was conducted. Themes were reviewed and agreed upon by consensus and assessed for validity by two senior researchers.

Results: Sixty-two reflective essays were included from 11 unique professional programs. Resulting themes included (1) …

Powered Haulage Fatalities In Appalachian Coal Mines, Nirmala T. Myers, Noemi B. Hall, Nadia T. Saif, A. Scott Laney

Journal of Appalachian Health

The recent death of a 33-year-old mother of three at a Central Appalachian surface coal mine highlights the persistent dangers faced by miners, particularly from powered haulage incidents. As of December 2, 28 mining fatalities have occurred in the U.S. in 2024, with four in Appalachian coal mines attributed to powered haulage. These deaths underscore the urgent need to address this cause of fatalities in the mining industry and to provide a safe workplace to protect all miners.

Spatiotemporal Variability And Functional Redundancy Obscure Effects Of Urbanization On Strawberry Pollinators, Kyla D. Schulte, Caleb J. Wilson, Anna Tawril, Mary A. Jamieson

Entomology Faculty Publications

Pollination services across rural–urban gradients may vary as land cover and other environmental attributes differentially influence pollinators. Most studies examining crop pollination, however, have been conducted in rural environments, while research in urban areas has lagged behind despite growing interest in urban agriculture. In this study, we hypothesized that increased urbanization would alter pollinator community composition due to a reduction in natural areas within the surrounding landscape, potentially decreasing pollinator abundance. To evaluate this hypothesis, we conducted a three-year study using strawberries as a focal study crop. We characterized the abundance, diversity, and community composition of bees across 10 farms …

A Maturity Model For Clinical Trials Management Ecosystem, Shruti Sehgal, E. Chris Pua, Svetlana Rojevsky, Michael J. Becich, Joshua Fehrmann, Boyd M. Knosp, Adam Wilcox, Jeffery C. Talbert, Catherine K. Craven, Justin Starren

Biostatistics Faculty Publications

Introduction: Managing clinical trials is a complex process requiring careful integration of human, technology, compliance, and operations for success. We collaborated with experts to develop a multi-axial Clinical Trials Management Ecosystem (CTME) maturity model (MM) to help institutions identify best practices for CTME capabilities. Methods: A working group of research informaticists was established. An online session on maturity models was hosted, followed by a review of the candidate domain axes and finalization of the axes. Next, maturity level attributes were defined for min/max levels (level 1 and level 5) for each axis of the CTME MM, followed by the intermediate …

Advancing Workforce Development And Scientific Collaboration, Emily Slade, Claudine T. Jurkovitz, Shari Messinger, Robert A. Oster, Gina Maria Pomann, Sandra L. Taylor, Ann M. Brearley

Biostatistics Faculty Publications

A clinical and translational scientist (CTS) often seeks to increase their knowledge of statistical topics to effectively conduct biomedical research studies. A common method for obtaining this knowledge is through existing online educational materials that are suggested by a biostatistical collaborator or identified by the CTS. However, the volume of available educational materials on diverse statistical topics makes the task of identifying high-quality educational resources at an appropriate level challenging and time consuming for CTSs and collaborative biostatisticians. In response to these challenges, the Biostats4You website was created, where existing online educational materials for a variety of statistical topics are …