Digital Commons Network^™

Microglia Prevent Beta-Amyloid Plaque Formation In The Early Stage Of An Alzheimer's Disease Mouse Model With Suppression Of Glymphatic Clearance, Weixi Feng, Yanli Zhang, Ze Wang, Hanrong Xu, Ting Wu, Charles Marshall, Junying Gao, Ming Xiao

Physical Therapy Faculty Publications

BACKGROUND: Soluble beta-amyloid (Aβ) can be cleared from the brain through various mechanisms including enzymatic degradation, glial cell phagocytosis, transport across the blood-brain barrier, and glymphatic clearance. However, the relative contribution of each clearance system and their compensatory effects in delaying the pathological process of Alzheimer's disease (AD) are currently unknown.

METHODS: Fluorescent trace, immunofluorescence, and Western blot analyses were performed to compare glymphatic clearance ability and Aβ accumulation among 3-month-old APP695/PS1-dE9 transgenic (APP/PS1) mice, wild-type mice, aquaporin 4 knock out (AQP4^−/−) mice, and AQP4^−/−/APP/PS1 mice. The consequence of selectively eliminating microglial cells, or downregulating apolipoprotein …

Diversity And Ethnobotany Of Fodder Plants In The Himalayan Rangelands: A Case Of The Uttarakhand Mountains, India, Vir Singh, R. D. Gaur

IGC Proceedings (1977-2023)

No abstract provided.

A Resource‐Explicit Population Model For The Management Of A Dominant Shrub That Takes Into Account The Ruminants' Feeding Strategy, D. Magda, Cyril Agreil, E. Chambon-Dubreuil, M. Jarry, Michel Meuret

IGC Proceedings (1977-2023)

No abstract provided.

Study On Some Models Exploiting Pasture Industry In The South Of China, Keyun Li, Xiong Li

IGC Proceedings (1977-2023)

No abstract provided.

Pregnant Violence In Post-3.11 Fiction, Doug Slaymaker

Modern and Classical Languages, Literatures and Cultures Faculty Publications

This essay explores the violence and the threat of violence associated with pregnancy in Japanese fiction after the triple disasters—the earthquake, tsunami, and nuclear meltdown—of March 11, 2011. There is hardly a female character in this fiction that is not confronted with questions about pregnancy and childbirth. The queries are surely motivated by genuine concern about the humans involved, but they are just as often about control, about a woman’s body as a public item, about responsibility to the child, and then to society at large. Childbearing in a disaster zone is profoundly anxiety-producing; but it is also worth examining …

Kentucky Traffic Collision Facts 2019, Eric R. Green, Paul A. Ross, Christopher L. Blackden, Michael A. Fields, Kenneth R. Agent

Kentucky Transportation Center Research Report

KENTUCKY’S TRAFFIC COLLISION FACTS report is based on collision reports submitted to the Kentucky State Police Records Branch. As required by Kentucky Revised Statutes 189.635:

“Every law enforcement agency whose officers investigate a vehicle accident of which a report must be made...shall file a report of the accident...within ten days after investigation of the accident upon forms supplied by the bureau.”

The stated purpose of this requirement is to utilize data on traffic collisions for such purposes as will improve the traffic safety program in the Commonwealth.

Environmental Conservation, Jennifer A. Bartlett

Library Faculty and Staff Publications

No abstract provided.

Sod2 Deficiency In Cardiomyocytes Defines Defective Mitochondrial Bioenergetics As A Cause Of Lethal Dilated Cardiomyopathy, Sudha Sharma, Susmita Bhattarai, Hosne Ara, Grace Sun, Daret K. St. Clair, Md Shenuarin Bhuiyan, Christopher Kevil, Megan N. Watts, Paari Dominic, Takahiko Shimizu, Kevin J. Mccarthy, Hong Sun, Manikandan Panchatcharam, Sumitra Miriyala

Toxicology and Cancer Biology Faculty Publications

Electrophilic aldehyde (4-hydroxynonenal; 4-HNE), formed after lipid peroxidation, is a mediator of mitochondrial dysfunction and implicated in both the pathogenesis and the progression of cardiovascular disease. Manganese superoxide dismutase (MnSOD), a nuclear-encoded antioxidant enzyme, catalyzes the dismutation of superoxide radicals (O2^•-) in mitochondria. To study the role of MnSOD in the myocardium, we generated a cardiomyocyte-specific SOD2 (SOD2Δ) deficient mouse strain. Unlike global SOD2 knockout mice, SOD2Δ mice reached adolescence; however, they die at ~4 months of age due to heart failure. Ultrastructural analysis of SOD2Δ hearts revealed altered mitochondrial architecture, with prominent disruption of the …

Nlrp3 Inflammasome Signaling Regulates The Homing And Engraftment Of Hematopoietic Stem Cells (Hspcs) By Enhancing Incorporation Of Cxcr4 Receptor Into Membrane Lipid Rafts, Mateusz Adamiak, Ahmed K. Abdel-Latif, Kamila Bujko, Arjun Thapa, Krzysztof Anusz, Michał Tracz, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak

Internal Medicine Faculty Publications

Fast and efficient homing and engraftment of hematopoietic stem progenitor cells (HSPCs) is crucial for positive clinical outcomes from transplantation. We found that this process depends on activation of the Nlrp3 inflammasome, both in the HSPCs to be transplanted and in the cells in the recipient bone marrow (BM) microenvironment. For the first time we provide evidence that functional deficiency in the Nlrp3 inflammasome in transplanted cells or in the host microenvironment leads to defective homing and engraftment. At the molecular level, functional deficiency of the Nlrp3 inflammasome in HSPCs leads to their defective migration in response to the major …

Current Role Of Laser Interstitial Thermal Therapy In The Treatment Of Intracranial Tumors, Farhan A. Mirza, Rida Mitha, Muhammad Shahzad Shamim

Neurosurgery Faculty Publications

Laser interstitial thermal therapy (LITT) is gaining popularity in the treatment of both primary and secondary intracranial tumors. The goal of LITT is to deliver thermal energy in a predictable, controlled, and minimally invasive fashion. It can be particularly valuable in patients with recurrent tumors who, due to previous radiation or surgery, may have a potentially higher risk of wound breakdown or infection with repeat craniotomy. Deep-seated lesions that are often inaccessible through open approaches (thalamus, hypothalamus, mesial basal temporal lobe, brainstem) may also be suitable targets. The experience and data published thus far on this modality is limited but …

Sward Allowance At Early Lactation Of Primiparous Dairy Cows: Iii-Metabolic Profiles, A. Meikle, D. A. Mattiauda, G. Uriarte, L. Adrien, Pablo Soca, P. Chilibroste

IGC Proceedings (1977-2023)

No abstract provided.

Dynamics Of Seedling Emerging And Survival Rates Of Stipa Baicalensis Steppe: Community Under Two Utilizing Regimes, Mingjiu Wang, Q. F. Li, F. L. Shi, J. L. He

IGC Proceedings (1977-2023)

No abstract provided.

Rangeland, Ecological Integrity And Sustainability: An Analysis In The Himalayan Mountain Context, Vir Singh, Babita Bohra, Manisha Joshi

IGC Proceedings (1977-2023)

No abstract provided.

Benefit Evaluation Of Rangeland Convertion Program (Rcp) In Typical Project Area Of Inner Mongolia, Ying Han, Xiangyang Hou

IGC Proceedings (1977-2023)

No abstract provided.

Importation Of Macrocyclic Lactone Resistant Cyathostomins On A Us Thoroughbred Farm, Martin K. Nielsen, M. Banahan, R. M. Kaplan

Maxwell H. Gluck Equine Research Center Faculty Publications

Anthelmintic resistance in equine cyathostomins is both widespread and highly prevalent in the benzimidazole and tetrahydropyrimidine classes; however, reports of resistance to macrocyclic lactone (ML) drugs are sparse and sporadic. This study reports a case of clear ML resistance in a group of Thoroughbred yearlings imported from Ireland to the US in 2019. Fecal egg count reduction (FECR) following ivermectin administered in February 2020 demonstrated 100% reduction in the US bred yearlings, but 93.5%, 70.5%, and 74.5% reduction in three groups of the imported yearlings. The two former groups were then retreated with ivermectin, yielding FECRs of 33.8% and 23.5%, …

Effect Of Grazing Intensity On Photosynthesis And Soil Respiration Of Alpine Grassland In Tibet, Y. F. Wan, Q. Z. Gao, Y. Li, X. B. Qin, W. Z. Jiancun, B. S. Wang

IGC Proceedings (1977-2023)

No abstract provided.

Relationship Between Different Grassland Types And Their Volatile Patterns To Enhance The Traceability Of Italian Typical Alpine Dairy Products, P. Aceto, S. Belviso, A. Cavallero, L. Falchero, A. Fossi, M. Giordano, R. Paoletti, Efisio Piano, A. Tava, G. Zeppa

IGC Proceedings (1977-2023)

No abstract provided.

Long-Time Effects Of Grazing On Patagonian Rangelands (Argentina), Gabriel E. Oliva, G. Humano, D. Ferrante

IGC Proceedings (1977-2023)

No abstract provided.

Xinjiang Grasslands Ecological Conservation And Herdsman Increase Investigation And Discussion Collecting A Countermeasure, Xuanzheng Guo, Zhiguo Dong, Li Li

IGC Proceedings (1977-2023)

No abstract provided.

Evaluation Of Grassland Resources In Etuoke Front Banner, Ying De, Tegen Ao, Burenjiya

IGC Proceedings (1977-2023)

No abstract provided.

Natural Resource Management: Building The Case For Civic Participation In Managing The Environment, Karen Cosgrove

IGC Proceedings (1977-2023)

No abstract provided.

Detection Of Hydroperoxides Using Chemically-Stimulated Luminescence From Structured Compound Semiconductors, William L. Boatright

Animal and Food Sciences Faculty Patents

A method of monitoring for the presence of a hydroperoxide in an aqueous or non-polar environment includes steps of exposing a structured compound semiconductor material with peroxidase activity to the hydroperoxide in the environment and detecting electromagnetic radiation emitted by the structured compound semiconductor material with peroxidase activity upon exposure to the hydroperoxide. The luminescence emitting semiconductor material with peroxidase activity consists of a primary semiconductor material with a dopant prepared on a phytate scaffold.

The Impact Of Overgrazing On Needlegrass‐Peashrub‐Forbs Community, D. Bolormaa, B. Avaadorj, B. Enkhmaa, Ts. Altanzul

IGC Proceedings (1977-2023)

No abstract provided.

Initial Study On The Construction Of Evaluation Index System Of The Herdsman Rights And Interests Protection--Taking Tianshan Pasture Of Urumqi, Xinjiang As An Example, Ying Ao, Litao Feng, Weifeng Chen

IGC Proceedings (1977-2023)

No abstract provided.

Application Of Nuclear Techniques In Improving Pasture/Range Management, Majid Ajorlo, Ramdzani B. Abdullah

IGC Proceedings (1977-2023)

No abstract provided.

Physical And Hydric Characterization Of A "Red‐Yellow Dystrophic Latossolo" Under Different Tillage System And Grassland Systems, Wellington W. Rocha, Rita De Cássia Ribeiro Carvalho, Bruno Da Silva Pires, Ayeska Hübner Braga Nunes

IGC Proceedings (1977-2023)

No abstract provided.

Tdp-43 Mediated Blood-Brain Barrier Permeability And Leukocyte Infiltration Promote Neurodegeneration In A Low-Grade Systemic Inflammation Mouse Model, Frank Zamudio, Anjanet R. Loon, Shayna Smeltzer, Khawla Benyamine, Nanda K. Navalpur Shanmugam, Nicholas J. F. Stewart, Daniel C. Lee, Kevin Nash, Maj-Linda B. Selenica

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Neuronal cytoplasmic inclusions containing TAR DNA-binding protein 43 (TDP-43) are a neuropathological feature of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's Disease (AD). Emerging evidence also indicates that systemic inflammation may be a contributor to the pathology progression of these neurodegenerative diseases.

METHODS: To investigate the role of systemic inflammation in the progression of neuronal TDP-43 pathology, AAV9 particles driven by the UCHL1 promoter were delivered to the frontal cortex of wild-type aged mice via intracranial injections to overexpress TDP-43 or green fluorescent protein (GFP) in corticospinal motor neurons. Animals were then subjected …

Rho Gtpases: Big Players In Breast Cancer Initiation, Metastasis And Therapeutic Responses, Brock Humphries, Zhishan Wang, Chengfeng Yang

Toxicology and Cancer Biology Faculty Publications

Rho GTPases, a family of the Ras GTPase superfamily, are key regulators of the actin cytoskeleton. They were originally thought to primarily affect cell migration and invasion; however, recent advances in our understanding of the biology and function of Rho GTPases have demonstrated their diverse roles within the cell, including membrane trafficking, gene transcription, migration, invasion, adhesion, survival and growth. As these processes are critically involved in cancer initiation, metastasis and therapeutic responses, it is not surprising that studies have demonstrated important roles of Rho GTPases in cancer. Although the majority of data indicates an oncogenic role of Rho GTPases, …

Neutrophil: A New Player In Metastatic Cancers, Mengyue Wu, Mutian Ma, Zhenya Tan, Hong Zheng, Xia Liu

Toxicology and Cancer Biology Faculty Publications

The interaction between cancer cells and immune cells is important for the cancer development. However, much attention has been given to T cells and macrophages. Being the most abundant leukocytes in the blood, the functions of neutrophils in cancer have been underdetermined. They have long been considered an “audience” in the development of cancer. However, emerging evidence indicate that neutrophils are a heterogeneous population with plasticity, and subpopulation of neutrophils (such as low density neutrophils, polymorphonuclear-myeloid-derived suppressor cells) are actively involved in cancer growth and metastasis. Here, we review the current understanding of the role of neutrophils in cancer development, …

Mesencephalic Astrocyte-Derived Neurotrophic Factor (Manf) Regulates Neurite Outgrowth Through The Activation Of Akt/Mtor And Erk/Mtor Signaling Pathways, Wen Wen, Yongchao Wang, Hui Li, Hong Xu, Mei Xu, Jacqueline A. Frank, Murong Ma, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Neurite outgrowth is essential for brain development and the recovery of brain injury and neurodegenerative diseases. In this study, we examined the role of the neurotrophic factor MANF in regulating neurite outgrowth. We generated MANF knockout (KO) neuro2a (N2a) cell lines using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 and demonstrated that MANF KO N2a cells failed to grow neurites in response to RA stimulation. Using MANF siRNA, this finding was confirmed in human SH-SY5Y neuronal cell line. Nevertheless, MANF overexpression by adenovirus transduction or addition of MANF into culture media facilitated the growth of longer neurites in RA-treated N2a …