Digital Commons Network^™

Spiny Mice (Acomys) Exhibit Attenuated Hallmarks Of Aging And Rapid Cell Turnover After Uv Exposure In The Skin Epidermis, Wesley Wong, Austin Kim, James R. Monaghan, Ashley W. Seifert, Malcolm Maden, Justin D. Crane

Biology Faculty Publications

The study of long-lived and regenerative animal models has revealed diverse protective responses to stressors such as aging and tissue injury. Spiny mice (Acomys) are a unique mammalian model of skin wound regeneration, but their response to other types of physiological skin damage has not been investigated. In this study, we examine how spiny mouse skin responds to acute UVB damage or chronological aging compared to non-regenerative C57Bl/6 mice (M. musculus). We find that, compared to M. musculus, the skin epidermis in A. cahirinus experiences a similar UVB-induced increase in basal cell …

Grassland And Water Resources: Recent Trends And Future Challenges In Temperate Zones, Benoît Marc

IGC Proceedings (1977-2023)

No abstract provided.

Rangeland Management And Hydrology, K. Wood, H. Rubio, C. Wood

IGC Proceedings (1977-2023)

No abstract provided.

Determination Of Intensity And Socio‐Economic Natural Resources Degradation Factors In Iran Territory, Nasser Ansari, S. J. Sayedaghlaghi, M. H. Ghasemi

IGC Proceedings (1977-2023)

No abstract provided.

Combating Acquired Resistance To Mapk Inhibitors In Melanoma By Targeting Abl1/2-Mediated Reactivation Of Mek/Erk/Myc Signaling, Rakshamani Tripathi, Zulong Liu, Aditi Jain, Anastasia Lyon, Christina Meeks, Dana Richards, Jinpeng Liu, Daheng He, Chi Wang, Marika Nespi, Andrey Rymar, Peng Wang, Melissa Wilson, Rina Plattner

Pharmacology and Nutritional Sciences Faculty Publications

Metastatic melanoma remains an incurable disease for many patients due to the limited success of targeted and immunotherapies. BRAF and MEK inhibitors reduce metastatic burden for patients with melanomas harboring BRAF mutations; however, most eventually relapse due to acquired resistance. Here, we demonstrate that ABL1/2 kinase activities and/or expression are potentiated in cell lines and patient samples following resistance, and ABL1/2 drive BRAF and BRAF/MEK inhibitor resistance by inducing reactivation of MEK/ERK/MYC signaling. Silencing/inhibiting ABL1/2 blocks pathway reactivation, and resensitizes resistant cells to BRAF/MEK inhibitors, whereas expression of constitutively active ABL1/2 is sufficient to promote resistance. Significantly, nilotinib (2nd generation …

Comparison Of Native And Non-Native Predator Consumption Rates And Prey Avoidance Behavior In North America And Europe, Ayse Gül Ünlü, John J. Obrycki, Roman Bucher

Entomology Faculty Publications

Novel predator–prey interactions can contribute to the invasion success of non-native predators. For example, native prey can fail to recognize and avoid non-native predators due to a lack of co-evolutionary history and cue dissimilarity with native predators. This might result in a competitive advantage for non-native predators. Numerous lady beetle species were globally redistributed as biological control agents against aphids, resulting in novel predator–prey interactions. Here, we investigated the strength of avoidance behavior of the pea aphid (Acyrthosiphon pisum) toward chemical cues of native lady beetles and non-native Asian Harmonia axyridis and European Coccinella septempunctata and Hippodamia variegata …

Distributed Overgrazing: A Key Cause Of Grassland Degradation In Inner Mongolia, Qian Zhang, Wenjun Li, Yina Xie, Changling Li, Yanbo Li

IGC Proceedings (1977-2023)

No abstract provided.

Fire And Grazing To Improve Wildlife Habitat On Introduced Grass Monocultures In Texas, J. Alfonso Ortega‐S., Luis E. Ramirez, Wendy Austin, Leonard A. Brennan, G. Allen Rasmussen, Caesar Kleberg

IGC Proceedings (1977-2023)

No abstract provided.

Range Rehabiltation Technologies In Uzbekstan, T. Mukimov, A. Hamidov, M. Nasyrov, D. Johnson, Sh. Sindarov

IGC Proceedings (1977-2023)

No abstract provided.

Evaluation Of Fencing Grassland And Stopping Grazing On Grassland Restoration In Inner Mongolia, Shurun Liu

IGC Proceedings (1977-2023)

No abstract provided.

Toward A Century Of Language Attitudes Research: Looking Back And Moving Forward, Marko Dragojevic, Fabio Fasoli, Jennifer Cramer, Tamara Rakić

Communication Faculty Publications

The study of language attitudes is concerned with the social meanings people assign to language and its users. With roots in social psychology nearly a century ago, language attitudes research spans several academic disciplines and draws on diverse methodological approaches. In an attempt to integrate this work and traverse disciplinary boundaries and methodological proclivities, we propose that language attitudes—as a unified field—can be organized into five distinct—yet interdependent and complementary—lines of research: documentation, explanation, development, consequences, and change. After highlighting some of the key findings that have emerged from each area, we discuss several opportunities and challenges for future research.

Reasons Of The Deterioration Of Grassland Eco‐Environment In Inner Mongolia Pasturing Areas, Haishan

IGC Proceedings (1977-2023)

No abstract provided.

Monitoring Cattle Utilization And Behavior In A Mediterranean Oak Woodland, I. Schoenbaum, Zalmen Henkin, A. Brosh, J. Kigel, Eugene D. Ungar, Amit Dolev

IGC Proceedings (1977-2023)

No abstract provided.

Genome-Wide Association Study Of Smoking Trajectory And Meta-Analysis Of Smoking Status In 842,000 Individuals, Ke Xu, Boyang Li, Kathleen A. Mcginnis, Rachel Vickers-Smith, Cecilia Dao, Ning Sun, Rachel L. Kember, Hang Zhou, William C. Becker, Joel Gelernter, Henry R. Kranzler, Hongyu Zhao, Amy C. Justice, Va Million Veteran Program

Epidemiology and Environmental Health Faculty Publications

Here we report a large genome-wide association study (GWAS) for longitudinal smoking phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we identified 18 loci for smoking trajectory of current versus never in European Americans, one locus in African Americans, and one in Hispanic Americans. Functional annotations prioritized several dozen genes where significant loci co-localized with either expression quantitative trait loci or chromatin interactions. The smoking trajectories were genetically correlated with 209 complex traits, for 33 of which smoking was either a causal or a consequential factor. We also performed European-ancestry meta-analyses for smoking status in the MVP …

Oral Microbiome And Gingival Tissue Apoptosis And Autophagy Transcriptomics, Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Elliot Neumann, Luis Orraca, Janis Gonzalez Martinez, Octavio A. Gonzalez

Center for Oral Health Research Faculty Publications

Objective: This study focused on documenting characteristics of the gingival transcriptome during various stages of periodontitis targeting genes associated with apoptotic and autophagic pathways and changes that specifically associate with features of the oral microbiome.

Methods: Macaca mulatta (n = 18; 12–23 years) were examined at baseline and 0.5, 1, and 3 months of disease progression, as well as 5 months with clinical disease resolution. 16S sequencing and microarray analyses examined changes in the microbiome and gingival transcriptome, respectively, at each time point from every animal.

Results: Specific patterns of apoptotic and autophagic genes were identified related to the …

Comparative Analysis Of Intestinal Helminth Infections In Colic And Non-Colic Control Equine Patients, Heidrun Gehlen, Nadine Wulke, Antonia Ertelt, Martin K. Nielsen, Simone Morelli, Donato Traversa, Roswitha Merle, Douglas Wilson, Georg Von Samson-Himmelstjerna

Maxwell H. Gluck Equine Research Center Faculty Publications

All around the world, intestinal helminths constitute one of the most prevalent life-long occurring infections and re-infections affecting all horse age groups. A range of parasite species among strongyles, ascarids, and tapeworms is known to have the potential to cause colic in horses. However, there is a lack of current scientific evidence on the actual relevance of helminth infection levels in the context of colic in horses kept during prevailing epidemiological conditions. Thus, a prospective case-control study on the occurrence of intestinal helminths in a total of 620 mainly adult equine clinic patients was conducted to investigate the association between …

Study On Soil Properties Of Degraded Desert Plain Grassland In North Tianshan Of Xinjiang, Yanmin Fan, Jinzhong Zhu, Caihong Wang

IGC Proceedings (1977-2023)

No abstract provided.

Self Rehabilitation Of Degraded Mongolian Rangeland By Grazing Exclosure, A. Darhiihuu, O. Lkhagvajav, A. Mels, B. Baatar, B. Densambuu, L. Namdag, T. Sainkhuu, Andreas Lüscher, J. Nösberger

IGC Proceedings (1977-2023)

No abstract provided.

Rethinking Overgrazing And Strategies For Its Management In Inner Mongolia, Dalintai Churiya

IGC Proceedings (1977-2023)

No abstract provided.

Grassland Deterioration In The Source Region Of Yangtze‐Yellow Rivers In China And Integrated Control Of Ecological Environment, Quangong Chen, Yulin Mao

IGC Proceedings (1977-2023)

No abstract provided.

Effects Of Housing System On Dairy Heifer Replacement Cost From Birth To Calving: Evaluating Costs Of Confinement, Dry-Lot, And Pasture-Based Systems And Their Impact On Total Rearing Investment, Anna Catherine Hawkins, Kenneth H. Burdine, Donna M. Amaral-Phillips, Joao H. C. Costa

Animal and Food Sciences Faculty Publications

Replacement heifer rearing is critical for the future of dairy operations, to improve genetic merit and maintain herd size. A myriad of options exist on how to manage, feed, and ultimately raise replacement heifers. Pasture is perceived to offer optimal welfare and an economical housing system for replacement animals, but confinement systems are gaining popularity. This study investigates the costs associated with replacement heifer management decisions from birth to calving, considering the factors of housing systems, labor, feed, and health. The objective of this study was to develop an economic model to determine the cost of raising a replacement heifer …

Reclamation Of Saline Soils Through Revegetation In Australia: Plants, Processes And People, E. G. Barrett‐Lennard

IGC Proceedings (1977-2023)

No abstract provided.

Pasture Grass And Fodder Evaluation And Selection For Dry Season Feeding In Nakuru, Kenya, N. Ondabu, R. Kenana, J. Mwangi

IGC Proceedings (1977-2023)

No abstract provided.

The Grazemore Decision Support System To Optimise Utilisation Of Grazed Grass In Dairy Production, Linda Karlsson

IGC Proceedings (1977-2023)

No abstract provided.

Study On Root System Morphology Of Creeping‐Rooted Alfalfa And Related Analysis Of Soil Physical Factor, Jinpeng Zhang

IGC Proceedings (1977-2023)

No abstract provided.

Studying Of The Modis Data Potentials To Assess The Pastureland Production In The Arid Region Of Semirom-Iran, H. Yeganeh, S. J. Khajedin, A. Soffanian, A. Jabarzare

IGC Proceedings (1977-2023)

No abstract provided.

Neuronal Calcium Imaging, Excitability, And Plasticity Changes In The Aldh2-/- Mouse Model Of Sporadic Alzheimer's Disease, Adam O. Ghoweri, Peter Gagolewicz, Hilaree N. Frazier, John C. Gant, R. David Andrew, Brian M. Bennett, Olivier Thibault

Pharmacology and Nutritional Sciences Faculty Publications

BACKGROUND: Dysregulated signaling in neurons and astrocytes participates in pathophysiological alterations seen in the Alzheimer's disease brain, including increases in amyloid-β, hyperphosphorylated tau, inflammation, calcium dysregulation, and oxidative stress. These are often noted prior to the development of behavioral, cognitive, and non-cognitive deficits. However, the extent to which these pathological changes function together or independently is unclear.

OBJECTIVE: Little is known about the temporal relationship between calcium dysregulation and oxidative stress, as some reports suggest that dysregulated calcium promotes increased formation of reactive oxygen species, while others support the opposite. Prior work has quantified several key outcome measures associated with …

Improving Land Productivity And Sustainability By Developing Lucerne And Livestock Production In Huanxian County, Gansu Province, China, Fuzhong Zhang, Guifeng Hou, Tingyu Duan, Shenghua Chang

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of Lambs' Early Weaning On Their Growth Performance And The Pasture's Stocking Rate, Liping Zhang, D. Fang, J. F. Xu, J. P. Wu, Z. M. Lei

IGC Proceedings (1977-2023)

No abstract provided.

Responses Of Vegetative Propagation Of Reaumuria Soongorica To Grazing And Fenced Non‐Grazing, Y. J. Zeng, Yanrong Wang

IGC Proceedings (1977-2023)

No abstract provided.