Digital Commons Network^™

Using Microhistological Techiques To Predict Botanical Composition Of Horse Diets On Cool‐Season Grass Pasture, Jesse Ira Morrison, S. Ray Smith, Glen E. Aiken

IGC Proceedings (1977-2023)

No abstract provided.

Ecological Pratacultural Construction And Sustainable: Development Strategies In Guizhou, Bentian Mo, Changsong Feng, Xinshi Lu

IGC Proceedings (1977-2023)

No abstract provided.

Repurposing Anti-Inflammasome Nrtis For Improving Insulin Sensitivity And Reducing Type 2 Diabetes Development, Jayakrishna Ambati, Joseph Magagnoli, Hannah Leung, Shao-Bin Wang, Chris A. Andrews, Dongxu Fu, Akshat Pandey, Srabani Sahu, Siddharth Narendran, Shuichiro Hirahara, Shinichi Fukuda, Jian Sun, Lekha Pandya, Meenakshi Ambati, Felipe Pereira, Akhil Varshney, Tammy Cummings, James W. Hardin, Babatunde Edun, Charles L. Bennett, Kameshwari Ambati, Benjamin J. Fowler, Nagaraj Kerur, Christian Röver, Norbert Leitinger, Brian C. Werner, Joshua D. Stein, S. Scott Sutton, Bradley D. Gelfand

Ophthalmology and Visual Science Faculty Publications

Innate immune signaling through the NLRP3 inflammasome is activated by multiple diabetes-related stressors, but whether targeting the inflammasome is beneficial for diabetes is still unclear. Nucleoside reverse-transcriptase inhibitors (NRTI), drugs approved to treat HIV-1 and hepatitis B infections, also block inflammasome activation. Here, we show, by analyzing five health insurance databases, that the adjusted risk of incident diabetes is 33% lower in patients with NRTI exposure among 128,861 patients with HIV-1 or hepatitis B (adjusted hazard ratio for NRTI exposure, 0.673; 95% confidence interval, 0.638 to 0.710; P < 0.0001; 95% prediction interval, 0.618 to 0.734). Meanwhile, an NRTI, lamivudine, improves insulin sensitivity and reduces inflammasome activation in diabetic and insulin resistance-induced human cells, as well as in mice fed with high-fat chow; mechanistically, inflammasome-activating short interspersed nuclear element (SINE) transcripts are elevated, whereas SINE-catabolizing DICER1 is reduced, in diabetic cells and mice. These data suggest the possibility of repurposing an approved class of drugs for prevention of diabetes.

Rna Nanoparticle For Treatment Of Gastric Cancer, Peixuan Guo, Daxiang Cui, Dan Shu, Yi Shu, Chunlei Zhang

Pharmaceutical Sciences Faculty Patents

The presently-disclosed subject matter relates to RNA-based composition and method to treat gastric cancer in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure and composition containing a multiple branched RNA nanoparticle, a gastric cancer targeting module, and an effective amount of a therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanoparticle composition to treat gastric cancer in a subject having or at risk of having gastric cancer.

The Impact Of Feeding Cannabidiol (Cbd) Containing Treats On Canine Response To A Noise-Induced Fear Response Test, Elizabeth M. Morris, Susanna E. Kitts-Morgan, Dawn M. Spangler, Kyle R. Mcleod, Joao H. C. Costa, David L. Harmon

Animal and Food Sciences Faculty Publications

Interest is increasing regarding use of Cannabidiol (CBD) in companion animals due to anecdotal evidence of beneficial behavioral and health effects. The purpose of this investigation was to evaluate the influence of CBD on behavioral responses to fear-inducing stimuli in dogs. Sixteen dogs (18.1 ± 0.2 kg) were utilized in a replicated 4 × 4 Latin square design experiment with treatments arranged in a 2 × 2 factorial, consisting of control, 25 mg CBD, trazodone (100 mg for 10–20 kg BW, 200 mg for 20.1–40 kg BW), and the combination of CBD and trazodone. A fireworks model of noise-induced fear …

Sustainability Assessment Of Animal Production Systems In The (Sub)Tropics: Review And Prospectson Combining Life Cycle Assessment (Lca) With Other Environmental Impact Assessment Methods, Andrea C. Mayer

IGC Proceedings (1977-2023)

No abstract provided.

A Test Of The Key Resource Hypothesis In The Richtersveld, South Africa, Gareth Hempson, Andrew Illius, Howard Hendricks, Susanne Vetter

IGC Proceedings (1977-2023)

No abstract provided.

New Approaches For Coping With Pastoral Risk, M. W. Demment, D. Layne Coppock, R. Kaitho

IGC Proceedings (1977-2023)

No abstract provided.

Fluorometry--An Evolving Methodology For Range Animal Ecologists, Dean M. Anderson, Gary D. Rayson

IGC Proceedings (1977-2023)

No abstract provided.

Natural And Cultural Resources, Qualities Of The Products And Local Development In Rangeland And Grassland Areas In France: Animal Products In The "Pdo System", C. Béranger, J. Bonnemaire

IGC Proceedings (1977-2023)

No abstract provided.

Forage Production Estimate Of Incienso (Flourensiathurifera (Mol.) Dc.), Repanda (Atriplex Repanda Phil.) And Numularia (Atriplex Nummularia Lindl.) According To Shrub Size And Annual Rainfall, P. Azócar, A. Mansilla, D. Troncoso, D. Patón

IGC Proceedings (1977-2023)

No abstract provided.

Rats Genetically Selected For High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin By Upregulation Of Hepatic Biliverdin Reductase-A (Bvra) And Suppression Of Ugt1a1, Terry D. Hinds Jr., Justin F. Creeden, Darren M. Gordon, Adam C. Spegele, Steven L. Britton, Lauren G. Koch, David E. Stec

Pharmacology and Nutritional Sciences Faculty Publications

Exercise in humans and animals increases plasma bilirubin levels, but the mechanism by which this occurs is unknown. In the present study, we utilized rats genetically selected for high capacity running (HCR) and low capacity running (LCR) to determine pathways in the liver that aerobic exercise modifies to control plasma bilirubin. The HCR rats, compared to the LCR, exhibited significantly higher levels of plasma bilirubin and the hepatic enzyme that produces it, biliverdin reductase-A (BVRA). The HCR also had reduced expression of the glucuronyl hepatic enzyme UGT1A1, which lowers plasma bilirubin. Recently, bilirubin has been shown to activate the peroxisome …

Beef Cattle Performance On Panicum Maximum Pastures Under Two Levels Of Fertilization In Brazil, Valéria P. B. Euclides, Manuel C. M. Macedo, Jean Amorim Costa, Wellington Fernandez

IGC Proceedings (1977-2023)

No abstract provided.

Short‐Term Response Of Preferred And Unpreferred Species To Sheep Grazing In A Patagonian Steppe, M. D. Valenta, R. A. Golluscio

IGC Proceedings (1977-2023)

No abstract provided.

Vegetation Response To Grazing Management In A Mediterranean Grassland: A Long‐Term Synthesis, Marcelo Sternberg, Zalmen Henkin, Avi Perevolotsky, Eugene D. Ungar

IGC Proceedings (1977-2023)

No abstract provided.

The Influence Of Tree Thinning On Grass Dry Matter Yield, With And Without Grazing By Herbivore Game Species In The Marakele Park, South Africa, G. N. Smit, F. C. Pienaar

IGC Proceedings (1977-2023)

No abstract provided.

Grazing Disturbance A Benefit To Species Diversity In Re‐Established Native Grass Stands, Michael P. Schellenberg, Alan D. Iwaasa

IGC Proceedings (1977-2023)

No abstract provided.

The Use Of Criteria And Indicator Monitoring Of Ecosystem Sustainability To Assess Ecosystem Services On Grasslands/Rangelands, R. Dennis Child, Janette Kaiser, Ralph Crawford

IGC Proceedings (1977-2023)

No abstract provided.

Applicability Of Criteria And Indicators For Sustainable Grassland Management To Rangelands Of Patagonia (Argentina), Gabriel E. Oliva, Andrés F. Cibils

IGC Proceedings (1977-2023)

No abstract provided.

Indicators Of Sustainability In African Ranglands, Walter J. Lusigi, Leornad Berry

IGC Proceedings (1977-2023)

No abstract provided.

Microglial-Associated Responses To Comorbid Amyloid Pathology And Hyperhomocysteinemia In An Aged Knock-In Mouse Model Of Alzheimer's Disease, David J. Braun, Edgardo R. Dimayuga, Josh M. Morganti, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Elevated blood homocysteine levels, termed hyperhomocysteinemia (HHcy), is a prevalent risk factor for Alzheimer's disease (AD) in elderly populations. While dietary supplementation of B-vitamins is a generally effective method to lower homocysteine levels, there is little if any benefit to cognition. In the context of amyloid pathology, dietary-induced HHcy is known to enhance amyloid deposition and certain inflammatory responses. Little is known, however, about whether there is a more specific effect on microglia resulting from combined amyloid and HHcy pathologies.

METHODS: The present study used a knock-in mouse model of amyloidosis, aged to 12 months, given 8 weeks of …

Experiences With Grazing The New Annual Pasture Legume Biserrula Pelecinus L. In Southern Australia Production Benefits And Risk Of Photosensitisation, Clinton K. Revell, N. Robertson, I. Williams

IGC Proceedings (1977-2023)

No abstract provided.

Grazing Impacts On The Dynamics Of Two Long Lived Perennial Grasses In Tropical Australia, David M. Orr, Peter J. O'Reagain

IGC Proceedings (1977-2023)

No abstract provided.

Testing Non‐Equilibrium Theory: Effects Of Grazing On Plant Community Composition And Soil Nutrient Availability In Dry Southern Mongolian Steppes, Karsten Wesche, Katrin Ronnenberg

IGC Proceedings (1977-2023)

No abstract provided.

The Use Of Faecal Nirs To Monitor Diet Quality Different Grazing Systems In Tropical Savannas, Andrew I. White, L. P. Hunt, S. R. Petty, Dennis P. Poppi

IGC Proceedings (1977-2023)

No abstract provided.

Linear Analysis Method To Calculate The Specific Forage Ingestion By Livestock, Andrea Pardini, V. Pratesi, N. Staglianò

IGC Proceedings (1977-2023)

No abstract provided.

Monitoring Of Inner Mongolian Grassland Using Sustainable Roundtable Indictors, Mengli Zhao, Guodong Han, Mingjun Wang, Xiaoyu Wang, Chunli Li, Zhongwu Wang, Dennis Chlld, Lakhdar Benkobi, Walter D. Willms

IGC Proceedings (1977-2023)

No abstract provided.

Indicators Of Sustainability For Production And Biodiversity Conservation In Australian Rangelands, Margaret H. Friedel, G. N. Bastin, A. K. Smyth

IGC Proceedings (1977-2023)

No abstract provided.

Tonic And Phasic Amperometric Monitoring Of Dopamine Using Microelectrode Arrays In Rat Striatum, Martin Lundblad, David A. Price, Jason J. Burmeister, Jorge E. Quintero, Peter Huettl, Francois Pomerleau, Nancy R. Zahniser, Greg A. Gerhardt

Neuroscience Faculty Publications

Here we report a novel microelectrode array recording approach to measure tonic (resting) and phasic release of dopamine (DA) in DA-rich areas such as the rat striatum and nucleus accumbens. The resulting method is tested in intact central nervous system (CNS) and in animals with extensive loss of the DA pathway using the neurotoxin, 6-hydroxyDA (6-OHDA). The self-referencing amperometric recording method employs Nafion-coated with and without m-phenylenediamine recording sites that through real-time subtraction allow for simultaneous measures of tonic DA levels and transient changes due to depolarization and amphetamine-induced release. The recording method achieves low-level measures of both tonic and …

Neurotropic Lineage Iii Strains Of Listeria Monocytogenes Disseminate To The Brain Without Reaching High Titer In The Blood, Taylor E. Senay, Jessica L. Ferrell, Filip G. Garrett, Taylor M. Albrecht, Jooyoung Cho, Katie L. Alexander, Tanya Myers-Morales, Olivia F. Grothaus, Sarah E. F. D'Orazio

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Listeria monocytogenes is thought to colonize the brain using one of three mechanisms: direct invasion of the blood-brain barrier, transportation across the barrier by infected monocytes, and axonal migration to the brain stem. The first two pathways seem to occur following unrestricted bacterial growth in the blood and thus have been linked to immunocompromise. In contrast, cell-to-cell spread within nerves is thought to be mediated by a particular subset of neurotropic L. monocytogenes strains. In this study, we used a mouse model of foodborne transmission to evaluate the neurotropism of several L. monocytogenes isolates. Two strains preferentially colonized the brain …