Digital Commons Network^™

Lung Cancer Prevention Among Appalachian Kentucky Women, Jessica R. Thompson, Nancy E. Schoenberg, Pamela C. Hull

Anthropology Faculty Publications

Purpose: Appalachian Kentucky (KY) residents experience the highest lung cancer rates in the US with declines lagging among women; we sought to uncover barriers and facilitators to lung cancer prevention for Appalachian KY women and to identify community-specific interventions. Approach: We utilized concept mapping, a participatory mixed method, to generate consensus on perceived barriers and facilitators. Setting/Participants: We recruited 71 adult women from Appalachian KY counties. Method: After collecting online concept mapping data, we used multidimensional scaling to generate a point map of perceived similarities and hierarchical cluster analysis to create a thematic cluster map. We compared average cluster ratings …

Satellite Cells Choreograph An Immune Cell-Fibrogenic Cell Circuit During Mechanical Loading In Geriatric Skeletal Muscle, Nicholas T. Thomas, Camille R. Brightwell, Allison M. Owen, Alexander R. Keeble, Sabin Khadgi, Yuan Wen, Christopher S. Fry, Kevin A. Murach

Physiology Faculty Publications

Muscle stem cells, or satellite cells (SCs), decline in number throughout the lifespan and may become senescent in very old age. Whether and how remaining SCs contribute to muscle adaptation in the oldest-old is unclear. Using acute mechanical overload in geriatric SC replete and depleted mice (28-month-old) combined with single-cell RNA-sequencing, we show: (i) subsets of geriatric SCs display signs of senescence as well as normal fate progression during overload, (ii) SCs express markers that may contribute to the regulation of innervation, (iii) the presence of SCs during overload enhances global intercellular communication and increases mRNA levels of the cell …

“Literally Made Me Cry”: The Impact Of Course Material Costs On University Of Kentucky Students, Stephen Krueger

Library Reports and White Papers

The Student Course Materials Cost Survey was administered September 16 – October 6, 2024. It was open to current students at the University of Kentucky (UK). The goals were to help UK Libraries better understand how the cost of course materials affects students at UK and to provide a snapshot of student spending across the university. The questions were based on similar research done at other institutions in Virginia (Virginia Course Materials Survey, 2021) and Florida (2022 Student Textbook and Instructional Materials Survey, 2022). Other work based on those surveys includes the 2023 Illinois Course Materials Survey (CARLI, 2023) and …

Guidance On Minimum Information Requirements (Mir) From Designing To Reporting Human Biomonitoring (Hbm), Maryam Zare Jeddi, Karen S. Galea, Jillian Ashley-Martin, Julianne Nassif, Tyler Pollock, Devika Poddalgoda, Konstantinos M. Kasiotis, Kyriaki Machera, Holger M. Koch, Marta Esteban López, Ming Kei Chung, Jihyon Kil, Kate Jones, Adrian Covaci, Yu Ait Bamai, Mariana F. Fernandez, Robert Pasanen Kase, Henriqueta Louro, Maria J. Silva, Tiina Santonen, Andromachi Katsonouri, Argelia Castaño, Lesliam Quirós-Alcalá, Elizabeth Ziying Lin, Krystal Pollitt, Ana Virgolino, Paul T.J. Scheepers, Lisa Jo Melnyk

Epidemiology and Environmental Health Faculty Publications

Human biomonitoring (HBM) provides an integrated chemical exposures assessment considering all routes and sources of exposure. The accurate interpretation and comparability of biomarkers of exposure and effect depend on harmonized, quality-assured sampling, processing, and analysis. Currently, the lack of broadly accepted guidance on minimum information required for collecting and reporting HBM data, hinders comparability between studies. Furthermore, it prevents HBM from reaching its full potential as a reliable approach for assessing and managing the risks of human exposure to chemicals. The European Chapter of the International Society of Exposure Science HBM Working Group (ISES Europe HBM working group) has established …

The Effects Of Overexpressing K2p Channels In Various Tissues On Physiology And Behaviors, Alaina C. Taul, Elizabeth R. Elliott, Douglas A. Harrison, Robin L. Cooper

Biology Faculty Publications

Two-pore-domain K⁺ channels (K2p), known previously as leak channels, are responsible for maintaining the resting membrane potential of cells. Fifteen subtypes are known to exist in humans and eleven are known in Drosophila melanogaster, as well as six subfamilies; however, little is known about the expression of these subtypes in various animal tissues or the impact of altered expression on cellular physiology. The Drosophila melanogaster model allows for selective misexpression of certain neuron subsets, providing insight into individual cell types and the animal’s physiology more generally. Prior research on the overexpression of K2p channels and the resulting behavioral and …

Making Sense Of Myc In Skeletal Muscle, Ronald G. Jones, Sebastian Edman, Nathan Serrano, Yuan Wen, John J. Mccarthy, Christopher S. Fry, Ferdinand Von Walden, Kevin A. Murach

Physiology Faculty Publications

No abstract provided.

Proto-Oncogene Hras Transcript Level And Overall Survival In Stages Ii And Iii Colorectal Cancer, Donghyun Kim, Saima Sharif, Juan Antonio Raygoza Garay, Avanish S. Bhakta, Patrick M. Boland, Michael J. Cavnar, Michelle L. Churchman, Hassan Hatoum, Lyen C. Huang, Joseph Kim, Richard Kim, Robert W. Lentz, Sarbajit Mukherjee, Mary T. O'Donnell, Benjamin Quartey, Matthew J. Reilley, Robert J. Rounbehler, Bodour Salhia, Bryan P. Schneider, Carlos H. Chan

Surgery Faculty Publications

Background: Mutational landscape is prognostic in colorectal cancer (CRC). Rat sarcoma (RAS) oncogenes, such as KRAS and NRAS, with driver mutations, portend poor survival outcomes, whereas pathologic mutations in HRAS are extremely rare, and their prognostic value remains uncertain. Methods: This retrospective study analyzed the Oncology Research Information Exchange Network (ORIEN) alliance tumor RNA-Seq data in Stages II and III CRC to investigate the association between RAS gene expression and survival outcomes. Results: High transcript levels of HRAS were associated with superior overall survival (OS). The high HRAS-associated OS benefit was most pronounced in patients with right-sided primary expressing low …

Who Reconstitutes The Chemotherapy? The Educational And Practice Needs Of Oncology Pharmacists In West Africa: A Call For Multidisciplinary Team Approach In Oncology Care., Runcie C.W. Chidebe, Ramatu M. Alabelewe, Krishna Prasad Sapkota, Darlingtina K. Esiaka, Candidus C. Nwakasi, Gloria C. Okwu, Jacinta Emejulu, Adamu A. Umar, Ndifreke Okwuegbunam, Funsho David, Toyosi Adepoju, Agha A. Agha, Ejike S. Ugwu, Simeon C. Aruah, Richard Mshelia, Rob Duncombe, Noel N. Wannang, Peace C. Babalola, R. Donald Harvey, Cindy O'Bryant, Folakemi T. Odedina

Behavioral Science Faculty Publications

PURPOSE: Oncology pharmacists (OPs) play a crucial role in cancer care, treatment, survivorship, and multidisciplinary teams (MDTs). OPs have specialized training in designing, administering, monitoring, and modifying oncology chemotherapy; managing adverse events; and evaluating clinical trials and investigational drugs. Yet, the state of OP has remained largely unknown in the clinical oncology workforce of the West African region. Therefore, this study aimed to understand who reconstitutes chemotherapy and to explain the OP educational and practice needs, challenges, and solutions in Nigeria.

MATERIALS AND METHODS: Using a concurrent embedded mixed method design, 35 OPs completed a questionnaire, and 12 others responded …

Recommended Forages For Ethiopian Environments And Current Strategies For Utilization, A Mengistu

IGC Proceedings (1977-2023)

Ethiopia has great variations in relief with large areas of lowlands below 1.000 m, extensive plateaus at altitudes of 1 500 to 2 000 m and highlands with cultivation extending to about 3 000 m. Rainfall generally increases with altitude and is higher in the western and south central regions. Ethiopian environments can be classified as sub-humid in much of south­central and western zones, semi-arid in the south, the central Rift Valley and the northern highlands, arid in the eastern lowl­ands and humid around Jimma in the south central region. The strong effect of altitude on temperature results in temperate …

Rcpneoperu Trial: A Cluster Randomized Pilot Trial To Assess Traditional Neonatal Resuscitation Compared To Partially Virtual Training In Remote Areas., Carlos A Delgado, Enrique Gómez Pomar, Pablo Velásquez, Víctor Sánchez, Roberto Shimabuku, Luis Huicho

Pediatrics Faculty Publications

OBJECTIVE: To assess the effects of a neonatal resuscitation training program using traditional training and partial distance learning.

METHOD: Through an open cluster-randomized trial, the authors compared a traditional approach involving face-to-face theory and practice sessions using information and communication technology to offer theory and distance examination, followed by face-to-face practice. Twelve health facilities were allocated by blocked randomization. Comparisons were made adjusting for clustering in qualitative and quantitative data. The primary outcome was the percentage of infants with heart rates ≥100 per minute at the second minute after birth. The authors performed a cluster-level analysis for cluster randomized trials, …

Robust Engineered Catalyst For The Conversion Of Brown Grease To Renewable Diesel Via Decarboxylation/Decarbonylation, Great C. Umenweke, Brian Hogston, Olivier Heintz, Gilles Caboche, Robert B. Pace, Eduardo Santillan-Jimenez

Chemistry Faculty Publications

A novel engineered Ni-Cu/Al₂O₃ decarboxylation/decarbonylation catalyst achieved quantitative conversion of brown grease, excellent yield of diesel-like hydrocarbons, effective heteroatom removal, and remarkable resistance to deactivation for hundreds of hours on stream. This offers an industrial alternative to hydrotreating for transforming waste oleaginous feedstocks into renewable diesel and sustainable aviation fuel.

Sisyphus And The Digital Library: Keep Rolling That Boulder Up The Hill (Careful, It's Heavy), Ruth E. Bryan, Sarah Dorpinghaus, Megan M. Mummey

Library Presentations

Oftentimes, archivists and programmers feel like Sisyphus of Greek myth, continually rolling our boulder, the digital library, up the hill of stakeholder expectations. Since 1998, the University of Kentucky Libraries has provided online access to digital and digitized archival content through ExploreUK.uky.edu and other sites. Like many other institutions, UK Libraries has faced technological, organizational, and communication challenges in this endeavor. This presentation explores how UK Libraries responded to these challenges by expanding the decision-making team, after years of unclear responsibility and ownership, to reinvigorate internal interest and investment in the local digital library system and workflows.

Measurement Of Moisture Levels In Oils And Lubricants Using A Novel Moisture Sensor, Aaron Swartz, Ronak Ali

Electrical and Computer Engineering Graduate Research

It is very challenging to measure moisture levels in oils. There is not a good method to measure it. Using the novel moisture sensor invented by Dr. Zhi David Chen, we tried various methods to measure the moisture levels in oils. The initial trials are to immerse the sensor chip into the oils to see any sensor reading changes with the change of moisture levels in oils. It was observed that the sensor reading was unstable even after immersion into the oil for two weeks. The idea for immersion of the sensor chip into the oils failed due to the …

The Rhetoric Of Responsibilization: A Rhetorical Analysis Of Pre-Exposure Prophylaxis Campaigns For Hiv Prevention, Catherine M. Pabalate

Kentucky Undergraduate Journal for the Health Humanities

Responsibilization refers to the process by which patients are made accountable for their health and wellbeing, which is determined by their habits and behaviors. Though responsibilization affords greater agency to patients, it can also result in anxiety and guilt when the patient appears "deviant" or "noncompliant." Because sexual behavior is attributed to the causality of HIV/AIDS, patients’ sexual patterns and choices are included within their medical decision-making. This rhetorical analysis focuses on pharmaceutical campaigns and commercials for pre-exposure prophylaxis (PrEP), which were released between 2012 and 2024 and are targeted towards patients at-risk for HIV/AIDS. Findings suggest that specific rhetorical …

How To Gender Include, Stephen Krueger

Library Faculty and Staff Publications

Gender inclusion is not an optional part of library work—at least, it isn’t if we want all those “Libraries Are For Everyone” signs to be true. And yet, the reality is that many libraries fail the most basic aspects of gender inclusion for patrons, employees, or both. Even in libraries where Trans 101 trainings do occur and are well received, or where the baseline of knowledge among employees is relatively high, the question remains: What now?

This article intends to answer that question. Very broadly speaking, gender inclusion work in libraries means sustained action to ensure that some patrons and …

From Disruption To Recovery: Charter School Performance During And After The Covid-19 Pandemic, Adam Kho, Shelby Smith, Ron Zimmer

Public Policy and Administration Faculty Publications

In recent decades, an increasing number of students have pursued alternative educational options, including charter schools, as school choice has continued to expand. This trend was accelerated by the COVID-19 pandemic. While it is well established that students experienced widespread learning loss during the pandemic, it remains unclear whether the extent of that loss or the pace of recovery has differed between charter and traditional public schools (TPS). In the current study, we examine the effects of Tennessee charter schools on student achievement during and after the pandemic. Using student-level data from 2017-18 to 2022-23, we estimate the charter school …

Development Of A Health And Wellness Assessment For Kytc Personnel, Gabriel Dadi, Farshid Taherpour, Caitlin Pope

Kentucky Transportation Center Research Report

Highway construction workers operate in high-stress, hazardous settings where they have to perform physically taxing labor in environments where exposure to variable weather conditions, heavy equipment, high volumes of vehicle traffic, and other conditions that induce stress and anxiety are the norm. Up to 70% of workers in this industry have reported experiencing mental health issues, including secondary traumatic stress, post-traumatic stress disorder, depression, anxiety, and substance abuse disorders. Few state departments of transportation, however, offer adequate resources staff can draw on to effectively manage their psychological well-being. To help Kentucky Transportation Cabinet (KYTC) roadway maintenance and construction workers develop …

Aggregator Zone Selection For Ev Smart Controls Based-On Ml Clustering Of Grid Strength, Distance, And Charging Homogeneity, Rosemary E. Alden, Sam H. Lowe Ii, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Smart electric vehicle (EV) charging control methods from a central utility hub often require communication infrastructure over a large service area of electric power distribution systems with a large number of nodes. Industry standards such as Open Charge Point Protocol (OCPP) 2.1 have evolved to include topologies for local controllers to the individual chargers, i.e. EV aggregator zones. A machine learning (ML) application of k-means clustering is proposed to establish zones for coordination of EV charging based on grid strength and EV owner decision-making to charge per day. Very large-scale distribution networks including the IEEE 123 and 8500 benchmark feeders …

From Gains To Liver Pain, Benjamin I. Burke, John J. Mccarthy, Ahmed Ismaeel

Physiology Faculty Publications

A recent study from Liu et al. described the role of skeletal muscle-derived extracellular vesicles in promoting liver fibrosis as an outcome of chronic overtraining in mice. Here, we highlight this work and discuss its implications within the fields of exercise physiology and inter-organ communication.

Evaluating Forage Quality As Animal Production Per Unit Of Forage And Land Area, D A. Rohweder, L Miller

IGC Proceedings (1977-2023)

The need to more adequately express feed value in forages and, that will communicate this value among agricultural scien­tists, agri-business clientele and producers has long been recognized world wide. Modern dairy, beef and sheep producers are becoming increasingly concerned about forage quality ; its translation into animal products per unit land area ; and its effect along with forage yield on enterprise profits. The Hay Marketing Task Force-Forage Analysis Subcom­mittee organized by the American Forage and Grassland Council in 1975 proposed hay standards based on in vivo digestible dry matter or energy availability (DDM) and dry matter intake (DMI) predicated …

Enhancing Communication For Individuals With Complex Communication Needs: The Critical Role Of Training And Evidence-Based Aac Strategies, Rachel H. Williams

Early Childhood, Special Education, and Counselor Education Faculty Publications

Communication is a basic human right, as affirmed by the National Joint Committee for the Communication Needs of Persons with Severe Disabilities (NJC, 2024). For individuals with complex communication needs (CCN), special considerations must be taken into account to ensure equitable access to this right and must be supported through appropriate services, tools, and strategies. Augmentative and alternative communication (AAC) systems are essential for many individuals with CCN, enabling access to expressive and receptive language. However, successful AAC implementation requires well-trained educators, speech-language pathologists, and support staff who understand how to assess, model, and support communication effectively (Brady et al., …

Impact Wv: Adapting Patient Navigation Models Of Care To Improve Services To Caregivers Of Infants Exposed To Substances In Utero, Charlotte S. Workman Bsms, Ccrp, Lesley Cottrell, Mawyah Bashatah, Aisha Hashmi, Kayla Richard, Poornima Murthy, Susan Harrison, Ashleigh Mckinsey, Amy Bott, Sydney Leary, Cody Smith, Melina Danko

Journal of Appalachian Health

Patient navigation (PN) is a healthcare service delivery model designed to partner clients with service providers to reduce challenges to health care, as well as to improve access to care by identifying opportunities to coordinate services for clients. The IMPACT WV project at the West Virginia University Center for Excellence in Disabilities (WVU CED) implemented PN models of care for caregivers of infants exposed to substances in utero. The purpose of this program was to reduce burden for potentially at-risk families and improve caregiver and infant outcomes as a result. To understand the processes that influence the implementation of PN …

Patient-Clinician Communication In The Appalachian Region: A Scoping Review, Kawther Al Ksir, Hadii M. Mamudu, Chidiebube J. Ugwu, Emily K. Flores, Tracy Fasolino, Holly Wei, Rick L. Wallace, Florence M. Weierbach

Journal of Appalachian Health

Introduction: Effective communication between patients and clinicians is a critical component of quality health care, influencing disease prevention, management, and outcomes. In regions with unique socioeconomic and geographic challenges, communication barriers can further exacerbate health disparities. Understanding the factors that facilitate or hinder patient-clinician communication is essential for developing targeted interventions that improve health care delivery.

Purpose: This review explores the existing literature on patient-clinician communication concerning cardiovascular disease (CVD) in the Appalachian Region with the aim to understand existing gaps and interventions.

Methods: PubMed and Web of Science databases were utilized to conduct a systematic search. The Population, Concept, …

Determinants Of Willingness To Share Wearable Health Data With Health Care Providers In Appalachian Populations: An Exploratory Study, Gilbert Munoz Cornejo, Joonghee Lee

Journal of Appalachian Health

Background: Wearable health devices capture metrics (e.g., physical activity, ECG, sleep) that can enhance care when shared with providers. Yet, willingness to share wearable data may differ in Appalachia, where chronic disease burdens, mistrust, and limited infrastructure pose unique challenges.

Objective: This study explored (1) which sociodemographic, health, and digital behaviors correlate with willingness to share wearable data and (2) how these insights can guide region-specific interventions in Appalachia.

Methods: We analyzed 320 Appalachian respondents from the Health Information National Trends Survey (HINTS 6). Descriptive statistics and logistic regression models examined willingness to share wearable data. Because of small cell …

Beyond The Legislature’S Website: Strategies And Tools For State Legislative Research That Informs Advocacy Work, Jennifer Horne

Library Faculty and Staff Publications

As the nation’s state legislatures increasingly decide the issues that affect citizens most directly, the ability to identify, track, and understand state legislation is key to successful advocacy efforts. While all state legislative websites provide the status and authoritative text of the bill, this may be insufficient to understand what the bill seeks to do and why the change is being proposed. To find plain English summaries and necessary context and background information on proposed bills, advocates may also need to find appropriate news sources and identify key stakeholders—those who care the most about the bill or are the most …

An Agrin-Yap/Taz Rigidity Sensing Module Drives Egfr-Addicted Lung Tumorigenesis., Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T. K. Boopathy, Aravind Sivakumar, Cheng-Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine Fillmore Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty

Markey Cancer Center Faculty Publications

Despite epidermal growth factor receptor (EGFR) is a pivotal oncogene for several cancers, including lung adenocarcinoma (LUAD), how it senses extracellular matrix (ECM) rigidity remain elusive in the context of the increasing role of tissue rigidity on various hallmarks of cancer development. Here it is shown that EGFR dictates tumorigenic agrin expression in lung cancer cell lines, genetically engineered EGFR-driven mouse models, and human specimens. Agrin expression confers substrate stiffness-dependent oncogenic attributes to EGFR-reliant cancer cells. Mechanistically, agrin mechanoactivates EGFR through epidermal growth factor (EGF)-dependent and independent modes, thereby sensitizing its activity toward localized cancer cell-ECM adherence and bulk rigidity …

Shared Roles Of Immune And Stromal Cells In The Pathogenesis Of Human Bronchiolitis Obliterans Syndrome, Patrick W. Mellors, Ana N. Lange, Bruno Casino Remondo, Maksim Shestov, Joseph D. Planer, Andrew R. Peterson, Yun Ying, Su Zhou, Jason D. Christie, Joshua M. Diamond, Edward Cantu, Maria C. Basil, Saar Gill

Surgery Faculty Publications

Bronchiolitis obliterans syndrome (BOS) is a progressive, fatal obstructive lung disease that occurs following lung transplant, where it is termed chronic lung allograft dysfunction BOS (CLAD-BOS), or as the primary manifestation of pulmonary chronic graft versus host disease (cGVHD-BOS) following allogeneic hematopoietic stem cell transplant. Disease pathogenesis is poorly understood; however, chronic alloreactivity is common to both conditions, suggesting a shared pathophysiology. We performed single-cell RNA-Seq (scRNA-Seq) on explanted human lungs from 4 patients with CLAD-BOS, 3 patients with cGVHD-BOS, and 3 deceased controls to identify cell types, genes, and pathways enriched in BOS to better understand disease mechanisms. In …

Sex Linkage Of Growth And Forage Attributes In Buffalograss (Buchloe Dactyloides), J A. Quinn

IGC Proceedings (1977-2023)

Buchloe dactyloides (Nutt.) Engelm. is a perennial, sod-form­ing shortgrass of central North America (Hitchcock, 1951), thriving under semiarid conditions and increasing under mod­erate to heavy grazing (Quinn, 1987). The species is largely dioecious, and sex ratios are either 1 : 1 or female-biased (Quinn and Engel, 1986). Isolated plants under controlled conditions are strictly male, strictly female, or monoecious (0 to 20 %, depending on the population). Over the last half-century, buffalograss has been widely used in central North America for reseeding depleted rangelands and for erosion control (Quinn, 1985), and recently it has received renewed attention as a turf …

The Integration Of Seed Activities Into An International Pastures Network, J E. Ferguson, R Schaus, A Peralta

IGC Proceedings (1977-2023)

The International Network for Evaluation of Tropical Pastures, known by its spanish acronym RIEPT, was initiated in 1979 for the evaluation germplasm and pastures, the devel­opment of methodology and professional communication in lowland Tropical America (Toledo 1982). Since then the RIEPT has constantly expanded, both in the number of countries and institutions participating, the number of materi­als under evaluation and the range of evaluation sequences. Initially, the major source of seeds was CIAT. By 1985 as the RIEPT expanded, seed availability became a constraint and national research institutions were challenged to develop their own expertise and supply of seeds (Ferguson …

Smart Home Hvac Digital Twin Ml Meta-Model For Electric Power Distribution Systems With Solar Pv And Cta-2045 Controls, Rosemary E. Alden, Evan S. Jones, Steven B. Poore, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Building modeling, specifically heating, ventilation, and air conditioning (HVAC) load and equivalent energy storage calculations, represent a key focus for decarbonization of buildings and smart grid controls. In this paper, an ultra-fast one minute resolution Hybrid Machine Learning Model (HMLM) is proposed as part of a novel contribution in the field of residential physics-based smart home surrogate modeling. Emulation of white box models, or digital twins, with editable parameters through machine learning (ML) meta-modeling serves as an alternative to wide-spread experimental big data collection. The HMLM employs combined k-means clustering with multiple linear regression (MLR) to emulate minutely HVAC power …